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1.发明授权Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster 有权与FK-520聚酮化合物基因簇内的fkbA基因相关的分离的核酸公开(公告)号：US06503737B1
公开(公告)日：2003-01-07
申请号：US09410551
申请日：1999-10-01
Applicant: Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
Inventor： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC: C12P1962
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。
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公开(公告)号：USRE39762E1
公开(公告)日：2007-08-07
申请号：US11299244
申请日：2005-12-09
Applicant: Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
Inventor： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC: C07D515/00 , C07D498/00
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.
Abstract translation: 具有式但不包括FK-506，FK-520,18-羟基-FK520和18-羟基-FK-506的聚酮化合物。
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3.发明授权Polynucleotides encoding the fkbA gene of the FK-520 polyketide synthase gene cluster 有权编码FK-520聚酮化合物基因簇的fkbA基因的多核苷酸公开(公告)号：US06759536B2
公开(公告)日：2004-07-06
申请号：US09940316
申请日：2001-08-27
Applicant: Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
Inventor： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC: C07D22118
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。
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公开(公告)号：US06660862B2
公开(公告)日：2003-12-09
申请号：US09825621
申请日：2001-04-03
Applicant: Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
Inventor： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC: C07D51500
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Polyketide compounds of the formula but not including FK-506, FK-520, 18-hydroxy-FK520 and 18-hydroxy-FK-506.
Abstract translation: 具有式但不包括FK-506，FK-520,18-羟基-FK520和18-羟基-FK-506的聚酮化合物。
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5.发明授权Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster 有权编码FK-520聚酮化合物基因簇的fkbB基因的多核苷酸公开(公告)号：US07714118B2
公开(公告)日：2010-05-11
申请号：US10885305
申请日：2004-07-06
Applicant: Christopher Reeves , Kai Wu
Inventor： Christopher Reeves , Kai Wu
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。
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Patent Agency Ranking
6.发明申请Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster 有权编码FK-520聚酮化合物基因簇的fkbB基因的多核苷酸公开(公告)号：US20090186378A1
公开(公告)日：2009-07-23
申请号：US10885305
申请日：2004-07-06
Applicant: Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
Inventor： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
CPC classification number: C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。
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公开(公告)号：US09695472B2
公开(公告)日：2017-07-04
申请号：US12950729
申请日：2010-11-19
IPC: C12Q1/68 , B82Y30/00 , B01L3/00 , G01N27/414
CPC classification number: C12Q1/6874 , B01J2219/00317 , B01J2219/00511 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00641 , B01J2219/00722 , B01L3/5085 , B82Y30/00 , C12Q1/6825 , G01N27/414 , C12Q2565/301 , C12Q2533/101 , C12Q2521/101 , C12Q2565/607 , C12Q2525/125 , C12Q2521/319
Abstract: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing electronic sensors to monitor changes in solutions contained in the reaction regions. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.
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公开(公告)号：US08795523B2
公开(公告)日：2014-08-05
申请号：US13430171
申请日：2012-03-26
Applicant: Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
Inventor： Xing Su , David J. Liu , Kai Wu , Kenneth B. Swartz , Mineo Yamakawa
IPC: H05K13/04 , G01N33/53 , G01N33/553
CPC classification number: G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。
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公开(公告)号：US08563240B2
公开(公告)日：2013-10-22
申请号：US12319168
申请日：2008-12-31
Applicant: Xing Su , Kai Wu , David J. Liu
Inventor： Xing Su , Kai Wu , David J. Liu
CPC classification number: C12Q1/6874 , C12Q1/6837 , C12Q2565/607 , C12Q2565/518 , C12Q2525/117 , C12Q2537/149 , C12Q2525/113 , C12Q2521/319
Abstract: Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction regions containing sensors to monitor changes in solutions or bound molecules contained in the reaction regions. Additional embodiments provide devices and methods for sequencing DNA using arrays of reaction regions that allow for optical monitoring of solutions in the reaction regions. Chemical amplification schemes that allow DNA to be sequenced in which multiple nucleotide addition reactions are performed to detect the incorporation of a base are disclosed. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.
Abstract translation: 本发明的实施方案提供了使用包含传感器的反应区域的阵列来测序DNA的装置方法，以监测反应区域中包含的溶液或结合分子的变化。 另外的实施方案提供了使用允许对反应区域中的溶液进行光学监测的反应区域阵列来测序DNA的装置和方法。 公开了允许进行多核苷酸加成反应进行DNA测序以检测碱基掺入的化学扩增方案。 通过使用大阵列中包含的平行反应测序DNA，可以快速测序DNA。
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公开(公告)号：US08158008B2
公开(公告)日：2012-04-17
申请号：US13197918
申请日：2011-08-04
Applicant: Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
Inventor： Xing Su , David J. Liu , Kenneth B. Swartz , Kai Wu , Mineo Yamakawa
IPC: G01N1/00 , G01N21/00 , G01N33/48 , G01N33/53 , G01N33/553
CPC classification number: G01N1/4044 , B01L3/502761 , B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0424 , B01L2400/043 , B01L2400/0638 , B01L2400/086 , G01N35/0098 , G01N35/08 , G01N2015/0038 , G01N2015/0092 , H01F7/20 , H01F7/206 , H01F2007/068 , Y10S436/805 , Y10S436/806 , Y10T29/49117 , Y10T29/4913 , Y10T29/49155 , Y10T436/25
Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括样品区，清洁区和检测区。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。
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