公开(公告)号：US06577392B1

公开(公告)日：2003-06-10

申请号：US09728374

申请日：2000-11-28

申请人： Ralph B. Nielsen ,  Sigrid C. Kuebler ,  Thomas S. Lee ,  Adam Safir ,  Miroslav Petro

发明人： Ralph B. Nielsen ,  Sigrid C. Kuebler ,  Thomas S. Lee ,  Adam Safir ,  Miroslav Petro

IPC分类号： G01N2100

CPC分类号： B01D15/08 ,  B01D15/14 ,  B01D15/1871 ,  B01D15/1885 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/88 ,  G01N33/44 ,  G01N33/442 ,  G01N35/085 ,  G01N35/1097 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/625 ,  B01D15/34

摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

摘要翻译： 公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。 优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。 还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。 所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

公开(公告)号：US06559255B2

公开(公告)日：2003-05-06

申请号：US09520583

申请日：2000-03-08

申请人： Gerrit Klaerner ,  Adam Safir ,  Ralph B. Nielsen ,  Bernd Jandeleit ,  Peter Huefner ,  Yunxiao Li

发明人： Gerrit Klaerner ,  Adam Safir ,  Ralph B. Nielsen ,  Bernd Jandeleit ,  Peter Huefner ,  Yunxiao Li

IPC分类号： C08F222

CPC分类号： C08F220/58 ,  C08F4/00 ,  G01N33/54353

摘要： Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

公开(公告)号：US06507945B1

公开(公告)日：2003-01-14

申请号：US09305830

申请日：1999-05-05

申请人： William C. Rust ,  Ralph B. Nielsen

发明人： William C. Rust ,  Ralph B. Nielsen

IPC分类号： G06F944

CPC分类号： G05B19/0426 ,  B01J19/0046 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695

摘要： Methods and apparatus for controlling an automated material handling procedure. The method includes receiving a recipe file comprising component information and mapping information; interacting with a user to create a procedure for executing a set of material handling steps; and causing a automated material-handling apparatus to carry out the set of material-handling steps by executing the procedure. The mapping information relates a source component and a destination component. The mapping information defines one or more transfers of at least one source component material to at least one destination component location. The method includes providing to the user an assortment of pre-programmed code objects and receiving from the user a selection and arrangement of the pre-programmed code objects. The procedure is defined by the user's selection and arrangement. The procedure contains at least one first pre-programmed code object operable to read and interpret the recipe file and at least one second pre-programmed code object operable to interpret a mapping read from the recipe file.

摘要翻译： 用于控制自动化材料处理程序的方法和装置。 该方法包括接收包括组件信息和映射信息的配方文件; 与用户交互以创建用于执行一组材料处理步骤的过程; 并且使自动物料处理装置通过执行该程序来执行一组物料处理步骤。 映射信息涉及源组件和目标组件。 映射信息将至少一个源组件材料的一个或多个传输定义到至少一个目的地组件位置。 该方法包括向用户提供各种预先编程的代码对象并从用户接收预编程代码对象的选择和布置。 该过程由用户的选择和安排来定义。 该过程包含至少一个第一预编程代码对象，其可操作以读取和解释配方文件，以及至少一个第二预编程代码对象，其可操作以解释从配方文件读取的映射。

公开(公告)号：US06175409B1

公开(公告)日：2001-01-16

申请号：US09285335

申请日：1999-04-02

申请人： Ralph B. Nielsen ,  Sigird C. Kuebler ,  James Bennett ,  Adam Safir ,  Miroslav Petro

发明人： Ralph B. Nielsen ,  Sigird C. Kuebler ,  James Bennett ,  Adam Safir ,  Miroslav Petro

IPC分类号： G01N1506

CPC分类号： B01D15/08 ,  B01D15/14 ,  B01D15/1871 ,  B01D15/1885 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/88 ,  G01N33/44 ,  G01N33/442 ,  G01N35/085 ,  G01N35/1097 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/625 ,  B01D15/34

摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

摘要翻译： 公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。 优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。 还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。 所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

公开(公告)号：US6151123A

公开(公告)日：2000-11-21

申请号：US112247

申请日：1998-07-08

申请人： Ralph B. Nielsen

发明人： Ralph B. Nielsen

IPC分类号： C07B61/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/55

CPC分类号： G01N21/6428 ,  G01N21/6452 ,  C40B40/00

摘要： Methods and apparatus for screening diverse arrays of materials are provided. In particular, the present invention provides techniques for interrogating organic materials, inorganic materials, or polymers on predefined regions of a substrate, using optical probe molecules to measure properties of these materials. This invention involves the use of environment-sensitive probes, such as dye probes, to enable parallel, rapid and efficient characterization of important material properties, including glass-transition temperatures, polarity, hydrogen bonding and other intermolecular interactions. These methods can be applied to crystalline or amorphous materials, polymeric or small-molecule materials, pure materials or mixtures, and to materials in bulk, particles, thin films, dispersions, emulsions, and solutions.

