公开(公告)号：US20060121612A1

公开(公告)日：2006-06-08

申请号：US10531520

申请日：2003-10-16

申请人： Hideji Tajima ,  Yoshiro Okami

发明人： Hideji Tajima ,  Yoshiro Okami

IPC分类号： C12N15/87 ,  C12M3/00

CPC分类号： C12N15/64 ,  C12M35/02 ,  C12N13/00 ,  C12N15/87 ,  C12N15/895 ,  Y10T428/2982

摘要： The invention relates to an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material with the object of providing an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material whereby a biological material can be efficiently introduced into a host. The invention comprises: one or more packing units in which a mixture solution containing a large number of magnetic supports carrying a biological material to be introduced into a host such as cells upon using, together with a large number of the hosts in a liquid is pooled; and an introduction treatment unit in which a magnetic force affecting the inside of the packing unit is controlled so as to move the magnetic supports relatively with respect to the host so that the biological material can be introduced into the host.

公开(公告)号：US07071006B2

公开(公告)日：2006-07-04

申请号：US10042373

申请日：2001-12-27

申请人： Hideji Tajima ,  Yoshiro Okami

发明人： Hideji Tajima ,  Yoshiro Okami

IPC分类号： G01N33/553

CPC分类号： C12M33/04 ,  G01N33/54313 ,  G01N33/5434 ,  G01N35/0098 ,  G01N2446/10 ,  Y10S436/80 ,  Y10S436/808 ,  Y10S436/819 ,  Y10S436/822 ,  Y10S436/828 ,  Y10T428/2982

摘要： Carriers hold remote-acting bodies which can be manipulated by a remote force, and also hold a micro-substance which is a target substance of an assay. The remote-acting bodies are manipulated in order to control the positions of the micro-substances, so as to execute assays for various target substances efficiently, at low cost, easily, and reliably. Various aspects of interest include the carriers which hold the micro-substances, a system suspending the carriers, an apparatus for manipulating the carriers, and a method of controlling the position of the carriers.

摘要翻译： 携带者具有可以由远程力量操纵的远程作用体，并且还保持作为测定的目标物质的微物质。 为了控制微量物质的位置，操纵远程作用体，以低成本，容易且可靠地有效地进行各种目标物质的测定。 感兴趣的各个方面包括保持微量物质的载体，悬挂载体的系统，用于操纵载体的装置以及控制载体位置的方法。

公开(公告)号：US08580544B2

公开(公告)日：2013-11-12

申请号：US10531520

申请日：2003-10-16

申请人： Hideji Tajima ,  Yoshiro Okami

发明人： Hideji Tajima ,  Yoshiro Okami

IPC分类号： C12N13/00 ,  C12N15/74

CPC分类号： C12N15/64 ,  C12M35/02 ,  C12N13/00 ,  C12N15/87 ,  C12N15/895 ,  Y10T428/2982

摘要： The invention relates to an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material with the object of providing an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material whereby a biological material can be efficiently introduced into a host.The invention comprises: one or more packing units in which a mixture solution containing a large number of magnetic supports carrying a biological material to be introduced into a host such as cells upon using, together with a large number of the hosts in a liquid is pooled; and an introduction treatment unit in which a magnetic force affecting the inside of the packing unit is controlled so as to move the magnetic supports relatively with respect to the host so that the biological material can be introduced into the host.

摘要翻译： 本发明涉及一种用于引入生物材料的装置，引入生物材料的方法和用于引入生物材料的磁性载体，其目的是提供用于引入生物材料的装置，引入生物材料的方法， 以及用于引入生物材料的磁性载体，由此可以将生物材料有效地引入主体。 本发明包括：一个或多个填充单元，其中将含有大量磁性载体的混合溶液与大量主体在液体中一起被收集，所述混合溶液在使用时携带携带待引入主体如细胞的生物材料的混合溶液 ; 以及引导处理单元，其中控制影响包装单元内部的磁力，以相对于主机移动磁性支架，使得生物材料可以被引入到主机中。

