公开(公告)号：US5443791A

公开(公告)日：1995-08-22

申请号：US927254

申请日：1992-08-07

申请人： G. Richard Cathcart ,  Thomas Brennan-Marquez ,  John A. Bridgham ,  George S. Golda ,  Harry A. Guiremand ,  Marianne Hane ,  Louis B. Hoff ,  Eric Lachenmeier ,  Melvyn N. Kronick ,  Douglas H. Keith ,  Paul E. Mayrand ,  Michael L. Metzker ,  William J. Mordan ,  Lincoln J. McBride ,  John Shigeura ,  Chen-Hanson Ting ,  Norman M. Whiteley

发明人： G. Richard Cathcart ,  Thomas Brennan-Marquez ,  John A. Bridgham ,  George S. Golda ,  Harry A. Guiremand ,  Marianne Hane ,  Louis B. Hoff ,  Eric Lachenmeier ,  Melvyn N. Kronick ,  Douglas H. Keith ,  Paul E. Mayrand ,  Michael L. Metzker ,  William J. Mordan ,  Lincoln J. McBride ,  John Shigeura ,  Chen-Hanson Ting ,  Norman M. Whiteley

IPC分类号： B01L3/14 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N21/01 ,  G01N1/10 ,  G01N21/11 ,  G01N35/08

CPC分类号： G01N35/0099 ,  B01L3/50825 ,  G01N35/0098 ,  B01F2215/0037 ,  G01N2035/00079 ,  G01N2035/00237 ,  G01N2035/00356 ,  G01N2035/00435 ,  G01N2035/0403 ,  G01N2035/0475 ,  G01N2035/0491 ,  G01N2035/1013 ,  G01N2035/102 ,  G01N2035/1034 ,  G01N2035/1058 ,  G01N2035/106 ,  G01N35/028 ,  G01N35/1004 ,  G01N35/109 ,  Y10S435/809 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.

摘要翻译： 液体处理仪器具有工作表面，其具有用于模块化站的注册以支持液体容器，具有连接到感测电路的移液管尖端的移液管装置，用于移动吸头的机器人翻译系统以及具有标识用户界面的控制系统 用于编程和编辑。 在工作表面上注册的量块提供了使用感应尖端的校准，工件表面上的注册腔提供模块化站。 在工作台上有一个洗手台，用于吸取吸头。 基于液体处理系统的自动化实验室具有加热和冷却以及可密封的孵化站以及磁选机。 公开了使用装置输送液体的方法，以最小的尖端污染抽吸以将容器中的液体混合并验证工作面。 公开了一种用于最小化加工期间的蒸发和交叉污染的鸭嘴盖，并且是用于储存和运输液体的容器的一部分。

公开(公告)号：US5428470A

公开(公告)日：1995-06-27

申请号：US916306

申请日：1992-07-17

申请人： Donald P. Labriola, II

发明人： Donald P. Labriola, II

IPC分类号： G01N33/483 ,  G01N35/00 ,  G01N35/04 ,  G05B19/042 ,  G05B19/416 ,  G01N33/00

CPC分类号： G01N35/00732 ,  G01N35/00584 ,  G05B19/0421 ,  G05B19/416 ,  G01N2035/00326 ,  G01N2035/00455 ,  G01N2035/00683 ,  G01N2035/00752 ,  G01N2035/0475 ,  G01N35/00871 ,  G05B2219/25197 ,  G05B2219/25232 ,  G05B2219/25314 ,  G05B2219/33189 ,  G05B2219/33273 ,  G05B2219/34047 ,  G05B2219/34205 ,  G05B2219/37175 ,  G05B2219/41127 ,  G05B2219/41326 ,  G05B2219/42034 ,  G05B2219/42237 ,  G05B2219/43162 ,  Y10T436/115831 ,  Y10T436/12

摘要： An automated analytical system module design essentially electrically isolates modular elements within the analyzer system with inter-module communications provided via packet-based communications. The modules may include a motor controller which estimates motor temperature to enable high initial torque with motor failure prediction and detection. The modules in such a system can be identified on serial communications loops by a module reset and count-off process.

