公开(公告)号：US11969517B2

公开(公告)日：2024-04-30

申请号：US17444598

申请日：2021-08-06

申请人： Drexel University

发明人： Kara L. Spiller ,  Sina Nassiri

IPC分类号： A61K38/20 ,  A61L26/00 ,  A61L27/20 ,  A61L27/56 ,  C08L5/04 ,  C08L5/08 ,  C08L89/00 ,  C08L89/04

CPC分类号： A61L26/0066 ,  A61K38/2026 ,  A61K38/2066 ,  A61L26/0023 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/008 ,  A61L27/20 ,  A61L27/56 ,  C08L5/04 ,  C08L5/08 ,  C08L89/00 ,  C08L89/04 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/426 ,  A61L2300/608 ,  A61L2300/622

摘要： One aspect of the invention provides a method of treating a chronic wound including administering to the wound at least one agent from a delivery system wherein the agent induces sequential conversion of a first population of wound macrophages in the wound to M2A macrophages and a second population of wound macrophages to M2C macrophages. The sequential conversion of the wound macrophages promotes tissue remodeling.

公开(公告)号：US20240000994A1

公开(公告)日：2024-01-04

申请号：US18218174

申请日：2023-07-05

申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Charlotte A.E. HAUSER ,  Hepi Hari SUSAPTO

IPC分类号： A61L26/00

CPC分类号： A61L26/0047 ,  A61L26/008 ,  A61L26/0066

摘要： Described are nanogels suitable for scaffolds for encapsulating human dermal fibroblasts for non-healing chronic wounds. Peptide nanogels Ac-IVZK-NH2 and Ac-IVFK-NH2 are selected and produce silver nanoparticles in situ within the nanogels to assess their efficacy on micropigs with full-thickness excision wounds. The in situ generation of the silver nanoparticles is done solely through UV irradiation and no reducing agent is used. Application of the peptide nanogels on full thickness micropig wounds demonstrate that the scaffolds are biocompatible and do not trigger wound inflammation. This suggests that scaffolds are safe for topical application. A comparison of the effect of both nanogels even without the addition of the silver nanoparticles, reveals that the scaffold itself has a high potential as an antibacterial agent, which may suppress both the inflammatory reaction and the activity of proteases. The effect on wound closure of the peptide nanogels is comparable to standard care hydrogels.

公开(公告)号：US11839694B2

公开(公告)日：2023-12-12

申请号：US15091435

申请日：2016-04-05

申请人： Massachusetts Institute of Technology ,  Versitech Limited

发明人： Rutledge Ellis-Behnke ,  Yu-Xiang Liang ,  Gerald E. Schneider ,  Kwok-Fai So ,  David K. C. Tay ,  Shuguang Zhang

IPC分类号： A61K38/08 ,  A61L26/00 ,  A61K9/00 ,  A61K38/10

CPC分类号： A61L26/0047 ,  A61K9/0019 ,  A61K38/08 ,  A61K38/10 ,  A61L26/0066 ,  A61L2400/04

摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self: assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.

公开(公告)号：US20230190995A1

公开(公告)日：2023-06-22

申请号：US17935096

申请日：2022-09-24

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Donald R. Griffin ,  Westbrook Weaver ,  Tatiana Segura ,  Dino Di Carlo ,  Philip Scumpia

IPC分类号： A61L26/00 ,  A61L27/18 ,  A61L27/58 ,  A61K47/62 ,  A61K9/06 ,  A61K31/795 ,  A61L27/22 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61L26/008 ,  A61L26/0019 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/18 ,  A61L27/58 ,  A61K47/62 ,  A61K9/06 ,  A61K31/795 ,  A61L26/0066 ,  A61L26/0047 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/34 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/00

摘要： A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

公开(公告)号：US20180353543A1

公开(公告)日：2018-12-13

申请号：US15752193

申请日：2016-08-11

申请人： KAMADA LTD.

发明人： Ayelet COOPER ,  Nachum YONAH ,  Liliana BAR

IPC分类号： A61K35/16 ,  A61K38/01 ,  A61K38/38 ,  A61K38/40 ,  A61K38/48 ,  A61P17/02

CPC分类号： A61K35/16 ,  A61K8/64 ,  A61K8/66 ,  A61K8/983 ,  A61K9/00 ,  A61K9/0014 ,  A61K38/014 ,  A61K38/38 ,  A61K38/40 ,  A61K38/44 ,  A61K38/4833 ,  A61L26/0047 ,  A61P17/02 ,  A61Q19/00 ,  A61Q19/08 ,  C07K16/065 ,  C12Y116/03001 ,  A61K2300/00

摘要： The present invention provides compositions and methods for improving wound healing, reducing scar formation and/or promoting skin health and aesthetic appearance. In particular, the present invention provides protein compositions that are derived from Cohn fraction IV and/or IV-1 useful in promoting wound healing and for cosmetic care of the skin.

