公开(公告)号：US20070005112A1

公开(公告)日：2007-01-04

申请号：US11517860

申请日：2006-09-07

申请人： Robert Greenberg ,  Neil Talbot ,  Jerry Ok ,  Jordan Neysmith ,  Dao Zhou

发明人： Robert Greenberg ,  Neil Talbot ,  Jerry Ok ,  Jordan Neysmith ,  Dao Zhou

IPC分类号： A61N1/00

CPC分类号： A61N1/3758 ,  A61N1/0543 ,  A61N1/36046 ,  A61N1/375 ,  H01L21/563 ,  H01L23/49827 ,  H01L23/49838 ,  H01L23/4985 ,  H01L24/81 ,  H01L2224/0557 ,  H01L2224/05571 ,  H01L2224/05573 ,  H01L2224/13169 ,  H01L2224/13178 ,  H01L2224/16225 ,  H01L2224/16227 ,  H01L2224/32225 ,  H01L2224/73204 ,  H01L2224/81469 ,  H01L2224/81478 ,  H01L2224/81815 ,  H01L2924/00014 ,  H01L2924/01019 ,  H01L2924/01046 ,  H01L2924/01077 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/14 ,  H01L2924/1461 ,  H05K1/028 ,  H05K1/0306 ,  H05K1/09 ,  H05K1/111 ,  H05K1/113 ,  H05K1/115 ,  H05K1/189 ,  H05K3/10 ,  H05K3/188 ,  H05K3/305 ,  H05K3/321 ,  H05K3/328 ,  H05K3/3436 ,  H05K3/361 ,  H05K3/4015 ,  H05K3/4038 ,  H05K3/4084 ,  H05K3/423 ,  H05K3/4644 ,  H05K3/4652 ,  H05K3/4691 ,  H05K13/0469 ,  H05K2201/09127 ,  H05K2201/1028 ,  H05K2201/10287 ,  H05K2201/10295 ,  H05K2201/10977 ,  H05K2203/05 ,  H05K2203/06 ,  H05K2203/0733 ,  H05K2203/09 ,  H05K2203/107 ,  H05K2203/1446 ,  H01L2924/00 ,  H01L2224/05599

摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.

摘要翻译： 本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法以及所得到的电子封装，其适于植入生物组织，例如用于视网膜或皮质电极阵列，以使视力恢复 对某些无意识的个人。 密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。 所得到的电子装置是生物相容的并且适合长期植入生物体组织。

公开(公告)号：US20070293749A1

公开(公告)日：2007-12-20

申请号：US11820744

申请日：2007-06-19

申请人： Dao Zhou ,  Jerry Ok ,  Neil Talbot ,  Brian Mech ,  James Little ,  Robert Greenberg

发明人： Dao Zhou ,  Jerry Ok ,  Neil Talbot ,  Brian Mech ,  James Little ,  Robert Greenberg

IPC分类号： A61B5/04

CPC分类号： A61N1/0543 ,  A61N1/36046

摘要： The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. The present invention provides A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

摘要翻译： 本发明提供具有增加的稳定性的可植入电极，其具有聚集结构，其中电极的表面被包括填充有棒或柱的开口的材料覆盖。 本发明提供了具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。 本发明提供一种具有增加的稳定性的电极的制造方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。 本发明提供了一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

公开(公告)号：US20060259109A1

公开(公告)日：2006-11-16

申请号：US11489777

申请日：2006-07-19

申请人： Dao Zhou ,  Robert Greenberg ,  Neil Talbot

发明人： Dao Zhou ,  Robert Greenberg ,  Neil Talbot

IPC分类号： A61N1/05

CPC分类号： A61L31/088 ,  A61N1/05 ,  A61N1/0565 ,  C25D5/08 ,  C25D5/10 ,  C25D9/06

摘要： An implantable electrode and method for manufacturing the electrode wherein the electrode has a strong, adherent surface coating of iridium oxide or titanium nitride on a platinum surface, which demonstrates an increase in surface area of at least five times when compared to smooth platinum of the same geometry. The iridium oxide coating may be formed on platinum by a physical deposition process, such as sputtering. The process of electroplating the iridium oxide surface coating is accomplished by voltage control processes. A gradient coating of iridium oxide ranging in composition from essentially pure platinum to essentially pure iridium oxide is produced by sputtering.