公开(公告)号：US09453229B2

公开(公告)日：2016-09-27

申请号：US14050272

申请日：2013-10-09

申请人： UNIVERSAL BIO RESEARCH CO. LTD. ,  Yoshiro Okami

发明人： Hideji Tajima ,  Yoshiro Okami

IPC分类号： C12N13/00 ,  C12M1/00 ,  B01L1/00 ,  C12N15/64 ,  C12M1/42 ,  C12N15/87 ,  C12N15/89

CPC分类号： C12N15/64 ,  C12M35/02 ,  C12N13/00 ,  C12N15/87 ,  C12N15/895 ,  Y10T428/2982

摘要： The invention relates to an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material with the object of providing an apparatus for introducing a biological material, a method of introducing a biological material, and a magnetic support for introducing a biological material whereby a biological material can be efficiently introduced into a host.The invention comprises: one or more packing units in which a mixture solution containing a large number of magnetic supports carrying a biological material to be introduced into a host such as cells upon using, together with a large number of the hosts in a liquid is pooled; and an introduction treatment unit in which a magnetic force affecting the inside of the packing unit is controlled so as to move the magnetic supports relatively with respect to the host so that the biological material can be introduced into the host.

摘要翻译： 本发明包括：一个或多个填充单元，其中将含有大量磁性载体的混合溶液与大量主体在液体中一起被收集，所述混合溶液在使用时携带携带待引入主体如细胞的生物材料的混合溶液 ; 以及引导处理单元，其中控制影响包装单元内部的磁力，以相对于主机移动磁性支架，使得生物材料可以被引入到主机中。

公开(公告)号：US09316615B2

公开(公告)日：2016-04-19

申请号：US13805382

申请日：2011-06-22

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N27/447 ,  G01N33/553 ,  G01N1/02 ,  G01N35/00

CPC分类号： G01N27/447 ,  G01N1/02 ,  G01N27/44739 ,  G01N33/553 ,  G01N35/0098

摘要： The disclosed device for trapping biologically-relevant substances can easily collect biologically-relevant substances from a thin tissue section or a gel in which said biologically-relevant substance have been fractionated. Said device is provided with: trapping bodies for trapping biologically-relevant substances; carriers that hold the trapping bodies; and electrodes for charging the trapping bodies. The trapping bodies are charged and brought into contact with a prescribed position on a thin tissue section that contains biologically-relevant substances or a gel in which biologically-relevant substances have been fractionated, thereby trapping said biologically-relevant substances from said gel or thin tissue section.

摘要翻译： 所公开的用于捕获生物相关物质的装置可以容易地从薄组织切片或凝胶中收集生物相关物质，其中所述生物相关物质已被分馏。 所述装置设有：用于捕获生物相关物质的捕集体; 持有捕集体的载体; 以及用于对捕获体充电的电极。 捕获体被带电并与包含生物相关物质或其中生物相关物质已经分馏的凝胶的薄组织部分上的规定位置接触，从而从所述凝胶或薄组织捕获所述生物相关物质 部分。

公开(公告)号：US09260744B2

公开(公告)日：2016-02-16

申请号：US11991506

申请日：2006-09-01

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N21/64 ,  G01N33/545 ,  C12Q1/68 ,  G01N30/60 ,  B01L3/02 ,  G01N33/543 ,  G01N35/10 ,  G01N35/00 ,  B01L3/00

CPC分类号： C12Q1/6804 ,  B01J2219/00292 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01L3/0275 ,  B01L3/502 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0838 ,  B01L2300/1827 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/6073 ,  G01N33/54313 ,  G01N35/10 ,  G01N2035/00564 ,  G01N2035/00574 ,  G01N2035/1055 ,  Y10T436/11

摘要： An object of the present invention is to provide a various-substance holder including a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured. The various-substance holder is configured so that each of the plurality of particulate carriers or at least one of the particulate carriers belonging to the plural sets of the particulate carriers are labeled according to types of the chemical substances or for each of the particulate carriers or each set of the particulate carriers so as to be mutually identifiable before the particulate carriers are introduced and held in the carrier holding portion.

