Device and method for detecting biochemical reactions and/or bindings
    5.
    发明申请
    Device and method for detecting biochemical reactions and/or bindings 审中-公开
    用于检测生化反应和/或结合的装置和方法

    公开(公告)号:US20050112652A1

    公开(公告)日:2005-05-26

    申请号:US10968847

    申请日:2004-10-19

    IPC分类号: B01L3/00 C12Q1/68

    摘要: Device having a two-dimensionally formed support material which has, spread across at least one surface area, a plurality of pores which stretch throughout from one surface of the support material to the opposite surface, wherein the pores are bound in each case by a pore boundary area of pore walls formed in the support material along particular longitudinal axes of the pores, and at least part of the pore walls have at least in some sections a layered structure containing a first layer forming the pore boundary area and a second layer adjacent to the first layer and spaced apart from the pore boundary area, and wherein the refractive index nwaveguide of the first layer is greater than the refractive index n2 of the second layer.

    摘要翻译: 具有二维形成的支撑材料的装置,其具有穿过至少一个表面区域延伸的多个孔,其从支撑材料的一个表面延伸到相对的表面,其中孔在每种情况下都被孔隙结合 沿着孔的特定纵向轴线形成在支撑材料中的孔壁的边界区域,并且孔壁的至少一部分至少在一些部分中具有包含形成孔边界区域的第一层的层状结构和与孔边界相邻的第二层 第一层并且与孔边界区间隔开,并且其中第一层的折射率nλ波导大于第二层的折射率n 2 2 N。

    Partially Oxidized Macroporous Silicon with Discontinuous Silicon Walls
    7.
    发明申请
    Partially Oxidized Macroporous Silicon with Discontinuous Silicon Walls 审中-公开
    具有不连续硅壁的部分氧化大孔硅

    公开(公告)号:US20080041714A1

    公开(公告)日:2008-02-21

    申请号:US11568113

    申请日:2005-03-07

    CPC分类号: G01N33/54373 G02B1/02

    摘要: A device and method for producing a “biochip base module” for detecting biochemical reactions for the study of enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and other binding reactions in the field of genome, proteome, or active-agent research. A flat macroporous support material having a multiplicity of 500 nm to 100 μm diameter pores distributed over at least one surface region and extending from one surface through to the opposite surface of the support material. The device has two or more regions having pores with SiO2 pore walls. These regions are each surrounded by a frame or box of walls with a silicon core arranged parallel to the longitudinal axes of the pores and is open towards the surfaces. The silicon core merges into silicon dioxide over the cross section towards the outer side of the walls forming the frame, and each individual frame is spatially isolated from the frames surrounding it.

    摘要翻译: 用于检测生物化学反应以用于研究酶学反应,核酸杂交,蛋白质 - 蛋白质相互作用以及基因组,蛋白质组学或活性剂研究领域的其他结合反应的“生物芯片基本模块”的装置和方法。 一种扁平的大孔支撑材料,其具有分布在至少一个表面区域上并从支撑材料的一个表面到另一表面延伸的多个直径为500nm至100μm的多孔的孔。 该装置具有两个或多个具有具有SiO 2孔壁的孔的区域。 这些区域各自被框架或箱体围绕,其中硅芯布置成平行于孔的纵向轴线并朝向表面敞开。 硅芯在横截面上并入二氧化硅中,朝向形成框架的壁的外侧,并且每个单独的框架与围绕它的框架在空间上隔离。

    Macroporous support for chemical amplification reactions
    8.
    发明申请
    Macroporous support for chemical amplification reactions 审中-公开
    大孔支持化学扩增反应

    公开(公告)号:US20060263799A1

    公开(公告)日:2006-11-23

    申请号:US11357731

    申请日:2006-02-17

    IPC分类号: C12Q1/68 C12P19/34 C12M1/34

    摘要: A method for carrying out an amplification of nucleic acids in pores of a two-dimensionally designed macroporous support material according to one embodiment includes the step of providing a predetermined part of a reaction mixture necessary for the amplification of a nucleic acid in pores of the support material. A device for carrying out the amplification of nucleic acids according to one embodiment includes a two-dimensionally designed macroporous support material having a multiplicity of pores, wherein a predetermined part of a reaction mixture for carrying out an amplification of nucleic acids is provided in the pores.

    摘要翻译: 根据一个实施方案的用于在二维设计的大孔载体材料的孔中进行核酸扩增的方法包括以下步骤:提供必​​要的预定部分的反应混合物,所述反应混合物在载体的孔中扩增核酸 材料。 根据一个实施方案的用于进行核酸扩增的装置包括具有多个孔的二维设计的大孔载体材料,其中在孔中提供用于进行核酸扩增的反应混合物的预定部分 。