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公开(公告)号：US20180016304A1
公开(公告)日：2018-01-18
申请号：US15549874
申请日：2016-03-03
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte A. E. Hauser , Michael R. Reithofer , Yihua Loo
CPC classification number: C07K11/00 , A61K47/34 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2400/06 , A61L2430/34 , G01N2800/7095
Abstract: The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these depsipeptides in formulating hydrogels, co-gels or co-hydrogels, and pharmaceutical compositions or biomedical device or surgical implants or kits comprising these depsipeptides for various therapeutic applications such as regenerative medicine, tissue regeneration and tissue re-placement.
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公开(公告)号：US09120841B2
公开(公告)日：2015-09-01
申请号：US13731525
申请日：2012-12-31
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo
IPC: A61K31/74 , A61K47/48 , A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02 , A61K38/08 , A61K38/07 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/06 , C07K7/06 , C07K5/08 , C07K5/10 , A61K9/06 , C07K5/103 , C07K5/083 , A61K47/42 , A61L27/22 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/14 , A61L31/16 , A61L15/32 , A61L15/44 , A61L15/60 , A61K9/00 , A61K9/70
CPC classification number: C07K7/06 , A61K9/0019 , A61K9/06 , A61K9/7023 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/42 , A61L15/32 , A61L15/44 , A61L15/60 , A61L27/22 , A61L27/52 , A61L27/54 , A61L31/043 , A61L31/145 , A61L31/16 , A61L2300/25 , A61L2400/06 , C07K5/08 , C07K5/0808 , C07K5/10 , C07K5/101 , C07K7/00
Abstract: The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid.
Abstract translation: 本发明提供两亲性线性肽和/或拟肽以及包含两亲性线性肽/拟肽的水凝胶。
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公开(公告)号：US10449257B2
公开(公告)日：2019-10-22
申请号：US14356116
申请日：2012-11-05
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo , Andrew C. A. Wan , Michael Reithofer
IPC: A61K47/36 , A61K31/7088 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/19 , A61K47/18 , A61L26/00 , A61L27/26 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/54 , C08L5/00 , C08L5/04 , C08L5/08 , C08L5/10 , C08L5/16 , C08L71/02 , C08L89/00 , C12N5/00 , C12N15/113
Abstract: The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
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Patent Agency Ranking
公开(公告)号：US20140349933A1
公开(公告)日：2014-11-27
申请号：US14356116
申请日：2012-11-05
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo , Andrew C.A. Wan , Michael Reithofer
IPC: A61K47/36 , A61K38/18 , C12N5/00 , A61K31/7088 , A61K47/48 , A61K47/18 , C12N15/113
CPC classification number: A61K47/36 , A61K31/7088 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/1825 , A61K38/19 , A61K47/183 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L26/0095 , A61L27/26 , A61L27/3834 , A61L27/48 , A61L27/52 , A61L27/54 , C08L5/00 , C08L5/04 , C08L5/08 , C08L5/10 , C08L5/16 , C08L71/02 , C08L89/00 , C12N5/0068 , C12N15/113 , C12N2310/11 , C12N2320/32 , C12N2533/30 , C12N2533/50 , C12N2533/72
Abstract: The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
Abstract translation: 本发明涉及包含至少一种非肽聚合物和至少一种具有以下通式的肽的复合水凝胶：Z-（X）m-（Y）n-Z'p，其中Z是N-末端保护基 ; X在每次出现时独立地选自脂族氨基酸，脂族氨基酸衍生物和甘氨酸; Y在每次出现时独立地选自极性氨基酸和极性氨基酸衍生物; Z'是C端保护基; m是选自2至6的整数; n选自1或2; 本发明还涉及生产复合水凝胶的方法，使用复合水凝胶来递送药物和其它生物活性剂/部分，作为促进组织再生的植入物或可注射剂 ，以及作为伤口愈合的局部剂。 本发明还涉及包含复合水凝胶的装置和药物或化妆品组合物以及复合水凝胶的医疗用途。
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公开(公告)号：US20140093473A1
公开(公告)日：2014-04-03
申请号：US13731525
申请日：2012-12-31
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo
CPC classification number: C07K7/06 , A61K9/0019 , A61K9/06 , A61K9/7023 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/42 , A61L15/32 , A61L15/44 , A61L15/60 , A61L27/22 , A61L27/52 , A61L27/54 , A61L31/043 , A61L31/145 , A61L31/16 , A61L2300/25 , A61L2400/06 , C07K5/08 , C07K5/0808 , C07K5/10 , C07K5/101 , C07K7/00
Abstract: The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid.
Abstract translation: 本发明提供两亲性线性肽和/或拟肽以及包含两亲性线性肽/拟肽的水凝胶。
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公开(公告)号：US20220127565A1
公开(公告)日：2022-04-28
申请号：US17429132
申请日：2020-02-07
Applicant: Agency for Science, Technology and Research
Inventor： Yihua Loo , Chwee Aun Andrew Wan , Chih Urn Benjamin Tai
IPC: C12N5/0735 , C07K11/00
Abstract: There is provided a self-assembly amphiphilic peptide having the formula (I): XYZ (I), wherein X is a polar moiety at the N-terminus; X and Z each independently has between 1 to 4 residues of aliphatic amino acids or analogs or derivatives thereof, and wherein the average degree of hydrophobicity of the residues in block Z is more than the average degree of hydrophobicity of the residues in block Y. Disclosed are compositions and hydrogel comprising the peptide thereof. Also disclosed are methods of treatment for tissue regeneration, wound healing and methods of culture of stem cells, tissues and organoids.
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公开(公告)号：US10179194B2
公开(公告)日：2019-01-15
申请号：US15039952
申请日：2014-12-01
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte Hauser , Yihua Loo
IPC: A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61L27/52 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/062 , C07K5/083 , C07K5/103 , C07K7/06 , A61L27/38 , A61L27/50 , A61L27/54 , B33Y10/00
Abstract: The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydrogels and to methods for preparing continuous fibres and to methods for obtaining multi-cellular constructs with defined, precise geometrics. The present invention further relates to various uses of such hydrogels for obtaining mini-hydrogel arrays and 3D organoid structures or 3D macromolecular biological constructs.
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8.发明申请NOVEL ULTRASHORT HYDROPHOBIC PEPTIDES THAT SELF-ASSEMBLE INTO NANOFIBROUS HYDROGELS AND THEIR USES 审中-公开自组装成NANOFIBROUS HYDROGELS及其用途的新型超声波疏水性肽公开(公告)号：US20170002041A1
公开(公告)日：2017-01-05
申请号：US15039922
申请日：2014-11-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Charlotte Hauser , Yihua Loo
CPC classification number: C07K7/06 , A61K38/00 , A61L26/0047 , A61L26/008 , A61L27/227 , A61L27/38 , A61L27/52 , A61L31/047 , A61L31/145 , A61L2400/06 , A61L2400/12 , A61L2430/34 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/101 , C12N5/0062 , C12N5/0068 , C12N2533/50
Abstract: The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerative medicine, injectable therapies, delivery of bioactive moieties, wound healing, 2D and 3D synthetic cell culture substrate, biosensor development, biofunctionalized surfaces, and biofabrication.
Abstract translation: 本发明涉及能够形成（纳米纤维）水凝胶的疏水肽和/或肽模拟物和包含所述疏水性肽和/或肽模拟物的水凝胶以及各种用途，例如再生医学，可注射治疗，递送生物活性部分，伤口愈合 2D和3D合成细胞培养基质，生物传感器开发，生物功能化表面和生物制造。
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