公开(公告)号：US5976472A

公开(公告)日：1999-11-02

申请号：US951180

申请日：1997-10-15

Applicant: Dilip K. Chatterjee ,  Syamal K. Ghosh ,  Edward P. Furlani

Inventor： Dilip K. Chatterjee ,  Syamal K. Ghosh ,  Edward P. Furlani

IPC: B01F5/06 ,  B01F13/00 ,  B01J19/00

CPC classification number: B01F5/0682 ,  B01F13/0059 ,  B01F13/0093 ,  B01F5/0691 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/00891 ,  B01J2219/00909

Abstract: An integrated micro-ceramic chemical plant having a unitary ceramic body formed from multiple ceramic layers in the "green" state which are sintered together including the unitary ceramic body defining a catalytic reaction chamber position and a first and second passages for providing communication with the catalytic reaction chamber position so that two or more fluids may be delivered to such reaction chamber position for reaction. The integrated micro-ceramic chemical plant further includes a unitary ceramic body defining a receiving chamber which includes the catalytic reaction chamber position, a movable member insertable into the receiving chamber and defining a plurality of catalytic reaction chambers. The movable member moves to the catalytic reaction chamber position where one of the catalytic reaction chambers is in communication with the first and second passages to cause the catalytic reaction of the fluids to produce reaction products.

Abstract translation: 一种整体式微陶瓷化工厂，其具有由“绿色”状态的多个陶瓷层形成的单一陶瓷体，其被烧结在一起，包括限定催化反应室位置的整体陶瓷体和用于与催化剂连通的第一和第二通道 反应室位置，使得两个或更多个流体可以被输送到这样的反应室位置进行反应。 集成的微陶瓷化学设备还包括一体的陶瓷体，其限定包括催化反应室位置的接收室，可插入接收室并限定多个催化反应室的活动件。 可动件移动到催化反应室位置，其中一个催化反应室与第一和第二通道连通，引起流体的催化反应产生反应产物。

公开(公告)号：US09862663B2

公开(公告)日：2018-01-09

申请号：US14640465

申请日：2015-03-06

Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Inventor： Arockiadoss Thevasahayam

IPC: C07C29/147 ,  B01J19/08 ,  B01J35/00 ,  C07C29/00 ,  C01G49/00 ,  B01J23/78 ,  B01J19/00

CPC classification number: C07C29/147 ,  B01J19/0093 ,  B01J19/087 ,  B01J23/78 ,  B01J35/0033 ,  B01J2219/00792 ,  B01J2219/00799 ,  B01J2219/00835 ,  B01J2219/00846 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01J2219/0093 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/0854 ,  B01J2219/0866 ,  B01J2219/0869 ,  B01J2219/0877 ,  B01J2219/0892 ,  B01J2219/1945 ,  C01G49/0036 ,  C01P2004/64 ,  C01P2006/42 ,  C07C29/00 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/08

Abstract: Systems and methods are disclosed for synthesizing one or more simple alcohols from mixtures including organic acids, water, and a superparamagnetic catalyst exposed to fluctuating magnetic fields under ambient conditions.

公开(公告)号：US20150157743A1

公开(公告)日：2015-06-11

申请号：US14618732

申请日：2015-02-10

Applicant: ABT Molecular Imaging, Inc.

Inventor： Aaron McFarland ,  Atilio Anzellotti ,  Daniel Hillesheim ,  Clive Brown-Proctor ,  Mark Haig Khachaturian ,  Andrew Land

IPC: A61K51/04 ,  G21K5/02 ,  B01J19/00

CPC classification number: G21K5/02 ,  A61K51/025 ,  A61K51/0402 ,  A61K51/0406 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0491 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00909

Abstract: Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall.

Abstract translation: 微流体放射性药物生产系统和用于合成正电子发射断层扫描（PET）的大约但不小于十（10）个单位剂量的放射性药物生物标志物的方法。 来自加速器或其他放射性同位素发生器的放射性同位素与有机和含水试剂一起引入反应容器中，并将混合物加热以合成预先选定的放射性药物的溶液。 通过通过固相萃取纯化组分，捕集和释放组分和过滤器的组合来纯化溶液。 合成方法减少了废物，并允许在现场生产标记放射性药物并且靠近给予患者的单位剂量的位置。 在现场，按需要的小剂量放射性药物的生产减少放射性药物的合成和该放射性药物的给药之间的时间，通过衰减最小化活性同位素的损失，并允许总体产生较少量的放射性同位素。

公开(公告)号：US08173073B2

公开(公告)日：2012-05-08

申请号：US12915149

申请日：2010-10-29

Applicant: Arkadij M. Elizarov ,  Carroll Edward Ball ,  Jianzhong Zhang ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  Lawrence Diener ,  Sean Ford ,  Reza Miraghaie

Inventor： Arkadij M. Elizarov ,  Carroll Edward Ball ,  Jianzhong Zhang ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  Lawrence Diener ,  Sean Ford ,  Reza Miraghaie