公开(公告)号：US09938378B2

公开(公告)日：2018-04-10

申请号：US14112742

申请日：2012-04-20

申请人： Donald Wellings

发明人： Donald Wellings

IPC分类号： C08G69/48 ,  A61L15/32 ,  C08J3/12 ,  C08J3/24 ,  C12N11/02 ,  C12N11/06 ,  A61L26/00 ,  G01N33/532 ,  G01N33/543 ,  G01N33/58 ,  C07H21/00 ,  C07K1/04 ,  C08B37/00 ,  C12N5/00 ,  C12N11/08 ,  C09D177/04

CPC分类号： C08G69/48 ,  A61L15/32 ,  A61L26/0019 ,  A61L26/0047 ,  A61L2300/434 ,  C07H21/00 ,  C07K1/042 ,  C08B37/00 ,  C08J3/126 ,  C08J3/24 ,  C08J2477/00 ,  C09D177/04 ,  C12N5/0018 ,  C12N11/02 ,  C12N11/06 ,  C12N11/08 ,  G01N33/532 ,  G01N33/54313 ,  G01N33/585 ,  Y10T428/249991 ,  Y10T428/2998

摘要： The invention provides a non-particulate cross-linked poly-ϵ-lysine polymer. The poly-ϵ-lysine and cross linker are linked by amide bonds and may the cross linker has at least two functional groups capable of reacting with an alpha carbon amine of poly-ϵ-lysine. The polymer is suitably insoluble in water and other solvents and is provided in macro form for example a sheet, article or fiber. The macro form polymer is useful in a wide range of applications including wound treatment, as a medical diagnostic comprising a particulate support and a functional material bound or retained by the support and solid phase synthesis of peptides, oligonucleotides, oligosaccharides, immobilization of species, cell culturing and in chromatographic separation.

公开(公告)号：US20180064782A1

公开(公告)日：2018-03-08

申请号：US15818602

申请日：2017-11-20

申请人： Arch Biosurgery, Inc.

发明人： Terrence Norchi ,  Steven Kates ,  Rutledge Ellis-Behnke

IPC分类号： A61K38/10 ,  A61L31/14 ,  A61L31/04 ,  A61K9/70 ,  A61K38/02 ,  A61L26/00 ,  A61L27/22 ,  A61L15/32 ,  A61L31/16

CPC分类号： A61K38/10 ,  A61K9/70 ,  A61K9/7007 ,  A61K38/02 ,  A61L15/32 ,  A61L26/0028 ,  A61L26/0047 ,  A61L27/22 ,  A61L27/227 ,  A61L31/043 ,  A61L31/047 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/418 ,  A61L2400/12

摘要： Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable. In one embodiment, the mesh is formed from one or more self-assembling peptides. The peptides can be in the form of fibers, such as nanofibers. The peptides can be assembled prior to formation of the mesh or after the mesh has been formed but before it is applied. Alternatively, the mesh can be prepared from unassembled peptides, which assemble at the time of application. The peptides can assemble upon contact with bodily fluids (e.g., blood) or can be contacted with an ionic solution to initiate assembly.

公开(公告)号：US09833539B2

公开(公告)日：2017-12-05

申请号：US15100222

申请日：2013-12-28

申请人： NANJING TECH UNIVERSITY (CN)

发明人： Hong Xu ,  Bo Chi ,  Rui Wang ,  Xiaohai Feng ,  Sha Li ,  Jinfeng Liang ,  Pingkai Ouyang

IPC分类号： C08G69/40 ,  A61L26/00 ,  C08J3/075 ,  A61L15/32 ,  A61L15/60 ,  C08G69/10 ,  C08G69/48 ,  C12P13/08

CPC分类号： A61L26/0019 ,  A61L15/32 ,  A61L15/60 ,  A61L26/0047 ,  A61L26/008 ,  A61L26/009 ,  A61L2300/252 ,  A61L2300/802 ,  A61L2430/34 ,  C08G69/10 ,  C08G69/40 ,  C08G69/48 ,  C08J3/075 ,  C08J2377/04 ,  C08J2389/00 ,  C12P13/08 ,  C08L77/04

摘要： The present invention discloses a ε-polylysine hydrogel and the preparation method and application of the as-described ε-polylysine hydrogel. The polylysine hydrogel is non-toxic to a recipient, and has biodegradability and biocompatibility. The wound tissue healing material prepared by the present invention can be used in wound tissue adhesion in an efficient, stable, safe manner.

公开(公告)号：US09750844B2

公开(公告)日：2017-09-05

申请号：US14857189

申请日：2015-09-17

申请人： ACADEMIA SINICA ,  NATIONAL TAIWAN OCEAN UNIVERSITY

发明人： Jyh-Yih Chen ,  Chang-Jer Wu ,  Han-Ning Huang

IPC分类号： A61L26/00 ,  A61L15/46 ,  A61L15/32

CPC分类号： A61L26/0047 ,  A61L15/32 ,  A61L15/325 ,  A61L15/46 ,  A61L26/0033 ,  A61L26/0066 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/412

摘要： The preset invention relates to a new method for wound healing, particularly in burns, comprising Epinecidin-1 (Epi-1) or Pardaxin (GE33), optionally in the incorporation into collagen.

公开(公告)号：US20170196993A1

公开(公告)日：2017-07-13

申请号：US15324144

申请日：2015-07-08

申请人： Agency for Science, Technology and Research

发明人： Charlotte Hauser ,  Ming Ni

IPC分类号： A61K49/00 ,  A61L27/22 ,  C12Q1/02 ,  A61K9/14 ,  A61K47/42 ,  A61L26/00 ,  A61L27/52

CPC分类号： A61K49/00 ,  A61K9/14 ,  A61K47/42 ,  A61L26/0047 ,  A61L26/008 ,  A61L27/227 ,  A61L27/52 ,  C07K5/06034 ,  C07K5/0808 ,  C07K5/101 ,  C07K14/78 ,  C12Q1/02

摘要： Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings.