公开(公告)号：US20180072798A1

公开(公告)日：2018-03-15

申请号：US15558937

申请日：2016-03-17

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  National University of Singapore

Inventor： Cheng-I WANG ,  Katja FINK ,  Paul MACARY ,  Roland ZUEST ,  Meihui XU

IPC: C07K16/10 ,  G01N33/569

CPC classification number: C07K16/1081 ,  A61K2039/505 ,  A61P31/12 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/185 ,  Y02A50/386 ,  Y02A50/53

Abstract: Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.

公开(公告)号：US09902942B2

公开(公告)日：2018-02-27

申请号：US14768213

申请日：2013-02-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Peter Stanley Gagnon

IPC: C12N7/00 ,  B01D15/22 ,  B01D15/34 ,  B01D15/36 ,  B01D15/42 ,  B01D61/14 ,  B01D15/38

CPC classification number: C12N7/00 ,  B01D15/22 ,  B01D15/34 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3847 ,  B01D15/424 ,  B01D61/145 ,  C12N2710/00051 ,  C12N2750/00051 ,  C12N2795/10151 ,  C12N2795/14151

Abstract: A method of purifying a sample that includes a desired virus includes the steps of (i) providing a packed chromatographic column having negatively charged porous particles, (ii) equilibrating the column to the conditions to which the desired virus in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the negatively charged porous particles within the packed chromatographic column, (iv) eluting the desired virus from the packed chromatographic column, where the desired virus is in a purer state and in the conditions to which the packed chromatographic column was equilibrated.

公开(公告)号：US20180044640A1

公开(公告)日：2018-02-15

申请号：US15553285

申请日：2016-05-16

Applicant: Agency for Science, Technology and Research

Inventor： Hong Fang Lu ,  Meng Fatt Leong ,  Tze Chiun Lim ,  Andrew Chwee Aun WAN, Wan

IPC: C12N5/077 ,  G01N33/50 ,  G01N33/483

CPC classification number: C12N5/0657 ,  C12N5/0068 ,  C12N2500/36 ,  C12N2500/90 ,  C12N2500/98 ,  C12N2501/15 ,  C12N2501/415 ,  C12N2501/999 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/90 ,  C12N2535/00 ,  G01N33/4833 ,  G01N33/502 ,  G01N33/5061 ,  G01N33/5082

Abstract: The present invention relates to a method for producing a contractile cellular construct, comprising the steps of: a) seeding pre-selected cells onto a mold, wherein the pre-selected cells comprise signal emitting agents; and b) culturing the pre-selected cells to produce the cellular construct. The said method is exemplified by mixing cardiomyocytes with fluorescent microbeads, seeding the suspension on a polydimethylsiloxane (PDMS) mold and culturing to form a contractile device comprising of cardiac muscles. The present invention also relates to a method for measuring the contractility of the cellular construct by measuring the displacement of the signal emitting agents, and a method for screening a method for screening one or more agents for modulating the contractility of a contractile cellular construct.

公开(公告)号：US20180044481A1

公开(公告)日：2018-02-15

申请号：US15551591

申请日：2016-02-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Xian Jun LOH ,  Sing Shy LIOW

IPC: C08G81/02 ,  C08G63/685 ,  C08G63/682 ,  C08G63/91 ,  C08G63/06

CPC classification number: C08G81/027 ,  C08F8/44 ,  C08F20/34 ,  C08F220/34 ,  C08F293/005 ,  C08F2438/01 ,  C08G18/4283 ,  C08G18/73 ,  C08G18/755 ,  C08G18/7621 ,  C08G18/7664 ,  C08G18/7671 ,  C08G63/06 ,  C08G63/6822 ,  C08G63/6852 ,  C08G63/912 ,  C08G2230/00 ,  C08L2203/02

Abstract: Provided herein is a polymer having formula I: where m, n, and R1 are as defined herein, and the polymer has a number average molecular weight of the polymer of from 500 to 80,000 Daltons. Also provided herein are block copolymers of the polymer of formula I, as well as processes to make the polymer and block copolymers thereof.

公开(公告)号：US09890205B2

公开(公告)日：2018-02-13

申请号：US14555060

申请日：2014-11-26

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Peter Gagnon

IPC: C07K16/00 ,  C07K16/16 ,  C07K1/18 ,  C07K16/22 ,  B01D15/36 ,  C07K1/16 ,  C07K16/24 ,  C07K16/32

CPC classification number: C07K16/00 ,  B01D15/363 ,  C07K1/16 ,  C07K1/165 ,  C07K1/18 ,  C07K16/22 ,  C07K16/241 ,  C07K16/32

Abstract: A method of purifying a sample containing a desired protein includes the steps of (i) providing a packed chromatographic column having positively charged porous particles, (ii) equilibrating the column to the conditions to which the desired protein in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the positively charged porous particles within the packed chromatographic column, (iv) eluting the desired protein from the packed chromatographic column, where the desired protein is in a purer state and in the conditions to which the packed chromatographic column was equilibrated; where the desired protein is an antibody, an antibody fragment, an antibody derivative, or an antibody fusion protein.

