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    Gastrointestinal stimulation device
    1.
    发明授权
    Gastrointestinal stimulation device 有权
    胃肠道刺激装置

    公开(公告)号：US07054690B2

    公开(公告)日：2006-05-30

    申请号：US10691735

    申请日：2003-10-22

    申请人： Mir A. Imran

    发明人： Mir A. Imran

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36007

    摘要： A fixation device for holding stimulating electrodes in electrical contact with the wall of a portion of the gastrointestinal tract is provided. In one embodiment, the fixation device includes an expandable member that fixes the electrodes in electrical contact with the gastrointestinal tract wall. Also provided is an implantable device and method for controlling the opening and/or closing of the pylorus. In particular a device and method is provided for stimulating the duodenum to control the closing/and or opening of the pylorus.Finally, a method is provided for treating obesity by controlling the pylorus to retain food in the stomach for a desired period of time, among other things to provide a feeling of satiety and/or to reduce hunger. One aspect includes controlling the pylorus's contraction by electrical stimulation of the duodenum.

    摘要翻译： 提供了用于保持与胃肠道的一部分的壁电接触的刺激电极的固定装置。 在一个实施例中，固定装置包括固定电极与胃肠道壁电接触的可扩张构件。 还提供了一种用于控制幽门的打开和/或关闭的可植入装置和方法。 特别地，提供了一种用于刺激十二指肠以控制幽门的关闭和/或打开的装置和方法。 最后，提供了一种通过控制幽门以将食物保留在胃中一段期望的时间来提供饱腹感和/或减少饥饿的方法来治疗肥胖症的方法。 一方面包括通过十二指肠的电刺激来控制幽门的收缩。

    Composition as an additive to create clear stable solutions and microemulsions with a combustible liquid fuel to improve combustion
    2.
    发明授权
    Composition as an additive to create clear stable solutions and microemulsions with a combustible liquid fuel to improve combustion 失效
    组合物作为添加剂，用可燃液体燃料产生清晰的稳定溶液和微乳液以改善燃烧

    公开(公告)号：US06884271B2

    公开(公告)日：2005-04-26

    申请号：US10078820

    申请日：2002-02-19

    申请人： Deborah Wenzel

    发明人： Deborah Wenzel

    IPC分类号： C10L1/10 ,  C10L1/12 ,  C10L1/14 ,  C10L1/18 ,  C10L1/182 ,  C10L1/22 ,  C10L1/32 ,  C10L10/02 ,  C10L1/032

    CPC分类号： C10L1/1824 ,  C10L1/10 ,  C10L1/125 ,  C10L1/1266 ,  C10L1/14 ,  C10L1/143 ,  C10L1/1852 ,  C10L1/1881 ,  C10L1/1883 ,  C10L1/1985 ,  C10L1/2222 ,  C10L1/2225 ,  C10L1/2227 ,  C10L1/226 ,  C10L1/328 ,  C10L10/02

    摘要： The present invention relates to an additive composition for a combustible fuel to produce improved combustion and reduced exhaust pollution of the combusted fuel, which additive composition comprises: a) one or more water-soluble alcohols having between 1 and 5 carbon atoms, in an anhydrous state or as a 0.5-36% aqueous solution, and one or more of the following: b) one or more straight- or branched- chain alcohols having between 6-18 carbon atoms; c) one or more ethoxylated alcohols having between 12 and 18 carbon atoms where the ethylene oxide add-on is less than 5 moles; d) a fatty acid of the structure R—(C═O)—OH having from 10 to 24 carbon atoms with e) a source of nitrogen in an anhydrous state or as an aqueous solution; wherein components a) to e), when combined with mixing with said combustible fuel, form a clear, stable microemulsion having a viscosity similar to the liquid fossil fuel. Combustion is improved and pollutant and particulate levels are reduced.

