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公开(公告)号：US06913931B2
公开(公告)日：2005-07-05
申请号：US10263592
申请日：2002-10-03
CPC分类号： B01L3/5027 , B01J2219/00527 , B01J2219/00608 , B01J2219/0061 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00677 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00889 , B01L3/5088 , B01L2200/0642 , B01L2300/0636 , B01L2300/0819 , B01L2300/089 , B01L2400/0457 , B82Y30/00 , Y10T436/11 , Y10T436/110833 , Y10T436/112499 , Y10T436/143333 , Y10T436/2575
摘要： Devices, methods and systems for low volume microarray processing are disclosed. The microarray devices preferably include a plurality of reactant sites on a reactant surface. The reactant sites include reactants that operate to capture one or more selected analytes that can then be detected based on an electromagnetic signal, e.g., fluorescence, that is emitted by each analyte in response to excitation energy incident on the microarray device. Mixing and/or distribution of the analyte sample over the reactant surface is accomplished by tilting the reactant surface such that the analyte sample flows over the reactant surface under the force of gravity. The tilting is performed such that a portion of the analyte sample accumulates in a bead along a first edge of the reactant surface. The reactant surface is then tilted in a different direction such that a portion of the analyte sample flows over the reactant surface and accumulates at a second edge. The reactant surface preferably generates sufficient capillary forces with the analyte sample such that the analyte sample is retained on the reactant surface. The tilting and resultant flow may be performed as many times as necessary to obtain the desired mixing and/or distribution of analyte sample over the reactant surface.
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公开(公告)号：US06783838B2
公开(公告)日：2004-08-31
申请号：US09845946
申请日：2001-04-30
申请人： Patrick L. Coleman , Kurt J. Halverson , James I. Hembre , Sanjay L. Patil , Anila Prabhu , Raj Rajagopal , Jerald K. Rasmussen , Barbara C. Swenson , Patrick S. Quint
发明人： Patrick L. Coleman , Kurt J. Halverson , James I. Hembre , Sanjay L. Patil , Anila Prabhu , Raj Rajagopal , Jerald K. Rasmussen , Barbara C. Swenson , Patrick S. Quint
IPC分类号： B23B500
CPC分类号： B82Y30/00 , B01J2219/00351 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/545 , G01N33/548 , Y10S530/81 , Y10S530/816 , Y10T428/24355 , Y10T428/24446 , Y10T428/24628 , Y10T428/263 , Y10T428/264 , Y10T428/31725 , Y10T428/31757 , Y10T428/31855 , Y10T436/2575
摘要： A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed.
摘要翻译： 公开了具有包括可收缩聚合物膜，离子涂层和任选的水凝胶的离子表面的涂覆层压板。 公开了一种将样品分子从基质转移到具有离子表面的涂覆层压体的方法。
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公开(公告)号：US07033667B2
公开(公告)日：2006-04-25
申请号：US10739807
申请日：2003-12-18
申请人： Jessica L. Voss-Kehl , Kurt J. Halverson , Caroline M. Ylitalo , Matthew R. Lehmann , Steven J. Botzet
发明人： Jessica L. Voss-Kehl , Kurt J. Halverson , Caroline M. Ylitalo , Matthew R. Lehmann , Steven J. Botzet
IPC分类号： B32B3/00
CPC分类号： H05K3/105 , H05K3/12 , H05K3/125 , H05K3/22 , H05K2201/0125 , H05K2201/0257 , H05K2201/0329 , H05K2203/013 , H05K2203/1105 , Y10S428/901 , Y10T428/24917 , Y10T428/2857 , Y10T428/31504 , Y10T428/31678 , Y10T428/31938
摘要： Methods of creating fine featured circuits by printing a circuit trace onto polymer shrink films or other biaxially-oriented polymer films are disclosed. The shrink films are heated and shrunk after printing, annealing the circuit trace to form conductive features. Compositions suitable for printing onto the films and articles made using the method and composition are also disclosed.
摘要翻译： 公开了通过将电路迹线印刷到聚合物收缩膜或其它双轴取向聚合物膜上来制造精细特征电路的方法。 收缩膜在印刷后被加热和收缩，对电路迹线退火以形成导电特征。 还公开了适用于印刷在使用该方法和组合物制成的薄膜和制品上的组合物。
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4.发明授权Systems and methods for detecting an analyte of interest in a sample using microstructured surfaces 有权使用微结构化表面检测样品中感兴趣的分析物的系统和方法公开(公告)号：US09488563B2
公开(公告)日：2016-11-08
申请号：US14122343
申请日：2012-06-26
CPC分类号： G01N15/042 , B01L3/5021 , B01L2300/042 , B01L2300/047 , B01L2300/069 , B01L2300/0832 , B01L2400/0409 , C12Q1/02 , G01N1/4077 , G01N15/04 , G01N21/07 , G01N2001/4083 , G01N2015/0065 , G01N2015/045 , G01N2333/245 , Y10T436/25375 , Y10T436/255
摘要： Method for detecting an analyte of interest in a sample. The method can include providing a container comprising a microstructured surface, and centrifuging the container toward the microstructured surface to form a sediment and a supernatant of the sample. Following centrifugation, the container can be inverted to decant at least a portion of the supernatant of the sample from the second portion, such that a concentrate (e.g., comprising the sediment) of the sample is retained in the microstructured surface. The concentrate can then be interrogated in the microstructured surface for the analyte of interest. In some embodiments, at least a portion of the second portion can be substantially transparent, such that the concentrate can be interrogated from the outside of the container, without requiring that the container be opened prior to interrogation.
