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65 条记录 (耗时 0.032 秒)

    Methods and materials for detection of target species
    33.
    发明授权
    Methods and materials for detection of target species 有权
    检测目标物种的方法和材料

    公开(公告)号：US08570518B2

    公开(公告)日：2013-10-29

    申请号：US11701292

    申请日：2007-01-31

    申请人： Nicholas M. Sampas ,  Rene P. Helbing ,  Bo U. Curry ,  Julie E. Fouquet ,  Carol T. Schembri

    发明人： Nicholas M. Sampas ,  Rene P. Helbing ,  Bo U. Curry ,  Julie E. Fouquet ,  Carol T. Schembri

    IPC分类号： G01N21/00

    CPC分类号： G01N21/648 ,  G01N21/7703 ,  G01N2021/7709 ,  G01N2021/7786

    摘要： A test system includes an optical medium, a binding agent capable of capturing a target complex, and a light detector. The optical medium provides a light path, and the binding agent is positioned to hold the target complex in an evanescent field created by propagation of light along the light path. The complex interacts with the evanescent field and emits light that the detector positioned to detect. The optical medium and the detector can be included in an optical integrated circuit where detected light passes through the optical medium transverse to the direction of the light path.

    摘要翻译： 测试系统包括光学介质，能够捕获目标复合物的粘合剂和光检测器。 光学介质提供光路，并且粘合剂被定位成将目标复合体保持在通过沿着光路的光的传播产生的消逝场中。 复合体与ev逝场相互作用并发射检测器定位以检测的光。 光学介质和检测器可以包括在光学集成电路中，其中检测到的光穿过光学介质横向于光路的方向。

    Test strips including flexible array substrates and method of hybridization
    36.
    发明授权
    Test strips including flexible array substrates and method of hybridization 有权
    测试条包括柔性阵列底物和杂交方法

    公开(公告)号：US07364896B2

    公开(公告)日：2008-04-29

    申请号：US10286117

    申请日：2002-10-31

    申请人： Carol T. Schembri

    发明人： Carol T. Schembri

    IPC分类号： C12M1/34 ,  G01N15/06 ,  C07H21/02 ,  A61K38/00 ,  C07K1/00

    CPC分类号： B01L9/54 ,  B01J19/0046 ,  B01L3/5027 ,  B01L3/505 ,  B01L3/5085 ,  B01L7/00 ,  B01L2300/0636 ,  G01N35/00009 ,  G01N2035/00158

    摘要： Individual and aggregate test strip arrays having a backing strip supporting a flexible array substrate which supports an addressable collection of probes are taught. Hybridization cells for use with the individual test strip arrays are also disclosed, and in particular embodiments the hybridization cells closely fit a portion or all of the individual test strip arrays. Array hybridization systems that include test strip arrays and hybridization cells are disclosed with methods for performing a hybridization assay on a sample solution.

    摘要翻译： 教导了具有支撑支撑可寻址的探针集合的柔性阵列基板的背衬条的单个和聚集测试条阵列。 还公开了用于单个测试条阵列的杂交细胞，并且在特定实施方案中，杂交细胞与单个测试条阵列的一部分或全部紧密配合。 公开了包括测试条阵列和杂交细胞的阵列杂交系统，用于对样品溶液进行杂交测定。

    Apparatus and method for simultaneously conducting multiple chemical reactions
    39.
    发明授权
    Apparatus and method for simultaneously conducting multiple chemical reactions 有权
    同时进行多次化学反应的装置和方法

    公开(公告)号：US06682702B2

    公开(公告)日：2004-01-27

    申请号：US09938909

    申请日：2001-08-24

    申请人： Phillip W. Barth ,  Douglas A. Amorese ,  Carol T. Schembri

    发明人： Phillip W. Barth ,  Douglas A. Amorese ,  Carol T. Schembri

    IPC分类号： B01L300

    CPC分类号： G01N35/028 ,  G01N2035/00158 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A method and apparatus for simultaneously conducting multiple chemical reactions combine a test sample with a chemical reactant in a plurality of closed reaction chambers to produce reaction products. The method comprises assembling a plate having the test sample in a plurality of spatially arranged wells with a microarray of similarly spatially arranged surface bound chemical reactants to form the sealed apparatus having the plurality of closed reaction chambers. The apparatus is sealed such that it is gas, liquid and/or fluid tight. The seal may be accomplished with a flexible array substrate or a flexible gasket, and one or more of mechanical clamps, external fluid pressure, radiation, heat, vacuum and an adhesive. The sealed apparatus can be subjected to various reaction conditions, such as intense mechanical agitation and a controlled temperature environment. A kit comprises one or more of the elements of the apparatus.

    摘要翻译： 用于同时进行多个化学反应的方法和装置将测试样品与多个封闭反应室中的化学反应物组合以产生反应产物。 该方法包括将具有测试样品的板组装在具有类似空间布置的表面结合的化学反应物的微阵列的多个空间排列的孔中，以形成具有多个封闭反应室的密封装置。 该装置被密封，使得其是气体，液体和/或流体密封的。 密封可以用柔性阵列基底或柔性垫片以及机械夹具，外部流体压力，辐射，热量，真空和粘合剂中的一种或多种完成。 密封装置可以经受各种反应条件，例如强烈的机械搅拌和受控的温度环境。 套件包括装置的一个或多个元件。