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    System and method for heating, cooling and heat cycling on microfluidic device
    7.
    发明授权
    System and method for heating, cooling and heat cycling on microfluidic device 有权
    微流体装置上加热，冷却和热循环的系统和方法

    公开(公告)号：US07648835B2

    公开(公告)日：2010-01-19

    申请号：US12199613

    申请日：2008-08-27

    申请人： Wayne L. Breidford ,  Christy A. Lancaster ,  Jon W. Hayenga ,  Ronald L. Bardell ,  Jeffrey F. Tonn ,  Bernhard H. Weigl

    发明人： Wayne L. Breidford ,  Christy A. Lancaster ,  Jon W. Hayenga ,  Ronald L. Bardell ,  Jeffrey F. Tonn ,  Bernhard H. Weigl

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5027 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2300/1877

    摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.

    摘要翻译： 微流控卡上集成的热交换系统。 根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。 微流控卡包括一个或多个含有放热或吸热材料的储存器。 一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。 可以在单个卡上包括多个储存器以提供变化的温度。 测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。 根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予 独立电路中的分析流体。 根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

    SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE
    10.
    发明申请
    SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE 有权
    用于加热，冷却和热循环的微流控装置的系统和方法

    公开(公告)号：US20090081771A1

    公开(公告)日：2009-03-26

    申请号：US12199613

    申请日：2008-08-27

    申请人： Wayne L. Breidford ,  Christy A. Lancaster ,  Jon W. Hayenga ,  Ronald L. Bardell ,  Jeffrey F. Tonn ,  Bernhard H. Weigl

    发明人： Wayne L. Breidford ,  Christy A. Lancaster ,  Jon W. Hayenga ,  Ronald L. Bardell ,  Jeffrey F. Tonn ,  Bernhard H. Weigl

    IPC分类号： C12M1/40

    CPC分类号： B01L3/5027 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2300/1877

    摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.

    摘要翻译： 微流控卡上集成的热交换系统。 根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。 微流控卡包括一个或多个含有放热或吸热材料的储存器。 一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。 可以在单个卡上包括多个储存器以提供变化的温度。 测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。 根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予 独立电路中的分析流体。 根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。