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    Method and apparatus for providing hermetic electrical feedthrough
    52.
    发明授权
    Method and apparatus for providing hermetic electrical feedthrough 有权
    用于提供密封电馈通的方法和装置

    公开(公告)号：US08163397B2

    公开(公告)日：2012-04-24

    申请号：US13165388

    申请日：2011-06-21

    申请人： Jerry Ok ,  Robert J. Greenberg

    发明人： Jerry Ok ,  Robert J. Greenberg

    IPC分类号： H05K1/03

    CPC分类号： H05K3/4046 ,  H01L21/486 ,  H01L23/10 ,  H01L2924/0002 ,  H05K1/0306 ,  H05K2201/10287 ,  H05K2201/10416 ,  Y10T29/49139 ,  Y10T29/49146 ,  Y10T29/49147 ,  Y10T29/49162 ,  Y10T29/49163 ,  Y10T428/24926 ,  H01L2924/00

    摘要： A method and apparatus suitable for forming hermetic electrical feedthroughs in a ceramic sheet having a thickness of .ltoreq.40 mils. More particularly, the method yields an apparatus including a hermetic electrical feedthrough which is both biocompatible and electrochemically stable and suitable for implantation in a patient's body. The method involves: (a) providing an unfired, ceramic sheet having a thickness of .ltoreq.40 mils and preferably comprising .ltoreq.99% aluminum oxide; (b) forming multiple blind holes in said sheet; (c) inserting solid wires, preferably of platinum, in said holes; (d) firing the assembly of sheet and wires to a temperature sufficient to sinter the sheet material but insufficient to melt the wires; and (e) removing sufficient material from the sheet lower surface so that the lower ends of said wires are flush with the finished sheet lower surface.

    摘要翻译： 一种适用于在厚度为40密耳的陶瓷片中形成气密电馈通件的方法和装置。 更具体地，该方法产生一种包括生物相容性和电化学稳定性并且适于植入患者体内的气密电馈通装置。 该方法包括：（a）提供厚度为40密耳，优选包含99.99％氧化铝的未烧制的陶瓷片; （b）在所述片材中形成多个盲孔; （c）将优选铂的实心线插入所述孔中; （d）将片材和电线的组件烧制到足以烧结片材但不足以熔化电线的温度; 以及（e）从片材下表面去除足够的材料，使得所述电线的下端与成品片材下表面齐平。

    Trans-retinal flexible circuit electrode array
    53.
    发明授权
    Trans-retinal flexible circuit electrode array 有权
    视网膜软电路电极阵列

    公开(公告)号：US08131375B2

    公开(公告)日：2012-03-06

    申请号：US11521281

    申请日：2006-09-13

    申请人： Robert J. Greenberg ,  Mark S. Humayun

    发明人： Robert J. Greenberg ,  Mark S. Humayun

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/0543 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/118 ,  H05K3/28 ,  H05K2201/0133

    摘要： Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally.The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.

    摘要翻译： 申请人提出了通过将眼睛外部电子放置在眼睛的外部并通过平面进入眼睛并从眼睛刺穿视网膜（视网膜切开术）以刺激眼底的方式来组合视网膜下和视网膜方法。 本发明是用于视网膜下刺激的改进的电极阵列。 诸如聚酰亚胺之类的硬聚合物是生物相容性强的，用于支撑电极阵列和支撑在薄柔性电路阵列中的迹线。 在本发明中，申请人利用薄聚酰亚胺的尖锐特性，在电极阵列的末端形成点。 这使得柔性电路电极阵列既可以是电极阵列，也可以是手术工具，以切割视网膜，并在阵列下方以单一动作滑动阵列。

    Low profile package for an implantable device
    55.
    发明授权
    Low profile package for an implantable device 有权
    用于植入式装置的薄型包装

    公开(公告)号：US08090448B2

    公开(公告)日：2012-01-03

    申请号：US12205659

    申请日：2008-09-05

    申请人： Robert J. Greenberg ,  Joseph H. Schulman

    发明人： Robert J. Greenberg ,  Joseph H. Schulman

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0543 ,  A61N1/36046 ,  A61N1/37247 ,  A61N1/375 ,  H01L2224/16225 ,  Y10T29/49165

    摘要： The present invention is a low profile hermetic package for an implantable medical device. The package includes a non-conductive substrate including a plurality of straight conductive vias through the non-conductive substrate. A conductive cover hermetically enclosing an electronics circuit is bonded to the non-conductive substrate. The device is low profile. The width of the non-conductive substrate is grater than the height of the cover.