公开(公告)号：US20060259108A1

公开(公告)日：2006-11-16

申请号：US11488806

申请日：2006-07-17

申请人： Andy Hung ,  Robert Greenberg ,  Dao Zhou ,  Jack Judy ,  Neil Talbot

发明人： Andy Hung ,  Robert Greenberg ,  Dao Zhou ,  Jack Judy ,  Neil Talbot

IPC分类号： A61N1/05

CPC分类号： A61N1/05 ,  A61N1/0526 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551

摘要： The present invention is a micro-machined electrode for neural-electronic interfaces which can achieve a ten times lower impedance and higher charge injection limit for a given material and planar area.

公开(公告)号：US20080076007A1

公开(公告)日：2008-03-27

申请号：US11928114

申请日：2007-10-30

申请人： Dao Zhou ,  Robert Greenberg

发明人： Dao Zhou ,  Robert Greenberg

IPC分类号： H01M4/86 ,  C25D3/50

CPC分类号： H01M4/8853 ,  B01D53/945 ,  B01D2255/1021 ,  B01J23/08 ,  B01J23/40 ,  B01J23/42 ,  B01J23/44 ,  B01J23/468 ,  B01J35/002 ,  B01J37/0215 ,  B01J37/348 ,  C25D3/50 ,  C25D5/16 ,  C25D21/12 ,  H01M4/8807 ,  H01M4/90 ,  H01M4/92 ,  H01M4/921 ,  H01M4/94 ,  H01M8/00 ,  H01M8/1007 ,  Y02P70/56 ,  Y02T10/22

摘要： An improved platinum and method for manufacturing the improved platinum wherein the platinum having a fractal surface coating of platinum, platinum gray, with a increase in surface area of at least 5 times when compared to shiny platinum of the same geometry and also having improved resistance to physical stress when compared to platinum black having the same surface area. The process of electroplating the surface coating of platinum gray comprising plating at a moderate rate, for example at a rate that is faster than the rate necessary to produce shiny platinum and that is less than the rate necessary to produce platinum black. Platinum gray is applied to manufacture a fuel cell and a catalyst.

摘要翻译： 一种改进的铂和用于制造改进的铂的方法，其中具有铂的分形表面涂层的铂，白金灰，与相同几何形状的闪亮铂相比，表面积增加至少5倍，并且还具有改善的耐 与具有相同表面积的铂黑相比，物理应力。 电镀铂灰的表面涂层的过程包括以适中的速率镀覆，例如以比产生闪亮铂所需的速率更快的速率并且小于生产铂黑所需的速率的速率。 铂灰应用于制造燃料电池和催化剂。

公开(公告)号：US20080046041A1

公开(公告)日：2008-02-21

申请号：US11926057

申请日：2007-10-28

申请人： Robert Greenberg ,  Kelly McClure ,  James Little ,  Rongqing Dai ,  Arup Roy ,  Richard Castro ,  John Reinhold ,  Kea-Tiong Tang ,  Sumit Yadav ,  Chunhong Zhou ,  Dao Zhou ,  Pishoy Maksy

发明人： Robert Greenberg ,  Kelly McClure ,  James Little ,  Rongqing Dai ,  Arup Roy ,  Richard Castro ,  John Reinhold ,  Kea-Tiong Tang ,  Sumit Yadav ,  Chunhong Zhou ,  Dao Zhou ,  Pishoy Maksy

IPC分类号： A61N1/08

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36142 ,  A61N1/36185

摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

摘要翻译： 在电刺激神经组织中，重要的是防止过度刺激和不平衡刺激，这将导致对神经组织，电极或两者的损伤。 至关重要的是神经组织不会受到高于安全阈值的任何直流或交流电流的影响。 此外，重要的是识别有缺陷的电极，因为继续使用可能导致神经和电极损坏。 本发明提出了防止神经组织损伤的系统和刺激器控制机制。

