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公开(公告)号：US20230384573A1
公开(公告)日：2023-11-30
申请号：US18447583
申请日：2023-08-10
Applicant: BERKELEY LIGHTS, INC.
Inventor： Andrew W. McFarland , Daniele Malleo , J. Tanner Nevill , Russell A. Newstrom , Keith J. Breinlinger , Paul M. Lundquist , Justin K. Valley , Jonathan Cloud Dragon Hubbard
CPC classification number: G02B21/082 , G02B27/141 , B01L3/502715 , B01L9/527 , B01L3/50273 , G01N27/44721 , G01N27/44791 , G02B21/26 , G02B21/32 , G02B21/361 , G02B27/145 , B01L2200/027 , B01L2200/0647 , B01L2300/0645 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , B01L2400/0424 , B01L2400/0427 , B01L2400/0677 , G02B19/0028
Abstract: A system for operating an electrokinetic device includes a support configured to hold and operatively couple with the electrokinetic device, an integrated electrical signal generation subsystem configured to apply a biasing voltage across a pair of electrodes in the electrokinetic device, and a light modulating subsystem configured to emit structured light onto the electrokinetic device. The system can further include a thermally controlled flow controller, and/or be configured to measure impedance across the electrokinetic device. The system can be a light microscope, including an optical train. The system can further include a light pipe, which can be part of the light modulating system, and which can be configured to supply light of substantially uniform intensity to the light modulating system or directly to the optical train.
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22.发明授权公开(公告)号：US11802264B2
公开(公告)日：2023-10-31
申请号：US17067971
申请日：2020-10-12
Applicant: Berkeley Lights, Inc.
Inventor： Volker L. S. Kurz , Troy A. Lionberger , Eric K. Sackmann , Kai W. Szeto , Paul M. Lebel , Brandon R. Bruhn , Keith J. Breinlinger , Eric D. Hobbs , Andrew W. McFarland , J. Tanner Nevill , Xiaohua Wang
CPC classification number: C12M23/16 , B01L3/502761 , C12M23/20 , C12M33/12 , B01L2200/0668 , B01L2300/1822 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0454 , B01L2400/086
Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.
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23.发明授权公开(公告)号：US11192108B2
公开(公告)日：2021-12-07
申请号：US16033811
申请日：2018-07-12
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Andrew W. McFarland , J. Tanner Nevill
IPC: B01L3/00
Abstract: A microfluidic device can comprise a plurality of interconnected microfluidic elements. A plurality of actuators can be positioned abutting, immediately adjacent to, and/or attached to deformable surfaces of the microfluidic elements. The actuators can be selectively actuated and de-actuated to create directed flows of a fluidic medium in the microfluidic (or nanofluidic) device. Further, the actuators can be selectively actuated and de-actuated to create localized flows of a fluidic medium in the microfluidic device to move reagents and/or micro-objects in the microfluidic device.
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24.发明申请公开(公告)号：US20210102150A1
公开(公告)日：2021-04-08
申请号：US17067971
申请日：2020-10-12
Applicant: Berkeley Lights, Inc.
Inventor： Volker L.S. Kurz , Troy A. Lionberger , Eric K. Sackmann , Kai W. Szeto , Paul M. Lebel , Brandon R. Bruhn , Keith J. Breinlinger , Eric D. Hobbs , Andrew W. McFarland , J. Tanner Nevill , Xiaohua Wang
Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.
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公开(公告)号：US10821439B2
公开(公告)日：2020-11-03
申请号：US15659855
申请日：2017-07-26
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Eric D. Hobbs , Daniele Malleo , J. Tanner Nevill , Mark P. White
Abstract: A microfluidic apparatus is provided having one or more sequestration pens configured to isolate one or more target micro-objects by changing the orientation of the microfluidic apparatus with respect to a globally active force, such as gravity. Methods of selectively directing the movements of micro-objects in such a microfluidic apparatus using gravitational forces are also provided. The micro-objects can be biological micro-objects, such as cells, or inanimate micro-objects, such as beads.
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Patent Agency Ranking
公开(公告)号：US10800652B2
公开(公告)日：2020-10-13
申请号：US16123882
申请日：2018-09-06
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Daniele Malleo , Gaetan L. Mathieu , J. Tanner Nevill , Alexander H. Slocum , Mark P. White
IPC: B81B7/02 , B03C5/00 , B03C5/02 , G01N27/447 , B03C7/02 , G01N33/543 , B01L3/00 , C12M3/06 , C12M1/00 , C12M1/34 , G01N33/50
Abstract: A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.
