公开(公告)号：US20150343420A1

公开(公告)日：2015-12-03

申请号：US14648546

申请日：2013-11-29

Applicant: DAICEL CORPORATION

Inventor： Takafumi ONISHI ,  Yasuto MORISHITA ,  Masahiro MIYAMOTO

IPC: B01J20/28 ,  B01J20/32 ,  B01J20/26 ,  B01J20/286

CPC classification number: B01J20/28016 ,  B01J20/22 ,  B01J20/24 ,  B01J20/26 ,  B01J20/265 ,  B01J20/281 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3255 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289 ,  B01J20/3293 ,  C07B57/00 ,  C07K1/22 ,  C07K17/04 ,  C08G81/00 ,  C09D183/02 ,  C12N15/09 ,  C12N15/1006 ,  G01N30/88 ,  G01N2030/8877

Abstract: Provided is a separating agent comprising a carrier and a ligand fixed on a surface of a carrier by chemical bonding, in which the carrier is a core-shell particle formed of a non-porous core and a porous shell, the shell having a pore diameter of 9 nm or more and formed of a hydrolysate of polyalkoxysiloxane, and the ligand is an optically active polymer, optically inactive polyester, protein, nucleic acid, or optically active organic compound with a molecular weight of 50 to 1000.

Abstract translation: 提供了一种分离剂，其包含通过化学键合固定在载体的表面上的载体和配体，其中载体是由无孔芯和多孔壳形成的核 - 壳颗粒，壳具有孔径 9nm以上，由聚烷氧基硅氧烷的水解产物形成，配体为分子量为50〜1000的光学活性聚合物，光学活性聚酯，蛋白质，核酸或光学活性有机化合物。

公开(公告)号：US20150316515A1

公开(公告)日：2015-11-05

申请号：US14677719

申请日：2015-04-02

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Stephan M. Koza ,  Pamela C. Iraneta ,  Kevin D. Wyndham

IPC: G01N30/06 ,  G01N30/72

CPC classification number: G01N30/06 ,  B01D15/305 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3272 ,  C08F220/54 ,  C08F220/56 ,  C08F222/385 ,  C08F230/08 ,  C08L33/14 ,  G01N30/7233 ,  G01N2030/027

Abstract: The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances.

公开(公告)号：US09162223B2

公开(公告)日：2015-10-20

申请号：US13724245

申请日：2012-12-21

Applicant: NORTH CAROLINA STATE UNIVERSITY

Inventor： Ruben G. Carbonell ,  Stefano Menegatti ,  Amith D. Naik

IPC: B01J39/26 ,  B01J20/286 ,  B01D15/38 ,  B01J20/32

CPC classification number: B01J39/26 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/3251 ,  B01J20/3272

Abstract: This invention is directed to the production of improved chromatographic resins and method of making and using such resins.

Abstract translation: 本发明涉及改进色谱树脂的制备及其制备和使用方法。

公开(公告)号：US09149791B2

公开(公告)日：2015-10-06

申请号：US13205247

申请日：2011-08-08

Applicant: Alexander A. Gorkovenko

Inventor： Alexander A. Gorkovenko

IPC: B01J20/285 ,  B01J20/286 ,  B01J20/29 ,  B01J20/32 ,  C08B37/00

CPC classification number: B01J20/286 ,  B01J20/285 ,  B01J20/29 ,  B01J20/3272 ,  C08B37/006

Abstract: The present invention relates to novel carbohydrate polyether compositions that are soluble in aqueous media and particularly to carbohydrate polyether compositions exhibiting reverse thermogelation properties in aqueous media. Also, since the carbohydrate polyethers of the present invention can be conveniently controlled with respect to functionality, molecular weight, polydispersity index, microstructure and tertiary structure, they can be customized for use in a variety of applications.

Abstract translation: 本发明涉及可溶于水性介质的新型碳水化合物聚醚组合物，特别涉及在含水介质中显示出反向热凝胶化性能的碳水化合物聚醚组合物。 此外，由于本发明的碳水化合物聚醚可以根据官能度，分子量，多分散指数，微结构和三级结构方便地控制，因此可以定制用于各种应用。

公开(公告)号：US09134306B2

公开(公告)日：2015-09-15

申请号：US14071494

申请日：2013-11-04

Applicant: Intrinsic Bioprobes, Inc.

Inventor： Kemmons Tubbs ,  Karl F. Gruber ,  Randall W. Nelson

IPC: G01N30/60 ,  G01N33/543 ,  B01J20/281 ,  B01J20/286 ,  B01J20/32 ,  B82Y30/00 ,  G01N33/68 ,  G01N30/02

CPC classification number: G01N33/6845 ,  B01J20/28097 ,  B01J20/281 ,  B01J20/286 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3265 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/54 ,  B01J2220/64 ,  B82Y30/00 ,  G01N30/02 ,  G01N30/48 ,  G01N30/6095 ,  G01N33/54366 ,  G01N33/545 ,  G01N33/6803 ,  G01N2570/00 ,  H01J49/164 ,  H01J49/40 ,  Y10T436/255 ,  B01D15/3804

Abstract: Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.

