利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

130 条记录 (耗时 0.045 秒)

    BIOCOMPATIBLE PACKAGING FOR LONG TERM IMPLANTABLE SENSORS AND ELECTRONICS
    61.
    发明申请
    BIOCOMPATIBLE PACKAGING FOR LONG TERM IMPLANTABLE SENSORS AND ELECTRONICS 审中-公开
    用于长期可植入式传感器和电子产品的生物易燃包装

    公开(公告)号：US20160287101A1

    公开(公告)日：2016-10-06

    申请号：US15076184

    申请日：2016-03-21

    申请人： California Institute of Technology

    发明人： Yu-Chong Tai ,  Yang Liu ,  Aubrey M. Shapero

    IPC分类号： A61B5/0215 ,  A61B5/021

    CPC分类号： A61B5/02156 ,  A61B5/02141 ,  A61B5/0215 ,  A61B2562/0247 ,  A61B2562/12 ,  A61B2562/162 ,  A61B2562/168 ,  G01L9/00

    摘要： An implantable medical device is described. In an example, the implantable medical device includes an electromechanical substrate and sensor, such as a pressure sensor, disposed on the substrate. At least a portion of the sensor is packaged via a liquid encapsulation. The packaging includes a shaped flexible outer membrane that surrounds at least the portion of the sensor. The packaging also includes a hydrophobic liquid disposed between at least the portion of the pressure sensor and the flexible outer membrane. The implantable medical device can be a part of a medical system used for monitoring medical conditions or performing medical operations based on the implantable medical device. Additionally, manufacturing methods are described for packaging the sensor in a liquid encapsulation.

    摘要翻译： 描述了可植入医疗装置。 在一个示例中，可植入医疗装置包括设置在基底上的机电衬底和诸如压力传感器的传感器。 传感器的至少一部分通过液体封装进行封装。 该包装包括至少围绕传感器的该部分的成形的柔性外膜。 该包装还包括设置在压力传感器的至少部分与柔性外膜之间的疏水性液体。 可植入医疗装置可以是用于监视医疗状况或基于可植入医疗装置执行医疗操作的医疗系统的一部分。 另外，描述了用于将传感器封装在液体封装中的制造方法。

    IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it
    62.
    发明授权
    IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it 有权
    IC加工聚合物纳米液相色谱系统芯片及其制备方法

    公开(公告)号：US09288915B2

    公开(公告)日：2016-03-15

    申请号：US13680030

    申请日：2012-11-17

    申请人： City of Hope ,  California Institute of Technology

    发明人： Yu-Chong Tai ,  Qing He ,  Jun Xie ,  Changlin Pang ,  Terry D. Lee ,  Damien Rodger ,  Matthieu Liger

    IPC分类号： G01N30/60 ,  G01N27/26 ,  H05K3/28 ,  G03F1/80 ,  G01N30/64

    CPC分类号： H05K3/284 ,  G01N30/6047 ,  G01N30/6095 ,  G01N2030/645 ,  G03F1/80 ,  G01N2030/625

    摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanoliter/picoliter-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.

    摘要翻译： 根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。 微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。 该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。 交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。 集成在色谱柱出口处的电化学/电导率传感器测量分离信号。 自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。 使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

    3-coil wireless power transfer system for eye implants
    65.
    发明授权
    3-coil wireless power transfer system for eye implants 有权
    3线圈无线电力传输系统用于眼睛植入

    公开(公告)号：US09078743B2

    公开(公告)日：2015-07-14

    申请号：US13973847

    申请日：2013-08-22

    申请人： California Institute of Technology ,  University of Southern California

    发明人： Yu-Chong Tai ,  Yu Zhao ,  Mark Humayun ,  James D. Weiland

    IPC分类号： A61F2/14 ,  A61N1/36 ,  A61N1/378 ,  A61N1/05

    CPC分类号： A61F9/007 ,  A61F2/14 ,  A61F2250/0001 ,  A61N1/0529 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/36046 ,  A61N1/3605 ,  A61N1/3787 ,  C23F1/00 ,  H01F27/2804 ,  H01F2027/2809

    摘要： A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.