摘要翻译： 本发明的目的是提供一种各种物质保持器，其包括多个颗粒载体或多组颗粒载体，多种化学物质可固定或固定在其上，载体保持部分保持多个颗粒载体或 多组微粒载体处于基本静止的状态，从而能够外部测量多个颗粒载体或多组颗粒载体。 各种物质保持器被构造成使得属于多组颗粒载体的多个颗粒载体或至少一个颗粒载体的每一个根据化学物质的类型或每个颗粒载体或 每一组颗粒载体在颗粒载体被引入并保持在载体保持部分之前是可相互辨别的。

公开(公告)号：US09182395B2

公开(公告)日：2015-11-10

申请号：US13132041

申请日：2009-12-25

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： C12M1/00 ,  C12Q1/68 ,  C12M1/34 ,  C12M3/00 ,  G01N15/06 ,  G01N21/64 ,  G01N33/52 ,  G01N33/00 ,  G01N33/543 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N33/54386 ,  B01L3/508 ,  B01L3/52 ,  B01L2200/10 ,  B01L2300/0636 ,  C12Q1/6804 ,  G01N33/54326 ,  G01N33/54393 ,  G01N35/026 ,  G01N35/1009 ,  Y10T436/143333 ,  Y10T436/25125 ,  C12Q2563/143

摘要： This invention relates to an assay device and a method for pretreating a specimen containing a biologically-relevant substance and then assaying the biologically-relevant substance. Biologically-relevant substances used in the assay method include microorganisms, cells, viruses, nucleic acids, polysaccharides, proteins (including antigens, antibodies, chromoproteins, and enzymes), peptides, nucleic acids, and small molecules. This pretreatment method removes contaminants from the biologically-relevant substances using supports such as magnetic particles, gels, resins, membranes, and solid-phased reagents. Therefore, in the assay method the following steps are generally carried out (i) a pretreatment step of treating a specimen using one or more first supports and then one or more second supports, and (ii) the assay step carried out after the pretreatment step. In particular, the pretreatment method reduces false positives and false negatives in the assay.

摘要翻译： 本发明涉及一种用于预处理含有生物相关物质并然后测定生物相关物质的试样的测定装置和方法。 用于测定方法的生物相关物质包括微生物，细胞，病毒，核酸，多糖，蛋白质（包括抗原，抗体，色蛋白和酶），肽，核酸和小分子。 这种预处理方法使用诸如磁性颗粒，凝胶，树脂，膜和固相试剂的载体从生物相关物质中除去污染物。 因此，在测定方法中，通常进行以下步骤：（i）使用一种或多种第一载体然后一种或多种第二载体处理样品的预处理步骤，和（ii）在预处理步骤之后进行的测定步骤 。 特别地，预处理方法减少了测定中的假阳性和假阴性。

公开(公告)号：US08828331B2

公开(公告)日：2014-09-09

申请号：US13484358

申请日：2012-05-31

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N33/00 ,  G01N1/24 ,  C12M1/16 ,  G01N30/60 ,  B01L3/02 ,  C12Q1/68 ,  G01N33/543 ,  G01N35/10 ,  G01N35/00 ,  B01L3/00

CPC分类号： C12Q1/6804 ,  B01J2219/00292 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/005 ,  B01J2219/0052 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01L3/0275 ,  B01L3/502 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0838 ,  B01L2300/1827 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/6073 ,  G01N33/54313 ,  G01N35/10 ,  G01N2035/00564 ,  G01N2035/00574 ,  G01N2035/1055 ,  Y10T436/11

摘要： A various-substance holder, a various-substance holder treating apparatus, and a various-substance holder treating method are provided which enable the mutual identification of particulate carriers to which various substances are or can be immobilized without the need to arrange the particulate carriers at predetermined positions or in a predetermined order, eliminating the need for time and effort to arrange the various substances at predetermined positions or in a predetermined order to allow treatments to be quickly and easily achieved. The various-substance holder has a plurality of particulate carriers or plural sets of particulate carriers to which plural types of chemical substances are or can be immobilized and a carrier holding portion holding the plurality of particulate carriers or the plural sets of particulate carriers in a substantially stationary state such that the plurality of particulate carriers or the plural sets of particulate carriers can be externally measured.