公开(公告)号：US20180037495A1

公开(公告)日：2018-02-08

申请号：US15549143

申请日：2016-02-04

Applicant: AGENCY FOR SCIENCE. TECHNOLOGY AND RESEARCH ,  WANGI INDUSTRIAL CO. PTE LTD

Inventor： Mark Allen MOXEY ,  Mohamed Sultan Mohiddin SAIFULLAH ,  Karen Siew Ling CHONG ,  Tian Poh KHOO ,  Ker Yee CHEW ,  Li Kang CHEAH

IPC: C03C17/30 ,  C09D183/04 ,  C03C17/34

CPC classification number: C03C17/30 ,  C03C17/3405 ,  C03C2217/73 ,  C03C2217/732 ,  C08G77/045 ,  C08G77/20 ,  C09D183/04

Abstract: This invention relates to a UV-curable coating material comprising an organosilica compound such as POSS or octahedral oligomeric silsesquioxane which is functionalized with a UV-curable functional group. The material further comprises at least one UV-curable cross-linker. The coating material comprises surface structures in the nano-sized range and can be used in a nanoimprint coating process where the material is coated on a substrate such as glass and a mold is pressed against the material to form an imprint before curing by UV radiation.

公开(公告)号：US20180036371A1

公开(公告)日：2018-02-08

申请号：US15550768

申请日：2016-02-11

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wanjin HONG ,  Shixiong TAN ,  Weiping HAN

IPC: A61K38/17

CPC classification number: A61K38/1709 ,  A61K38/16 ,  G01N33/6893 ,  G01N2800/02 ,  G01N2800/04 ,  G01N2800/042

Abstract: The present disclosure describes to a method of treating a metabolic disease in a subject, wherein the method comprises administration of dermatopontin to a subject, wherein the dermatopontin is recombinant dermatopontin and the metabolic disease is selected from a group consisting of weight gain, diet-induced weight gain, obesity, morbid obesity, metabolic syndrome, glucose homeostasis, insulin resistance, type I diabetes, type if diabetes and cardiovascular disease. Disclosed herein is also a method of determining or making a prognosis of a subject's susceptibility to metabolic diseases and obesity, the method comprising measuring the level of circulating dermatopontin in a sample obtained from a subject; and comparing the level of circulating dermatopontin obtained with the level of dermatopontin previously determined in a control; and determining the susceptibility of the subject to metabolic disease and obesity based on the difference between the level of circulating dermatopontin and the level of dermatopontin in the control.

公开(公告)号：US20180033631A1

公开(公告)日：2018-02-01

申请号：US15551821

申请日：2016-03-09

Applicant: Agency for Science, Technology and Research

Inventor： Lakshmi Kanta Bera ,  Yee Chong Loke ,  Surani Bin Dolmanan ,  Sudhiranjan Tripathy ,  Wai Hoe Tham

IPC: H01L21/285 ,  H01L29/205 ,  H01L29/40 ,  H01L21/28 ,  H01L29/49 ,  H01L29/51 ,  H01L29/778 ,  H01L29/66 ,  H01L29/20 ,  H01L29/45

CPC classification number: H01L21/28575 ,  H01L21/28264 ,  H01L29/2003 ,  H01L29/205 ,  H01L29/404 ,  H01L29/452 ,  H01L29/4958 ,  H01L29/517 ,  H01L29/66462 ,  H01L29/7786 ,  H01L29/7787

Abstract: A method for fabrication of high electron mobility transistor (HEMT) semiconductor devices is presented. The method includes providing a substrate, growing a HEMT layer structure on the substrate; and self-aligned common metal stack formation of source, drain and gate electrodes on the HEMT layer structure using a single lithographic mask.

公开(公告)号：US20180026196A1

公开(公告)日：2018-01-25

申请号：US15716303

申请日：2017-09-26

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jun LI ,  Kok Haw ONG ,  Zhikuan CHEN ,  Yujun ZHAO ,  Siew Lay LIM ,  Ivy WONG ,  Lee YANG ,  Kang Yee SEAH

IPC: H01L51/00 ,  C08G75/32 ,  C09D5/24 ,  H01L51/42 ,  C08L65/00 ,  C08K3/04 ,  C08G61/12

CPC classification number: H01L51/0036 ,  C08G61/123 ,  C08G61/126 ,  C08G75/32 ,  C08G2261/124 ,  C08G2261/1412 ,  C08G2261/143 ,  C08G2261/3142 ,  C08G2261/3223 ,  C08G2261/3246 ,  C08G2261/364 ,  C08G2261/414 ,  C08G2261/91 ,  C08K3/045 ,  C08L65/00 ,  C09D5/24 ,  H01L51/0002 ,  H01L51/0007 ,  H01L51/0037 ,  H01L51/0043 ,  H01L51/4253 ,  H01L2251/308 ,  Y02E10/549 ,  Y02P70/521 ,  C08K3/04

Abstract: There is provided p-type organic polymers of general formula I. The polymers may be useful as semi-conducting material. Thus, thin films and devices comprising such polymers are also provided.

公开(公告)号：US20180024136A1

公开(公告)日：2018-01-25

申请号：US15549868

申请日：2016-02-11

Applicant: National University of Singapore ,  Agency for Science, Technology and Research

Inventor： Young-Tae CHANG ,  Beomsue KIM

IPC: G01N33/58 ,  C07D405/10 ,  C07D311/82 ,  C07D405/12 ,  C07D413/10

CPC classification number: G01N33/582 ,  C07D311/82 ,  C07D405/10 ,  C07D405/12 ,  C07D413/10 ,  C12Q1/04

Abstract: The present invention relates to the synthesis and characterization of an Abcg2 targeted fluorescence probe (compound of formula I), as well as live imaging of neural stem/progenitor cells (NSPCs) and isolation of live NSPCs using said probe.