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179 条记录 (耗时 0.073 秒)

    Methods of alteration of surface affinities using non-chemical force-creating fields
    62.
    发明授权
    Methods of alteration of surface affinities using non-chemical force-creating fields 有权
    使用非化学力创造领域改变表面亲和力的方法

    公开(公告)号：US07659053B2

    公开(公告)日：2010-02-09

    申请号：US11181371

    申请日：2005-07-14

    申请人： Xingyu Jiang ,  Rosaria Ferrigno ,  George M. Whitesides

    发明人： Xingyu Jiang ,  Rosaria Ferrigno ,  George M. Whitesides

    IPC分类号： C12Q1/00 ,  G01N33/53

    CPC分类号： B82Y30/00 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3225 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3274 ,  B01J20/3285 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B05D3/14 ,  B05D3/207 ,  G01N33/54353 ,  G01N2610/00 ,  Y10S436/823 ,  Y10T436/118339

    摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.

    摘要翻译： 本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学， 产生场和/或力，例如电场。 场/力可以通过任何合适的技术来产生。 例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或 从而改变表面的至少一部分的化学成分。 在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。 在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。 在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。 在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使新的测定方法 用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

    Adjustable solubility in sacrificial layers for microfabrication
    64.
    发明申请
    Adjustable solubility in sacrificial layers for microfabrication 有权
    用于微细加工的牺牲层中可调节的溶解度

    公开(公告)号：US20090236310A1

    公开(公告)日：2009-09-24

    申请号：US11918269

    申请日：2006-04-14

    申请人： Vincent Linder ,  Byron Gates ,  Declan Ryan ,  Babak Amirparviz ,  George M. Whitesides

    发明人： Vincent Linder ,  Byron Gates ,  Declan Ryan ,  Babak Amirparviz ,  George M. Whitesides

    IPC分类号： B44C1/22

    CPC分类号： B81C1/00246 ,  B81C2201/0108 ,  B81C2203/0735 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002

    摘要： The present invention provides fabrication methods using sacrificial materials comprising polymers. In some embodiments, the polymer may be treated to alter its solubility with respect to at least one solvent (e.g., aqueous solution) used in the fabrication process. The preparation of the sacrificial materials is rapid and simple, and dissolution of the sacrificial material can be carried out in mild environments. Sacrificial materials of the present invention may be useful for surface micromachining, bulk micromachining, and other microfabrication processes in which a sacrificial layer is employed for producing a selected and corresponding physical structure.

    摘要翻译： 本发明提供了使用包含聚合物的牺牲材料的制造方法。 在一些实施方案中，可以处理聚合物以改变其相对于在制造过程中使用的至少一种溶剂（例如水溶液）的溶解度。 牺牲材料的制备是快速和简单的，牺牲材料的溶解可以在温和的环境中进行。 本发明的牺牲材料可用于表面微加工，体微加工和其它微加工工艺，其中牺牲层用于产生选定的和相应的物理结构。

    Elastomeric mask and use in fabrication of devices
    68.
    发明授权
    Elastomeric mask and use in fabrication of devices 有权
    弹性面膜和用于制造器件

    公开(公告)号：US07282240B1

    公开(公告)日：2007-10-16

    申请号：US09694074

    申请日：2000-10-20

    申请人： Rebecca J. Jackman ,  David C. Duffy ,  George M. Whitesides ,  Kathleen Vaeth ,  Klavs F. Jensen

    发明人： Rebecca J. Jackman ,  David C. Duffy ,  George M. Whitesides ,  Kathleen Vaeth ,  Klavs F. Jensen

    IPC分类号： B05D1/32

    CPC分类号： C23C14/042 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F1/00 ,  G03F7/0002 ,  G03F7/0007 ,  G03F7/12 ,  H01L27/3211 ,  H01L27/3244 ,  H01L27/3281 ,  H01L51/0011 ,  H01L51/56

    摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.

    摘要翻译： 提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。 掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。 然后可以从掩模的表面简单地剥离掩模，留下图案化材料。 描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。 第一沉积步骤，随后通过上掩模的重新定向以暴露不同的一组下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。 通过所述技术提供像素化的有机电致发光器件。