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    BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF
    31.
    发明申请
    BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF 有权
    生物可降解聚（氨基甲酸酯）及其用途

    公开(公告)号：US20100036084A1

    公开(公告)日：2010-02-11

    申请号：US12507999

    申请日：2009-07-23

    申请人： Robert S. Langer ,  David M. Lynn ,  David Putnam ,  Mansoor M. Amiji ,  Daniel G. Anderson

    发明人： Robert S. Langer ,  David M. Lynn ,  David Putnam ,  Mansoor M. Amiji ,  Daniel G. Anderson

    IPC分类号： C08G63/685

    CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K31/711 ,  A61K31/713 ,  A61K47/59 ,  A61K47/593 ,  A61K47/6929 ,  B82Y5/00 ,  C08G63/685 ,  C08G73/02 ,  C08G73/0273 ,  C08G73/06 ,  C08G73/0611 ,  C08G73/0616 ,  C12N15/88

    摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

    摘要翻译： 描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（β-氨基酯）。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

    CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
    36.
    发明申请
    CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF 有权
    交联，可降解的聚合物及其用途

    公开(公告)号：US20080145338A1

    公开(公告)日：2008-06-19

    申请号：US11758078

    申请日：2007-06-05

    申请人： Daniel Griffith Anderson ,  Jason Alan Burdick ,  Robert S. Langer

    发明人： Daniel Griffith Anderson ,  Jason Alan Burdick ,  Robert S. Langer

    IPC分类号： A61K47/32 ,  C08G73/00 ,  C08F2/48 ,  A61K35/00

    CPC分类号： C08L79/02 ,  C08F283/00 ,  C08F290/06 ,  C08F290/061 ,  C08F290/065 ,  C08F299/024 ,  C08F299/0485 ,  C08G63/6858 ,  C08G73/02

    摘要： Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.

    摘要翻译： 丙烯酸酯封端的聚（β-氨基酯）被交联以形成用于医疗和非医学领域的材料。 将聚合起始材料与自由基引发剂，热引发剂或光引发剂组合，并且根据所使用的引发剂将用于交联的混合物加热或暴露于光。 由于聚合物骨架中的可水解的酯键导致的所得材料在生理条件下是可生物降解的。 这些交联材料特别用作药物递送载体，组织工程支架和制造微型装置。 这些材料也可以用作塑料，涂料，粘合剂，油墨等。制备的交联材料表现出广泛的降解时间，质量损失曲线和机械性能。 因此，可以调整材料的性质以达到期望的用途。 制备交联聚（β-氨基酯）文库的高通量方法允许快速筛选和设计可降解聚合物用于各种应用。

    Highly convertible endolumenal prostheses and methods of manufacture
    37.
    发明授权
    Highly convertible endolumenal prostheses and methods of manufacture 失效
    高度可转换的腔内假体和制造方法

    公开(公告)号：US07377939B2

    公开(公告)日：2008-05-27

    申请号：US10988814

    申请日：2004-11-15

    申请人： Michael S. Williams ,  Robert S. Langer ,  Yadong Wang

    发明人： Michael S. Williams ,  Robert S. Langer ,  Yadong Wang

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61L31/04 ,  A61L31/041 ,  A61L31/14 ,  A61L2400/16

    摘要： Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastomeric and exhibits shape memory behavior, a hydrogel, or some combination thereof. Polymers used to fabricate the prostheses are selectively synthesized to exhibit desired characteristics such as crystallinity, strain fixity rate, strain recovery rate, elasticity, tensile strength, mechanical strength, cross-linking density, extent physical cross-linking, extent of covalent cross-linking, extent of interpenetrating networks, rate of erosion, heat of fusion, crystallization temperature, and acidity during erosion. The endolumenal prostheses convert to the deployed configuration following delivery to a treatment site, upon exposure to an initiator either present within the body naturally or introduced into the body.

    摘要翻译： 公开了容易且广泛地从输送配置转换成展开构型的腔内假体。 腔内假体可以由一种或多种形状记忆聚合物，高模量弹性体，弹性体和表现出形状记忆行为的聚合物，水凝胶或其某些组合制成。 用于制造假体的聚合物被选择性地合成以显示所需的特性，例如结晶度，应变固定率，应变恢复速率，弹性，拉伸强度，机械强度，交联密度，物理交联程度，共价交联程度 互穿网络的程度，侵蚀速率，熔化热，结晶温度和侵蚀过程中的酸度。 在暴露于身体内自然存在或引入体内的引发剂之后，腔内假体转化为部署构型。

    Microscale lyophilization and drying methods for the stabilization of molecules
    38.
    发明授权
    Microscale lyophilization and drying methods for the stabilization of molecules 有权
    用于稳定分子的微型冷冻干燥方法

    公开(公告)号：US07354597B2

    公开(公告)日：2008-04-08

    申请号：US10308579

    申请日：2002-12-03

    申请人： Audrey M. Johnson ,  Michael J. Cima ,  Robert S. Langer

    发明人： Audrey M. Johnson ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61F2/02 ,  A61K9/14

