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公开(公告)号：US06423271B1
公开(公告)日：2002-07-23
申请号：US09527069
申请日：2000-03-16
IPC分类号： G01N1500
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/5085 , B01L7/52 , B01L2200/0647 , B01L2200/0684 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0421 , B01L2400/0424 , B01L2400/0475 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： A multilayer, laminated device for performing fluidic operations includes a first exterior support layer, an adjacent layer disposed in laminated relationship with a portion of the exterior support layer, a second exterior support layer disposed in laminated relationship with a portion of the adjacent layer, and a fluidic pump that is disposed in the adjacent layer. The fluidic pump includes a first gear rotationally mounted to the adjacent layer, the first gear having a magnet contained therein. A second gear is rotationally mounted to the adjacent layer, the second gear having a magnet contained therein, the second gear being engaged with the first gear in a meshed relationship.
摘要翻译： 用于进行流体操作的多层层压装置包括第一外部支撑层，与外部支撑层的一部分层压关系设置的相邻层，与相邻层的一部分层叠的第二外部支撑层，以及 设置在相邻层中的流体泵。 流体泵包括旋转地安装到相邻层的第一齿轮，第一齿轮具有容纳在其中的磁体。 第二齿轮被旋转地安装到相邻层，第二齿轮具有容纳在其中的磁体，第二齿轮以啮合关系与第一齿轮接合。
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公开(公告)号：US06287517B1
公开(公告)日：2001-09-11
申请号：US08753962
申请日：1996-12-04
IPC分类号： G01N1500
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/5085 , B01L7/52 , B01L2200/0647 , B01L2200/0684 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0421 , B01L2400/0424 , B01L2400/0475 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： Methods of manufacture and devices for performing active biological operations utilize laminated structures. In the preferred embodiment, a first planar sample support includes at least one sample through hole, a planar electrode is disposed adjacent the first planar sample support, and includes an electrode through region, a second planar support includes a vent through hole, the planar electrode being in a laminated relationship between the first planar sample support and the second planar support, further characterized in that the sample through hole, electrode through hole and vent through hole are in overlapping arrangement. Preferably, some or all of the through holes, through regions and vent through holes are aligned. In one embodiment, the lateral dimension of the vent through hole is larger than the lateral dimension of the electrode through hole. In an alternative embodiment, the lateral dimension of the sample through hole is larger than the lateral dimension of the vent through hole.
摘要翻译： 制造方法和进行活性生物操作的装置利用层叠结构。 在优选实施例中，第一平面样品支架包括至少一个样品通孔，平面电极邻近第一平面样品支架设置，并且包括电极通过区域，第二平面支撑件包括通气孔，平面电极 在所述第一平面样品支撑件和所述第二平面支撑件之间处于层叠关系，其特征还在于，所述样品通孔，电极通孔和通气孔通过重叠布置。 优选地，一些或全部通孔，通过区域和排气通孔对准。 在一个实施例中，排气通孔的横向尺寸大于电极通孔的横向尺寸。 在替代实施例中，样品通孔的横向尺寸大于通气孔的横向尺寸。
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公开(公告)号：US20140072002A1
公开(公告)日：2014-03-13
申请号：US14024607
申请日：2013-09-11
IPC分类号： H01S5/00
CPC分类号： H01S5/0085 , B82Y20/00 , H01S5/0014 , H01S5/0078 , H01S5/0428 , H01S5/06226 , H01S5/1085 , H01S5/22 , H01S5/34313 , H01S5/4006 , H01S5/50
摘要： Disclosed are systems and methods for using a semiconductor optical amplifier (SOA) as an optical modulator for pulsed signals. In accordance with the principles of the invention, the SOA can be biased with a negative voltage to suppress transmission and improve modulator extinction and biased with a positive pulsed signal with sufficient amplitude to forward bias the amplifier (SOA), both transmitting the carrier and increasing its amplitude by means of a gain provided by the SOA under forward biased conditions. In addition, the forward bias voltage may be selected to compensate for losses within the SOA.
