专利检索 ipc:"C12N15/52" 第 1 页

1.

发明公开
METHODS FOR REGULATING NITROGEN METABOLISM DURING THE PRODUCTION OF ETHANOL FROM CORN BY METABOLICALLY ENGINEERED YEAST STRAINS 审中-公开

公开(公告)号：US20240360484A1

公开(公告)日：2024-10-31

申请号：US18443045

申请日：2024-02-15

申请人： Lallemand Hungary Liquidity Management LLC

发明人： Aaron Argyros , Trisha Barrett

IPC分类号： C12P7/06 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/34 , C12N9/50 , C12N9/60 , C12N15/52 , C12P7/10

CPC分类号： C12P7/06 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1029 , C12N9/2428 , C12N9/50 , C12N9/60 , C12N9/93 , C12N15/52 , C12Y104/01002 , C12Y104/01004 , C12Y104/01014 , C12Y603/01002 , C12Y603/04006 , C12P7/10 , C12Y101/01001 , C12Y101/01002 , C12Y102/0101 , C12Y197/01004 , C12Y203/01054 , C12Y302/01003 , C12Y304/23041 , Y02E50/10

摘要： The present invention provides for a mechanism to reduce glycerol production and increase nitrogen utilization and ethanol production of recombinant microorganisms. One aspect of this invention relates to strains of S. cerevisiae with reduced glycerol productivity that get a kinetic benefit from higher nitrogen concentration without sacrificing ethanol yield. A second aspect of the invention relates to—metabolic modifications resulting in altered transport and/or intracellular metabolism of nitrogen sources present in corn mash.

2.

发明公开
CANCER VACCINES TARGETING SURVIVIN AND USES THEREOF 审中-公开

公开(公告)号：US20240358809A1

公开(公告)日：2024-10-31

申请号：US18765553

申请日：2024-07-08

申请人： Inovio Pharmaceuticals, Inc.

发明人： Jian YAN , Anna SLAGER , Bradley GARMAN , Neil COOCH

IPC分类号： A61K39/00 , A61K39/39 , A61P35/00 , C07K16/40 , C12N15/52 , C12N15/62

CPC分类号： A61K39/00115 , A61K39/39 , A61P35/00 , C07K16/40 , C12N15/52 , C12N15/62 , A61K2039/53 , A61K2039/55527 , A61K2039/575

摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens are disclosed. Methods of treating a subject with a Survivin-expressing tumor and methods of preventing a Survivin-expressing tumor are disclosed. Synthetic consensus Survivin antigens are disclosed.

3.

发明授权
Compositions for treating pathological calcification conditions, and methods using same 有权

公开(公告)号：US12128087B2

公开(公告)日：2024-10-29

申请号：US17369830

申请日：2021-07-07

申请人： YALE UNIVERSITY

发明人： Demetrios Braddock , Ronald Albright

IPC分类号： A61K38/17 , A01K67/0271 , A61K38/02 , A61K38/04 , A61K38/46 , A61K48/00 , A61P9/10 , A61P13/12 , C07K7/06 , C07K14/745 , C12N9/96 , C12N15/52 , C12N15/62 , C12N15/85 , C12Q1/6883

CPC分类号： A61K38/1741 , A01K67/0271 , A61K38/02 , A61K38/04 , A61K38/46 , A61K38/465 , A61K48/0058 , A61P9/10 , A61P13/12 , C07K7/06 , C07K14/745 , C12N9/96 , C12N15/52 , C12N15/625 , C12N15/85 , C12Q1/6883 , C12Y301/04001 , C12Y306/01009 , A01K2207/15 , A01K2207/20 , A01K2227/105 , A01K2267/0387 , C07K2319/01 , C07K2319/30 , C07K2319/31 , C07K2319/33 , C07K2319/70 , C12N2840/007

摘要： The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.

4.

发明授权
Production of steviol glycosides in recombinant hosts 有权

公开(公告)号：US12123042B2

公开(公告)日：2024-10-22

申请号：US17899069

申请日：2022-08-30

申请人： EVOLVA SA

发明人： Helene Lunde Robertsen , Iben Nordmark Andersen , Adam Matthew Takos , Swee Chuang Lim Hallwyl , Francesca Ambri , Manuel Quiros Asensio , Michael Dalgaard Mikkelsen , Jens Houghton-Larsen , Veronique Douchin , Jane Dannow Dyekjaer , Simon Carlsen , Nina Nicoline Rasmussen , Esben Halkjaer Hansen

IPC分类号： C12P19/56 , A23L27/30 , C07H15/256 , C12N9/02 , C12N9/10 , C12N9/88 , C12N9/90 , C12N15/52

CPC分类号： C12P19/56 , A23L27/36 , C07H15/256 , C12N9/0042 , C12N9/0073 , C12N9/1085 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y106/02004 , C12Y114/13078 , C12Y114/13079 , C12Y205/01029 , C12Y402/03019 , C12Y505/01013 , A23V2002/00 , C07K2319/00

摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

5.

发明授权
Generation of acyl amino acids 有权

公开(公告)号：US12123004B2

公开(公告)日：2024-10-22

申请号：US17260984

申请日：2019-07-18

申请人： Modular Genetics, Inc.