    CPC分类号： F26B5/06

    摘要： Methods and systems are provided for microscale lyophilization or microscale drying of agents of interest, such as pharmaceutical agents or other molecules that are unstable or easily degraded in solution. The drying method includes (a) providing a liquid comprising an agent of interest dissolved or dispersed in a volatile liquid medium; (b) depositing a microquantity (between 1 nL and 10 μL) of the liquid onto a preselected site of a substrate; and then (c) drying the microquantity by volatilizing the volatile liquid medium to produce a dry, solid form of the agent of interest. The lyophilization method includes freezing the microquantity of liquid after step (b) and before step (c). By processing the agent of interest in microquantities in controlled contact with a substrate surface, improved heat and mass transfer is provided, yielding better process control over drying of the agent of interest compared to conventional bulk drying or lyophilization.

    摘要翻译： 提供的方法和系统用于微量冻干或微量干燥感兴趣的试剂，例如不稳定或容易在溶液中降解的药剂或其它分子。 干燥方法包括（a）提供包含溶解或分散在挥发性液体介质中的感兴趣剂的液体; （b）将液体的微量（在1nL和10μL之间）沉积到衬底的预选位置; 然后（c）通过挥发挥发性液体介质来干燥微量，以产生干燥，固体形式的感兴趣的试剂。 冻干方法包括在步骤（b）之后和步骤（c）之前冷冻液体的微量。 通过加工与基材表面受控接触的微量级的感兴趣的试剂，提供了改进的热和质量传递，与传统的大体积干燥或冻干相比，可以对感兴趣的试剂的干燥产生更好的工艺控制。

    Microchip drug delivery devices
    39.
    发明授权
    Microchip drug delivery devices 失效
    Microchip药物输送装置

    公开(公告)号：US07070590B1

    公开(公告)日：2006-07-04

    申请号：US09665303

    申请日：2000-09-19

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： Devices are provided for the controlled release of drug or other molecules. The devices include (1) a substrate, which optionally includes two or more substrate portions bonded together, (2) at least two reservoirs in the substrate, (3) a release system disposed in the reservoirs that includes the molecules for release and optionally a matrix material, and (4) active or passive means for controlling release of the molecules from the reservoirs. In one embodiment, a reservoir cap is positioned on, or within a portion of, the reservoir and over the molecules, so that the molecules are controllably released from the device by diffusion through or upon disintegration of the reservoir cap.

    摘要翻译： 提供了用于药物或其他分子的控制释放的装置。 这些装置包括（1）基材，其任选地包括两个或更多个粘结在一起的基底部分，（2）基底中的至少两个储存器，（3）设置在储存器中的释放系统，其包括用于释放的分子， 基质材料，（4）用于控制分子从储层释放的主动或被动方式。 在一个实施例中，储存器盖位于储存器的一部分上，或位于储存器的一部分上方，并位于分子上方，使得分子通过扩散通过储存器盖的分解或分解而可控制地从装置释放。

    Three dimensional microfabrication
    40.
    发明授权
    Three dimensional microfabrication 失效
    三维微细加工

    公开(公告)号：US06977223B2

    公开(公告)日：2005-12-20

    申请号：US10794610

    申请日：2004-03-05

    申请人： Paul M. George ,  Robert S. Langer ,  David A. Lavan

    发明人： Paul M. George ,  Robert S. Langer ,  David A. Lavan

    IPC分类号： C25D1/00 ,  C25D1/10 ,  C25D3/38 ,  C25D5/02 ,  C25D5/16 ,  G02B6/124 ,  G02B6/13 ,  H01L21/288 ,  H01L21/768 ,  H01L21/44

    CPC分类号： C25D1/00 ,  B81C99/0095 ,  C25D1/003 ,  C25D1/10 ,  C25D3/38 ,  C25D5/022 ,  C25D5/16 ,  G02B6/124 ,  G02B6/13 ,  H01L21/2885 ,  H01L21/76838

    摘要： Method for making three-dimensional structures. A template is provided having at least two conductive regions separated by a non-conductive region. The template is disposed in an electrolyte in an electrodeposition cell and a voltage is established between one of the conductive regions and an electrode in the cell. Material is deposited on the one of the conductive regions connected to the voltage and subsequently bridges to the other conductive region with material deposition continuing on both of the at least two regions. The non conductive region may be a gap and the gap dimension is selected to regulate height differences between the at least two conductive regions.

    摘要翻译： 制作三维结构的方法。 提供了具有由非导电区域隔开的至少两个导电区域的模板。 将模板设置在电沉积电池中的电解质中，并且在电池中的一个导电区域和电极之间建立电压。 材料沉积在连接到电压的导电区域中的一个上，并且随后在至少两个区域两者上继续材料沉积而桥接到另一个导电区域。 非导电区域可以是间隙，并且选择间隙尺寸以调节至少两个导电区域之间的高度差。