IPC: G21C1/00 ,  B01J19/00 ,  B01J8/00 ,  G01N23/00 ,  G01N30/02

CPC classification number: C07H5/02 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00909

Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Abstract translation: 公开了以快速，有效和紧凑的方式全面自动合成用于成像的放射性化合物的方法和装置，例如通过正电子发射断层摄影（PET）。 特别地，本发明的各种实施例提供了在具有不受限制的气体流过反应器的微流体装置上的整个放射合成循环的自动，独立，免手动操作，从目标水开始并产生纯化的PET放射性示踪器 时间比传统化学系统短。 因此，本发明的一个方面涉及用于放射性标记的化合物的放射合成的微流体芯片，包括反应室，连接到反应室的一个或多个流动通道，连接到所述反应室的一个或多个通气口，以及一个或多个 更一体化的阀来实现进出所述反应室的流量控制。

公开(公告)号：US20110259834A1

公开(公告)日：2011-10-27

申请号：US12766349

申请日：2010-04-23

Applicant: Seh Kwang LEE

Inventor： Seh Kwang LEE

IPC: B01J19/00 ,  B01J8/08 ,  B81B1/00

CPC classification number: B01J8/02 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2400/0409

Abstract: A microreactor may include a reaction channel having at least one curved microchannel, the at least one curved microchannel having an outer and inner curved surfaces and being configured to generate a centrifugal force, an inlet configured to supply at least one reactant into the reaction channel, and an outlet bifurcated into a first sub-outlet in communication with the inner curved surface of the at least one curved microchannel and a second sub-outlet in communication with the outer curved surface of the at least one curved microchannel.

Abstract translation: 微反应器可以包括具有至少一个弯曲微通道的反应通道，所述至少一个弯曲微通道具有外弯曲表面和内弯曲表面，并被配置成产生离心力，入口构造成将至少一种反应物供应到反应通道中， 以及分岔成与所述至少一个弯曲微通道的内弯曲表面连通的第一子出口的出口和与所述至少一个弯曲微通道的外弯曲表面连通的第二子出口。

公开(公告)号：US20110139728A1

公开(公告)日：2011-06-16

申请号：US13058500

申请日：2009-08-05

Applicant: Jürgen Kern ,  Thomas Runowski ,  Marcus Paul Grün ,  Gerhard Ruffert ,  Rebeka Zecirovic ,  Jörg-Rainer Schmitz ,  Helmut Mothes ,  Olaf Stange ,  Frank Herbstritt

Inventor： Jürgen Kern ,  Thomas Runowski ,  Marcus Paul Grün ,  Gerhard Ruffert ,  Rebeka Zecirovic ,  Jörg-Rainer Schmitz ,  Helmut Mothes ,  Olaf Stange ,  Frank Herbstritt

IPC: B01D17/02 ,  B01J19/00 ,  B81B1/00

CPC classification number: B01D11/0415 ,  B01D11/0496 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00907 ,  B01J2219/00909

Abstract: The invention relates to a device for separation of substance mixtures on the micro scale. The invention further relates to a process for separating substance mixtures using the inventive device. The device is a device for separating substance mixtures and for performing chemical reactions between immiscible fluid media on the micro scale, comprising a first channel plate with at least one first process channel for a first fluid medium, an inlet and an outlet, and a connecting or distributing channel in each case, which connects the inlet to the first process channel, and a further connecting or distributing channel which connects the first process channel to the outlet, a second channel plate with at least one second process channel for a second fluid medium immiscible with the first, an inlet and an outlet, and a connecting or distributing channel in each case, which connects the inlet to the second process channel, and a further connecting or distributing channel which connects the second process channel to the outlet, and a microscreen as a separating means between the two process channel, wherein the microscreen has a multitude of orifices which have an aspect ratio of 1.5 to 10.

Abstract translation: 本发明涉及用于在微量级分离物质混合物的装置。 本发明还涉及使用本发明的装置分离物质混合物的方法。 该装置是用于分离物质混合物并用于在微量级上进行不混溶的流体介质之间的化学反应的装置，包括具有至少一个用于第一流体介质的第一工艺通道的第一通道板，入口和出口以及连接 或在每个情况下分配通道，其将入口连接到第一处理通道，以及将第一处理通道连接到出口的另一个连接或分配通道，具有用于第二流体介质的至少一个第二处理通道的第二通道板 与第一进口和出口不混溶，以及将入口连接到第二处理通道的每种情况下的连接或分配通道，以及将第二处理通道连接到出口的另外的连接或分配通道，以及 显微屏作为两个处理通道之间的分离装置，其中微量筛具有多个孔，其长宽比为1.5 到10。

公开(公告)号：US20100296986A1

公开(公告)日：2010-11-25

申请号：US12308303

申请日：2007-07-13

Applicant: Ando Feyh

Inventor： Ando Feyh

IPC: B01D39/10 ,  C23F1/00 ,  C25F3/00

CPC classification number: B01D67/0062 ,  B01D61/18 ,  B01D63/081 ,  B01D63/088 ,  B01D69/02 ,  B01D69/10 ,  B01D2313/10 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00844 ,  B01J2219/00907 ,  B01J2219/00909 ,  B01L3/502753

Abstract: A microscreen and its production method for filtering particles in microfluidics applications. The microscreen includes an at least regionally p-doped Si substrate having a recess, a macroporous membrane connected to the Si substrate via n-doped regions, the recess of the Si substrate being situated directly under the membrane to form a cavity.

