ADJUSTABLE INTRAOCULAR LENS
    83.
    发明申请
    ADJUSTABLE INTRAOCULAR LENS 审中-公开
    可调节内窥镜

    公开(公告)号:US20120268710A1

    公开(公告)日:2012-10-25

    申请号:US13537939

    申请日:2012-06-29

    摘要: Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.

    摘要翻译: 公开了用于改变诸如人工晶状体的透镜的功率的方法和装置。 在一种方法中,透镜包含含有可交联侧基的单一聚合物基质,其中当交联时聚合物基体的体积增加。 镜头不含有游离单体。 当暴露于紫外线辐射时,交联使得透镜的暴露部分体积增加,导致折射率增加。 在另一种方法中,透镜包含含有可光漂白的发色团的聚合物基质。 在紫外线照射下,光漂白导致曝光部分的折射率降低,透镜厚度没有变化。 这些方法避免了等待发生扩散以改变透镜形状的需要,并且避免了第二次暴露于辐射以锁定透镜变化的需要。

    Method for sterilization of hydrogel contact lenses
    86.
    发明授权
    Method for sterilization of hydrogel contact lenses 有权
    水凝胶隐形眼镜灭菌方法

    公开(公告)号:US07968050B2

    公开(公告)日:2011-06-28

    申请号:US12229111

    申请日:2008-08-20

    摘要: The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.

    摘要翻译: 本发明提供一种水溶液,用于消毒和储存由水凝胶材料,优选含有(含氧化烯)的水凝胶材料制成的眼科装置,优选隐形眼镜。 溶液包含一种或多种有机缓冲剂,例如Good缓冲液或双 - 氨基多元醇; 具有多个羟基的有机张力调节剂,其量足以提供约200至约450 mosm / l的渗透压,其中所述水溶液的pH为约5.5至约8.5,条件是所述水溶液包括 浓度为约15mM或更低和约5000ppm氯化钠的磷酸盐缓冲液。 本发明还提供使用本发明的水溶液对眼科装置进行消毒和储存的方法。

    2-Quinoxalinol Salen Compounds and Uses Thereof
    87.
    发明申请
    2-Quinoxalinol Salen Compounds and Uses Thereof 审中-公开
    2-喹喔啉醇Salen化合物及其用途

    公开(公告)号:US20090286968A1

    公开(公告)日:2009-11-19

    申请号:US12429933

    申请日:2009-04-24

    CPC分类号: C07D241/44 C07D241/52

    摘要: Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of cations.

    摘要翻译: 公开了2-喹喔啉醇salen化合物,特别是2-喹喔啉醇salen席夫碱配体。 所公开的2-喹喔啉醇盐化合物可用作与阳离子形成络合物的配体,此外,所形成的络合物可用作氧化反应的催化剂。 所公开的2-喹喔啉醇salen化合物也可以与固体支持物缀合并用于选择性固相萃取或阳离子检测的方法中。