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    Phytases, nucleic acids encoding them and methods for making and using them
    3.
    发明授权
    Phytases, nucleic acids encoding them and methods for making and using them 有权

    公开(公告)号：US09695403B2

    公开(公告)日：2017-07-04

    申请号：US13321465

    申请日：2010-05-20

    申请人： David P. Weiner ,  Arne I. Solbak, Jr. ,  Ryan McCann

    发明人： David P. Weiner ,  Arne I. Solbak, Jr. ,  Ryan McCann

    IPC分类号： C12N9/16 ,  A23L7/00

    CPC分类号： C12N9/16 ,  Y02E50/17 ,  Y10T428/2982

    摘要： This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The invention further provides phytases which have increased gastric lability. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate.

    Isomerases, nucleic acids encoding them and methods for making and using them
    4.
    发明授权
    Isomerases, nucleic acids encoding them and methods for making and using them 有权
    异构酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US08541220B2

    公开(公告)日：2013-09-24

    申请号：US12810067

    申请日：2008-12-22

    申请人： David P. Weiner ,  Ellen G. Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    发明人： David P. Weiner ,  Ellen G. Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    IPC分类号： C12N9/90 ,  C12N9/88 ,  C12N9/48 ,  C12N9/42 ,  C12N9/16 ,  C02F3/34 ,  A62D3/00 ,  C07H21/04 ,  C07K1/00 ,  A21D2/00 ,  A23L1/10 ,  D21C3/20

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化立体化学 在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

    Lyase enzymes, nucleic acids encoding them and methods for making and using them
    7.
    发明授权
    Lyase enzymes, nucleic acids encoding them and methods for making and using them 有权
    裂解酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US08735107B2

    公开(公告)日：2014-05-27

    申请号：US13287567

    申请日：2011-11-02

    申请人： David P. Weiner ,  Alexander Varvak ,  Toby Richardson ,  Mircea Podar ,  Ellen Burke ,  Shaun Healey

    发明人： David P. Weiner ,  Alexander Varvak ,  Toby Richardson ,  Mircea Podar ,  Ellen Burke ,  Shaun Healey

    IPC分类号： C12P13/24 ,  C12P13/22

    CPC分类号： C12N9/88 ,  C12P7/42 ,  C12P13/222 ,  C12P13/225 ,  C12P13/24 ,  C12Y403/01005 ,  C12Y403/01023 ,  D06M16/003

    摘要： This invention provides polypeptides having lyase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having ammonia lyase activity, e.g., phenylalanine ammonia lyase, tyrosine ammonia lyase and/or histidine ammonia lyase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. X═NO2, Cl, Br, NH2, OH, H, alkyl at one or several o, m, and p positions R═H or alkyl.

    摘要翻译： 本发明提供了具有裂解酶活性的多肽，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 一方面，本发明涉及具有氨裂解酶活性的多肽，例如苯丙氨酸氨裂解酶，酪氨酸氨裂解酶和/或组氨酸氨裂解酶活性，包括耐热和耐热活性，以及​​编码这些酶的多核苷酸，以及制备和使用这些多核苷酸 和多肽。 本发明的多肽可用于多种药物，农业和工业环境。 在一个或几个o，m和p位置R = H或烷基时，X = NO 2，Cl，Br，NH 2，OH，H。

    Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
    8.
    发明授权
    Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 有权
    转移酶和氧化还原酶，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：US08709772B2

    公开(公告)日：2014-04-29

    申请号：US12810057

    申请日：2008-12-31

    申请人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca ,  Erin Marasco

    发明人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin Cuenca ,  Erin Marasco

    IPC分类号： C12N9/10 ,  C12Q1/00 ,  C12Q1/68 ,  C12P21/06 ,  C12P21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P7/00 ,  C12P13/04 ,  C07H21/04

    CPC分类号： C12N9/1096 ,  A21D8/042 ,  A61K38/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0014 ,  C12N9/10 ,  C12N15/1137 ,  C12N15/63 ,  C12N15/86 ,  C12P7/10 ,  C12Q1/6876 ,  C12Y206/01021 ,  D06L4/40 ,  D06M16/003 ,  G01N33/573 ,  Y02E50/16 ,  Y02P20/52 ,  Y02T50/678

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine+2-oxoglutarate pyruvate+D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid+H2O+acceptor a 2-oxo acid+NH3+reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有转移酶活性的酶，例如转氨酶活性，例如d-氨基酸转移酶活性和/或氧化还原酶活性，例如 ，脱氢酶活性，例如脱氨酸脱氢酶活性和/或催化化学基团的转移，催化转氨酶，催化反应：D-丙氨酸+ 2-氧戊二酸酯<=>丙酮酸盐+ D-谷氨酸盐和/或催化 催化氢原子的去除和/或催化反应：D-氨基酸+ H 2 O +受体 2-氧代酸+ NH 3 +还原受体。 因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    9.
    发明申请
    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    异构体，编码它们的核酸及其制备和使用它们的方法

    公开(公告)号：US20110053245A1

    公开(公告)日：2011-03-03

    申请号：US12810067

    申请日：2008-12-22

    申请人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    发明人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    IPC分类号： C12N9/90 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12N15/82 ,  C12N15/85 ,  C12P21/02 ,  C12P19/34 ,  A23L1/172 ,  D21C3/20 ,  C12N9/42 ,  C12N9/48 ,  C12N9/24 ,  C12N9/08 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化原子在分子内的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化 仅具有一个不对称中心的基底中的不对称碳原子周围的立体化学反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了酶，组合物，药物组合物的制备方法，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。