    摘要翻译： 本发明是用于可植入医疗装置的薄型密封包装。 该封装包括非导电衬底，其包括穿过非导电衬底的多个直的导电通孔。 气密地封装电子电路的导电盖被粘合到非导电基底上。 该设备薄型。 非导电性基板的宽度比盖的高度大。

    Pixel re-mapping for visual prosthesis
    57.
    发明授权
    Pixel re-mapping for visual prosthesis 有权
    视觉假体的像素重新映射

    公开(公告)号：US07962221B2

    公开(公告)日：2011-06-14

    申请号：US11493471

    申请日：2006-07-25

    申请人： Robert J. Greenberg ,  Richard Williamson

    发明人： Robert J. Greenberg ,  Richard Williamson

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36046

    摘要： A method and apparatus for adjusting a visual image provided to a patient. In one embodiment, an image may be presented to the patient to obtain the patient's subjective perception of the image, and the patient may either manipulate the image to obtain a desired adjustment, or guide a clinician performing the adjustment. In another embodiment, the clinician may make objective observations of, for example, the position of an electrode array on the patient's retina, and make adjustments accordingly. The adjustment may be a spatial adjustment comprising a re-mapping performed to decreases image distortion resulting from differences in the patient's perception of stimulation of different areas of the retina. Such distortion may result from differences between the patient's perception of stimulation falling within the macula, and stimulation falling within the periphery surrounding the macula. The adjustment may also compensate for translations or rotations of the electrode array on the retina.

    摘要翻译： 一种用于调整提供给患者的视觉图像的方法和装置。 在一个实施例中，可以向患者呈现图像以获得患者对图像的主观感知，并且患者可以操纵图像以获得期望的调整，或指导进行调整的临床医师。 在另一个实施例中，临床医生可以对例如患者视网膜上的电极阵列的位置进行客观观察，并进行相应的调整。 调整可以是空间调整，其包括执行的重新映射，以减少由于患者对视网膜的不同区域的刺激的感知的差异而导致的图像失真。 这种变形可能由患者对黄斑内的刺激感知以及落在黄斑周围周边的刺激之间的差异引起。 该调整还可以补偿视网膜上的电极阵列的平移或旋转。

    Electrode with increased stability and method of manufacturing the same
    58.
    发明授权
    Electrode with increased stability and method of manufacturing the same 有权
    增加稳定性的电极及其制造方法

    公开(公告)号：US07937153B2

    公开(公告)日：2011-05-03

    申请号：US11820744

    申请日：2007-06-19

    申请人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

    发明人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0543 ,  A61N1/36046

    摘要： An implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. An implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

    摘要翻译： 具有增加的稳定性的可植入电极具有聚集结构，其中电极的表面被包括充满棒或柱的开口的材料覆盖。 具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。 一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。 一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

    Video processing methods for improving visual acuity and/or perceived image resolution
    59.
    发明授权
    Video processing methods for improving visual acuity and/or perceived image resolution 有权
    用于改善视力和/或感知图像分辨率的视频处理方法

    公开(公告)号：US07925354B2

    公开(公告)日：2011-04-12

    申请号：US11879982

    申请日：2007-07-19

    申请人： Robert J. Greenberg ,  Richard P. Williamson ,  Joseph H. Schulman ,  Reza P. Rassool ,  Lee J. Mandell ,  Abraham N. Seidman

    发明人： Robert J. Greenberg ,  Richard P. Williamson ,  Joseph H. Schulman ,  Reza P. Rassool ,  Lee J. Mandell ,  Abraham N. Seidman

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36046

    摘要： A method and apparatus for improving visual acuity when providing a visual image from a “high” resolution input device to a “low” resolution output device. The described invention is of particular use when the output device is an array of electrodes as part of a retinal prosthesis used to restore vision to a visually-impaired patient. In that various limitations may, within the foreseeable future, limit the density of such an electrode array (and thus the resolution of the output image), the present invention teaches techniques to assign processed pixel subsets of a higher resolution image to a single electrode. By varying the pixel subsets, e.g., by jittering, and/or altering the processing criteria, the perceived visual acuity may be further improved. Alternatively and additionally, such processing may be further extended to drive neighboring electrodes in combination to thus stimulate virtual electrode sites and thus further enhance visual acuity.

    摘要翻译： 当从“高”分辨率输入装置向“低”分辨率输出装置提供视觉图像时，用于提高视力的方法和装置。 当输出设备是用作将视力恢复到视觉障碍患者的视网膜假体的一部分的电极阵列时，所描述的本发明是特别有用的。 因此，在可预见的将来可能会限制这种电极阵列的密度（因此输出图像的分辨率）的各种限制，本发明教导了将更高分辨率图像的经处理的像素子集分配给单个电极的技术。 通过例如通过抖动和/或改变处理标准来改变像素子集，可以进一步改善感知的视敏度。 另外地和另外地，这样的处理可以进一步延伸以组合驱动相邻电极，从而刺激虚拟电极位置，从而进一步提高视敏度。