-
公开(公告)号：US09677675B2
公开(公告)日：2017-06-13
申请号：US14413556
申请日：2013-07-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , Sebastien Cirou , Virginie Buisson , Christine Abouayad El Idrissi , Jim Kelly
Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).
-
公开(公告)号：US09676069B2
公开(公告)日：2017-06-13
申请号：US14311399
申请日：2014-06-23
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Jean-Louis Weissenbach , Rene Reinbigler , Jean-Luc Beulay , Frans Mels , Cecile Delbos
IPC: B01D25/12 , B01D25/127 , B01D25/164 , B01D61/18 , B01D61/20 , B01D63/08 , B23P19/04 , B01D25/19
CPC classification number: B23P19/04 , B01D25/127 , B01D25/14 , B01D25/164 , B01D25/19 , B01D61/18 , B01D61/20 , B01D63/082 , B01D2313/02 , B01D2313/06 , B01D2313/105 , B01D2313/125 , Y10T29/49826
Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.
-
公开(公告)号：US09573230B2
公开(公告)日：2017-02-21
申请号：US14506946
申请日：2014-10-06
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Jean-Louis Weissenbach , Rene Reinbigler , Jean-Luc Beulay , Frans Mels , Cecile Delbos
IPC: B01D25/12 , B01D25/127 , B01D25/164 , B01D25/19 , B01D61/18 , B01D61/20 , B01D63/08 , B23P19/04
CPC classification number: B23P19/04 , B01D25/127 , B01D25/14 , B01D25/164 , B01D25/19 , B01D61/18 , B01D61/20 , B01D63/082 , B01D2313/02 , B01D2313/06 , B01D2313/105 , B01D2313/125 , Y10T29/49826
Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.
Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管和机械连接，其包括相对于歧管可移动地安装的夹板，并且适于将至少一个盒压靠在歧管上，用于驱动和引导夹板的装置， 所述歧管和所述板，致动器，其设置有主体和可相对于所述主体移动的构件，所述构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由所述歧管承载，并且所述主体 承载杆并且通过杆将板驱动到夹紧位置，在该夹紧位置处，构件处于中间缩回位置，在该夹紧位置中，其已经相对于其延伸位置移动比预定行程更短的行程。
-
公开(公告)号：US09482351B2
公开(公告)日：2016-11-01
申请号：US13972301
申请日：2013-08-21
Applicant: EMD Millipore Corporation
Inventor： Stephen Proulx , Joseph Almasian , Naren Renganath , Stephen Tingley , Martin Morrissey
IPC: A61M5/00 , F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , F16K3/26 , F16K17/40 , F16K15/18 , F16L37/107
CPC classification number: F16K5/00 , A61M39/10 , A61M39/16 , A61M39/18 , A61M39/22 , A61M2039/1027 , A61M2039/222 , F16K3/265 , F16K13/04 , F16K15/18 , F16L37/107
Abstract: The present invention relates to a process for the sterile transfer of fluids, be they liquids or gases. It uses a presterilized device comprised of a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to a downstream component such as a filter, pipeline, sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components. The device is attached to an upstream component and the face and the first end of the plunger are steam sterilized in place.
-
公开(公告)号：US20160244710A1
公开(公告)日：2016-08-25
申请号：US14915796
申请日：2014-10-03
Applicant: EMD MILLIPORE CORPORATION
Inventor： Amy Wood , Dave Kraus , Anne Hansen , Kara Der , James McSweeney
CPC classification number: C12M27/02 , B01F3/04269 , B01F3/04531 , B01F7/22 , B01F13/0863 , B01F15/0022 , B01F15/00344 , B01F15/0085 , B01F2003/04297 , B01F2003/04631 , B01F2003/04673 , B01F2215/0073 , C12M29/06 , C12Q3/00
Abstract: An aeration device, and containers or vessels incorporating the same. The aeration device can comprise a plurality of interchangeable aeration elements that can produce gas bubble of different sizes and deliver them to the contents of the container. Also disclosed are containers, such as a disposable or single-use container, optionally having one or more inlets and one or more outlets, an aeration device including a plurality of aeration elements, and a mixer to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container can be a bioreactors and the aeration device controls the dissolved gas concentration content of the bioreactor contents, thereby facilitating proper growth of cell cultures in the bioreactor.
