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166 条记录 (耗时 0.046 秒)

    High throughput microfluidic systems and methods
    62.
    发明授权
    High throughput microfluidic systems and methods 有权
    高通量微流体系统和方法

    公开(公告)号：US07316801B2

    公开(公告)日：2008-01-08

    申请号：US10244227

    申请日：2002-09-16

    申请人： Joseph E. Kercso ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Andrew W. Toth ,  Calvin Y. H. Chow ,  J. Wallace Parce

    发明人： Joseph E. Kercso ,  Steven A. Sundberg ,  Jeffrey A. Wolk ,  Andrew W. Toth ,  Calvin Y. H. Chow ,  J. Wallace Parce

    IPC分类号： G01N21/00 ,  B01L3/02

    CPC分类号： G01N35/028 ,  G01N2035/00148 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/119163 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.

    摘要翻译： 本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。 多孔板沿着输送系统行进到具有微流体装置的测试台。 在测试台处，每个板从输送机中取出，多孔板的孔依次与微流体装置的输入端对准。 在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。 可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络 芯片。 具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

    DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
    68.
    发明授权
    DNA sequencing using multiple fluorescent labels being distinguishable by their decay times 有权
    使用多个荧光标记的DNA测序可通过其衰变时间来区分

    公开(公告)号：US06716394B2

    公开(公告)日：2004-04-06

    申请号：US10179686

    申请日：2002-06-24

    申请人： Morten Jensen ,  J. Wallace Parce

    发明人： Morten Jensen ,  J. Wallace Parce

    IPC分类号： G01N1506

    CPC分类号： C12Q1/6869 ,  C12Q2563/107 ,  C12Q2561/12

    摘要： A method is provided for identifying components of a mixture by labeling the individual components with fluorescent agents having different fluorescence lifetimes. The components are subsequently separated, fluorescent labels detected and their lifetimes measured. Based on the measured fluorescent lifetimes, the components of mixtures of small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified.

    摘要翻译： 提供了通过用具有不同荧光寿命的荧光剂标记各个组分来鉴定混合物组分的方法。 随后分离组分，检测荧光标记物并测定其寿命。 基于测量的荧光寿命，可以鉴定小有机分子，聚合物，肽，糖和核酸的混合物的组分。