公开(公告)号：US20070092975A1

公开(公告)日：2007-04-26

申请号：US11507689

申请日：2006-08-22

申请人： Radislav Potyrailo ,  Prashant Shrikhande ,  Scott Boyette ,  Caibin Xiao ,  Andrew Leach

发明人： Radislav Potyrailo ,  Prashant Shrikhande ,  Scott Boyette ,  Caibin Xiao ,  Andrew Leach

IPC分类号： G01N21/77

CPC分类号： G01N21/78 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0427 ,  B01L2400/0448 ,  G01N21/80 ,  G01N35/00069 ,  G01N2021/7766 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2575

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以使用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20070092407A1

公开(公告)日：2007-04-26

申请号：US11259643

申请日：2005-10-26

申请人： Caibin Xiao ,  Radislav Potyrailo ,  William Morris ,  Scott Boyette ,  LiJie Yu ,  Theodore Cecconie ,  Andrew Leach ,  Prashant Shrikhande

发明人： Caibin Xiao ,  Radislav Potyrailo ,  William Morris ,  Scott Boyette ,  LiJie Yu ,  Theodore Cecconie ,  Andrew Leach ,  Prashant Shrikhande

IPC分类号： G01N21/29 ,  G01N21/41

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20060210440A1

公开(公告)日：2006-09-21

申请号：US11391743

申请日：2006-03-29

申请人： Radislav Potyrailo ,  Timothy Sivavec ,  Joseph Salvo

发明人： Radislav Potyrailo ,  Timothy Sivavec ,  Joseph Salvo

IPC分类号： G01N27/00

CPC分类号： G01N21/7703 ,  G01N21/1702

摘要： A system that includes a device is provided in which the device includes a piezoelectric substrate; a sensor layer disposed on the substrate and operable to interact with, or react with, a target species; a first and a second electrode that are spaced from each other and in communication with the substrate; a first detector operable to detect the interaction or the reaction of the sensor layer with the target species based on a change in an optical characteristic of electromagnetic radiation propagated through the substrate; and a second detector operable to acoustically detect the interaction or the reaction of the sensor layer with the target species. Associated methods are provided.

摘要翻译： 提供一种包括装置的系统，其中所述装置包括压电基板; 传感器层，其设置在所述基板上并且可操作以与目标物种相互作用或与目标物质反应; 第一和第二电极，彼此间​​隔开并与衬底连通; 第一检测器，其可操作以基于传播通过所述衬底的电磁辐射的光学特性的变化来检测所述传感器层与所述目标物质的相互作用或反应; 以及第二检测器，其可操作以声学地检测传感器层与目标物种的相互作用或反应。 提供相关方法。

公开(公告)号：US20060138079A1

公开(公告)日：2006-06-29

申请号：US11021399

申请日：2004-12-27

申请人： Radislav Potyrailo ,  Scott Boyette ,  Canan Hardwicke ,  Andrew Leach

发明人： Radislav Potyrailo ,  Scott Boyette ,  Canan Hardwicke ,  Andrew Leach

IPC分类号： B23P15/00 ,  B29C33/40 ,  B05D1/36 ,  B29C35/08

CPC分类号： B29C35/0894 ,  B01J2219/00286 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01L3/5027 ,  B29L2031/756

摘要： A method for making a microfluidic device comprises providing a processing substrate, forming a negative stamp on the processing substrate using a direct write process, disposing a coating material on the processing substrate, curing the coating material to produce a cured coating material, and separating the processing substrate and the negative stamp from the cured coating material, wherein a plurality of channels are formed in the cured coating material corresponding to a location of the negative stamp.

摘要翻译： 一种制造微流体装置的方法包括：提供处理基板，使用直接写入工艺在处理基板上形成负印模，在处理基板上设置涂层材料，固化涂层材料以产生固化涂层材料， 处理基板和来自固化涂层材料的负印模，其中在对应于负印模的位置的固化涂层材料中形成多个通道。

公开(公告)号：US20050111328A1

公开(公告)日：2005-05-26

申请号：US10952635

申请日：2004-09-29

申请人： Radislav Potyrailo ,  William Morris ,  Andrew Leach

发明人： Radislav Potyrailo ,  William Morris ,  Andrew Leach

IPC分类号： B01L3/00 ,  G01N21/59 ,  G01N35/00 ,  G11B5/55

CPC分类号： G01N21/5907 ,  B01J2219/00536 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01L3/502715 ,  B01L3/545 ,  B01L2300/024 ,  B01L2300/0806 ,  G01N35/00069