Abstract translation: 曝气装置，以及装有该装置的容器或容器。 曝气装置可以包括多个可互换曝气元件，其可以产生不同尺寸的气泡并将其输送到容器的内容物。 还公开了容器，例如一次性或一次性容器，可选地具有一个或多个入口和一个或多个出口，包括多个通气元件的曝气装置和用于引起混合，分散，均质化和/或 包含或添加到容器中的一种或多种成分的循环。 容器可以是生物反应器，曝气装置控制生物反应器内容物的溶解气体浓度含量，从而促进生物反应器中细胞培养物的适当生长。
-
Patent Agency Ranking
公开(公告)号：US09296983B2
公开(公告)日：2016-03-29
申请号：US14032358
申请日：2013-09-20
Applicant: EMD Millipore Corporation
Inventor： Pierre Guedon
CPC classification number: C12M33/07 , B01L3/567 , G01N1/10 , G01N35/1097 , G01N2001/022
Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.
-
公开(公告)号：US09295947B2
公开(公告)日：2016-03-29
申请号：US14190560
申请日：2014-02-26
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
-
158.发明申请Processes for Filtering Liquids Using Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems with Recirculation of Retentate 审中-公开使用单道切向流过滤系统过滤液体的过程和具有再渗透的切向流过滤系统公开(公告)号：US20160059160A1
公开(公告)日：2016-03-03
申请号：US14839852
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/04 , B01D63/12 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2313/44 , B01D2315/10
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
Abstract translation: 公开了过滤液体进料的方法。 在一个版本中，该方法包括使液体进料通过单通道切向流过滤（SPTFF）系统，并且在分离的容器中从系统中回收渗余物和渗透物，而不通过SPTFF系统再循环。 在另一个版本中，过滤液体进料的方法包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从体系中回收渗透物和一部分滞留物，而不通过TFF系统再循环 剩余的残留物通过TFF系统至少一次。 该方法可以使用包括歧管段的SPTFF或TFF系统来执行，以串行化进料和滞留物的流动路径，而不需要转向板。
-
公开(公告)号：US20160040113A1
公开(公告)日：2016-02-11
申请号：US14782487
申请日：2014-03-17
Applicant: EMD Millipore Corporation
Inventor： Kara Der , Anne Hansen , James McSweeney , David Kraus , Jeffrey Pearsons , Amy Wood
Abstract: A container, such as a disposable or single use bioreactor, optionally having one or more inlets and one or more outlets and a mixer associated with the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The container includes a flexible baffle shaped and positioned within the container to improve mixing, particularly to improve low shear mixing. The baffle is positioned within the container so as to disrupt the vortex formed by the mixer, or prevent formation of a vortex. The baffle is shaped with both horizontal and vertical elements to enhance disruption of the vortex across the entire vessel height and provide homogeneous mixing throughout all operating volumes. In certain embodiments, the baffle is X-shaped.
Abstract translation: 一个容器，例如一次性或单次使用的生物反应器，任选地具有一个或多个入口和一个或多个出口以及与该容器相关联的混合器，以使包含或添加到一个或多个成分中的一种或多种成分混合，分散，均化和/或循环 容器 容器包括形状并定位在容器内的柔性挡板以改善混合，特别是改善低剪切混合。 挡板位于容器内，以便破坏由混合器形成的涡流，或防止形成涡流。 挡板被成形为具有水平和垂直元件，以增强跨越整个容器高度的涡流的破坏，并在整个操作体积中提供均匀的混合。 在某些实施例中，挡板是X形的。
-
公开(公告)号：US20150360180A1
公开(公告)日：2015-12-17
申请号：US14736646
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Herbert Lutz , Joseph Parrella
CPC classification number: B01D61/145 , B01D61/142 , B01D61/18 , B01D63/082 , B01D65/02 , B01D2313/18 , B01D2315/10 , B01D2319/022 , B01D2319/04 , B01D2321/04 , B01D2321/06 , B01D2321/164 , C07K1/34 , Y10T29/49828
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
Abstract translation: 本发明在各种实施例中提供了混合单通道切向流过滤组件，一次性单通道切向流过滤组件，可扩展单通道切向流过滤组件和可适应的模块化单通道切向流过滤组件。 在其它实施方案中，本发明涉及在单程切向流过滤组件中从过滤膜的表面回收蛋白质并用于清洗切向流过滤组件的方法。 在另外的实施例中，本发明提供了增加单通切向流过滤组件的处理能力的方法。
-
-
-
-
-
-
-
-
-
Search Results
488
records
(took 0.029 seconds)
