中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

503 records (took 0.035 seconds)

    Ion mobility spectrometer with high throughput
    12.
    发明授权
    Ion mobility spectrometer with high throughput 有权

    公开(公告)号：US09683963B2

    公开(公告)日：2017-06-20

    申请号：US14418856

    申请日：2013-05-02

    Applicant: LECO Corporation

    Inventor： Anatoly N. Verenchikov

    IPC: H01J49/00 ,  G01N27/62 ,  H01J49/06 ,  H01J49/40

    CPC classification number: G01N27/622 ,  H01J49/00 ,  H01J49/06 ,  H01J49/061 ,  H01J49/40

    Abstract: A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local RF field barrier opposed to a switching DC field. Alternatively, the speed and charge throughput of ion mobility separator are improved by arranging coaxial mobility cell followed by conical coaxial ion channel. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the IMS. The invention is particularly suited for rapid dual gas chromatography, fast CE. Preferably, the accelerated and wide bore IMS is coupled to a multi-reflecting time-of-flight mass spectrometer with a fast encoded orthogonal acceleration. Speed and sensitivity of IMS with fast pulsing MR-TOF make it practical to arrange analytical methods of comprehensive and orthogonal separation in multiple analytical dimensions.

    Miniaturized ion mobility spectrometer
    13.
    发明授权
    Miniaturized ion mobility spectrometer 有权

    公开(公告)号：US09646811B2

    公开(公告)日：2017-05-09

    申请号：US14597132

    申请日：2015-01-14

    Applicant: Rapiscan Systems, Inc.

    Inventor： William J Kaye ,  Robert M. Stimac

    IPC: H01J49/00 ,  G01N27/62 ,  H01J49/02

    CPC classification number: H01J49/0013 ,  G01N27/622 ,  H01J49/00 ,  H01J49/022

    Abstract: By utilizing the combination of a unique electronic ion injection control circuit in conjunction with a particularly designed drift cell construction, the instantly disclosed ion mobility spectrometer achieves increased levels of sensitivity, while achieving significant reductions in size and weight. The instant IMS is of a much simpler and easy to manufacture design, rugged and hermetically sealed, capable of operation at high temperatures to at least 250° C., and is uniquely sensitive, particularly to explosive chemicals.

    Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
    14.
    发明授权
    Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis 有权
    通过频谱控制氢氘交换

    公开(公告)号：US09484194B2

    公开(公告)日：2016-11-01

    申请号：US13885913

    申请日：2011-11-16

    Applicant: Jeffery Mark Brown ,  Steven Derek Pringle ,  Keith Richardson

    Inventor： Jeffery Mark Brown ,  Steven Derek Pringle ,  Keith Richardson

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/26

    CPC classification number: H01J49/0077 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/0054 ,  H01J49/0072 ,  H01J49/06 ,  H01J49/065 ,  H01J49/26

    Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.

    Abstract translation: 公开了一种质谱仪，其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应 器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

    Evaluation peptide for use in quantification of protein using mass spectrometer, artificial standard protein, and method for quantifying protein
    15.
    发明授权
    Evaluation peptide for use in quantification of protein using mass spectrometer, artificial standard protein, and method for quantifying protein 有权
    用于使用质谱仪定量蛋白质的评估肽，人造标准蛋白质和用于定量蛋白质的方法

    公开(公告)号：US09481710B2

    公开(公告)日：2016-11-01

    申请号：US13202474

    申请日：2010-01-27

    Applicant: Sumio Ohtsuki ,  Junichi Kamiie ,  Tetsuya Terasaki

    Inventor： Sumio Ohtsuki ,  Junichi Kamiie ,  Tetsuya Terasaki

    IPC: C12Q1/37 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K7/06 ,  C07K7/08 ,  G01N33/68 ,  H01J49/00

    CPC classification number: C07K7/06 ,  C07K7/08 ,  G01N33/6848 ,  H01J49/00

    Abstract: Disclosed is an evaluation peptide for evaluating the efficiency of a pretreatment in the quantification of a protein using a mass spectrometer, having high reliability and high general versatility. Also disclosed is an artificial standard protein comprising the evaluation peptide. Further disclosed is a method for quantifying a protein utilizing the artificial standard protein. Specifically disclosed is a method for selecting a peptide which consists of an amino acid sequence not agreeing with that in a naturally occurring protein and a variant thereof and capable of being detected by mass spectrometry and which has an amino acid that can be recognized by a protein-digesting enzyme, and using the peptide as an evaluation peptide for use in the quantification of a protein by a mass spectrometer.