摘要： A system and method employing optical disk drives for quantitative analysis of chemical and biochemical parameters, in which sensor materials disposed on an optical disk are responsive to physical, chemical, biochemical, and other parameters in the environment. The light interacts with the sensor materials when the light propagates through the sensor material, reflects off the optical media's reflective layer, and propagates back through the sensor region. The interacted light is captured by a photodetector, which outputs a response analog signal, for example, an analog voltage signal, which is indicative of a condition of the environment to which the sensor materials have been exposed. The system includes software algorithms which cause the laser source and optical detector to move to a specified location or logical block address of the disk, measure the optical signal during disk rotation, display a map of the sensor material response, and reduce the noise level in the measured signal.

摘要翻译： 一种使用光盘驱动器进行化学和生物化学参数的定量分析的系统和方法，其中设置在光盘上的传感器材料响应于环境中的物理，化学，生物化学和其它参数。 当光传播通过传感器材料时，光与传感器材料相互作用，从光学介质的反射层反射并传播回传感器区域。 相互作用的光被光电检测器捕获，光电检测器输出响应模拟信号，例如模拟电压信号，其表示传感器材料暴露于的环境的状况。 该系统包括使激光源和光学检测器移动到盘的指定位置或逻辑块地址的软件算法，在盘旋转期间测量光信号，显示传感器材料响应的映射，并降低噪声水平 测量信号。

公开(公告)号：US20050054116A1

公开(公告)日：2005-03-10

申请号：US10656594

申请日：2003-09-05

申请人： Radislav Potyrailo ,  Joseph Wetzel

发明人： Radislav Potyrailo ,  Joseph Wetzel

IPC分类号： B01J19/00 ,  C40B60/14 ,  G01N1/10

CPC分类号： B01J19/0046 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00756 ,  C40B60/14 ,  Y10T436/2575

摘要： A system for creating a combinatorial coating sensor library comprises a delivery mechanism in fluid communication with a source of organic polymer reactants and a substrate having at least one delivery area; a reaction source operative to apply at least one reactive environment to the delivery area; and a controller in communication with the delivery mechanism in a manner effective to apply a plurality of organic reactants to the substrate, and further wherein the controller is in communication with the reaction source in a manner effective to react at least one of the plurality of organic reactants on the substrate into an organic block copolymer coating.

摘要翻译： 用于产生组合涂层传感器库的系统包括与有机聚合物反应物源流体连通的输送机构和具有至少一个输送区域的基底; 反应源，其可操作以将至少一个反应性环境施加到所述输送区域; 以及控制器，其以有效地将多种有机反应物施加到所述衬底的方式与所述递送机构连通，并且其中所述控制器以有效地使所述多个有机反应物中的至少一种有机反应物反应的方式与所述反应源连通 将基材上的反应物转变成有机嵌段共聚物涂层。

公开(公告)号：US20120001731A1

公开(公告)日：2012-01-05

申请号：US13145172

申请日：2010-01-28

申请人： Radislav Potyrailo ,  Vincent F. Pizzi ,  Hanno Ehring ,  Cheryl M. Surman ,  Klaus Gebauer ,  Mircea Georgescu

发明人： Radislav Potyrailo ,  Vincent F. Pizzi ,  Hanno Ehring ,  Cheryl M. Surman ,  Klaus Gebauer ,  Mircea Georgescu

IPC分类号： G06K7/01

CPC分类号： G06K19/07749 ,  A61M39/10 ,  A61M39/18 ,  A61M2205/3331 ,  A61M2205/6054 ,  B65B55/08 ,  G06K19/07798 ,  G06Q20/3278

摘要： This invention provides a system for operating RFID tags on a single-use connector. The system includes: a first single-use connector configured to receive a first RFID tag and a second single-use connector configured to receive a second RFID tag. The invention also includes a reader placed close to the first RFID tag and the second RFID tag. The reader is configured to: determine if the first RFID tag and the second RFID tag are gamma sterilized; determine if the first RFID tag and the second RFID tag were previously used; determine if the first RFID tag and the second RFID tag are authentic; and determine if the first RFID tag matches with the second RFID tag.

