公开(公告)号：US5114852A

公开(公告)日：1992-05-19

申请号：US500220

申请日：1990-03-27

申请人： Yoshiyasu Yabusaki ,  Hiroko Murakami ,  Toshiyuki Sakai ,  Megumi Shibata ,  Hideo Ohkawa

发明人： Yoshiyasu Yabusaki ,  Hiroko Murakami ,  Toshiyuki Sakai ,  Megumi Shibata ,  Hideo Ohkawa

IPC分类号： C12N15/09 ,  C12N1/16 ,  C12N1/19 ,  C12N9/02 ,  C12N15/00 ,  C12R1/865

CPC分类号： C12Y106/02004 ,  C12N9/0042 ,  C12N9/0077 ,  C07K2319/00

摘要： The present invention provides a chimeric enzyme gene which codes for a monooxygenase having both monooxygenase activity derived from cytochrome P-450 and reducing power supplying ability derived from NADPH-cytochrome P-450 reductase.The present invention further provides a yeast expression plasmid which contains said chimeric enzyme gene and expresses said monooxygenase gene; a transformed yeast strain which carries said yeast expression plasmid; a monooxygenase which has both the monooxygenase activity and the reducing power supplying ability as mentioned above; and a process for producing said monooxygenase.

摘要翻译： 本发明提供了编码具有源自细胞色素P-450的单加氧酶活性并降低由NADPH-细胞色素P-450还原酶衍生的供能能力的单加氧酶的嵌合酶基因。 本发明还提供含有所述嵌合酶基因并表达所述单加氧酶基因的酵母表达质粒; 携带所述酵母表达质粒的转化酵母菌株; 如上所述具有单加氧酶活性和还原能力供给能力的单加氧酶; 以及生产所述单加氧酶的方法。

公开(公告)号：US5060184A

公开(公告)日：1991-10-22

申请号：US587558

申请日：1990-09-24

申请人： Toshiyuki Sakai

发明人： Toshiyuki Sakai

IPC分类号： G06F17/22 ,  G06F17/27

CPC分类号： G06F17/2795

摘要： In a conventional word processing apparatus provided with a users' dictionary memory into or from which arbitrary words such as proper nouns can be stored or deleted, each word to be stored or deleted into or from the users' dictionary memory is required to be pointed out by a cursor in the case of the memory mode and to be pointed out by a print head in the case of the typewriter mode. Thus, a word processing apparatus is provided with a storage controlling arrangement for storing the word nearest to a pointer element of an outputting medium, which is a display or a printer, into the users' dictionary memory and a delete controlling arrangement for deleting the word nearest to the pointer element of the outputting medium from the users' dictionary memory.

公开(公告)号：US09975284B2

公开(公告)日：2018-05-22

申请号：US14372280

申请日：2013-01-17

申请人： Toshiyuki Sakai

发明人： Toshiyuki Sakai

IPC分类号： C08F255/08 ,  B29C45/00 ,  H01L33/56 ,  H01L33/48 ,  H01L33/60 ,  C08K5/3492 ,  B29B13/08 ,  B29C71/04 ,  C08K3/22 ,  C08K3/36 ,  C08K7/14 ,  C08L23/20 ,  B29C35/08 ,  H01L33/50 ,  H01L23/29 ,  B29K35/00 ,  B29L12/00 ,  B29K105/00 ,  B29K105/16 ,  B29K509/02 ,  B29K509/08 ,  H01L31/0216 ,  H01L33/46

CPC分类号： B29C45/0001 ,  B29B13/08 ,  B29C35/0866 ,  B29C71/04 ,  B29C2035/0877 ,  B29K2035/00 ,  B29K2039/00 ,  B29K2105/0032 ,  B29K2105/16 ,  B29K2509/02 ,  B29K2509/08 ,  B29L2012/00 ,  C08F255/08 ,  C08K3/22 ,  C08K3/36 ,  C08K5/34924 ,  C08K7/14 ,  C08K2003/2241 ,  C08L23/20 ,  H01L23/296 ,  H01L31/02167 ,  H01L33/46 ,  H01L33/48 ,  H01L33/501 ,  H01L33/56 ,  H01L33/60 ,  H01L2224/48091 ,  Y10T428/24273 ,  H01L2924/00014 ,  C08L9/00

摘要： Provided are an electron beam curable resin composition including polymethylpentene, and a crosslinking agent, in which the crosslinking agent has a saturated or unsaturated ring structure, at least one atom among atoms forming at least one ring is bonded to any allylic substituent of an allyl group, a methallyl group, an allyl group through a linking group, and a methallyl group through a linking group, and a molecular weight is 1,000 or less, a resin frame for reflectors using the resin composition, a reflector, and a molding method using the resin composition.

