公开(公告)号：US11793201B2

公开(公告)日：2023-10-24

申请号：US16892871

申请日：2020-06-04

申请人： Pro Farm Group, Inc.

发明人： Ratnakar Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana Lucia Cordova-Kreylos ,  Huazhang Huang

IPC分类号： A01N63/20 ,  A01N43/76 ,  A01N57/20 ,  C12N1/20 ,  A01N43/16 ,  A01N43/90 ,  A01N43/86 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12P17/18 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D263/32 ,  C07D263/34 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12P17/04 ,  C12N1/00 ,  C12R1/01 ,  C12R1/00 ,  A01N43/00

CPC分类号： A01N63/20 ,  A01N43/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/90 ,  A01N57/20 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12N1/205 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12P17/18 ,  A01N43/00 ,  C12N1/00 ,  C12R2001/00 ,  C12R2001/01 ,  A01N63/20 ,  A01N43/16 ,  A01N43/74 ,  A01N43/76 ,  A01N43/90

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US20230181482A1

公开(公告)日：2023-06-15

申请号：US18056367

申请日：2022-11-17

申请人： AstraZeneca AB

发明人： Martin HEMMERLING ,  Werngard CZECHTIZKY ,  David ULKOSKI ,  Aditya Ravindra POTE ,  Lennart LINDFORS

IPC分类号： A61K9/51 ,  A61K48/00 ,  C07D305/14 ,  C07D309/14 ,  C07D307/14 ,  C07D309/04 ,  C07D305/06 ,  C07D319/12 ,  C07D311/96 ,  C07D307/94

CPC分类号： A61K9/5123 ,  A61K9/5146 ,  A61K48/0033 ,  C07D305/14 ,  C07D309/14 ,  C07D307/14 ,  C07D309/04 ,  C07D305/06 ,  C07D319/12 ,  C07D311/96 ,  C07D307/94

摘要： Disclosed herein are compounds of Formula (I), Formula (III) or Formula (IIIa), or pharmaceutically acceptable salts thereof, wherein A, L, X1, X2, a, b, R1 and R2 are as defined herein. Also disclosed are lipid nanoparticles comprising a compound of Formula (I), Formula (III) or Formula (IIIa), or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a plurality of lipid nanoparticles comprising a compound of Formula (I), Formula (III) or Formula (IIIa), or a pharmaceutically acceptable salt thereof and a nucleic acid segment; as well as methods for delivering a nucleic acid segment comprising administering a plurality of lipid nanoparticles comprising a compound of Formula (I), Formula (III) or Formula (IIIa), or a pharmaceutically acceptable salt thereof, and a nucleic acid segment.

公开(公告)号：US20230133132A1

公开(公告)日：2023-05-04

申请号：US17798296

申请日：2021-02-05

申请人： Cytokinetics, Inc.

发明人： Antonio ROMERO ,  Aroop CHANDRA ,  Christopher Edward EVANS ,  Minxing SHEN

IPC分类号： C07D295/073 ,  C07D211/60 ,  C07D233/64 ,  C07D231/12 ,  C07C275/42 ,  C07C275/40 ,  C07D487/04 ,  C07D241/12 ,  C07D241/38 ,  C07D207/08 ,  C07D207/06 ,  C07D307/16 ,  C07D309/14 ,  C07D487/08 ,  C07D305/08 ,  C07D335/02 ,  C07D205/04 ,  C07D491/107 ,  C07D333/08 ,  C07D331/04 ,  C07D471/08 ,  C07D487/10 ,  C07D271/10 ,  C07D261/08 ,  C07D401/04 ,  C07D471/10 ,  C07D405/04 ,  C07D209/52 ,  C07D401/06 ,  C07D403/06 ,  C07D243/08 ,  C07D237/08 ,  C07D275/02 ,  C07D305/14 ,  C07D497/10 ,  C07D498/10 ,  C07D263/30 ,  C07D491/08 ,  C07D279/12 ,  C07D249/08

摘要： Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11632957B2

公开(公告)日：2023-04-25

申请号：US16794955

申请日：2020-02-19

申请人： CORTEVA AGRISCIENCE LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, Sr. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC分类号： A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US20230096220A1

公开(公告)日：2023-03-30

申请号：US17800261

申请日：2021-02-26

申请人： Zydus Lifesciences Limited

发明人： Rajiv SHARMA ,  Sameer AGARWAL

IPC分类号： A61K31/64 ,  C07C311/55 ,  C07D309/14 ,  C07D211/58 ,  C07D335/02 ,  C07D295/084 ,  C07D295/13 ,  C07C381/10 ,  A61K38/21 ,  A61K38/20 ,  A61K31/545 ,  A61K45/06

摘要： The present invention relates to novel compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as the compounds of the invention belong to the family of NOD-like receptor family (NLR) protein NLRP3 modulators. The present invention thus relates to novel NLRP3 modulators as well as to the use of the novel inhibitor compounds in the treatment of diseases or conditions in which interleukin 1β activity is implicated.

