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    Infusion Device
    241.
    发明申请
    Infusion Device 审中-公开
    输液装置

    公开(公告)号：US20160339169A1

    公开(公告)日：2016-11-24

    申请号：US15330023

    申请日：2016-07-26

    Applicant: STC.UNM

    Inventor： Mark Hauswald

    IPC: A61M5/145 ,  A61M5/14

    CPC classification number: A61M5/1452 ,  A61M5/1413 ,  A61M5/1414 ,  A61M5/14216 ,  A61M5/1422 ,  A61M5/1454 ,  A61M5/16809 ,  A61M5/31535 ,  A61M2202/048

    Abstract: A mechanical infusion pump device for injecting medication into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger connected to a filling plunger that is moved with the syringe plunger in a first syringe-filling direction to fill the syringe with fluid medication. Biasing weight(s) is/are provided on the filling plunger for exerting bias or force from gravity on the filling plunger and the syringe plunger in a second syringe-discharging direction to dispense medication from the syringe into the patient's IV when the filling plunger is released. Only a calibrated amount of medicine can be discharged to the patent's IV over time as determined by calibration of the biasing weights and the metering element located between the syringe and the patient's IV for a given viscosity of the medication.

    Abstract translation: 用于将药物注射到患者IV中的机械输液泵装置包括IV储存器和连接到IV贮存器的注射器，并且具有连接到填充柱塞的注射器柱塞，所述注射器柱塞与注射器柱塞在第一注射器填充方向上移动 用流体药物填充注射器。 在填充柱塞上提供偏压重量，以在第二注射器排出方向上施加来自填充柱塞和注射器柱塞的重力的偏压或力，以便当填充柱塞为止时将注射器中的药物从注射器分配到患者IV中 释放 对于给定的药物粘度，仅通过校准偏置重量和位于注射器和患者IV之间的计量元件确定的随着时间的推移，校准量的药物可以排出到专利IV。

    In Vivo Extraction of Interstitial Fluid Using Hollow Microneedles
    243.
    发明申请
    In Vivo Extraction of Interstitial Fluid Using Hollow Microneedles 审中-公开
    使用空心微针对间质液的体内提取

    公开(公告)号：US20160296149A1

    公开(公告)日：2016-10-13

    申请号：US15078870

    申请日：2016-03-23

    Applicant: Sandia Corporation ,  STC.UNM

    Inventor： Ronen Polsky ,  Philip Rocco Miller ,  Justin T. Baca

    IPC: A61B5/145 ,  A61B5/1477 ,  A61B5/1455

    CPC classification number: A61B5/14514 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/165 ,  A61B2010/008 ,  A61M2037/0061

    Abstract: A transdermal and/or intradermal diagnostic device comprising a combined hollow microneedle interstitial fluid (IF) extraction device and a detector can monitor biomarkers in-situ. For example, electrode transducers with optimally arrayed and designed microneedles can be combined with a suitable pumping method to determine biomarker levels in human subjects under intense physical exertion to monitor metabolic stress and fatigue. The device can perform real-time, in-situ measurements of lactate in human subjects. Monitoring of other biomarkers is straightforward.

    Abstract translation: 包括组合的中空微针间质液（IF）提取装置和检测器的透皮和/或皮内诊断装置可以原位监测生物标志物。 例如，具有最佳排列和设计的微针的电极传感器可以与合适的泵送方法结合，以确定强烈体力劳动下人体受试者的生物标志物水平，以监测代谢应激和疲劳。 该装置可以对人类受试者的乳酸进行实时，原位测量。 监测其他生物标志物是直接的。

    SYNTHETIC LONG READ DNA SEQUENCING
    244.
    发明申请
    SYNTHETIC LONG READ DNA SEQUENCING 审中-公开
    合成长读DNA序列

    公开(公告)号：US20160244811A1

    公开(公告)日：2016-08-25

    申请号：US15027069

    申请日：2014-09-24

    Applicant: STC.UNM

    Inventor： Jeremy Scott Edwards

    IPC: C12Q1/68

    CPC classification number: C12Q1/689 ,  C12Q1/6853 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2525/161 ,  C12Q2525/179 ,  C12Q2563/179

    Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

    Abstract translation: 本公开描述了通过组装多个较短的多核苷酸读取来测序DNA序列的长部分的方法。 通常，该方法包括将多个引物退火至变性DNA分子，将条形码多核苷酸附加到引物的5'末端，对DNA分子进行多个循环（1）合并，（2）分裂和 （3）将条形码多核苷酸添加到引物的5'末端，对条形码多核苷酸和基因组DNA进行测序，并组装具有相同条形码多核苷酸的短读多核苷酸序列。