摘要翻译： 提供了筛选各种材料阵列的方法和装置。 特别地，本发明提供了使用光学探针分子来测量这些材料的性质来询问有机材料，无机材料或聚合物在基底的预定区域上的技术。 本发明涉及使用环境敏感探针，例如染料探针，以使得能够平行，快速和有效地表征重要的材料性质，包括玻璃化转变温度，极性，氢键和其他分子间相互作用。 这些方法可以应用于结晶或无定形材料，聚合物或小分子材料，纯材料或混合物，以及本体，颗粒，薄膜，分散体，乳液和溶液中的材料。

公开(公告)号：US5196502A

公开(公告)日：1993-03-23

申请号：US788070

申请日：1991-11-05

申请人： S. Richard Turner ,  Brigitte I. Voit ,  Ralph B. Nielsen

发明人： S. Richard Turner ,  Brigitte I. Voit ,  Ralph B. Nielsen

IPC分类号： C08G63/123 ,  C08G63/06 ,  C08G63/12 ,  C08G83/00

CPC分类号： C08G83/003 ,  C08G63/065 ,  Y10S424/16

摘要： An improved method for producing multiply-branched polyester comprising condensing a reactant having the general formula Z.sup.1 --Ar--(Z.sup.2).sub.j, wherein j is 2 or 3, Ar is an aryl or heteroaryl group having from 1 to 3, solitary or linked or fused, five or six membered rings, and one of Z.sup.1 and Z.sup.2 is a carboxyl group and the other is a group having the general formula ##STR1## wherein R is an alkyl group having from 1 to 3 carbon atoms, X is selected from the group consisting of fluoro and chloro and g is an integer from 0 to about 7.

公开(公告)号：US07115234B2

公开(公告)日：2006-10-03

申请号：US10315512

申请日：2002-12-09

申请人： J. Christopher Freitag ,  Damian Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Richard Tiede

发明人： J. Christopher Freitag ,  Damian Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Richard Tiede

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10S526/92 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.

公开(公告)号：US06976383B2

公开(公告)日：2005-12-20

申请号：US10403302

申请日：2003-03-31

申请人： Miroslav Petro ,  Adam Safir ,  Ralph B. Nielsen ,  G. Cameron Dales ,  Eric D. Carlson ,  Thomas S. Lee

发明人： Miroslav Petro ,  Adam Safir ,  Ralph B. Nielsen ,  G. Cameron Dales ,  Eric D. Carlson ,  Thomas S. Lee

IPC分类号： B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  G01N1/00 ,  G01N15/02 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88 ,  G01N33/44 ,  G01N35/02 ,  G01N35/08 ,  G01N35/10

CPC分类号： G01N35/1097 ,  B01D15/08 ,  B01D15/14 ,  B01D15/161 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/6052 ,  G01N30/88 ,  G01N33/44 ,  G01N33/442 ,  G01N35/028 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/885 ,  Y10S210/13

摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

摘要翻译： 公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。 优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。 还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。 所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

公开(公告)号：US06787112B1

公开(公告)日：2004-09-07

申请号：US09724275

申请日：2000-11-28

申请人： Howard Turner ,  G. Cameron Dales ,  Lynn VanErden ,  Johannes A. M. VanBeek ,  Damian A. Hajduk ,  Ralph B. Nielsen ,  William C. Rust

发明人： Howard Turner ,  G. Cameron Dales ,  Lynn VanErden ,  Johannes A. M. VanBeek ,  Damian A. Hajduk ,  Ralph B. Nielsen ,  William C. Rust

IPC分类号： B01J1900

CPC分类号： B01L3/50851 ,  B01F13/0818 ,  B01F13/0827 ,  B01F15/00201 ,  B01F15/00207 ,  B01F15/00246 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  G01K13/00 ,  G01N11/16 ,  G01N35/1079 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/25 ,  Y10T436/25875

摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

摘要翻译： 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。 该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​装置，以及用于以不同于环境压力的压力将液体注入容器的系统。 单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。

公开(公告)号：US06726843B2

公开(公告)日：2004-04-27

申请号：US10179573

申请日：2002-06-24

申请人： Miroslav Petro ,  Ralph B. Nielsen ,  Jacqueline M. Regan

发明人： Miroslav Petro ,  Ralph B. Nielsen ,  Jacqueline M. Regan

IPC分类号： B01D1508

CPC分类号： C40B30/04 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00736 ,  B01J2219/00743 ,  B01J2219/00747 ,  B01J2219/00752 ,  G01N30/466 ,  G01N30/88 ,  G01N30/89 ,  G01N33/5085 ,  G01N33/558

摘要： Methods and apparatus for the evaluation of interactions between substances using inverse chromatography are disclosed. Preferably, interactions are evaluated between a liquid test sample and a solid phase comprising a receptor in the presence of a liquid carrier. Preferably, one of the modifying agent or receptor are members of a combinatorial library.

摘要翻译： 公开了使用反相色谱法评估物质之间相互作用的方法和装置。 优选地，在液体载体的存在下，在液体测试样品和包含受体的固相之间评估相互作用。 优选地，修饰剂或受体之一是组合文库的成员。