公开(公告)号：US20230002333A1

公开(公告)日：2023-01-05

申请号：US17869226

申请日：2022-07-20

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Yoshiaki Isshiki ,  Fumio Watanabe ,  Masaki Tomizawa ,  Kihito Hada ,  Kazuo Hattori ,  Kenichi Kawasaki ,  Ikumi Hyodo ,  Toshihiro Aoki

IPC分类号： C07D265/02 ,  C07D405/14 ,  C07D405/12 ,  C07C317/50 ,  C07C69/76 ,  C07D213/74 ,  C07F5/02 ,  C07D213/73 ,  C07C307/02 ,  C07F7/08 ,  C07D305/06 ,  C07D307/93 ,  C07D307/14 ,  C07D309/14 ,  C07D309/08 ,  C07D333/72 ,  C07D409/12 ,  C07C39/26 ,  C07C211/55 ,  C07D213/80 ,  C07D471/04 ,  C07C333/20

摘要： The present disclosure provides, for example, a compound represented by general formula (6) below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2═ or —N═, R2 is, for example, a halogen atom, R1 is, for example, —S(═O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

公开(公告)号：US20220395512A1

公开(公告)日：2022-12-15

申请号：US17663716

申请日：2022-05-17

申请人： TMEM16A Limited

发明人： Stephen Collingwood ,  Clive Mccarthy ,  Jonathan David Hargrave ,  Duncan Alexander Hay ,  Thomas Beauregard Schofield ,  Sarah Ellam ,  Craig Stephen Buxton ,  Matthew Habgood ,  Peter Neville Ingram ,  Chun Yan Ma ,  Spencer Charles Robert Napier ,  Abdul Kadar Shaikh ,  Matthew Raymond Smith ,  Christopher Charles Stimson ,  Edward Richard Walker

IPC分类号： A61K31/5377 ,  A61K31/167 ,  A61K31/351 ,  A61K31/4025 ,  A61K31/4045 ,  A61K31/416 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/498 ,  A61K45/06 ,  C07C233/76 ,  C07D209/18 ,  C07D213/81 ,  C07D231/56 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

公开(公告)号：US20220304312A1

公开(公告)日：2022-09-29

申请号：US17834252

申请日：2022-06-07

申请人： Marrone Bio Innovations, Inc.

发明人： Ratnakar N. Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana Lucia Cordova-Kreylos ,  Huazhang Huang

IPC分类号： A01N63/20 ,  A01N43/76 ,  A01N43/16 ,  A01N43/90 ,  A01N43/86 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12N1/20 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D263/32 ,  C07D263/34 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12P17/04

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US20220177456A1

公开(公告)日：2022-06-09

申请号：US17436297

申请日：2020-03-06

申请人： Denali Therapeutics Inc.

发明人： Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Katrina W. Lexa ,  Maksim Osipov ,  Zachary K. Sweeney ,  Arun Thottumkara

IPC分类号： C07D405/06 ,  C07D309/14 ,  C07D405/12 ,  C07D471/04 ,  C07D405/04

摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

公开(公告)号：US20220002309A1

公开(公告)日：2022-01-06

申请号：US17287781

申请日：2019-10-23

申请人： Metacrine, Inc.

发明人： Nicholas D. SMITH ,  Andrew R. HUDSON ,  Mi CHEN ,  Johnny Y. NAGASAWA ,  Iriny BOTROUS

IPC分类号： C07D491/107 ,  C07C237/24 ,  C07D309/14 ,  C07D295/185 ,  C07D257/04 ,  C07D241/18 ,  C07D273/01 ,  C07D498/08 ,  C07D307/22 ,  C07D307/93 ,  C07D233/60 ,  C07D205/04 ,  C07D231/12 ,  C07D241/04 ,  C07D239/42 ,  C07D239/34 ,  C07C311/14 ,  A61P1/16

摘要： Described herein are compounds that are semicarbazide-sensitive amine oxidase (SSAO) inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating or preventing a liver disease or condition.