摘要翻译： 本发明提供一种用于在一次性连接器上操作RFID​​标签的系统。 该系统包括：被配置为接收第一RFID标签的第一单用连接器和被配置为接收第二RFID标签的第二单用连接器。 本发明还包括靠近第一RFID标签和第二RFID标签放置的读取器。 读取器被配置为：确定第一RFID标签和第二RFID标签是否被伽马灭菌; 确定先前使用的第一RFID标签和第二RFID标签; 确定第一RFID标签和第二RFID标签是否是真实的; 并且确定第一RFID标签是否与第二RFID标签匹配。

公开(公告)号：US20070097366A1

公开(公告)日：2007-05-03

申请号：US11262210

申请日：2005-10-31

申请人： Steven LeBoeuf ,  Alexei Vertiatchikh ,  Stanton Weaver ,  Radislav Potyrailo ,  Xian-An Cao

发明人： Steven LeBoeuf ,  Alexei Vertiatchikh ,  Stanton Weaver ,  Radislav Potyrailo ,  Xian-An Cao

IPC分类号： G01N21/00

CPC分类号： G01N21/6486 ,  G01N21/15 ,  G01N21/532 ,  G01N21/645

摘要： Embodiments of the invention include a particle detection system that includes a light emitting source, a non-collimating reflector, a collimating reflector, and a detector. Light from the light emitting source is directed by the non-collimating reflector to an area through which a particle stream may be transmitted. Fluorescent light from the light striking particles is redirected to the collimating reflector and then on to the detector. Other embodiments include a single pump used to pull a pair of fluid flows through the detection system. Other embodiments include a plurality of light emitting sources whose light is directed to a particle stream by a single reflector. Other embodiments include a method for detecting particles.

摘要翻译： 本发明的实施例包括一种粒子检测系统，其包括发光源，非准直反射器，准直反射器和检测器。 来自发光源的光由非准直反射器引导到可以传播颗粒物流的区域。 来自光撞击颗粒的荧光被重定向到准直反射器，然后被引导到检测器上。 其他实施例包括用于拉动一对流体流过检测系统的单个泵。 其他实施例包括多个发光源，其光通过单个反射器被引导到颗粒流。 其他实施方案包括用于检测颗粒的方法。

公开(公告)号：US20060245933A1

公开(公告)日：2006-11-02

申请号：US11119480

申请日：2005-05-02

申请人： Ernest Balch ,  Thomas Gorczyca ,  Radislav Potyrailo ,  Jeffrey Fortin ,  Andrew Leach

发明人： Ernest Balch ,  Thomas Gorczyca ,  Radislav Potyrailo ,  Jeffrey Fortin ,  Andrew Leach

IPC分类号： F04F5/48

CPC分类号： B01L3/502738 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0887 ,  B01L2400/0638 ,  F16K99/0001 ,  F16K99/0034 ,  F16K99/0046 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084

摘要： A microfluidic system and method for its fabrication is disclosed comprising an interposed intermediate layer covering the channel-containing layers, said intermediate layers comprising an integral valve made from the intermediate layer material. A microfluidic system and method is also disclosed for actively pumping a fluid through an integrated layered device incorporating the above-mentioned channels, valves in communication with a chamber, the volume of which can be predictably controlled by interaction between a magnetizable assembly placed on pre-selected sides of the chamber.

摘要翻译： 公开了一种用于其制造的微流体系统及其方法，包括覆盖含通道层的中间层，所述中间层包括由中间层材料制成的整体阀。 还公开了一种微流体系统和方法，用于主动地泵送流体通过结合上述通道的集成分层装置，与腔室连通的阀，其容积可以通过放置在预定位置上的可磁化组件之间的相互作用来预测地控制， 选房侧。

公开(公告)号：US20060029516A1

公开(公告)日：2006-02-09

申请号：US10913909

申请日：2004-08-09

申请人： Radislav Potyrailo

发明人： Radislav Potyrailo

IPC分类号： G01N31/22

CPC分类号： G01N33/54393 ,  G01N33/54366

摘要： A sensor film as well as a method and sensor array for detecting at least one analyte is described. The method of detecting at least one analyte includes providing at least one sensor, disposing at least one sensor film on the sensor, placing the sensor disposed with the sensor film in an environment that may contain at least one analyte, and relating at least one quantitative response to the concentration of the analyte.

摘要翻译： 描述了传感器膜以及用于检测至少一种分析物的方法和传感器阵列。 检测至少一种分析物的方法包括提供至少一个传感器，在传感器上设置至少一个传感器膜，将传感器膜放置在可能含有至少一种分析物的环境中，并将至少一个定量 响应分析物的浓度。