公开(公告)号：US20140134620A1

公开(公告)日：2014-05-15

申请号：US14117785

申请日：2012-05-16

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： G01N21/64 ,  C12Q1/68 ,  G01N35/02

CPC分类号： G01N21/6428 ,  C12Q1/686 ,  G01N21/11 ,  G01N21/6452 ,  G01N21/6454 ,  G01N35/02 ,  G01N35/026 ,  G01N35/028 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2021/6484 ,  G01N2035/0403 ,  G01N2201/0846 ,  G01N2201/0853

摘要： The invention relates to an optical measurement device for a reaction vessel, and a method therefor. An object is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without an expansion of the device scale. The configuration includes: a vessel group in which two or more reaction vessels are arranged; a light guide stage having two or more linking portions to which front ends of light guide portions, which have a flexibility, that optically connect with the interior of the linked reaction vessels, are provided; a connecting end arranging body that has an arranging surface that arranges and supports along a predetermined path two or more connecting ends, to which back ends of the light guide portions, in which the front ends thereof are provided to the linking portions, are provided, the connecting ends are provided corresponding to the respective linking portions; a measurement device provided approaching or making contact with the arranging surface that has measuring ends that are successively optically connectable with the respective connecting ends along the predetermined path, and in which light from within the reaction vessels is receivable by means of optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that relatively moves the respective connecting ends arranged on the connecting end arranging body and the respective measuring ends such that they are successively optically connected.

摘要翻译： 本发明涉及一种用于反应容器的光学测量装置及其方法。 目的是以高效，快速和高可靠的方式测量反应容器内的光学状态，而不会扩大装置的尺度。 该构造包括：其中布置有两个或更多个反应容器的容器组; 提供了具有两个或更多个连接部分的光导台，与连接的反应容器的内部光学连接的具有柔性的导光部分的前端被设置到其上; 具有沿预定路径布置和支撑两个或多个连接端的布置表面的连接端部分布置体，其前端设置在连接部分上的导光部分的后端， 连接端对应于各个连接部分设置; 提供接近或与配置表面接触的测量装置，其具有沿着预定路径与各个连接端连续光学连接的测量端，并且来自反应容器内的光可通过连接之间的光学连接而被接收 端部和测量端; 以及导光切换机构，其相对移动设置在连接端排列体上的相应连接端和相应的测量端，使得它们被连续光学连接。

公开(公告)号：US20130288259A1

公开(公告)日：2013-10-31

申请号：US13879069

申请日：2011-10-14

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  B01L3/0217 ,  B01L3/0275 ,  B01L3/523 ,  B01L3/527 ,  B01L7/52 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2300/024 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1888 ,  C12Q1/6806 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2565/629 ,  G01N21/75 ,  G01N35/00732 ,  G01N35/04 ,  G01N35/1065 ,  G01N2035/00742 ,  G01N2035/00821 ,  G01N2035/00851 ,  G01N2035/0403 ,  G01N2035/103 ,  G01N2035/1048 ,  G01N2035/1055 ,  G01N2035/1062

摘要： In relation to an automated nucleic acid processor and an automated nucleic acid processing method using a multi function dispensing unit, processing involving extraction and amplification of the nucleic acid, can be consistently, quickly and efficiently conducted at a low cost with the use of a multi function dispensing unit, while saving user's trouble without expanding the scale of the device. The multi function dispensing unit includes: a nozzle head provided with a suction-discharge mechanism and nozzles detachably provided with dispensing tips; a container group having, at the very least housing parts for liquids and reaction containers for housing an amplification solution; a transfer mechanism that makes an interval between the nozzles and the container group relatively movable; a temperature controller whereby temperature control of the interior of the reaction vessels is possible; sealing liquids and/or sealing lids that are transportable to the reaction vessels using the nozzles, and which make the amplification solutions housed in the reaction vessels sealable within the reaction vessels; and a sealing control part that controls the suction-discharge mechanism or the transfer mechanism, such that the sealing liquid and/or the sealing lids seal the amplification solution within the reaction vessels when the housing of the amplification solution in the reaction vessels is completed.