-
公开(公告)号：US06727361B2
公开(公告)日：2004-04-27
申请号：US09993031
申请日：2001-11-06
IPC分类号： C07F958
CPC分类号： C07D213/74 , B01J2219/00722 , C07B2200/11 , C07D213/38 , C07D213/61 , C07D213/68 , C07F7/00 , C07F7/003 , C07F9/58 , C08F4/65908 , C08F4/65912 , C08F10/00 , C08F110/06 , C08F210/02 , C08F210/16 , C40B40/14 , C08F4/659 , C08F4/65904 , C08F2500/15 , C08F2500/02 , C08F210/10 , C08F212/08 , C08F210/14 , C08F4/64144 , C08F4/64113 , C08F4/64044
摘要： New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions.
摘要翻译： 公开了新配体，组合物，金属 - 配体络合物和具有吡啶基 - 胺配体的阵列，其催化单体聚合成聚合物。 这些具有铪金属中心的这些催化剂中的某些具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，异丁烯或苯乙烯。 某些催化剂在各种聚合条件下在溶液过程中将丙烯聚合成高分子量全同立构聚丙烯是特别有效的。
-
2.发明授权Silicone composition which can be crosslinked into an elastomer by hydrosilylation in the presence of carbene-based metal catalysts, and catalysts of this type 有权可以在卡宾系金属催化剂存在下通过氢化硅烷化反应交联成弹性体的有机硅组合物和这种催化剂公开(公告)号：US07563741B2
公开(公告)日：2009-07-21
申请号：US10515319
申请日：2003-05-23
申请人： Oliver Brummer , Eric D. Carlson , Thomas Crevier , Yves Giraud , Anne-Marie La Pointe , Sébastien Sterin
发明人： Oliver Brummer , Eric D. Carlson , Thomas Crevier , Yves Giraud , Anne-Marie La Pointe , Sébastien Sterin
摘要： This invention relates to silicone compositions which can be crosslinked, preferably into elastomers, by hydrosilylation of at least one PolyOrganoSiloxane -A- carrying unsaturated bonds, using at least one polyorganohydrosiloxane —B— in the presence of a carbene-based metal catalyst —C— as defined in the description and which optionally comprises at least one inhibitor -D- of the hydrosilylation reaction.
摘要翻译： 本发明涉及可通过使用至少一种聚有机氢硅氧烷-B-在卡宾基金属催化剂-C-的存在下，通过至少一种携带不饱和键的至少一种聚有机硅氧烷-A的氢化硅烷化来交联，优选为弹性体的硅氧烷组合物。 如说明书中所定义，并且任选地包含氢化硅烷化反应的至少一种抑制剂-D-。
-
公开(公告)号：US06738529B1
公开(公告)日：2004-05-18
申请号：US09415772
申请日：1999-10-08
IPC分类号： G06K936
CPC分类号： G01N35/085 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00335 , B01J2219/00337 , B01J2219/00344 , B01J2219/00351 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00452 , B01J2219/00495 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00691 , B01J2219/00702 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C07F15/0066 , C07F15/045 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , G01J4/00 , G01N15/0205 , G01N21/253 , G01N21/64 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , G01N33/44 , G01N2015/0288 , G01N2015/0294 , G01N2291/106 , Y10T436/112499 , Y10T436/113332 , Y10T436/115831
摘要： Computer programs and computer-implemented methods are disclosed for extracting and analyzing combinatorial chemical data from images. The invention receives a stream of data, identifies a plurality of regions of interest and determines a series of values for one or more regions of interest. The library includes a plurality of members. The data stream includes a series of images of the library. Each region of interest corresponds to a location in each of the images and to a location in the library. The series of values for each region includes a value for each of the images. Particular embodiments have the following features. The invention calculates a figure of merit for a library member from each series of values. The stream of data comprises a series of images generated at a frequency of greater than about 1, 6, 12 or 30 frames per second. The series of images is captured from a beginning of a combinatorial experiment to an end of a commercial experiment. The regions of interest are identified after the series of images has been captured. The images are infrared images. The figure of merit is an emittance change, a phase transition point or a thermoelectric figure of merit for a library member. Regions of interest are identified by a user and have a user-defined shape. The series of values for each region is determined based on a user-defined computation. A graphical representation of the figures of merit is displayed.
摘要翻译： 公开了用于从图像中提取和分析组合化学数据的计算机程序和计算机实现的方法。 本发明接收数据流，识别多个感兴趣区域并确定一个或多个感兴趣区域的一系列值。 图书馆包括多个成员。 数据流包括图书馆的一系列图像。 每个感兴趣区域对应于每个图像中的位置和库中的位置。 每个区域的一系列值包括每个图像的值。 具体实施例具有以下特征。 本发明根据每一系列值计算库成员的品质因数。 数据流包括以大于每秒大约1,6,12或30帧的频率生成的一系列图像。 从组合实验的开始到商业实验的结束捕获一系列图像。 在捕获一系列图像之后识别感兴趣的区域。 图像是红外图像。 品质因数是库成员的发射变化，相变点或热电优值。 感兴趣区域由用户识别并具有用户定义的形状。 基于用户定义的计算来确定每个区域的一系列值。 显示品质因数的图形表示。
-
公开(公告)号：US20060173150A1
公开(公告)日：2006-08-03
申请号：US10515319
申请日：2003-05-23
申请人： Oliver Brummer , Eric Carlson , Thomas Crevier , Yves Giraud , Anne-Marie La Pointe , Sebastien Sterin
发明人： Oliver Brummer , Eric Carlson , Thomas Crevier , Yves Giraud , Anne-Marie La Pointe , Sebastien Sterin
摘要： This invention relates to silicone compositions which can be crosslinked, preferably into elastomers, by hydrosilylation of at least one PolyOrganoSiloxane -A- carrying unsaturated bonds, using at least one polyorganohydrosiloxane —B— in the presence of a carbene-based metal catalyst —C— as defined in the description and which optionally comprises at least one inhibitor -D- of the hydrosilylation reaction.
