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公开(公告)号：US20050042137A1
公开(公告)日：2005-02-24
申请号：US10955811
申请日：2004-09-29
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
摘要翻译： 用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。 药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。 容器包括限定反应室侧壁的刚性框架。 该框架包括连接到该腔室的流动路径的至少一个通道。 容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。 此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。
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公开(公告)号：US08709363B2
公开(公告)日：2014-04-29
申请号：US13436475
申请日：2012-03-30
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
摘要翻译： 用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。 药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。 容器包括限定反应室侧壁的刚性框架。 该框架包括连接到该腔室的流动路径的至少一个通道。 容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。 此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。
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公开(公告)号：US20080057572A1
公开(公告)日：2008-03-06
申请号：US11977697
申请日：2007-10-24
申请人： Kurt Petersen , Michael Taylor , Farzad Pourahmadi , William McMillan , Ronald Chang , Stanley Sakai , Jesus Ching , Douglas Dority , Phillip Belgrader , M. Northrup
发明人： Kurt Petersen , Michael Taylor , Farzad Pourahmadi , William McMillan , Ronald Chang , Stanley Sakai , Jesus Ching , Douglas Dority , Phillip Belgrader , M. Northrup
IPC分类号： C12M3/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
摘要翻译： 本发明提供一种用于分析流体样品的盒。 盒提供用于有效分离样品中的细胞或病毒与剩余的样品流体，裂解细胞或病毒以从其中分离分析物（例如核酸），以及任选地分析物的化学反应和/或检测。 墨盒可用于各种诊断，生命科学研究，环境或法医应用，用于确定样品中一种或多种分析物的存在或不存在。
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公开(公告)号：US20050194316A1
公开(公告)日：2005-09-08
申请号：US11121541
申请日：2005-05-03
申请人： Farzad Pourahmadi , William McMillan , Jesus Ching , Ronald Chang , Lee Christel , Gregory Kovacs , M. Northrup , Kurt Petersen
发明人： Farzad Pourahmadi , William McMillan , Jesus Ching , Ronald Chang , Lee Christel , Gregory Kovacs , M. Northrup , Kurt Petersen
IPC分类号： G01N31/20 , B01D11/00 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/26 , C12M1/33 , C12M1/34 , C40B60/14 , G01N1/28 , G01N30/60 , G01N33/50 , G01N35/08 , G01N37/00
CPC分类号： G01N30/6095 , B01J2219/00432 , B01J2219/00529 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/0621 , B01L2200/0631 , B01L2200/0636 , B01L2200/10 , B01L2300/0816 , B01L2300/0883 , B01L2300/1827 , B01L2400/0421 , B01L2400/046 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/086 , C12M47/02 , C12M47/06 , C40B60/14 , G01N30/6091 , Y10T436/25375 , Y10T436/255
摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
摘要翻译： 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。
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公开(公告)号：US20060030038A1
公开(公告)日：2006-02-09
申请号：US11234656
申请日：2005-09-22
申请人： Michael Taylor , Phillip Belgrader , Farzad Pourahmadi , William McMillan , Ronald Chang , Jesus Ching
发明人： Michael Taylor , Phillip Belgrader , Farzad Pourahmadi , William McMillan , Ronald Chang , Jesus Ching
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M47/06
摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
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公开(公告)号：US20060019379A1
公开(公告)日：2006-01-26
申请号：US11234634
申请日：2005-09-22
IPC分类号： C12M1/02
CPC分类号： B01L3/508 , B01L3/5027 , B01L3/502707 , B01L3/502761 , B01L2200/025 , B01L2300/0848 , B01L2300/12 , C12M47/06 , C12N1/066 , C12N13/00
摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
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公开(公告)号：US20060027686A1
公开(公告)日：2006-02-09
申请号：US11233629
申请日：2005-09-22
申请人： Michael Taylor , Phillip Belgrader , Farzad Pourahmadi , William McMillan , Ronald Chang , Stanley Sakai , Jesus Ching
发明人： Michael Taylor , Phillip Belgrader , Farzad Pourahmadi , William McMillan , Ronald Chang , Stanley Sakai , Jesus Ching
CPC分类号： B01L3/502 , B01L2200/10 , B01L2300/0681 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , C12M47/06
摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
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8.发明授权Method and apparatus for thermally actuated self testing of silicon structures 失效用于硅结构的热致自我测试的方法和装置
公开(公告)号：US5355712A
公开(公告)日：1994-10-18
申请号：US758836
申请日：1991-09-13
IPC分类号： G01P21/00
CPC分类号： G01L9/0042 , G01L27/007 , G01P21/00
摘要： The present invention discloses a method and apparatus for testing the operational capability of flexure area equipped sensors especially those made of micromachined silicon. A thermal actuator beam is provided to bridge the structures which are joined by the flexure area. During the test, the beam's temperature is changed relative to that of the flexure area so as to provide a differential expansion or contraction. The result is that the flexure area bends and conventional bending sensors for the flexure area can sense the amount of bend. By comparing the actual amount of bend sensed with the amount expected from the temperature change applied to the beam, the operational capability can be determined.
摘要翻译： 本发明公开了一种用于测试装有挠曲区域的传感器，特别是由微加工硅制成的传感器的操作能力的方法和装置。 提供热致动器梁以桥接由弯曲区域连接的结构。 在测试期间，光束的温度相对于弯曲部分的温度改变，以便提供差别的膨胀或收缩。 结果是弯曲区域弯曲，弯曲区域的常规弯曲传感器可以感测弯曲量。 通过将感测到的实际弯曲量与应用于梁的温度变化的预期量进行比较，可以确定操作能力。
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公开(公告)号：US08268603B2
公开(公告)日：2012-09-18
申请号：US11234656
申请日：2005-09-22
申请人： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Jesus Ching
发明人： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Jesus Ching
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M47/06
摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
摘要翻译： 用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。 容器包括限定腔室的至少一个柔性壁。 该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。 该装置还包括用于增加腔室中的压力的压力源。 室的加压确保换能器与柔性壁之间的有效耦合。 该装置还可以包括室中的珠子，用于破裂细胞或病毒。
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公开(公告)号：US06887693B2
公开(公告)日：2005-05-03
申请号：US10006848
申请日：2001-11-07
申请人： William A. McMillan , Kurt E. Petersen , Lee A. Christel , Ronald Chang , Farzad Pourahmadi , Jesus Ching , Gregory T. A. Kovacs , M. Allen Northrup
发明人： William A. McMillan , Kurt E. Petersen , Lee A. Christel , Ronald Chang , Farzad Pourahmadi , Jesus Ching , Gregory T. A. Kovacs , M. Allen Northrup
CPC分类号： C12M47/06 , B01L2400/0622 , B01L2400/0644
摘要： A device for lysing components (e.g., cells, spores, or microorganisms) of a fluid sample comprises a cartridge having a lysing chamber for receiving the sample and having at least one solid phase in the lysing chamber for capturing the sample components to be lysed. An ultrasonic transducer is coupled to a wall of the lysing chamber to transfer ultrasonic energy to the captured sample components.
摘要翻译： 用于裂解流体样品的组分（例如，细胞，孢子或微生物）的装置包括具有用于接收样品并在裂解室中具有至少一个固相以用于捕获要裂解的样品组分的裂解室的筒。 超声换能器耦合到裂解室的壁以将超声能量转移到捕获的样品组分。
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