    摘要翻译： 本发明涉及一种用于可燃燃料的添加剂组合物，其用于产生改进的燃烧和减少燃烧的燃料的废气污染，该添加剂组合物包含：a）一种或多种具有1-5个碳原子的水溶性醇，在无水 状态或0.5-36％水溶液，以及一种或多种以下物质：b）一种或多种具有6-18个碳原子的直链或支链醇; c）一种或多种具有12-18个碳原子的乙氧基化醇，其中环氧乙烷加成物小于5摩尔; d）具有10-24个碳原子的结构R-（C-O）-OH的脂肪酸，e）无水状态的氮源或作为水溶液; 其中组分a）至e）当与所述可燃燃料的混合组合时形成具有类似于液体化石燃料的粘度的透明稳定的微乳液。 燃烧得到改善，污染物和颗粒物水平降低。

    Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
    3.
    发明授权
    Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof 有权
    用于治疗关节软骨，骨或软骨缺损和损伤的无细胞基质植入物及其使用方法

    公开(公告)号：US07217294B2

    公开(公告)日：2007-05-15

    申请号：US10882581

    申请日：2004-06-30

    申请人： Akihiko Kusanagi ,  Laurence J. B. Tarrant ,  Mary Beth Schmidt

    发明人： Akihiko Kusanagi ,  Laurence J. B. Tarrant ,  Mary Beth Schmidt

    IPC分类号： A61F2/30

    CPC分类号： A61F2/30756 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61L27/24 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/3654 ,  A61L27/52 ,  A61L27/58 ,  A61L2430/06

    摘要： An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted into an osteochondral or bone defect. A method for repair and restoration of the injured, damaged, diseased or aged cartilage or bone into its full functionality by implanting the acellular matrix implant between two layers of biologically acceptable sealants and/or the bone-inducing composition into the osteochondral bone or skeletal bone defect. A method for fabrication of the acellular matrix implant of the invention. A method for preparation of bone-inducing composition.

    摘要翻译： 一种用于治疗关节软骨，骨或软骨软骨缺损和损伤的无细胞基质植入物，以及使用植入关节软骨病变中的无细胞基质植入物治疗损伤的，损伤的，患病的或老化的关节软骨或骨的方法，以及 植入骨软骨或骨缺损的骨诱导组合物。 通过将无细胞基质植入物植入两层生物学上可接受的密封剂和/或骨诱导组合物进入骨软骨骨或骨骼骨中来修复和恢复损伤的，损伤的，患病的或老化的软骨或骨骼成为其全部功能的方法 缺陷。 本发明的无细胞基质植入物的制造方法。 骨诱导组合物的制备方法。

    Gastric anchor and method
    4.
    发明授权
    Gastric anchor and method 失效
    胃锚和方法

    公开(公告)号：US07016735B2

    公开(公告)日：2006-03-21

    申请号：US10290788

    申请日：2002-11-07

    申请人： Mir A. Imran ,  Oliver K. Colliou ,  Ted W. Layman ,  Deepak R. Gandhi ,  Sharon L. Lake

    发明人： Mir A. Imran ,  Oliver K. Colliou ,  Ted W. Layman ,  Deepak R. Gandhi ,  Sharon L. Lake

    IPC分类号： A61N1/18

    CPC分类号： A61B5/6882 ,  A61B5/4238 ,  A61B17/3421 ,  A61B17/3478 ,  A61B2017/00004 ,  A61B2017/00017 ,  A61B2017/00026 ,  A61B2017/00084 ,  A61B2017/00477 ,  A61B2017/306 ,  A61B2017/3488 ,  A61F5/0003 ,  A61M25/02 ,  A61M2025/0233 ,  A61M2025/028 ,  A61N1/0509 ,  A61N1/0517 ,  A61N1/36007 ,  A61N1/372 ,  G01N27/126 ,  G06F19/00