-
公开(公告)号：US07076115B2
公开(公告)日：2006-07-11
申请号：US10803115
申请日：2004-03-16
IPC分类号： G06K9/36
CPC分类号： G01N35/085 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00335 , B01J2219/00337 , B01J2219/00344 , B01J2219/00351 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00452 , B01J2219/00495 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00691 , B01J2219/00702 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C07F15/0066 , C07F15/045 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , G01J4/00 , G01N15/0205 , G01N21/253 , G01N21/64 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , G01N33/44 , G01N2015/0288 , G01N2015/0294 , G01N2291/106 , Y10T436/112499 , Y10T436/113332 , Y10T436/115831
摘要： Computer programs and computer-implemented methods implement techniques for evaluating experimental data from a library of materials. The techniques receive a plurality of images of a library of materials that includes an array of members associated with locations in the library. User input identifying a plurality of regions of interest is received. A series of reduced data values is determined for one or more of the regions of interest as a statistical function of a plurality of pixel values for pixels in the corresponding regions. A figure of merit is calculated from one or more of the series of reduced data values for a library member at the corresponding library location. The regions of interest include a plurality of pixels in the images and correspond to locations in the library.
摘要翻译： 计算机程序和计算机实现的方法实施用于从材料库评估实验数据的技术。 这些技术接收包括与库中的位置相关联的成员阵列的材料库的多个图像。 接收识别感兴趣区域的用户输入。 为一个或多个感兴趣区域确定一系列缩减数据值作为对应区域中的像素的多个像素值的统计函数。 从相应库位置的库成员的一系列缩减数据值中计算一个品质因数。 感兴趣的区域包括图像中的多个像素并且对应于库中的位置。
-
6.发明申请Apparatuses and methods for creating and testing pre-formulations and systems for same 审中-公开用于创建和测试预配制和相同系统的设备和方法公开(公告)号：US20070077657A1
公开(公告)日：2007-04-05
申请号：US11389621
申请日：2006-03-24
申请人： Eric Carlson , Peijun Cong , William Chandler , Henry Chau , Earl Danielson , Peter Desrosiers , Robert Doolen , Luping Wu , C. Ramberg , Thomas Crevier , Ralph Nielsen , Colin Masui , John Varni
发明人： Eric Carlson , Peijun Cong , William Chandler , Henry Chau , Earl Danielson , Peter Desrosiers , Robert Doolen , Luping Wu , C. Ramberg , Thomas Crevier , Ralph Nielsen , Colin Masui , John Varni
IPC分类号： G01N31/00
CPC分类号： B01L3/50255 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00315 , B01J2219/00335 , B01J2219/00364 , B01J2219/00373 , B01J2219/00423 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L7/00 , B01L2300/0829 , B01L2300/185 , C40B40/04 , C40B40/10 , C40B60/10 , C40B60/14 , G01N5/045 , G01N21/23 , G01N21/65 , G01N25/04 , G01N33/15 , G01N33/54366 , G01N35/028 , G01N2013/006 , G01N2021/651 , G01N2500/00 , G16C20/20 , G16C20/90 , Y10T117/10
摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
摘要翻译： 本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。 另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。 可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。
-
7.发明授权Catalyst ligands, catalyst compositions, catalyst metal complexes and processes for cross-coupling aromatic boron compounds with aromatic halogens or perfluoroalkylsulfonates 有权催化剂配体，催化剂组合物，催化剂金属络合物和芳香族硼化合物与芳族卤素或全氟烷基磺酸盐交叉偶联的方法
公开(公告)号：US6124476A
公开(公告)日：2000-09-26
申请号：US252182
申请日：1999-02-18
申请人： Anil Guram , Xiaohong Bei , Timothy S. Powers , Bernd Jandeleit , Thomas Crevier
发明人： Anil Guram , Xiaohong Bei , Timothy S. Powers , Bernd Jandeleit , Thomas Crevier
IPC分类号： B01J31/24 , C07B61/00 , C07C209/10 , C07C211/48 , C07D295/023 , C07D295/073 , C07F9/50 , C07F9/655 , C07F15/00 , C07D321/00 , C07D307/02 , C07F9/02
CPC分类号： C07F9/65515 , B01J31/2247 , B01J31/2404 , B01J31/2447 , C07C209/10 , C07D295/023 , C07D295/073 , C07F15/0066 , C07F9/5018 , C07F9/5022 , B01J2231/4211 , B01J2531/821 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/84
摘要： The present invention discloses new organic compounds (e.g., ligands), their metal complexes and compositions using those compounds. The invention also relates to the field of catalysis. In particular, this invention relates to new compounds which when combined with suitable metals or metal precursor compounds provide useful catalysts for various bond-forming reactions, including Suzuki cross-coupling reactions. The invention also relates to performing Suzuki cross coupling reactions with unreactive aryl-chlorides.
摘要翻译： 本发明公开了新的有机化合物（例如配体），它们的金属络合物和使用这些化合物的组合物。 本发明还涉及催化领域。 特别地，本发明涉及当与合适的金属或金属前体化合物组合时提供用于各种形成结合反应（包括Suzuki交叉偶联反应）的有用催化剂的新化合物。 本发明还涉及用非反应性芳基氯化物进行Suzuki交叉偶联反应。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.028 秒)
