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1.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20140315271A1
公开(公告)日：2014-10-23
申请号：US14238774
申请日：2012-08-22
IPC分类号： C12N13/00
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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公开(公告)号：US20130282136A1
公开(公告)日：2013-10-24
申请号：US13922787
申请日：2013-06-20
申请人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
发明人： Joseph Khoury , Laurence B. Tarrant , Sean R. Kirkpatrick , Richard C. Svrluga , Stephen M. Blinn
IPC分类号： A61L27/54
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2310/00359 , A61F2310/00976 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
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3.发明授权Method and system for sterilizing objects by the application of gas-cluster ion-beam technology 有权通过应用气体束离子束技术对物体进行灭菌的方法和系统公开(公告)号：US08530859B2
公开(公告)日：2013-09-10
申请号：US12492661
申请日：2009-06-26
CPC分类号： A61L2/087 , A61L2/20 , A61L12/10 , A61L2202/24 , H01J2237/0812
摘要： Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses.
摘要翻译： 公开了通过气簇离子束（GCIB）照射灭菌物体的方法和系统。 灭菌可以与对象的其他有益的GCIB表面处理结合使用。 物体可以是医疗装置或可手术植入的医疗假体。
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4.发明申请METHOD AND SYSTEM FOR STERILIZING OBJECTS BY THE APPLICATION OF BEAM TECHNOLOGY 审中-公开通过光束技术应用灭菌对象的方法和系统公开(公告)号：US20130022494A1
公开(公告)日：2013-01-24
申请号：US13358213
申请日：2012-01-25
IPC分类号： A61L2/08
CPC分类号： A61L2/087 , A61L2/20 , A61L12/10 , A61L2202/14 , A61L2202/24 , H01J37/08 , H01J37/20 , H01J37/30 , H01J2237/0812
摘要： Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation or by accelerated Neutral Beam are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses. The accelerated Neutral Beam is derived from an accelerated GCIB.
摘要翻译： 公开了通过气体簇离子束（GCIB）照射或加速中性束对物体进行灭菌的方法和系统。 灭菌可以与对象的其他有益的GCIB表面处理结合使用。 物体可以是医疗装置或可手术植入的医疗假体。 加速中性光束来自加速GCIB。
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5.发明申请METHOD AND SYSTEM FOR STERILIZING OBJECTS BY THE APPLICATION OF GAS-CLUSTER ION-BEAM TECHNOLOGY 有权通过应用气体离子束技术消毒物体的方法和系统公开(公告)号：US20090321658A1
公开(公告)日：2009-12-31
申请号：US12492661
申请日：2009-06-26
IPC分类号： A61L2/08
CPC分类号： A61L2/087 , A61L2/20 , A61L12/10 , A61L2202/24 , H01J2237/0812
摘要： Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses.
摘要翻译： 公开了通过气簇离子束（GCIB）照射灭菌物体的方法和系统。 灭菌可以与对象的其他有益的GCIB表面处理结合使用。 物体可以是医疗装置或可手术植入的医疗假体。
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公开(公告)号：US20180321583A1
公开(公告)日：2018-11-08
申请号：US16040385
申请日：2018-07-19
IPC分类号： G03F1/80 , H01L21/265 , G03F1/82 , H01J37/05 , H01J37/147 , H01J37/317 , H01L21/02 , H05H3/02 , H01L21/311 , B24B37/04 , H01L29/36
CPC分类号： G03F1/80 , B24B37/04 , G03F1/82 , H01J37/05 , H01J37/147 , H01J37/317 , H01J37/3171 , H01J2237/0041 , H01J2237/0812 , H01J2237/15 , H01L21/02115 , H01L21/02274 , H01L21/26506 , H01L21/26513 , H01L21/26566 , H01L21/31105 , H01L21/31111 , H01L29/36 , H05H3/02 , Y10T428/24355 , Y10T428/24479 , Y10T428/30
摘要： A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elation profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration.
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7.发明申请METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY 有权改善表面表面和物体的生物活性特征的方法改进的表面公开(公告)号：US20160228609A1
公开(公告)日：2016-08-11
申请号：US15130354
申请日：2016-04-15
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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8.发明授权公开(公告)号：US09315798B2
公开(公告)日：2016-04-19
申请号：US14238774
申请日：2012-08-22
IPC分类号： A61F2/02 , H01J37/317 , H01J37/05 , A61L27/14 , C12N13/00 , A61L27/06 , A61L27/16 , A61L27/38 , A61L27/50
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
摘要翻译： 包括二氧化钛，钛，钛合金和/或聚四氟乙烯（PTFE）的可植入物体的表面的生物活性的改善方法和由此制备的可植入物体形成加速的中性束，其由加速的气体 - 团簇离子束 （GCIB）在减压室中，将可植入物体引入减压室中，以及用GCIB衍生的中性光束照射所述可植入物体的表面的至少第一部分。
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9.发明申请METHOD FOR MODIFYING BIOCOMPATIBILITY CHARACTERISTICS OF A SURFACE OF A BIOLOGICAL MATERIAL WITH GAS CLUSTER ION BEAM 审中-公开生物材料与气体离子束表面生物化学特性的改进方法公开(公告)号：US20140236295A1
公开(公告)日：2014-08-21
申请号：US14238752
申请日：2012-08-21
CPC分类号： H05H3/00 , A61F2/0077 , A61F2/08 , A61F2/28 , A61F2250/0056 , C12N5/0068 , H05H3/02
摘要： A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.
摘要翻译： 用于制备用于植入的生物材料的方法提供用加速的中性束照射材料的表面的至少一部分。
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公开(公告)号：US20140236286A1
公开(公告)日：2014-08-21
申请号：US14238271
申请日：2012-08-17
CPC分类号： A61F2/82 , A61F2210/0076 , A61F2240/001 , A61F2250/0068 , A61L31/16 , A61L2300/602 , A61L2300/61 , A61L2400/18 , A61L2420/02 , A61L2420/08 , H01J27/026
摘要： A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed. Gas cluster ion beam and/or accelerated Neutral Beam derived from an accelerated gas cluster ion beam may be employed.
摘要翻译： 适于用作药物递送系统的用于手术植入物的医疗装置具有一个或多个具有阻挡层的药物负载孔，以控制药物从孔中的释放或洗脱，或者控制流体向孔中的向内扩散。 阻挡层是非聚合物，并且由药物材料本身通过束加工形成。 孔可以是空间控制药物递送的图案。 灵活的选择允许药物组合，每孔可变药物剂量，每孔多种药物，药物释放顺序和形态的时间控制。 还公开了形成这种药物递送系统的方法。 可以采用来自加速气体团簇离子束的气体团簇离子束和/或加速中性束。
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