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    Nucleic acid adaptors and uses thereof
    221.
    发明授权
    Nucleic acid adaptors and uses thereof 有权

    公开(公告)号：US10450608B2

    公开(公告)日：2019-10-22

    申请号：US15372938

    申请日：2016-12-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Bin Li ,  Zhoutao Chen ,  Tanya Biorac ,  Melvin Wei

    IPC: C12P19/34 ,  C12Q1/6876 ,  C12Q1/6806 ,  C12N15/10 ,  C12N9/12 ,  C12N9/20 ,  C12Q1/6832 ,  C12N15/64

    Abstract: Provided herein are compositions, systems, methods, and kits for joining together the ends of one or more polynucleotides using at least one pair of blocking oligonucleotide adaptors. Blocking oligonucleotide adaptors can comprise a double-stranded oligonucleotide adaptor (duplex) having an overhang cohesive portion that anneals with a blocking oligonucleotide which can be a separate single-stranded oligonucleotide. Also provided herein are compositions generated using the blocking oligonucleotide adapters, including circularized polynucleotides, that may be manipulated, for example, through nick translation, to yield a linear mate pair construct.

    FLUID DISPENSING SYSTEM WITH ROTATABLE PORT ASSEMBLY
    224.
    发明申请
    FLUID DISPENSING SYSTEM WITH ROTATABLE PORT ASSEMBLY 审中-公开

    公开(公告)号：US20190283908A1

    公开(公告)日：2019-09-19

    申请号：US16431530

    申请日：2019-06-04

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Steven R. Kjar

    IPC: B65B3/00 ,  C12M1/00 ,  B65B3/36 ,  F16K11/085 ,  A61M39/22 ,  B65B3/28 ,  B65B39/00

    Abstract: A manifold port assembly includes a housing bounding a compartment and having an inlet port and a plurality of outlet ports formed thereon and communicating with the compartment. A carousel bounds a plurality of fluid paths that extend therethrough from a corresponding first end to an opposing corresponding second end, at least a portion of each fluid path being spaced apart from the housing and being radially enclosed by the carousel, the carousel being rotatably disposed within the compartment of the housing so that when the first end or the second end of each fluid path is aligned with the inlet port on the housing, the other of the first end or second end of each fluid path is aligned with a corresponding different one of each of the plurality of outlet ports.

    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING
    225.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20190277799A1

    公开(公告)日：2019-09-12

    申请号：US16271979

    申请日：2019-02-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Melville DAVEY ,  Simon CAWLEY ,  Alan WILLIAMS

    IPC: G01N27/414 ,  G16B30/00

    Abstract: A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.

    Systems and methods for biological analysis
    226.
    发明授权
    Systems and methods for biological analysis 有权

    公开(公告)号：US10385383B2

    公开(公告)日：2019-08-20

    申请号：US15048324

    申请日：2016-02-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Ronald Danehy ,  Gary Lim ,  Jacob Freudenthal

    IPC: C12Q1/6806 ,  C12M1/32 ,  C12M1/00 ,  B01L3/00

    Abstract: A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.

    Preparation of electrophoresis gels, and related devices, systems, and methods
    230.
    发明授权
    Preparation of electrophoresis gels, and related devices, systems, and methods 有权

    公开(公告)号：US10359396B2

    公开(公告)日：2019-07-23

    申请号：US15349106

    申请日：2016-11-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kyle Bulloch ,  Thomas Diller

    IPC: G01N27/447

    Abstract: An apparatus for preparation of an electrophoresis slab gel may include a base having an opening configured to receive a cassette configured to contain an electrophoresis slab gel, a clamping mechanism configured to move relative to the base between an open position in which the clamping mechanism permits insertion of a cassette into the base, and a closed position in which the clamping mechanism is configured to clamp a cassette received in the base, a compressible pad operatively coupled to the clamping mechanism in a position to compress against a cassette received in the base in the closed position of the clamping mechanism. The cassette may include a first plate and a second plate, and a spacer mechanism separate from each of the first and second plates, the spacer mechanism configured to be positioned between the inner faces of the first plate and the second plate. When subjected to a clamping force exerted on the outer faces of the first and second plates, the spacer mechanism is configured to maintain a separation distance between the inner faces of the first and second plates, and provide a seal to prevent leakage of an electrophoresis gel solution introduced between the plates.

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