发明人： Kevin A. Jarrell , Michelle Pynn

IPC分类号： C12N15/52 , C12N1/20 , C12N9/02 , C12N9/10 , C12N9/90 , C12P13/14 , C12R1/125

CPC分类号： C12N15/52 , C12N1/20 , C12N9/0071 , C12N9/1007 , C12N9/90 , C12P13/14 , C12R2001/125 , C12Y502/01004

摘要： Engineered polypeptides or engineered microbial cells useful in synthesizing acyl amino acids are provided. In some embodiments, engineered polypeptides or engineered microbial cells are useful in synthesizing acyl amino acids with one or more hydroxyl and/or methyl groups at one or more positions of the fatty acid portion of the acyl amino acid (e.g., at ω-1, ω-2, and/or ω-3 positions of the fatty acid portion of the acyl amino acid). Also provided are methods of making acyl amino acids using engineered polypeptides and/or engineered microbial cells.

6.

发明授权
Methods to treat mucopolysaccharidosis type II or deficiency in iduronate-2-sulfatase using a recombinant adeno-associated virus (AAV) vector encoding iduronate-2-sulfatase 有权

公开(公告)号：US12121567B2

公开(公告)日：2024-10-22

申请号：US15717358

申请日：2017-09-27

申请人： Regents of the University of Minnesota , REGENXBIO Inc.

发明人： R. Scott McIvor , Lalitha R. Belur , Walter Low , Carolyn Fairbanks , Karen Kozarsky

IPC分类号： C12N15/11 , A61K38/43 , A61K38/47 , A61K48/00 , C12N7/00 , C12N15/00 , C12N15/113 , C12N15/52 , C12N15/85 , C12N15/86 , C12N15/861

CPC分类号： A61K38/47 , C12N7/00 , C12N15/86 , A61K48/00 , C12N2750/14143 , C12N2750/14171 , C12N2830/007 , C12Y302/01076

摘要： A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease.

7.

发明授权
Polypeptide variants 有权

公开(公告)号：US12116553B2

公开(公告)日：2024-10-15

申请号：US17735222

申请日：2022-05-03

申请人： The Procter & Gamble Company

发明人： Lars Beier , Lars Henrik Oestergaard , Annette Helle Johansen , Klaus Gori , Thomas Holberg Blicher , Gernot J. Abel , Steen Krogsgaard , Jens E Nielsen , Lars Giger , Neil Joseph Lant

IPC分类号： C11D3/386 , C11D3/00 , C11D3/48 , C12N9/22 , C12N15/52

CPC分类号： C11D3/38636 , C11D3/0068 , C11D3/386 , C11D3/38645 , C11D3/38654 , C11D3/48 , C12N9/22 , C12N15/52 , C11D2111/12 , C11D2111/14 , C12Y301/01074 , C12Y301/21001 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01015

摘要： Detergent compositions including polypeptide variants and methods of cleaning and/or treatment of surfaces using such compositions, and fabric treatment compositions including polypeptide variants. The compositions may include surfactants: anionic, nonionic and/or cationic.

8.

发明公开
STRAINS OF SACCHAROMYCES CEREVISIAE THAT EXHIBIT AN INCREASED ABILITY TO FERMENT OLIGOSACCHARIDES INTO ETHANOL WITHOUT SUPPLEMENTAL GLUCOAMYLASE AND METHODS OF MAKING AND USING THE SAME 审中-公开

公开(公告)号：US20240336929A1

公开(公告)日：2024-10-10

申请号：US18579192

申请日：2022-07-12

申请人： Xylogenics, Inc.

发明人： Joshua W. Heyen , Nadaraj Palaniappan , Kathryn A. Houin , Ross Cocklin , Mark G. Goebl

IPC分类号： C12N15/81 , C12N9/28 , C12N9/34 , C12N15/52 , C12P7/06 , C12R1/25 , C12R1/80 , C12R1/865

CPC分类号： C12N15/81 , C12N9/2417 , C12N9/2428 , C12N15/52 , C12P7/06 , C12N2510/02 , C12R2001/25 , C12R2001/80 , C12R2001/865

摘要： Disclosed herein is a yeast strain capable of fermenting corn mash into ethanol with no exogenous glucoamy lase resulting in greater speed and efficiency than the leading industrial strain. Said yeast strain causes enhanced co-fermentation of DP3 sugars, maltose and glucose in strains otherwise identical to commercial fuel ethanol yeast strains.

9.

发明公开
METHODS OF PRODUCING HMO BLEND PROFILES WITH LNFP-I AND LNT AS THE PREDOMINANT COMPOUNDS 审中-公开

公开(公告)号：US20240327886A1

公开(公告)日：2024-10-03

申请号：US18561233

申请日：2022-05-17

申请人： DSM IP Assets B.V.

发明人： Manos PAPADAKIS , Ted JOHANSON , Peter BECKER

IPC分类号： C12P19/04 , C07K14/245 , C12N1/20 , C12N9/10 , C12N15/52 , C12P19/18 , C12R1/19

CPC分类号： C12P19/04 , C07K14/245 , C12N1/20 , C12N9/1051 , C12N15/52 , C12P19/18 , C12R2001/19 , C12Y204/01062 , C12Y204/01069 , C12Y204/01222

摘要： This invention relates to a method of producing mixtures of various human milk oligosaccharides (HMOs) with unique HMO blend profiles, consisting predominantly of LNFP-I and LNT and of other HMOs in less significant amounts. The less abundant HMOs might be 2′-FL, LNT-II or DFL. The strategies for achieving specific HMO blends include strain engineering and fermentation methods.