摘要翻译： 公开了使用半导体光放大器（SOA）作为脉冲信号的光调制器的系统和方法。 根据本发明的原理，SOA可以用负电压偏置以抑制传输并改善调制器消光并且利用具有足够幅度的正脉冲信号来偏置放大器（SOA）的正向偏置，从而传输载波并增加 其幅度通过SOA在正向偏置条件下提供的增益。 此外，可以选择正向偏置电压来补偿SOA内的损耗。
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4.发明授权公开(公告)号：US06743211B1
公开(公告)日：2004-06-01
申请号：US09448107
申请日：1999-11-23
申请人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
发明人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
IPC分类号： A61M500
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150984 , A61B5/151 , A61B17/205 , A61M5/422 , A61M5/425 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要翻译： 提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。 装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔 或（4）这些方法的任何组合。 在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。 在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。
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5.发明授权Electronic device for performing active biological operations and method of using same 失效用于进行活性生物操作的电子装置及其使用方法公开(公告)号：US06726880B1
公开(公告)日：2004-04-27
申请号：US09596657
申请日：2000-06-19
申请人： Donald E. Ackley , Paul D. Swanson , Scott O. Graham , Elizabeth L. Mather , Timothy L. LeClair , William F. Butler
发明人： Donald E. Ackley , Paul D. Swanson , Scott O. Graham , Elizabeth L. Mather , Timothy L. LeClair , William F. Butler
IPC分类号： G01N1500
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/50273 , B01L3/502761 , B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2200/0689 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： An electronic device for performing biological operations includes a support substrate and an array of microlocations disposed on the substrate. The array of microlocations include electronically addressable electrodes. A first collection electrode is disposed on the substrate and adjacent to a first side of the array of microlocations. A second collection electrode is disposed on the substrate and adjacent to a second side of the array of microlocations, the second side of the array being opposite of the first side such that the array of microlocations is disposed between the first and second collection electrodes. A flow cell is supported on the substrate. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell.
摘要翻译： 用于进行生物学操作的电子设备包括支撑衬底和布置在衬底上的微位置阵列。 微位置阵列包括电子寻址电极。 第一收集电极设置在基板上并与微位置阵列的第一侧相邻。 第二收集电极设置在衬底上并且与微位置阵列的第二侧相邻，阵列的第二侧与第一侧相对，使得微位置阵列设置在第一和第二采集电极之间。 流动池被支撑在基底上。 优选地，收集电极的组合面积是流动池的占地面积的实质部分，优选地至少50％。
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6.发明授权Stacked, reconfigurable system for electrophoretic transport of charged materials 失效用于电荷运输带电材料的堆叠式可重构系统公开(公告)号：US06309602B1
公开(公告)日：2001-10-30
申请号：US09203725
申请日：1998-12-02
IPC分类号： G01N1500
CPC分类号： C12Q1/6816 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/5085 , B01L7/52 , B01L2200/0647 , B01L2200/0684 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0421 , B01L2400/0424 , B01L2400/0475 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： Methods, apparatus, and applications for use of a stacked, reconfigurable system for electrophoretic transport are provided. In one embodiment, a system having a first chamber including at least a bottom support and an intermediate support, and a second chamber, said second chamber including a bottom support and a top member, the first and second chambers being coupled through a via. Electrophoretic, and optional electro-osmotic and thermal, transport is effected. In another aspect of this invention, three or more chambers are coupled by an electrophoretic buss. The electrophoretic buss includes driving electrodes and is adapted to receive fluid containing materials for transport. The chambers are coupled to the electrophoretic buss and serve as a tap from the buss for delivery of charged materials. In one embodiment, certain functions are performed in different chambers. For example, the first chamber may receive the sample and perform sample processing functions, the second chamber may perform amplification procedures, yet a third chamber may perform hybridization or other assays, and yet another chamber may perform immunoassays. By separating various functions to different chambers, speed and sensitivity may be improved. In yet another aspect of this invention, analysis from a earlier stage may be utilized in a subsequent stage to reconfigure the system for optimum use. In one application, analysis at a first level is utilized to determine an action at a second level, such as the synthesis of a compound. The synthesized compound in response to a biohazard may comprise vaccine or antidote.