    摘要翻译： 公开了一种三线圈电磁感应电力传输系统，用于视网膜假体和其他植入物。 第三缓冲线圈设置在外部发射线圈和埋在体内的接收器线圈之间，以提高效率和对准失准的鲁棒性。 可以使用微机械加工技术来制造一个或多个线圈，以在生物相容绝缘体的带中布置导体，将绝缘导体迹线的长度彼此纵向折叠，然后将它们螺旋化成环。 轨迹通过在折叠线上移动来改变环中的轴向位置。 迹线上的一个或多个U形部分可以被折叠，使得相邻的迹线可以彼此相对地突出，从而延长可以卷绕成线圈的所得到的带状物。

    IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE
    67.
    发明申请
    IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE 有权
    加速渗透沉淀到硅胶中的原位加热沉淀

    公开(公告)号：US20150111023A1

    公开(公告)日：2015-04-23

    申请号：US14509226

    申请日：2014-10-08

    申请人： California Institute of Technology

    发明人： Yu-Chong Tai ,  Dongyang Kang

    IPC分类号： C09D165/04 ,  B05D1/02 ,  B05D3/02

    CPC分类号： C09D165/04 ,  B05D1/60 ,  C03C17/328 ,  C03C2217/20 ,  C03C2217/76 ,  C03C2218/152 ,  C08G2261/3424 ,  C08G2261/65 ,  Y10T428/249958

    摘要： Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

    摘要翻译： 描述了通过气相沉积聚合将聚对二甲苯N，C，D和AF-4等多孔材料涂覆在多孔材料中，其中被覆多孔材料的表面的温度被加热至60℃至120℃。 ，或80℃和85℃。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。

    ACCOMMODATING INTRAOCULAR LENS
    68.
    发明申请
    ACCOMMODATING INTRAOCULAR LENS 审中-公开
    住院镜片

    公开(公告)号：US20140227437A1

    公开(公告)日：2014-08-14

    申请号：US14256845

    申请日：2014-04-18

    申请人： California Institute of Technology ,  University of Southern California

    发明人： Charles DeBoer ,  Yu-Chong Tai ,  Mark Humayun ,  Wendian Shi

    IPC分类号： B29D11/00

    CPC分类号： B29D11/00009 ,  A61F2/1624 ,  A61F2/1635 ,  A61F2/1659 ,  A61F2240/001 ,  A61F2240/004 ,  A61F2250/0003 ,  A61L27/18 ,  A61L2430/04 ,  A61L2430/16 ,  B29D11/023 ,  C08L83/04

    摘要： Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.

    摘要翻译： 系统，装置和方法用于假体可注射的眼内透镜。 透镜可以由硅酮，氟硅酮和苯基取代的硅氧烷制成，并且对透气半透膜。 可以通过外科手术针来访问位于前侧但远离赤道的光路外侧的一个或多个有机硅弹性体贴片，以便填充或调整透镜内的光学透明流体。 可以调节流体以便设置透镜的基础屈光度，并在其初始插入之后调整透镜。 弹性体贴片的尺寸使得它们在针被取出后自我密封。 贴片中的直的或阶梯的狭缝可以使钝针更容易地进入透镜的内部。

    METHODS FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS
    70.
    发明申请
    METHODS FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS 有权
    癌症检测，诊断和预后的方法

    公开(公告)号：US20140038271A1

    公开(公告)日：2014-02-06

    申请号：US14020313

    申请日：2013-09-06

    申请人： University of Southern California ,  California Institute of Technology

    发明人： Amir Goldkorn ,  Yu-Chong Tai ,  Tong Xu ,  Bo Lu

    IPC分类号： G01N33/50

    CPC分类号： G01N33/57496 ,  C12N5/0693 ,  C12N2503/00 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Y207/07049 ,  G01N1/30 ,  G01N1/4077 ,  G01N33/5094 ,  G01N2001/4088 ,  G01N2333/9128 ,  Y10T436/25375

    摘要： The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.

    摘要翻译： 本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。 该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器， 尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。 本发明还提供了使用在各种应用中实时捕获的细胞的方法。