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    Microelectrode, microelectrode array and method for manufacturing the microelectrode
    1.
    发明授权
    Microelectrode, microelectrode array and method for manufacturing the microelectrode 有权
    微电极，微电极阵列及微电极制造方法

    公开(公告)号：US06896780B2

    公开(公告)日：2005-05-24

    申请号：US10020774

    申请日：2001-12-11

    申请人： Hae Sik Yang ,  Chi Hoon Jun ,  Chang Auck Choi ,  Youn Tae Kim

    发明人： Hae Sik Yang ,  Chi Hoon Jun ,  Chang Auck Choi ,  Youn Tae Kim

    IPC分类号： B81B7/04 ,  B01J19/00 ,  G01N27/403 ,  G01N27/28 ,  G01N27/327

    CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00853 ,  B01J2219/00873 ,  G01N27/403

    摘要： The present invention relates to a microelectrode, a microelectrode array, and a method of manufacturing the microelectrode of which temperature can be controlled. The microelectrode comprises a sealed cavity formed in a silicon substrate for thermal isolation, a microheater formed on the sealed cavity, and an electrode heated indirectly by the microheater. According to the present invention, it is possible to manufacture with CMOS process the microelectrode and the microelectrode array which have excellent electric insulation and thermal isolation between a microheater and a silicon substrate, which has a small power consumption, which has high heating and cooling speed and which has no corrosion.

    摘要翻译： 本发明涉及一种微电极，微电极阵列，以及可以控制温度的微电极的制造方法。 微电极包括形成在用于热隔离的硅衬底中的密封空腔，形成在密封空腔上的微加热器和由微加热器间接加热的电极。 根据本发明，可以通过CMOS工艺制造微电极和微电极阵列，其在微加热器和硅基板之间具有优异的电绝缘和热隔离，其功耗小，具有高的加热和冷却速度 没有腐蚀。

    Sensor structure and method of fabricating the same
    3.
    发明授权
    Sensor structure and method of fabricating the same 有权
    传感器结构及其制造方法

    公开(公告)号：US07824618B2

    公开(公告)日：2010-11-02

    申请号：US10913422

    申请日：2004-08-09

    申请人： Yong Shin Kim ,  Yun Tae Kim ,  Hae Sik Yang ,  Young Jun Kim ,  Seung Chul Ha ,  Yoon Seok Yang

    发明人： Yong Shin Kim ,  Yun Tae Kim ,  Hae Sik Yang ,  Young Jun Kim ,  Seung Chul Ha ,  Yoon Seok Yang

    IPC分类号： G01N27/00

    CPC分类号： G01N27/126

    摘要： Provided is a sensor structure comprising a heater and a temperature sensor at the center of a membrane having a well structure, allowing a temperature to be rapidly controlled with low power, and the object is analyzed using a conductivity change measured at two or more substrate temperatures with a pair of detecting electrode and a detecting layer implemented on the heater, wherein the sensing layer can include a conductive particle and a non-conductive organic composite.

    摘要翻译： 提供了一种传感器结构，其包括加热器和在具有井结构的膜的中心处的温度传感器，允许以低功率快速控制温度，并且使用在两个或更多个基板温度下测量的电导率变化来分析物体 具有一对检测电极和在加热器上实施的检测层，其中感测层可以包括导电颗粒和非导电有机复合材料。

    Method for performing multiplex PCR with cyclic changes of PCR parameters
    6.
    发明授权
    Method for performing multiplex PCR with cyclic changes of PCR parameters 失效
    用PCR参数循环变化进行多重PCR的方法

    公开(公告)号：US07183056B2

    公开(公告)日：2007-02-27

    申请号：US10697295

    申请日：2003-10-31

    申请人： Se Ho Park ,  Hae Sik Yang ,  Dae Sik Lee ,  Yong Beom Shin ,  Kyu Won Kim ,  Tae Hwan Yoon ,  Sung Jin Kim ,  Yun Tae Kim

    发明人： Se Ho Park ,  Hae Sik Yang ,  Dae Sik Lee ,  Yong Beom Shin ,  Kyu Won Kim ,  Tae Hwan Yoon ,  Sung Jin Kim ,  Yun Tae Kim

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/686 ,  C12Q2537/143 ,  C12Q2527/113 ,  C12Q2527/101

    摘要： The present invention is directed to an improved multiplex PCR method for obtaining at least two PCR products from one PCR solution. In the multiplex PCR method for having at least two DNA amplified products from a sample positioned in a PCR equipment, the object of the present invention is to provide a novel multiplex PCR method characterized in that a primer annealing temperature and an extension time be changed per cycle with constant periods. When a multiplex PCR is performed in accordance with the present invention, limitations in determining PCR conditions due to a various sizes of PCR products or dimers caused by primers can be eliminated, and time and efforts required for determining the PCR conditions to various samples can also be reduced. Further, not only refined DNAs like cDNA, genomic DNA, vector, etc, but blood can be directly used as a multiplex PCR sample, and PCR amplification reaction can be performed even with a sample having the smallest amounts.

    摘要翻译： 本发明涉及一种用于从一种PCR溶液获得至少两种PCR产物的改进的多重PCR方法。 本发明的目的是提供一种新的多重PCR方法，其特征在于，引物退火温度和延长时间根据 周期不变的周期。 当根据本发明进行多重PCR时，可以消除由于由引物引起的各种大小的PCR产物或二聚体导致的PCR条件的限制的限制，并且确定各种样品的PCR条件所需的时间和努力也可以 减少 此外，不仅可以将cDNA，基因组DNA，载体等精制DNA与血液直接用作多重PCR样品，即使使用量少的样品也能进行PCR扩增反应。

    Nanocatalyst-based biosensor
    7.
    发明申请
    Nanocatalyst-based biosensor 审中-公开
    基于纳米催化剂的生物传感器

    公开(公告)号：US20080102517A1

    公开(公告)日：2008-05-01

    申请号：US11708390

    申请日：2007-02-20

    申请人： Hae Sik Yang ,  Jagotamoy Das

    发明人： Hae Sik Yang ,  Jagotamoy Das

    IPC分类号： C12M1/34

    CPC分类号： C12Q1/26 ,  C12Q1/001

    摘要： Disclosed is a biosensor for electrochemically detecting the presence of an analyte and measuring its concentration. In the biosensor, an organic substance as a substrate is reduced to a substance having an amine group by the catalysis of a nanocatalyst label with a plurality of active sites in the presence of a reducing agent, the reduction is continuously carried out to amplify the substance having an amine group, and the amount of the substance having an amine group is measured by taking advantage of the fact that the substance having an amine group exhibits different electrochemical, chromatic or fluorescent properties from those of the substrate, so that the concentration of a biomarker is measured with high sensitivity within a short time. The electrochemical biosensor allows simple measurement of an analyte and has a low detection limit.

    摘要翻译： 公开了用于电化学检测分析物的存在并测量其浓度的生物传感器。 在生物传感器中，作为底物的有机物质通过在还原剂的存在下通过催化具有多个活性位点的纳米催化剂标记物而还原成具有胺基的物质，连续进行还原以扩增物质 具有胺基，具有胺基的物质的量通过利用具有胺基的物质与基底的物质具有不同的电化学，色度或荧光特性的事实来测量，使得 生物标志物在短时间内以高灵敏度测量。 电化学生物传感器允许分析物的简单测量并具有低检测限。