    摘要： A device, system and method for diagnosing and treating gastric disorders is provided. A functional device resides within the patient's stomach and is secured to the stomach wall by an attachment device. The functional device may be a sensor for sensing various parameters of the stomach or stomach environment, or may be a therapeutic delivery device. The functional device in one embodiment provides a device, system and method for gastric electrical stimulation where stimulating electrodes are secured to the wall of the stomach by the attachment device or otherwise. A preferred device includes: at least one stimulating electrode in electrical contact with the stomach wall; an electronics unit containing the electronic circuitry of the device; and an attachment mechanism for attaching the device to the stomach wall. The functional devices may be programmed to respond to sensed information or signals. An endoscopic delivery system delivers the functional device through the esophagus and into the stomach where it is attached the stomach wall. The endoscopic instruments attach or remove the attachment devices and functional devices from the stomach and may be used to assist in determining the optimal attachment location.

    摘要翻译： 提供了用于诊断和治疗胃疾病的装置，系统和方法。 功能装置位于患者的胃内，并通过附接装置固定到胃壁。 功能装置可以是用于感测胃或胃环境的各种参数的传感器，或者可以是治疗递送装置。 在一个实施例中的功能装置提供了用于胃电刺激的装置，系统和方法，其中刺激电极通过附接装置或其它方式固定到胃壁。 优选的装置包括：与胃壁电接触的至少一个刺激电极; 包含该装置的电子电路的电子单元; 以及用于将装置附接到胃壁的附接机构。 功能设备可以被编程为响应感测的信息或信号。 内窥镜递送系统通过食管将功能装置输送到胃中，在胃附着胃壁。 内窥镜器械将附接装置和功能装置从胃附接或移除，并且可以用于帮助确定最佳的附接位置。

    Electrical device including dielectric layer formed by direct patterning process
    5.
    发明授权
    Electrical device including dielectric layer formed by direct patterning process 失效
    电气设备包括通过直接图案化工艺形成的电介质层

    公开(公告)号：US06946736B2

    公开(公告)日：2005-09-20

    申请号：US10279304

    申请日：2002-10-23

    申请人： Karen K. Gleason ,  Christopher Ober ,  Daniel Herr

    发明人： Karen K. Gleason ,  Christopher Ober ,  Daniel Herr

    IPC分类号： G03F7/16 ,  G03F7/32 ,  G03F7/36 ,  H01L23/12

    CPC分类号： G03F7/32 ,  G03F7/167 ,  G03F7/36

    摘要： Provided is a process for lithographically patterning a material on a substrate comprising the steps of (a) depositing a radiation sensitive material on the substrate by chemical vapor deposition; (b) selectively exposing the radiation sensitive material to radiation to form a pattern; and (c) developing the pattern using a supercritical fluid (SCF) as a developer. Also disclosed is a microstructure formed by the foregoing process. Also disclosed is a process for lithographically patterning a material on a substrate wherein after steps (a) and (b) above, the pattern is developed using a dry plasma etch. Also disclosed is a microstructure comprising a substrate; and a patterned dielectric layer, wherein the patterned dielectric layer comprises at least one two-dimensional feature having a dimensional tolerance more precise than 7%. Also disclosed is a microelectronic structure comprising a substrate; a plurality of transistors formed on the substrate; and a plurality of conductive features formed within a dielectric pattern, wherein the plurality of conductive features include at least one two-dimensional feature having a dimensional tolerance more precise than 7%.

    摘要翻译： 提供了一种用于在衬底上光刻图案化材料的方法，包括以下步骤：（a）通过化学气相沉积在衬底上沉积辐射敏感材料; （b）将辐射敏感材料选择性地暴露于辐射以形成图案; 和（c）使用超临界流体（SCF）作为显影剂显影图案。 还公开了通过上述方法形成的微结构。 还公开了一种用于光刻图案化衬底上的材料的方法，其中在上述步骤（a）和（b）之后，使用干等离子体蚀刻显影图案。 还公开了一种包含基底的微结构; 以及图案化的介电层，其中所述图案化的介电层包括具有比7％更精确的尺寸公差的至少一个二维特征。 还公开了包括基底的微电子结构; 形成在所述基板上的多个晶体管; 以及形成在电介质图案内的多个导电特征，其中所述多个导电特征包括具有比7％更精确的尺寸公差的至少一个二维特征。