摘要翻译： 自动分析系统模块设计基本上将分析仪系统中的模块化元件电隔离，并通过基于分组的通信提供的模块间通信。 模块可以包括电动机控制器，该电动机控制器通过电动机故障预测和检测来估计电动机温度以实现高初始转矩。 这种系统中的模块可以通过模块复位和计数过程在串行通信环路上识别。

公开(公告)号：US5352963A

公开(公告)日：1994-10-04

申请号：US785553

申请日：1991-10-31

申请人： Steven A. Garand ,  Carl P. Daniel

发明人： Steven A. Garand ,  Carl P. Daniel

IPC分类号： H02P8/16 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H02P8/00

CPC分类号： G01N35/1002 ,  G01N35/028 ,  G01N2021/1759 ,  G01N2035/00079 ,  G01N2035/00455 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0463 ,  G01N2035/0475 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283 ,  G01N35/025

摘要： An improved control system for a stepper motor coil includes a flyback circuit that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.

摘要翻译： 用于步进电动机线圈的改进的控制系统包括回扫电路，其在线圈被通电并且以斩波模式操作时缓慢地消散线圈能量，同时当线圈切换到其断电阶段时迅速消散线圈能量。

公开(公告)号：US20190252910A1

公开(公告)日：2019-08-15

申请号：US16319223

申请日：2017-07-19

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Charles V. Cammarata ,  Thomas J. Bao

IPC分类号： H02J9/06 ,  H02P6/00 ,  G01N35/04

CPC分类号： H02J9/061 ,  B60L50/50 ,  G01N35/04 ,  G01N2035/0475 ,  G01N2035/0477 ,  H02J1/10 ,  H02J3/006 ,  H02P6/006

摘要： A modular in vitro diagnostics (IVD) vessel mover system providing redundant power management includes a plurality of modules which are configured to provide storage to one or more IVD samples. Each module comprising a power failover switch which is configured to receive internal power from an internal primary power source and transmit backup power to one or more of the plurality of modules.

公开(公告)号：US09778275B2

公开(公告)日：2017-10-03

申请号：US15034729

申请日：2014-10-30

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Colin Mellars

IPC分类号： G01N35/04 ,  G01N35/00 ,  G01N35/02 ,  B25J9/16

CPC分类号： G01N35/04 ,  B25J9/1687 ,  G01N35/0099 ,  G01N35/026 ,  G01N2035/0475 ,  G01N2035/0491 ,  G01N2035/0494 ,  G05B2219/37002 ,  G05B2219/45092

摘要： A system for placing sample tubes into tube receptacles includes a sample handling device that includes an electrical signal, relating to an operating condition, such as a position error, a tube receptacle, and a processor configured to control the sample handling device in response to the electrical signal. The processor observes the operating condition for signal artifacts that indicate that a sample vessel being placed has encountered a holding spring and subsequently the bottom of the tube receptacle. The processor provides substantially real-time control of the motion of the sample handling device in response.

公开(公告)号：US09776811B2

公开(公告)日：2017-10-03

申请号：US15083514

申请日：2016-03-29

申请人： AOI SEIKI CO., LTD.

发明人： Teruaki Itoh

IPC分类号： B65G54/02 ,  B65G33/04 ,  B65G35/06 ,  B65G37/00 ,  G01N35/04

CPC分类号： B65G54/02 ,  B65G35/066 ,  B65G37/00 ,  B65G54/025 ,  B65G2201/0261 ,  G01N35/04 ,  G01N2035/0406 ,  G01N2035/0475 ,  G01N2035/0477 ,  G01N2035/0484 ,  G01N2035/0487

摘要： A conveying device includes a carrier which includes a holder side member; a conveying passage which guides conveyance of the carrier; a spirally-shaped spiral member which is arranged below the carrier and extends along the conveying passage, the spiral member causing between the spiral member and the holder side member a first force which acts in a direction away from the holder side member or a second force which acts to draw in the holder side member; a partition wall portion which is provided between the carrier and the spiral member and partitions the carrier and the spiral member; and a rotary unit which rotates the spiral member axis-wise thereof.

公开(公告)号：US20170191933A1

公开(公告)日：2017-07-06

申请号：US15389897

申请日：2016-12-23

申请人： Gen-Probe Incorporated

发明人： David OPALSKY ,  Srajan RAGHUWANSHI ,  James BUI

IPC分类号： G01N21/64

CPC分类号： G01N21/645 ,  G01N21/0332 ,  G01N21/276 ,  G01N21/75 ,  G01N35/00732 ,  G01N35/025 ,  G01N2021/6441 ,  G01N2035/00356 ,  G01N2035/0455 ,  G01N2035/0475 ,  G01N2035/0484 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/12723

摘要： A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.

公开(公告)号：US20160299161A1

公开(公告)日：2016-10-13

申请号：US15034729

申请日：2014-10-30

申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.

