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424 条记录 (耗时 0.051 秒)

    Deuterated substituted dihydrofuranones and medicaments containing these compounds
    82.
    发明申请
    Deuterated substituted dihydrofuranones and medicaments containing these compounds 失效
    氘代取代的二氢呋喃酮和含这些化合物的药物

    公开(公告)号：US20050176814A1

    公开(公告)日：2005-08-11

    申请号：US10498709

    申请日：2002-12-11

    申请人： Rudolf-Giesbert Alken

    发明人： Rudolf-Giesbert Alken

    IPC分类号： C07D307/58 ,  A61K31/365 ,  A61P15/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D307/32

    CPC分类号： A61K31/365 ,  C07D307/32

    摘要： The invention concerns deuterated substituted dihydrofuranones and pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated substituted dihydrofuranones for the treatment of symptoms for the irritating states of degenerative joint disorders, of acute pain and primary dysmenorrhea. In addition, the invention discloses pharmaceutical compositions, which contain deuterated substituted dihydrofuranones as well as their physiologically compatible salts, in addition to pharmaceutically compatible adjuvants and/or additives, for the treatment of symptoms for the irritating states of degenerative joint disorders, of acute pain and primary dysmenorrhea.

    摘要翻译： 本发明涉及氘代取代的二氢呋喃酮和含有这些化合物的药物。 此外，本发明涉及氘代取代的二氢呋喃酮用于治疗退行性关节疾病，急性疼痛和原发性痛经的刺激状态的症状的用途。 此外，本发明还公开了药物组合物，除药学上相容的佐剂和/或添加剂之外，还含有氘代取代的二氢呋喃酮及其生理相容的盐，用于治疗急性疼痛的退行性关节疾病的刺激状态的症状 和原发性痛经。

    Novel lactone compound
    84.
    发明申请
    Novel lactone compound 失效
    新型内酯化合物

    公开(公告)号：US20050032887A1

    公开(公告)日：2005-02-10

    申请号：US10866600

    申请日：2004-06-10

    申请人： Junji Nakamura ,  Shigetaka Numasawa ,  Hiroyuki Kenmochi ,  Yoji Hori

    发明人： Junji Nakamura ,  Shigetaka Numasawa ,  Hiroyuki Kenmochi ,  Yoji Hori

    IPC分类号： C07D307/32 ,  A61K31/365 ,  C07D307/77 ,  C07D307/78 ,  C07D307/88 ,  C07D307/93

    CPC分类号： C07D307/77 ,  C07D307/88 ,  C07D307/93

    摘要： A novel monomer compound having a lactone moiety of the present invention can be converted into polymers usable as resist materials with excellent properties, etc., and an alcohol compound having a lactone moiety of the invention is useful as a material for the monomer compound. The compounds are represented by the following general formula [1]: wherein one of R1 and R2 represents a hydrogen atom, an acryloyl group, or a methacryloyl group, and the other represents an alkyl group; R3 and R4 independently represent a hydrogen atom or an alkyl group; R5 and R6 both represent a hydrogen atom or are combined to form a methylene chain that may have an alkyl group; and R7 and R8 independently represent a hydrogen atom or a methyl group.

    摘要翻译： 具有本发明的内酯部分的新型单体化合物可以转化为可用作具有优异性能等的抗蚀剂材料的聚合物，并且具有本发明的内酯部分的醇化合物可用作单体化合物的材料。 化合物由以下通式[1]表示：其中R 1和R 2之一表示氢原子，丙烯酰基或甲基丙烯酰基，另一个表示烷基; R 3和R 4独立地表示氢原子或烷基; R 5和R 6均表示氢原子或者被结合形成可具有烷基的亚甲基链; R 7和R 8独立地表示氢原子或甲基。

    Optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid
    85.
    发明授权
    Optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid 失效
    （+/-） - 3,4-二羟基丁酸的光学拆分方法

    公开(公告)号：US6069270A

    公开(公告)日：2000-05-30

    申请号：US972145

    申请日：1997-11-17

    申请人： Hiroyuki Nohira ,  Hiroaki Shitara ,  Satsuki Inagaki

    发明人： Hiroyuki Nohira ,  Hiroaki Shitara ,  Satsuki Inagaki

    IPC分类号： C07C51/487 ,  C07B57/00 ,  C07D307/32

    CPC分类号： C07C51/487

    摘要： An optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid, by reacting (.+-.)-3,4-dihydroxybutanoic acid with an optically active primary amine or secondary amine. Also a method for producing optically active 3-hydroxy-.gamma.-butyrolactone, by reacting (.+-.)-3,4-dihydroxybutanoic acid with an optically active primary amine or secondary amine for optical resolution, and ring closing the resulting optically active 3,4-dihydroxybutanoic acid.

    摘要翻译： （+/-） - 3,4-二羟基丁酸的光学拆分方法，通过使（+/-） - 3,4-二羟基丁酸与光学活性伯胺或仲胺反应。 还可以通过使（+/-） - 3,4-二羟基丁酸与光学活性伯胺或仲胺反应以进行光学拆分来制备光学活性的3-羟基-γ-丁内酯的方法，并将所得的光学活性3 ，4-二羟基丁酸。