公开(公告)号：US20150251127A1

公开(公告)日：2015-09-10

申请号：US14438711

申请日：2013-10-30

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Inventor： Florence Ricoul ,  Vincent Jousseaume ,  Muriel Matheron

IPC: B01D53/04 ,  C23C16/40 ,  C23C16/56

CPC classification number: B01D53/0423 ,  B01D2253/106 ,  B01D2253/311 ,  B01J20/10 ,  B01J20/28097 ,  B01J20/287 ,  B01J20/3078 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3272 ,  B01J20/3291 ,  B01J2220/54 ,  B01J2220/66 ,  C23C16/401 ,  C23C16/56 ,  G01N30/6095

Abstract: Gas chromatography column comprising a substrate, a channel formed in said substrate, a cover closing said substrate and a stationary phase covering the walls of said channel, wherein said stationary phase is made of SiOxCyHz with x between 1.6 and 1.8, y between 1 and 2.2 and z between 3 and 4, wherein said stationary phase is porous with a porosity of between 10% and 40%.

Abstract translation: 气相色谱柱，包括基底，在所述基底中形成的通道，封闭所述基底的盖和覆盖所述通道壁的固定相，其中所述固定相由SiO x CyHz制成，x在1.6和1.8之间，y在1和2.2之间 和z在3和4之间，其中所述固定相是多孔的，孔隙率在10％和40％之间。

公开(公告)号：US20150224472A1

公开(公告)日：2015-08-13

申请号：US14692986

申请日：2015-04-22

Applicant: KURARAY CO., LTD.

Inventor： Keisuke MORIKAWA ,  Yusuke AMANO ,  Naoyuki IWACHIDO ,  Naoki FUJIWARA ,  Takumi TAKAYAMA

IPC: B01J20/26 ,  C08J3/12 ,  B01J39/18 ,  C08F261/04 ,  B01J20/28 ,  B01J20/30

CPC classification number: B01J20/264 ,  B01D15/00 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/30 ,  B01J20/3014 ,  B01J20/3028 ,  B01J20/3071 ,  B01J20/3078 ,  B01J20/3085 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3272 ,  B01J20/3278 ,  B01J20/3293 ,  B01J20/3425 ,  B01J20/3475 ,  B01J39/18 ,  C02F1/285 ,  C02F2101/20 ,  C02F2101/22 ,  C08F8/32 ,  C08F255/02 ,  C08F261/04 ,  C08F271/02 ,  C08J3/12 ,  C08J9/26 ,  C08J2201/046 ,  C08J2323/08 ,  C08J2329/04 ,  C08J2351/06 ,  C08J2429/04 ,  C08J2451/06 ,  C22B3/24 ,  Y02P10/234 ,  Y10T428/2982 ,  C08F220/32 ,  C08F220/28 ,  C08F220/54

Abstract: Provided are graft copolymer particles enabling introduction of adsorptive functional groups adsorbing metals and others, a method for producing same, and an adsorbent using same. (1) Porous graft copolymer particles containing graft chains introduced into porous particles (particle surface having an average pore diameter of 0.01-50 μm) including at least one resin selected from olefin resins, water-insoluble modified polyvinyl alcohol resins, amide resins, cellulosic resins, chitosan resins and (meth)acrylate resins. (2) A method for producing porous graft copolymer particles including (I) melt-kneading a polymer A and a polymer B other than the polymer A to obtain a compound material, (II) extracting and removing the polymer B from the compound material to obtain a porous material of the polymer A, (III) granulating the porous material, and (IV) introducing graft chains into the porous particles. (3) An adsorbent of porous graft copolymer particles.

Abstract translation: 提供能够引入吸附金属等的吸附官能团的接枝共聚物颗粒，其制造方法和使用它们的吸附剂。 （1）含有接枝链的多孔接枝共聚物颗粒，其导入到多孔颗粒（平均孔径为0.01〜50μm的颗粒表面）中，包含至少一种选自烯烃树脂，水不溶性改性聚乙烯醇树脂，酰胺树脂，纤维素 树脂，壳聚糖树脂和（甲基）丙烯酸酯树脂。 （2）一种生产多孔接枝共聚物颗粒的方法，其包括（I）熔融捏合除聚合物A以外的聚合物A和聚合物B以获得复合材料，（II）从复合材料中提取和除去聚合物B至 获得聚合物A的多孔材料，（III）对多孔材料进行造粒，和（IV）将接枝链引入多孔颗粒中。 （3）多孔接枝共聚物颗粒的吸附剂。

公开(公告)号：US20150204824A1

公开(公告)日：2015-07-23

申请号：US14576682

申请日：2014-12-19

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Stephan M. Koza ,  Pamela C. Iraneta ,  Kevin D. Wyndham

IPC: G01N30/06

CPC classification number: G01N30/06 ,  B01D15/305 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3272 ,  B01J2220/82 ,  C08F230/08 ,  C08L33/14 ,  G01N2030/027

Abstract: The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances.