    Abstract translation: 公开了一种用于评估在使用质谱仪定量蛋白质中的预处理效率的评估肽，其具有高可靠性和高通用性。 还公开了包含评价肽的人造标准蛋白质。 另外公开了利用人造标准蛋白质定量蛋白质的方法。 具体公开的是选择由与天然存在的蛋白质及其变体不同的氨基酸序列组成的能够通过质谱法检测并且具有可被蛋白质识别的氨基酸的肽的方法 并且使用肽作为用于通过质谱仪定量蛋白质的评估肽。

    Electrokinetically controlled calibrant delivery
    16.
    发明授权
    Electrokinetically controlled calibrant delivery 有权
    电动控制校准品输送

    公开(公告)号：US09396916B2

    公开(公告)日：2016-07-19

    申请号：US14004236

    申请日：2012-03-08

    Applicant: Geoff C. Gerhardt ,  Keith Fadgen

    Inventor： Geoff C. Gerhardt ,  Keith Fadgen

    IPC: G01D18/00 ,  G12B13/00 ,  H01J49/00 ,  H01J49/04

    CPC classification number: H01J49/0009 ,  H01J49/00 ,  H01J49/04

    Abstract: An electrokinetic pump can be used to deliver calibrant (“lock mass”) ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user-friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.

    Abstract translation: 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效固态切换。

    Method for predicting breast cancer patient response to combination therapy
    19.
    发明授权
    Method for predicting breast cancer patient response to combination therapy 有权
    预测乳腺癌患者联合治疗反应的方法

    公开(公告)号：US09254120B2

    公开(公告)日：2016-02-09

    申请号：US13741634

    申请日：2013-01-15

    Applicant: Biodesix, Inc.

    Inventor： Joanna Röder ,  Julia Grigorieva ,  Heinrich Röder

    IPC: G01N31/00 ,  A61B10/00 ,  G01N33/574 ,  G01N33/68 ,  G06F19/24 ,  H01J49/00

    CPC classification number: A61B10/0041 ,  G01N33/57415 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2333/485 ,  G01N2333/71 ,  G01N2800/52 ,  G06F19/24 ,  H01J49/00

    Abstract: A mass-spectral method is disclosed for determining whether breast cancer patient is likely to benefit from a combination treatment in the form of administration of a targeted anti-cancer drug in addition to an endocrine therapy drug. The method obtains a mass spectrum from a blood-based sample from the patient. The spectrum is subject to one or more predefined pre-processing steps. Values of selected features in the spectrum at one or more predefined m/z ranges are obtained. The values are used in a classification algorithm using a training set comprising class-labeled spectra and a class label for the sample is obtained. If the class label is “Poor”, the patient is identified as being likely to benefit from the combination treatment. In a variation, the “Poor” class label predicts whether the patient is unlikely to benefit from endocrine therapy drugs alone, regardless of the patient's HER2 status.

    Abstract translation: 公开了用于确定乳腺癌患者是否可能以除了内分泌治疗药物之外的靶向抗癌药物的施用形式的组合治疗中受益的质谱方法。 该方法从患者的血液样品获得质谱。 光谱受一个或多个预定义的预处理步骤的限制。 获得在一个或多个预定义m / z范围内的光谱中所选特征的值。 这些值用于使用包括类标记光谱的训练集的分类算法，并且获得样本的类标签。 如果班级标签为“差”，患者被确定为可能从组合治疗中受益。 在一个变化中，“不良”类标签预测患者是否不太可能从单独的内分泌治疗药物中受益，无论患者的HER2状况如何。

    PLASMA CLEANING FOR MASS SPECTROMETERS
    20.
    发明申请
    PLASMA CLEANING FOR MASS SPECTROMETERS 有权
    等离子体清洗大量光谱仪

    公开(公告)号：US20160035550A1

    公开(公告)日：2016-02-04

    申请号：US14814147

    申请日：2015-07-30

    Applicant: Agilent Technologies, Inc.

    Inventor： Gershon Perelman ,  Mark Denning ,  Mehrnoosh Vahidpour ,  Guthrie Partridge

    IPC: H01J49/00 ,  H01J49/38 ,  H01J49/22 ,  H01J49/02 ,  H01J49/20

    CPC classification number: H01J49/00

    Abstract: A mass spectrometry (MS) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode. In the analytical mode a sample is analyzed, and plasma may or may not be actively generated. In the cleaning mode the plasma is actively generated, and the sample may or may not be analyzed.

    Abstract translation: 质谱（MS）系统可以通过产生等离子体并且与待清洁系统的内表面与等离子体接触来清洁。 可以在分析模式和清洁模式之间切换系统。 在分析模式下，分析样品，并且等离子体可能或可能不被主动产生。 在清洁模式中，主动地产生等离子体，并且样品可以被分析也可以不被分析。

Patent Agency Ranking