公开(公告)号：US20070265686A1

公开(公告)日：2007-11-15

申请号：US11796433

申请日：2007-04-27

申请人： Robert Greenberg ,  Kelly McClure ,  James Little ,  Rongqing Dai ,  Arup Roy ,  Richard Castro ,  John Reinhold ,  Kea-Tiong Tang ,  Sumit Yadav ,  Chunhong Zhou ,  Dao Zhou ,  Pishoy Maksy

发明人： Robert Greenberg ,  Kelly McClure ,  James Little ,  Rongqing Dai ,  Arup Roy ,  Richard Castro ,  John Reinhold ,  Kea-Tiong Tang ,  Sumit Yadav ,  Chunhong Zhou ,  Dao Zhou ,  Pishoy Maksy

IPC分类号： A61N1/08

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36142 ,  A61N1/36185

摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.

摘要翻译： 本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。 本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。 本公开中提出的装置包括能够执行所公开的方法的电路和系统。

公开(公告)号：US20070191911A1

公开(公告)日：2007-08-16

申请号：US11607201

申请日：2006-12-01

申请人： Robert Greenberg ,  Ione Fine ,  Arup Roy ,  Matthew McMahon ,  Mark Humayun ,  James Weiland ,  Alan Horsager ,  Dao Zhou ,  Amy Hines ,  Sumit Yadav ,  Rongqing Dai

发明人： Robert Greenberg ,  Ione Fine ,  Arup Roy ,  Matthew McMahon ,  Mark Humayun ,  James Weiland ,  Alan Horsager ,  Dao Zhou ,  Amy Hines ,  Sumit Yadav ,  Rongqing Dai

IPC分类号： A61N1/18

CPC分类号： A61N1/0543 ,  A61N1/36046 ,  A61N1/37247

摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.

摘要翻译： 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

公开(公告)号：US20070255319A1

公开(公告)日：2007-11-01

申请号：US11413771

申请日：2006-04-28

申请人： Robert Greenberg ,  Kelly McClure ,  James Little ,  Rongqing Dai ,  Arup Roy ,  Richard Castro ,  John Reinhold ,  Kea-Tiong Tang ,  Sumit Yadav ,  Chunhong Zhou ,  Dao Zhou ,  Pishoy Maksy

发明人： Robert Greenberg ,  Kelly McClure ,  James Little ,  Rongqing Dai ,  Arup Roy ,  Richard Castro ,  John Reinhold ,  Kea-Tiong Tang ,  Sumit Yadav ,  Chunhong Zhou ,  Dao Zhou ,  Pishoy Maksy

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36142 ,  A61N1/36185

摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

摘要翻译： 在电刺激神经组织中，重要的是防止过度刺激和不平衡刺激，这将导致对神经组织，电极或两者的损伤。 至关重要的是神经组织不会受到高于安全阈值的任何直流或交流电流的影响。 此外，重要的是识别有缺陷的电极，因为继续使用可能导致神经和电极损坏。 本发明提出了防止神经组织损伤的系统和刺激器控制机制。

公开(公告)号：US20070092786A1

公开(公告)日：2007-04-26

申请号：US11259822

申请日：2005-10-26

申请人： Dao Zhou

发明人： Dao Zhou

IPC分类号： H01M4/92 ,  C25D3/50

CPC分类号： C25D3/50 ,  A61N1/05

摘要： An electrode surface coating and method for manufacturing the electrode surface coating comprising a conductive substrate; a surface coating of platinum having a rough configuration and an increase in the surface area of 5 times to 500 times of the corresponding surface area resulting from the basic geometric shape of the electrode. A method for electroplating an electrode surface with platinum coating having a rough surface, comprising electroplating the surface of a conductive substrate at a rate such that the metal particles form on the conductive substrate faster than necessary to form shiny platinum and slower than necessary to form platinum black.