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93 条记录 (耗时 0.036 秒)

    Method and apparatus for sorting particles
    82.
    发明申请
    Method and apparatus for sorting particles 审中-公开
    颗粒分选方法和装置

    公开(公告)号：US20070065808A1

    公开(公告)日：2007-03-22

    申请号：US11603444

    申请日：2006-11-22

    申请人： Sebastian Bohm ,  John Gilbert ,  Manish Deshpande

    发明人： Sebastian Bohm ,  John Gilbert ,  Manish Deshpande

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： G01N15/1459 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N2015/149

    摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

    摘要翻译： 用于分选移动通过毛细管尺寸的封闭通道系统的颗粒的方法和装置包括气泡阀，用于选择性地产生压力脉冲以将具有预定特征的颗粒与颗粒流分离。 颗粒分选系统还可以包括用于吸收压力脉冲的缓冲器。 颗粒分选系统可以包括多个紧密耦合的分类模块，其被组合以进一步提高排序率。 颗粒分选系统可以包括用于串行排列颗粒流的多级分选装置，以便降低误差率。

    Microfabricated two-pin system for biomolecule crystallization
    83.
    发明申请
    Microfabricated two-pin system for biomolecule crystallization 审中-公开
    用于生物分子结晶的微型双引脚系统

    公开(公告)号：US20070054408A1

    公开(公告)日：2007-03-08

    申请号：US11595543

    申请日：2006-11-10

    申请人： John Gilbert ,  Jaishree Trikha

    发明人： John Gilbert ,  Jaishree Trikha

    IPC分类号： G01N33/00

    CPC分类号： C30B29/58 ,  C30B7/00

    摘要： A two-pin liquid handling system for crystallizing biomolecules comprises a pair of interacting pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The two-pin liquid handling system includes a temperature and humidity control element for controlling the temperature of the sample acquisition region to cause transpiration of water to and from a droplet of biomolecule solution to promote crystallization of the biomolecule.

    摘要翻译： 用于结晶生物分子的双针液体处理系统包括一对用于在其间保持液滴的相互作用的销。 每个引脚包括与另一个引脚间隔预定距离的尖端以限定采样区域。 双针液体处理系统包括温度和湿度控制元件，用于控制样品采集区域的温度，以使水与生物分子溶液液滴一起蒸发以促进生物分子的结晶。

    IMAGE ADAPTATION SYSTEM AND METHOD
    84.
    发明申请
    IMAGE ADAPTATION SYSTEM AND METHOD 审中-公开
    图像适应系统与方法

    公开(公告)号：US20070030452A1

    公开(公告)日：2007-02-08

    申请号：US11164814

    申请日：2005-12-06

    申请人： John Gilbert

    发明人： John Gilbert

    IPC分类号： G03B1/00

    CPC分类号： H04N9/3194 ,  H04N9/3185

    摘要： A system a method for correcting for optical distortions on a projection screen adapts a projection image to match an input image by adjusting the content of output pixels.

    摘要翻译： 一种用于校正投影屏幕上的光学失真的方法，通过调整输出像素的内容来调整投影图像以匹配输入图像。

    Optical detector for a particle sorting system
    85.
    发明申请
    Optical detector for a particle sorting system 有权

    公开(公告)号：US20060274313A1

    公开(公告)日：2006-12-07

    申请号：US11506522

    申请日：2006-08-18

    申请人： John Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    发明人： John Gilbert ,  Edward Sinofsky ,  Manish Deshpande

    IPC分类号： G01N21/00

    CPC分类号： G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6452 ,  G01N2015/1081

    摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

    Small molecule substrate based enzyme activity assays
    86.
    发明申请
    Small molecule substrate based enzyme activity assays 审中-公开

    公开(公告)号：US20060134696A1

    公开(公告)日：2006-06-22

    申请号：US11181666

    申请日：2005-07-13

    申请人： Nghia Chiem ,  John Gilbert

    发明人： Nghia Chiem ,  John Gilbert

    IPC分类号： C40B40/02 ,  C12Q1/48 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/37

    CPC分类号： G01N27/44791 ,  B01L3/0244 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N2035/1037