Abstract translation: 微滤器及其在微流体应用中过滤颗粒的生产方法。 微型屏幕包括具有凹陷的至少区域p掺杂的Si衬底，大孔膜通过n掺杂区域连接到Si衬底，Si衬底的凹部位于膜的正下方以形成空腔。

公开(公告)号：US20090242116A1

公开(公告)日：2009-10-01

申请号：US12428147

申请日：2009-04-22

Applicant: Ashish V. Pattekar ,  Mayuresh V. Kothare

Inventor： Ashish V. Pattekar ,  Mayuresh V. Kothare

IPC: B29C65/02

CPC classification number: C01B3/323 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0081 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00909 ,  B01J2219/00961 ,  B01J2219/00984 ,  C01B2203/00 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/066 ,  C01B2203/085 ,  C01B2203/1011 ,  C01B2203/1041 ,  C01B2203/1076 ,  C01B2203/1223 ,  C01B2203/1619 ,  C01B2203/1633 ,  C01B2203/1695 ,  Y02P20/52

Abstract: A method of bonding a capillary tube made of a thermally deformable material to a passage in a glass wafer comprising the steps of treating the surface of the capillary tube to render the surface bondable and wettable by a conventional epoxy resin; inserting a support inside the capillary to prevent inward deformation of the capillary during subsequent fabricating steps; inserting the supported capillary inside the port on the wafer; heating an end of the capillary proximate a bottom portion of the port to effect melting of a portion of the heated end of the capillaries; moving the melted end of the capillary into contact with a wall of the port at a desired location for the capillary in the port, thus forming a temporary seal between the capillary and the wall of the port; and introducing an epoxy around the capillary to bind the capillary to the wafer.

Abstract translation: 一种将由可热变形材料制成的毛细管结合到玻璃晶片中的通道的方法，包括以下步骤：处理毛细管的表面以使表面可用常规的环氧树脂粘结和润湿; 在毛细管内插入支撑件以防止在随后的制造步骤期间毛细管的向内变形; 将支撑的毛细管插入晶片的端口内; 在端口的底部附近加热毛细管的端部以使毛细血管的一部分加热端部熔化; 将毛细管的熔化端移动到端口的壁，在端口中的毛细管的期望位置处接触，从而在毛细管和端口的壁之间形成临时密封; 并在毛细管周围引入环氧树脂以将毛细管结合到晶片。

公开(公告)号：US20090236226A1

公开(公告)日：2009-09-24

申请号：US12077621

申请日：2008-03-20

Applicant: Po Ki Yuen

Inventor： Po Ki Yuen

IPC: G01N27/26 ,  B01J19/00 ,  B81C3/00

CPC classification number: B01J19/0093 ,  B01J2219/00804 ,  B01J2219/0081 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00909 ,  B01J2219/00912 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0874 ,  B33Y80/00 ,  Y10T29/494 ,  Y10T436/11 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: A “plug-n-play” modular microfluidic system is described herein which can be made by connecting multiple microfluidic components together to form a larger integrated system. For example, the modular microfluidic system includes a motherboard with interconnecting channels and integrated electrodes (or holes for electrodes to pass) which provide electronic connections to external data acquisition and system control devices. The modular microfluidic system can also include channel inserts (which are placed in the channels of the motherboard), heater units, actuator units, fitting components and microchips/modules with different functionalities which are placed on the motherboard.

Abstract translation: 本文描述了一种“即插即用”模块化微流体系统，其可以通过将多个微流体部件连接在一起以形成更大的集成系统来制造。 例如，模块化微流体系统包括具有互连通道的主板和用于提供与外部数据采集和系统控制装置的电连接的集成电极（或用于电极通过的孔）。 模块化微流体系统还可以包括放置在母板上的通道插入件（放置在母板的通道中），加热器单元，致动器单元，配件组件和具有不同功能的微型芯片/模块。

公开(公告)号：US07399448B2

公开(公告)日：2008-07-15

申请号：US11493998

申请日：2006-07-27

Applicant: Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

Inventor： Steven A. Sundberg ,  J. Wallace Parce ,  Calvin Y. H. Chow

IPC: G01N1/10 ,  B01L3/02

CPC classification number: G01N27/44791 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00891 ,  B01J2219/00909 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N27/44743 ,  G01N2035/00237 ,  G01N2035/1037 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.