公开(公告)号：US08569378B2

公开(公告)日：2013-10-29

申请号：US12669944

申请日：2008-07-18

申请人： Toshiyuki Sakai ,  Hitoshi Iikura ,  Ikumi Hyoudoh ,  Toshihiro Aoki ,  Noriyuki Furuichi ,  Masayuki Matsushita ,  Fumio Watanabe ,  Sawako Ozawa ,  Masahiro Sakaitani ,  Pil-Su Ho ,  Yasushi Tomii ,  Kenji Takanashi ,  Naoki Harada

发明人： Toshiyuki Sakai ,  Hitoshi Iikura ,  Ikumi Hyoudoh ,  Toshihiro Aoki ,  Noriyuki Furuichi ,  Masayuki Matsushita ,  Fumio Watanabe ,  Sawako Ozawa ,  Masahiro Sakaitani ,  Pil-Su Ho ,  Yasushi Tomii ,  Kenji Takanashi ,  Naoki Harada

IPC分类号： A01N41/02 ,  A01N41/06 ,  A01N43/16 ,  A61K31/16 ,  A61K31/18 ,  A61K31/35 ,  C07D311/00 ,  C07C331/00 ,  C07C381/00 ,  C07C303/00 ,  C07C309/00 ,  C07C311/00

CPC分类号： C07D405/14 ,  C07D407/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D491/052

摘要： The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N═ etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.

摘要翻译： 本发明提供了包含下述通式（11）表示的化合物或其药学上可接受的盐作为活性成分的p27蛋白诱导剂：其中，G1，G2，G3和G8各自独立地选自-N =等，环 G6选自二价芳基等，A选自氨基等，G4选自氧等，G5选自氧等，G7选自-CH2-等，R2选自C1- 6烷基等

公开(公告)号：US08213844B2

公开(公告)日：2012-07-03

申请号：US12541210

申请日：2009-08-14

申请人： Tomoharu Nishikawa ,  Toshiyuki Sakai

发明人： Tomoharu Nishikawa ,  Toshiyuki Sakai

IPC分类号： G03G15/08

CPC分类号： G03G15/0818 ,  G03G2215/0614 ,  G03G2221/163

摘要： A developing device for an image forming apparatus of a non-magnetic one-component type. The developing device has a developing roller having a body and a shaft. Bearings for supporting the shaft have a groove made in a contact surface that is in contact with the shaft, and grease is pooled in the groove. The contact surface of the shaft has a surface roughness from 0.2 to 0.5, and the grease has consistency from 265 to 385 ( 1/10 mm·20° C.).

摘要翻译： 一种用于非磁性单组分型图像形成装置的显影装置。 显影装置具有具有主体和轴的显影辊。 用于支撑轴的轴承具有在与轴接触的接触表面中形成的凹槽，并且润滑脂汇集在凹槽中。 轴的接触面的表面粗糙度为0.2〜0.5，润滑脂的稠度为265〜385（1/10 mm·20°C）。

公开(公告)号：USRE41853E1

公开(公告)日：2010-10-26

申请号：US11808252

申请日：2002-07-18

申请人： Haruo Wakayama ,  Toshiyuki Sakai ,  Keiko Hayashi ,  Yoshitaka Nishio ,  Junichi Matsumoto

发明人： Haruo Wakayama ,  Toshiyuki Sakai ,  Keiko Hayashi ,  Yoshitaka Nishio ,  Junichi Matsumoto

IPC分类号： C03B33/02 ,  B43L13/00

CPC分类号： C03B33/027 ,  B28D1/225 ,  B28D5/0011 ,  B28D5/022 ,  C03B33/07 ,  C03B33/10 ,  Y02P40/57 ,  Y10T83/0333 ,  Y10T83/0341

摘要： A scribing head 1 of this invention raises and lowers a scribing cutter by rotation of a servomotor 3. As a scribe pressure, a rotational torque of the servomotor 3 is transmitted to the scribing cutter. To form a scribe line across another scribe line which is formed earlier, the scribe pressure is raised temporarily when the scribing head passes the scribe line which is formed earlier. The rotational torque of the servomotor 3 is controlled at any of preset limits while the position of a cutter 6 of the scribing head shifts on the brittle substrate. The servomotor 3 is driven under position-control mode.

摘要翻译： 本发明的划线头1通过伺服电动机3的旋转而升高并降低划线刀。作为划痕压力，伺服电机3的旋转扭矩传递到划线刀。 为了在较早形成的另一划线上形成划线，当划线头通过较早形成的划线时，刻划压力暂时升高。 伺服电动机3的旋转扭矩被控制在任何预设限制，同时划线头的刀具6的位置在脆性衬底上移动。 伺服电机3在位置控制模式下被驱动。

公开(公告)号：US20100240613A1

公开(公告)日：2010-09-23

申请号：US12626443

申请日：2009-11-25

申请人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

发明人： Hisashi Kawasaki ,  Hiroyuki Abe ,  Kazuhide Hayakawa ,  Tetsuya Iida ,  Shinichi Kikuchi ,  Takayuki Yamaguchi ,  Toyomichi Nanayama ,  Hironori Kurachi ,  Masahiro Tamaru ,  Yoshikazu Hori ,  Mitsuru Takahashi ,  Takayuki Yoshida ,  Toshiyuki Sakai