摘要翻译： 提供了用于电泳运输的堆叠的可重新配置的系统的方法，装置和应用。 在一个实施例中，具有至少包括底部支撑件和中间支撑件的第一室的系统和第二室，所述第二室包括底部支撑件和顶部构件，所述第一室和第二室通过通孔联接。 进行电泳和可选的电渗透和热传输。 在本发明的另一方面，三个或更多个室通过电泳总线耦合。 电泳总线包括驱动电极并且适于接收含有运输材料的流体。 这些室被耦合到电泳总线上，并且用作用于传送带电材料的总线的水龙头。 在一个实施例中，在不同的室中执行某些功能。 例如，第一腔室可以接收样品并执行样品处理功能，第二腔室可以进行扩增过程，而第三腔室可以进行杂交或其他测定，而另一个室可以进行免疫测定。 通过将各种功能分离到不同的室，可以提高速度和灵敏度。 在本发明的另一方面，可以在后续阶段利用来自较早阶段的分析来重新配置系统以获得最佳使用。 在一个应用中，利用第一级的分析来确定第二级的作用，例如化合物的合成。 响应于生物危害的合成化合物可以包含疫苗或解毒剂。
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公开(公告)号：US6068818A
公开(公告)日：2000-05-30
申请号：US239569
申请日：1999-01-29
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/00 , G01N27/447 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , G01N1/14
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01L3/502707 , B01L3/502761 , B01L3/5085 , B82Y10/00 , B82Y5/00 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C19/00 , H01L25/50 , H01L29/6656 , H01L29/6659 , H01L29/66628 , H01L29/7834 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0858 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L3/502715 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G11C13/04 , H01L2924/0002
摘要： Methods of manufacture and devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In one embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. Preferably, the volume of the flow cell is more advantageously interrogated through use of relatively large collection and return electrodes, such as where the area of those electrodes relative to the footprint of the flowcell is at least 40%. In yet another embodiment, a first collection electrode is disposed adjacent an array, with a second collection electrode disposed on the at least an opposite portion of the array. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell. In yet another embodiment, a concentric ring design is provided. Various flip-chip embodiments are disclosed. A preferred embodiment utilizes a relatively small number of components, for example, five components, for a flip-chip device. A first substrate includes a via, through which solution flows to the underlying analytical chip, which a sealant between the chip and the first substrate. An overlying flow cell contains the solution. Novel manufacturing techniques are provided for utilizing the via as a shadow mask to constrain the flow of the sealant. A multiple site array system includes a row select and column select, which are preferably memory, and most preferably shift register memory. An improved current output circuit is of the current mirror type and serves to output selected current based upon input from the column select and row select.
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8.发明授权
公开(公告)号：US5612228A
公开(公告)日：1997-03-18
申请号：US634599
申请日：1996-04-24
申请人： Chan-Long Shieh , Donald E. Ackley
发明人： Chan-Long Shieh , Donald E. Ackley
CPC分类号： H01L51/0545 , H01L27/1214 , H01L27/1251 , H01L27/286 , H01L51/0035 , H01L51/0036 , H01L51/0038 , H01L51/0078
摘要： A method of fabricating a thin film transistor device including forming first and second spaced apart control electrodes on a surface of a supporting substrate and forming a dielectric layer over the control electrodes. Inorganic and organic thin film transistors are formed on the dielectric layer, one on each control electrode. The inorganic and organic thin film transistors are n-type and p-type conductivity, respectively, and may be integrated into a complementary circuit. Also, the thin film transistor device is fabricated at relatively low temperatures so that plastic supporting substrates can be utilized.
摘要翻译： 一种制造薄膜晶体管器件的方法，包括在支撑衬底的表面上形成第一和第二间隔开的控制电极，并在控制电极上形成电介质层。 无机和有机薄膜晶体管形成在每个控制电极上的电介质层上。 无机和有机薄膜晶体管分别是n型和p型导电性，并且可以集成到互补电路中。 此外，薄膜晶体管器件在相对低的温度下制造，从而可以利用塑料支撑衬底。
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公开(公告)号：US5293392A
公开(公告)日：1994-03-08
申请号：US922719
申请日：1992-07-31
申请人： Chan-Long Shieh , Donald E. Ackley
发明人： Chan-Long Shieh , Donald E. Ackley
CPC分类号： H01S5/18344 , H01S5/18308 , H01S5/2059 , H01S5/209
摘要： A top emitting vertical cavity surface emitting laser with an etch stop layer positioned in the top mirror stack so the stack can be etched to form a trench surrounding a mesa with the emitting area on the mesa and the trench confining current flow and lasing to the mesa.
摘要翻译： 顶部发射垂直腔表面发射激光器，其具有定位在顶部反射镜堆叠中的蚀刻停止层，使得可以蚀刻该堆叠以形成围绕台面的台面的沟槽，并且沟槽限制电流和激光到台面 。
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公开(公告)号：US5258316A
公开(公告)日：1993-11-02
申请号：US858288
申请日：1992-03-26
申请人： Donald E. Ackley , Chan-Long Shieh
发明人： Donald E. Ackley , Chan-Long Shieh
CPC分类号： H01S5/18327 , H01S2301/166 , H01S5/18305 , H01S5/18311 , H01S5/2063
摘要： VCSELs including a central active layer with upper and lower mirror stacks wherein a circular trench is formed in one mirror stack to define a lasing area. The trench reduces reflectivity to prevent lasing outside the operating area and an oxygen implant in the trench confines current distribution to maximize power output and efficiency. The trench allows self-alignment throughout most of the manufacturing process.
摘要翻译： VCSEL包括具有上反射镜和下反射镜叠层的中心活性层，其中在一个反射镜叠层中形成圆形沟槽以限定激光区域。 沟槽减少反射率以防止激光在工作区域外，并且沟槽中的氧注入限制电流分布以最大化功率输出和效率。 沟槽允许在大部分制造过程中自对准。
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