    摘要： The invention relates to a method of high throughput chemical analysis comprising the steps of combining one test compound with a solution comprising m enzyme(s) and n substrate(s), wherein m is an integer equal to one or greater, n is an integer equal to one or greater, and m+n≧3, incubating for a period of time said test compound within said solution, separating the chemical species in said combined solution by a chromatography step after said incubating step, and measuring the relative amounts of substrates and separately identifiable products produced therefrom by a chemical reaction catalyzed by said enzymes. The present SMSBEA assays are particularly well suited to enzyme-substrate systems in which both the substrate(s) and product(s) have mobilities such that they can be separated on short chromatography columns. The method of the invention is also particularly well suited to HTS applications in which an enzyme agonist or antagonist is sought. An advantage of the method is that the effects of a test compound on several enzymes may be analyzed simultaneously and without substantial purification of the enzyme solution, e.g., whole cell lysates.

    Elongate tubular member for use in medical device shafts
    88.
    发明申请
    Elongate tubular member for use in medical device shafts 审中-公开
    用于医疗器械轴的细长管状构件

    公开(公告)号：US20060100687A1

    公开(公告)日：2006-05-11

    申请号：US11269793

    申请日：2005-11-08

    申请人： Seamus Fahey ,  Eamonn McDermott ,  Liam Farrissey ,  John Gilbert ,  Colin Forde ,  Erik Trip

    发明人： Seamus Fahey ,  Eamonn McDermott ,  Liam Farrissey ,  John Gilbert ,  Colin Forde ,  Erik Trip

    IPC分类号： A61F2/06

    CPC分类号： A61M25/0051 ,  A61F2/95 ,  A61F2/966 ,  A61M25/0138 ,  A61M2025/0004 ,  A61M2025/0175

    摘要： The invention relates to a delivery catheter assembly (100) for a self-expanding stent or other device deployed in a similar manner, comprising: an inner shaft (1) located coaxially within an outer shaft (2). Each of the shafts (1, 2) comprises an elongate spiral-cut outer hypotube (12, 14). Each of the hypotubes (12, 14) has a plurality of slots (25) cut in the side wall thereof to increase the flexibility of the hypotube, and the slots are elongate slots (25) extending about the hypotube in a spiral or circumferential path which is interrupted at intervals by solid struts (20).

    摘要翻译： 本发明涉及一种用于自扩张支架或以类似方式部署的其他装置的输送导管组件（100），包括：同轴地位于外轴（2）内的内轴（1）。 每个轴（1,2）包括细长螺旋切割的外海波管（12,14）。 每个海波管（12,14）具有在其侧壁中切割的多个狭槽（25），以增加海波管的柔性，并且狭槽是沿着海波管以螺旋或圆周路径延伸的细长狭槽（25） 其间隔由实心支柱（20）中断。

    Droplet dispensing system
    90.
    发明申请
    Droplet dispensing system 审中-公开
    滴液分配系统

    公开(公告)号：US20050036920A1

    公开(公告)日：2005-02-17

    申请号：US10948014

    申请日：2004-09-23

    申请人： John Gilbert

    发明人： John Gilbert

    IPC分类号： B01L3/02 ,  C12Q1/00 ,  G01N27/447 ,  G01N35/10

    CPC分类号： C12Q1/00 ,  B01L3/0244 ,  B01L3/0248 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2400/0439 ,  G01N27/447 ,  G01N2035/1037 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： A droplet dispensing system for forming and dispensing droplets of a liquid sample is provided. The droplet dispensing system is fabricated on the tip of a dispensing pin. The tip of the dispensing pin includes a droplet ejection nozzle, a filling channel, a chamber and an actuator for ejecting droplets on demand. The system further includes a holder for mounting the dispensing pin. The holder also contains a control circuit for activating the actuator.

    摘要翻译： 提供了用于形成和分配液体样品的液滴的液滴分配系统。 液滴分配系统制造在分配销的尖端上。 分配销的末端包括液滴喷射喷嘴，填充通道，腔室和用于根据需要喷射液滴的致动器。 该系统还包括用于安装分配销的保持器。 支架还包含用于启动致动器的控制电路。