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公开(公告)号：US20190152771A1
公开(公告)日：2019-05-23
申请号：US16123882
申请日：2018-09-06
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Daniele Malleo , Gaetan L. Mathieu , J. Tanner Nevill , Alexander H. Slocum , Mark P. White
Abstract: A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.
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28.发明申请公开(公告)号：US20180298318A1
公开(公告)日：2018-10-18
申请号：US16010176
申请日：2018-06-15
Applicant: Berkeley Lights, Inc.
Inventor： Volker L.S. Kurz , Troy A. Lionberger , Erik K. Sackmann , Kai W. Szeto , Paul M. Lebel , Brandon R. Bruhn , Keith J. Breinlinger , Eric D. Hobbs , Andrew W. McFarland , J. Tanner Nevill , Xiaohua Wang
CPC classification number: C12M23/16 , B01L3/502761 , B01L2200/0668 , B01L2300/1822 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0454 , B01L2400/086 , C12M23/20 , C12M33/12
Abstract: Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices. Alternative motive modalities are useful to selectively dislodge and displace micro-objects, including biological cells, from a variety of locations within the enclosure of a microfluidic device.
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公开(公告)号：US09617145B2
公开(公告)日：2017-04-11
申请号：US14520510
申请日：2014-10-22
Applicant: Berkeley Lights, Inc.
Inventor： Keith J. Breinlinger , Daniele Malleo , Gaetan L. Mathieu , J. Tanner Nevill , Alexander H. Slocum , Mark P. White
CPC classification number: B81B7/02 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , B01L2200/0668 , B01L2300/044 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/087 , B01L2300/0877 , B01L2400/0424 , B01L2400/0433 , B01L2400/0454 , B01L2400/086 , B03C5/005 , B03C5/026 , B03C7/023 , B03C2201/26 , C12M23/16 , C12M41/46 , C12M47/02 , G01N27/447 , G01N27/44756 , G01N27/44791 , G01N33/5023 , G01N33/543 , G01N33/54326 , G01N35/10
Abstract: A group of micro-objects in a holding pen in a micro-fluidic device can be selected and moved to a staging area, from which the micro-objects can be exported from the micro-fluidic device. The micro-fluidic device can have a plurality of holding pens, and each holding pen can isolate micro-objects located in the holding pen from micro-objects located in the other holding pens or elsewhere in the micro-fluidic device. The selected group of micro-objects can comprise one or more biological cells, such as a clonal population of cells. Embodiments of the invention can thus select a particular group of clonal cells in a micro-fluidic device, move the clonal cells to a staging area, and export the clonal cells from the micro-fluidic device while maintaining the clonal nature of the exported group.
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公开(公告)号：US20160340632A1
公开(公告)日：2016-11-24
申请号：US15135252
申请日：2016-04-21
Applicant: BERKELEY LIGHTS, INC.
Inventor： Keith J. Breinlinger , Russell A. Newstrom , J. Tanner Nevill , Jason M. McEwen , David A. Weisbach
IPC: C12M1/00 , C12M1/34 , C12M3/06 , C12M3/00 , C12M1/04 , C12M1/26 , C12M1/12 , C12M1/24 , C12M1/02 , C12M1/36
CPC classification number: C12M23/58 , B01L3/502715 , B01L7/52 , C12M23/08 , C12M23/16 , C12M23/20 , C12M23/22 , C12M23/24 , C12M23/26 , C12M23/34 , C12M23/38 , C12M23/44 , C12M23/50 , C12M29/10 , C12M33/00 , C12M37/00 , C12M41/06 , C12M41/22 , C12M41/44 , C12M41/46 , C12M41/48
Abstract: A station for culturing biological cells in a microfluidic device is provided. The station includes one or more thermally conductive mounting interfaces, each mounting interface configured for having a microfluidic device detachably mounted thereon; a thermal regulation system configured for controlling a temperature of microfluidic devices detachably mounted on the one or more mounting interfaces; and a media perfusion system configured to controllably and selectively dispense a flowable culturing media into microfluidic devices detachably mounted on the one or mounting interfaces.
Abstract translation: 提供了一种用于在微流体装置中培养生物细胞的站。 该工位包括一个或多个导热安装接口，每个安装接口构造成具有可拆卸地安装在其上的微流体装置; 热调节系统，被配置为控制可拆卸地安装在所述一个或多个安装界面上的微流体装置的温度; 以及媒体灌注系统，被配置为可控地和选择性地将可流动培养介质分配到可拆卸地安装在所述一个或安装界面上的微流体装置中。
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