    Controlled release ampule containing a fumigant
    6.
    发明授权
    Controlled release ampule containing a fumigant 有权
    含有熏蒸剂的受控释放安瓿

    公开(公告)号：US06913805B2

    公开(公告)日：2005-07-05

    申请号：US10190085

    申请日：2002-07-03

    申请人： William W. Harlowe, Jr. ,  William A. McMahon ,  Donald J. Mangold ,  Bruce Bernstein

    发明人： William W. Harlowe, Jr. ,  William A. McMahon ,  Donald J. Mangold ,  Bruce Bernstein

    IPC分类号： G09B19/00 ,  A01M13/00

    CPC分类号： G09B19/00 ,  B27K3/02 ,  B27K3/0257 ,  Y10S424/08 ,  Y10S424/11 ,  Y10T428/1352

    摘要： The present invention provides an apparatus and method for controlled release of a fumigant into a wooden structure to prevent decay of that structure. According to the present invention, a fumigant in an ampule or container is inserted into the wooden structure. The ampule or container is made of a polymeric material that does not react with the fumigant, but having walls which are permeable to the fumigant such that, when inserted into the wooden structure, the rate of release of the fumigant through the walls of the ampule is slow enough to continuously treat and arrest decay of the wooden structure, particularly decay caused by fungi, over extended periods of time (i.e., 1, 5, 7, 10, 15, 20 or 30 years). The rate of release of the fumigant can be controlled by the type of fumigant, the shape of the container, the specific polymer used to make the container, and by the thickness of the container wall.

    摘要翻译： 本发明提供了一种用于将熏蒸剂控制释放到木结构中以防止该结构腐烂的装置和方法。 根据本发明，将安瓿或容器中的熏蒸剂插入木结构体中。 安瓿或容器由不与熏蒸剂反应的聚合材料制成，但是具有对熏蒸剂可渗透的壁，使得当插入木结构体中时，熏蒸剂通过安瓿壁的释放速率 足够慢，持续治疗和停止木结构的衰变，特别是由真菌引起的腐烂延长的时间（即1,5,7,10,15,20或30年）。 熏蒸剂的释放速度可以通过熏蒸剂的类型，容器的形状，用于制造容器的特定聚合物以及容器壁的厚度来控制。

    Bioluminescence regenerative cycle (BRC) for nucleic acid quantification
    7.
    发明授权
    Bioluminescence regenerative cycle (BRC) for nucleic acid quantification 有权

    公开(公告)号：US07141370B2

    公开(公告)日：2006-11-28

    申请号：US10186455

    申请日：2002-06-28

    申请人： Arjang Hassibi ,  Nader Pourmand

    发明人： Arjang Hassibi ,  Nader Pourmand

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6825 ,  C12Q1/689 ,  C12Q2565/301 ,  C12Q2545/114 ,  C12Q2531/113

    摘要： The present invention concerns methods of quantifying nucleic acids using a bioluminescence regenerative cycle (BRC). In BRC, steady state levels of bioluminescence result from processes that produce pyrophosphate. Pyrophosphate reacts with APS in the presence of ATP sulfurylase to produce ATP. The ATP reacts with luciferin in a luciferase-catalyzed reaction, producing light and regenerating pyrophosphate. The pyrophosphate is recycled to produce ATP and the regenerative cycle continues. Because the kinetic properties of ATP sulfurylase are much faster than luciferase, a steady state results wherein concentrations of ATP and pyrophosphate and the rate of light production remain relatively constant. Photons are counted over a time interval to determine the number of target molecules present in the initial sample. The BRC process has a controllable dynamic range up to seven orders of magnitude and is sensitive enough to detect a few thousand molecules of target nucleic acid.