发明人： Colin Mellars

IPC分类号： G01N35/00 ,  G01N35/02

CPC分类号： G01N35/04 ,  B25J9/1687 ,  G01N35/0099 ,  G01N35/026 ,  G01N2035/0475 ,  G01N2035/0491 ,  G01N2035/0494 ,  G05B2219/37002 ,  G05B2219/45092

摘要： A system for placing sample tubes into tube receptacles includes a sample handling device that includes an electrical signal, relating to an operating condition, such as a position error, a tube receptacle, and a processor configured to control the sample handling device in response to the electrical signal. The processor observes the operating condition for signal artifacts that indicate that a sample vessel being placed has encountered a holding spring and subsequently the bottom of the tube receptacle. The processor provides substantially real-time control of the motion of the sample handling device in response.

摘要翻译： 用于将样品管放置在管容器中的系统包括样品处理装置，其包括与诸如位置误差的操作条件相关的电信号，管插座和被配置为响应于所述样品处理装置控制样品处理装置的处理器 电信号。 处理器观察到信号伪影的操作条件，其指示被放置的样品容器遇到保持弹簧，随后遇到管容器的底部。 处理器响应地提供对样品处理装置的运动的基本上实时的控制。

公开(公告)号：US20160282378A1

公开(公告)日：2016-09-29

申请号：US15062267

申请日：2016-03-07

申请人： Roche Diagnostics Operations, Inc.

发明人： Michal Malinowski ,  Achim Sinz ,  Florian Mueller

IPC分类号： G01N35/02 ,  B60K7/00 ,  B65G45/22 ,  B65G45/10 ,  B65G54/02

CPC分类号： G01N35/026 ,  B60K7/0007 ,  B65G45/10 ,  B65G45/22 ,  B65G54/02 ,  G01N35/04 ,  G01N35/1004 ,  G01N2035/0475 ,  G01N2035/0477 ,  G01N2035/0489 ,  G01N2035/0496

摘要： A laboratory sample distribution system comprising a transport plane and a cleaning device for cleaning the transport plane is presented. The cleaning device is adapted to automatically clean the transport plane similar to sample container carriers moving also on the transport plane. A laboratory automation system comprising such a laboratory sample distribution system is also presented.

摘要翻译： 提供了一种实验室样品分配系统，其包括用于清洁输送平面的输送平面和清洁装置。 清洁装置适于自动地清洁运输平面，类似于也在运输平面上移动的样品容器载体。 还提供了包括这样的实验室样品分配系统的实验室自动化系统。

公开(公告)号：US20150217291A1

公开(公告)日：2015-08-06

申请号：US14590820

申请日：2015-01-06

申请人： Beckman Coulter, Inc.

发明人： Brian D. Wilson ,  Sami D. ALARURI ,  Matthew S. DAVIS ,  Matthew D. ERICKSON ,  Alan N. JOHNSON ,  Garrick A. MAURER ,  Mark F. SAUERBURGER ,  Daniel R. SCHMIDT ,  Joshua D. WILTSIE ,  Thomas M. STACHELEK ,  David L. YANG

IPC分类号： B01L7/00

CPC分类号： G01N35/04 ,  B01L3/021 ,  B01L3/0275 ,  B01L3/50825 ,  B01L3/5085 ,  B01L3/50851 ,  B01L3/52 ,  B01L3/545 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/043 ,  C12M41/12 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q3/00 ,  G01F23/24 ,  G01F23/26 ,  G01N1/31 ,  G01N1/38 ,  G01N35/00732 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/1002 ,  G01N35/1011 ,  G01N35/1016 ,  G01N35/1081 ,  G01N2035/00435 ,  G01N2035/00752 ,  G01N2035/00851 ,  G01N2035/0413 ,  G01N2035/0415 ,  G01N2035/0436 ,  G01N2035/0465 ,  G01N2035/0475 ,  G01N2035/1013 ,  G01N2035/1025 ,  G01N2035/1048 ,  G01N2035/1051 ,  G01N2035/1076 ,  G05B13/02 ,  G05B13/0205 ,  G16B99/00 ,  Y10T436/113332

摘要： Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

摘要翻译： 公开了用于处理和分析样品的系统和方法。 该系统可以使用可在不同处理位置处理的测定盒来处理样品，例如生物流体。 在某些情况下，该系统可用于PCR处理。 不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。 为了帮助准备样品，系统还可以包括可以包括加工车道的多个处理站。 在样品分析期间，在某些情况下，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。 该系统可用于准确快速地处理样品。