IPC分类号： A61K31/675 ,  C07D471/04 ,  A61K31/519 ,  C07F9/53 ,  A61K31/5377 ,  C07D487/04 ,  C07C275/30 ,  C07C275/50 ,  C07D239/545 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/519 ,  C07C275/30 ,  C07C275/50 ,  C07C2601/16 ,  C07D239/545 ,  C07D239/553 ,  C07D239/62 ,  C07D471/16 ,  C07D487/04 ,  C07F9/53

摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

摘要翻译： 本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。 本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。 此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

公开(公告)号：US07501257B2

公开(公告)日：2009-03-10

申请号：US10547072

申请日：2004-02-25

申请人： Toshiyuki Sakai ,  Hideki Ishihara

发明人： Toshiyuki Sakai ,  Hideki Ishihara

IPC分类号： C12Q1/48

CPC分类号： G01N33/574 ,  C12Q1/485 ,  G01N33/5011 ,  G01N2800/44

摘要： The present invention relates to a more accurate method of diagnosing cancer in a tissue or a cell by measuring the expression and activity of cell cycle related proteins and analyzing a cell cycle profile. In a cell cycle profile, at least two values of expression or activity of cell cycle related proteins are concurrently measured. The measurement of the cell cycle related protein is not limited as to the measurement method.

摘要翻译： 本发明涉及通过测量细胞周期相关蛋白的表达和活性并分析细胞周期特征来更准确地诊断组织或细胞中的癌症的方法。 在细胞周期谱中，同时测量细胞周期相关蛋白的至少两个表达或活性值。 细胞周期相关蛋白的测定不限于测定方法。

公开(公告)号：US07465541B1

公开(公告)日：2008-12-16

申请号：US10181614

申请日：2000-07-21

申请人： Toshiyuki Sakai

发明人： Toshiyuki Sakai

IPC分类号： C12N15/85 ,  C12N15/63 ,  C12N5/10 ,  C12Q1/68 ,  A61K31/593

CPC分类号： C12Q1/6886 ,  A61K48/00 ,  C12N15/85 ,  C12N2830/002 ,  C12Q2600/136

摘要： A 44-bp region that confers vitamin D3-responsiveness to the human p27Kip1 promoter in the human p27Kip1 transcriptional regulatory mechanism was revealed. This region also conferred vitamin D3-responsiveness to a heterogenous promoter. Moreover, it was found that vitamin D3 enhances the binding between the CCAAT box existing in the region and the NF-Y protein and also the binding between the Sp1 sequence (also existing in the region) and the Sp1 protein, thus inducing human p27Kip1 transcription. Also revealed were methods of screening for pharmaceutical agents that regulate the expression of the p27Kip1 gene using these molecular mechanisms.

摘要翻译： 揭示了在人p27Kip1转录调节机制中赋予维生素D3对人p27Kip1启动子的响应性的44-bp区域。 该区域还赋予异源启动子维生素D3反应性。 此外，发现维生素D3增强该区域存在的CCAAT盒与NF-Y蛋白之间的结合以及Sp1序列（也存在于该区域中）与Sp1蛋白之间的结合，从而诱导人p27Kip1转录 。 还揭示了使用这些分子机制筛选调节p27Kip1基因表达的药剂的方法。

公开(公告)号：US20080096368A1

公开(公告)日：2008-04-24

申请号：US11907939

申请日：2007-10-18

申请人： Toshiyuki Sakai

发明人： Toshiyuki Sakai

IPC分类号： H01L21/322

CPC分类号： H01L21/3221 ,  B23K26/40 ,  B23K26/53 ,  B23K26/57 ,  B23K2103/50 ,  H01L21/268 ,  H01L21/304 ,  H01L21/3043 ,  H01L21/67092 ,  H01L21/78

摘要： A water processing method for providing a gettering sink effect to a wafer having a plurality of streets which are formed in a lattice pattern on the front surface of a substrate and devices which are formed in a plurality of areas sectioned by the plurality of streets, comprising the steps of removing distortion produced on the rear surface of the substrate of the wafer whose rear surface of the substrate has been ground to a predetermined thickness; forming a gettering sink effect layer by applying a laser beam of a wavelength having permeability for the substrate of the wafer which has undergone the distortion removing step, with its focal point set to the inside of the substrate to form a deteriorated layer in the inside of the substrate; and dividing the wafer which has undergone the gettering sink effect layer forming step, into individual chips along the streets.

摘要翻译： 一种水处理方法，用于向具有在基板的前表面上形成为格子图案的多个街道的晶片提供吸气槽效应，以及形成在由多个街道划分的多个区域中的装置，其包括： 消除在衬底的背面被研磨成预定厚度的晶片的衬底后表面产生的变形的步骤; 通过将其焦点设置在衬底的内部，通过施加具有对于经过失真去除步骤的晶片的衬底的导电性的波长的激光束来形成吸气吸收效应层，以在衬底的内部形成劣化层 基材; 并且将经过吸水槽效应层形成步骤的晶片分成沿着街道的各个芯片。