摘要翻译： 用于检测样品中感兴趣的分析物的方法。 该方法可以包括提供包含微结构化表面的容器，并将容器离心到微结构化表面以形成样品的沉淀物和上清液。 离心后，将容器倒置以从第二部分倾析样品的上清液的至少一部分，使得样品的浓缩物（例如包含沉淀物）保留在微结构化表面中。 然后可以在微结构化表面中询问浓缩物用于感兴趣的分析物。 在一些实施例中，第二部分的至少一部分可以是基本上透明的，从而可以从容器的外部询问浓缩物，而不需要在询问之前打开容器。
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公开(公告)号：US09127300B2
公开(公告)日：2015-09-08
申请号：US13807058
申请日：2011-06-27
摘要： The disclosure provides culture devices and methods for a microorganism in a sample. The devices include a base member, a cover sheet, an adhesive layer coupled to the base member or the cover sheet, and a cold water-soluble gelling agent disposed on the base member; wherein the devices are substantially optically transmissive when the gelling agent is hydrated with a clear liquid. Methods of use include detecting or enumerating microorganisms. The methods further provide for detecting a microorganism by detecting the presence or size of an abiogenic gas bubble in a culture device.
摘要翻译： 本公开提供了样品中微生物的培养装置和方法。 这些装置包括基底部件，覆盖片，连接到基底部件或覆盖片的粘合剂层，以及设置在基底部件上的冷水溶性胶凝剂; 其中当胶凝剂与透明液体水合时，所述装置基本上是光学透射的。 使用方法包括检测或列举微生物。 该方法进一步提供了通过检测培养装置中的生物气泡的存在或大小来检测微生物。
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公开(公告)号：US20120322052A1
公开(公告)日：2012-12-20
申请号：US13571748
申请日：2012-08-10
CPC分类号： G01N1/38 , A61B10/0038 , A61B10/0096 , B01F11/0005 , B01F15/00837 , B01L3/502 , B01L2300/046 , B01L2300/0681 , G01N1/18 , G01N33/02 , G01N33/487 , G01N2001/4088 , Y10T436/25375 , Y10T436/25625
摘要： A system and method for preparing samples for analyte testing. The sample preparation system can include a freestanding receptacle. The method can include providing a liquid composition comprising a source and a diluent, and positioning the liquid composition in a reservoir defined by the freestanding receptacle. The method can further include filtering the liquid composition to form a filtrate comprising an analyte of interest, removing at least a portion of the filtrate from the sample preparation system to form a sample, and analyzing the sample for the analyte of interest.
摘要翻译： 用于制备分析物测试样品的系统和方法。 样品制备系统可以包括独立的容器。 该方法可以包括提供包含源和稀释剂的液体组合物，并将液体组合物定位在由独立容器限定的储存器中。 该方法还可以包括过滤液体组合物以形成包含感兴趣的分析物的滤液，从样品制备系统中除去至少一部分滤液以形成样品，并分析样品中感兴趣的分析物。
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公开(公告)号：US20120003626A1
公开(公告)日：2012-01-05
申请号：US13142288
申请日：2009-12-30
IPC分类号： C12Q1/04 , C12N1/20 , C12N1/14 , C12N1/10 , C12M1/26 , C12M1/34 , C12Q1/70 , C12N7/02 , C12N1/16 , B82Y15/00
摘要： The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions.
摘要翻译： 本公开描述了将浓缩剂浓缩在采样装置中的微生物和本文所述的采样装置的方法。 更具体地说，用于将来自大容量样品的微生物浓缩在采样装置中的浓缩剂的方法可以在各种条件下提供快速，低成本，简单（不涉及复杂的设备或程序）和/或有效过程。
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公开(公告)号：US20100248215A1
公开(公告)日：2010-09-30
申请号：US12743449
申请日：2008-11-19
申请人： Kurt J. Halverson , Stephen C.P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
发明人： Kurt J. Halverson , Stephen C.P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
CPC分类号： G01N1/38
摘要： A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.
摘要翻译： 用于制备和递送样品以进行分析物测试的系统和方法。 该系统可以包括与样品制备系统耦合的样品制备系统和样品递送系统。 样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。 样品输送系统可以包括定位成与储存器流体连通的阀，并适于控制样品从样品制备系统中的去除。 该方法可以包括向可变形的自支撑容器施加压力，以经由样品输送系统从样品制备系统移除样品。
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公开(公告)号：US06696286B1
公开(公告)日：2004-02-24
申请号：US09495092
申请日：2000-02-01
申请人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
发明人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
IPC分类号： C12M134
CPC分类号： C12Q1/02
摘要： A method for detecting a microorganism in a test sample is described. The method involves distributing microvolumes of a sample to a plurality of microcompartments of a culture device, incubating for a time sufficient to permit at least one cell division cycle of the microorganism, then detecting the presence or absence of the microorganism in the microcompartments. Also disclosed are devices for carrying out these methods.
摘要翻译： 描述了测试样品中微生物检测方法。 该方法包括将样品的微量体积分配到培养装置的多个微室中，孵育足以允许微生物的至少一个细胞分裂周期的时间，然后检测微室中的微生物的存在或不存在。 还公开了用于执行这些方法的装置。
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公开(公告)号：US06548607B2
公开(公告)日：2003-04-15
申请号：US10060798
申请日：2002-01-30
IPC分类号： C08F830
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要： High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
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