Abstract translation: 本发明涉及聚酰胺键合的亲水相互作用层析（HILIC）固定相和新型HILIC方法，用于表征本领域技术人员已知的作为聚糖的极性基团修饰的大生物分子。 本发明特别提供了设计用于有效分离大生物分子的新颖的聚酰胺键合材料，例如， 具有较大孔隙比例（即宽孔）的材料。 此外，本发明有利地提供了可以与本文所述的固定相材料组合使用的新型HILIC方法，以通过消除先前未解决的问题来有效分离蛋白质和肽糖型，例如蛋白质样品的柱上聚集，色谱检测的低灵敏度 的聚糖部分，并且由于受限的孔扩散和长的内部/颗粒间扩散距离而导致的峰的低分辨率。

公开(公告)号：US20150182943A1

公开(公告)日：2015-07-02

申请号：US14416381

申请日：2013-07-08

Applicant: DAICEL CORPORATION

Inventor： Toru Shibata ,  Satoshi Shinkura

IPC: B01J20/285 ,  C08G63/00 ,  C08G63/183 ,  B01J20/28 ,  B01J20/26

CPC classification number: B01J20/285 ,  B01D15/40 ,  B01J20/262 ,  B01J20/264 ,  B01J20/28016 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3272 ,  B01J2220/80 ,  C08G63/00 ,  C08G63/183

Abstract: An object of the present invention is to provide a stationary phase that increases the number of column stages and that exhibits an excellent molecular discrimination ability. It was discovered that the number of column stages can be increased and an excellent molecular discrimination ability can be realized by a stationary phase that contains a polymer having, in main chain repeat units, an aromatic ring that forms a portion of the main chain and a bipolar atomic group that forms a portion of the main chain, wherein the stationary phase has a specific surface area of 5 to 1000 m2/g.

Abstract translation: 本发明的目的是提供一种固定相，其增加了柱级数并表现出优异的分子识别能力。 已经发现，可以增加柱级数，并且通过含有在主链重复单元中具有形成主链的一部分的芳环的聚合物的固定相可以实现优异的分子鉴别能力， 形成主链部分的双极原子团，其中固定相的比表面积为5〜1000m2 / g。

公开(公告)号：US20150101978A1

公开(公告)日：2015-04-16

申请号：US14577444

申请日：2014-12-19

Applicant: Eco Verde Technologies, Inc.

Inventor： Curtis Elliott

IPC: C02F1/42

CPC classification number: A01N25/10 ,  A01N37/34 ,  A01N43/54 ,  A01N43/653 ,  A61K47/40 ,  B01J20/12 ,  B01J20/262 ,  B01J20/267 ,  B01J20/3204 ,  B01J20/3272 ,  B01J20/3293 ,  B09C1/002 ,  B09C1/08 ,  C02F1/285 ,  C02F1/42 ,  C02F1/50 ,  C02F1/683 ,  C02F1/688 ,  C02F3/00 ,  C02F2101/306 ,  C02F2103/06 ,  C02F2103/08 ,  C02F2305/04 ,  C08G8/22 ,  C08G8/36 ,  C08G8/38 ,  C08G65/2612 ,  C08G65/328 ,  C08G65/331 ,  C08G65/3317 ,  C08G65/337 ,  C08L2205/05 ,  C09D161/12 ,  C09D161/14 ,  C09D171/02

Abstract: Storage stable polyhydroxylated aromatic ether adducts of polyalkylene oxide are described. Reactive compositions are formed by combining an ether adduct with an aldehyde, optionally further adding a phenolic-aldehyde prepolymer. The reactive compositions are cured by removing water, by acidification, or both. The cured compositions sorb solvated compounds from environments containing water. The cured compositions are also useful for pre-loading with compounds that are subsequently released at a controlled rate into environments containing water.

Abstract translation: 描述了聚环氧烷的储存稳定的多羟基化芳基醚加合物。 通过将醚加合物与醛组合形成反应性组合物，任选地进一步加入酚醛预聚物。 反应性组合物通过除去水，酸化或两者来固化。 固化的组合物从含有水的环境中溶解化合物。 固化的组合物还可用于预先装载随后以受控速率释放到含有水的环境中的化合物。