    TREATMENT OF AUTOPHAGY-RELATED DISORDERS
    246.
    发明申请
    TREATMENT OF AUTOPHAGY-RELATED DISORDERS 审中-公开
    治疗自身免疫性疾病

    公开(公告)号：US20160136123A1

    公开(公告)日：2016-05-19

    申请号：US14898062

    申请日：2014-05-29

    Applicant: Vojo P. DERETIC ,  Michale MANDELL ,  STC.UNM

    Inventor： Vojo P. Deretic ,  Michael Mandell

    IPC: A61K31/201 ,  C12Q1/61 ,  C12Q1/44 ,  A61K45/06 ,  A61K38/53

    CPC classification number: A61K31/201 ,  A61K38/53 ,  A61K45/06 ,  C12N9/93 ,  C12Q1/44 ,  C12Q1/61 ,  C12Y603/02 ,  G01N2333/92 ,  G01N2405/00 ,  G01N2405/02 ,  G01N2500/20 ,  G01N2800/7028

    Abstract: The present invention relates to the use of neutral lipids, including triglycerides, diglycerides and monoglycerides which may be used to increase neutral lipids (lipid stores and/or lipid droplets) and neutral lipid stores in order to regulate (in particular, induce) autophagy and treat and/or prevent autophagy related disease states and/or conditions. In one embodiment, the invention relates to the use of neutral lipids and/or TRIM proteins which may be used to regulate (in particular, induce) autophagy, target autophagic substrates and treat and/or prevent autophagic disease states and/or conditions.

    Abstract translation: 本发明涉及使用中性脂质，包括甘油三酸酯，甘油二酯和甘油单酯，其可用于增加中性脂质（脂质储存和/或脂质液滴）和中性脂质储存物，以调节（特别是诱导）自噬和 治疗和/或预防自噬相关疾病状态和/或病症。 在一个实施方案中，本发明涉及可用于调节（特别是诱导）自噬，靶自噬底物并治疗和/或预防自噬性疾病状态和/或病症的中性脂质和/或TRIM蛋白的用途。

    Low power photonic control of microwave power using bulk illumination and RF resonance
    247.
    发明授权
    Low power photonic control of microwave power using bulk illumination and RF resonance 有权
    使用大容量照明和RF共振的微波功率的低功率光子控制

    公开(公告)号：US09306265B1

    公开(公告)日：2016-04-05

    申请号：US14083140

    申请日：2013-11-18

    Applicant: STC.UNM

    Inventor： Mani Hossein-Zadeh

    IPC: H01P7/08 ,  H01P7/00

    CPC classification number: H01P7/00 ,  H01P1/20363 ,  H01P7/082 ,  H01P7/088

    Abstract: A photonically controlled microwave device having a photosensitive substrate having an interior region comprising a high radio frequency (“RF”) field for a resonant RF mode. An RF resonator is patterned on a surface of the substrate, the pattern includes an aperture in the resonator positioned to direct light received from a light source to the interior region. The light source may have a wavelength that enables illumination of the interior region to generate free carriers or other photo-induced changes in RF permittivity. An optical boundary may be provided that recirculates the unabsorbed optical power inside the high RF field region until it is fully absorbed.

    Abstract translation: 一种具有感光基片的光子控制微波器件，其具有包括谐振射频模式的高射频（“RF”）场的内部区域。 在基板的表面上构图RF谐振器，该图案包括谐振器中的孔，其定位成将从光源接收的光引导到内部区域。 光源可以具有能够照射内部区域以产生自由载流子或其它光诱导的RF介电常数变化的波长。 可以提供光学边界，其使高RF场区域内的未吸收光功率再循环直到其被完全吸收。

    Photoacoustic imaging devices and methods of imaging
    250.
    发明授权
    Photoacoustic imaging devices and methods of imaging 有权
    光声成像装置和成像方法

    公开(公告)号：US09192306B2

    公开(公告)日：2015-11-24

    申请号：US14021933

    申请日：2013-09-09

    Applicant: STC.UNM

    Inventor： Jingkuang Chen

    IPC: A61B5/00 ,  A61B5/02 ,  A61B8/12 ,  A61B8/00 ,  A61B8/08

    CPC classification number: A61B5/0095 ,  A61B5/0086 ,  A61B5/02007 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/028 ,  Y10T29/49826

    Abstract: A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

    Abstract translation: 光声医学成像装置可以包括衬底，衬底上的超声换能器阵列，蚀刻在衬底上的至少一个凹槽，至少一个光纤和至少一个面。 每个光纤被布置在一个凹槽中。 每个刻面在一个凹槽中蚀刻并涂覆有具有高红外反射率的金属层。 每个光纤被配置为引导来自光源的红外光通过光纤并朝向相应的刻面。 小面被配置为将红外光反射到目标。

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