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    Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same
    7.
    发明申请
    Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same 失效
    新颖的促性腺激素释放激素，其前体肽和编码其的基因

    公开(公告)号：US20050143567A1

    公开(公告)日：2005-06-30

    申请号：US10312637

    申请日：2001-06-29

    申请人： Hiroyuki Minakata ,  Eiko Iwakoshi ,  Kyoko Kuroda

    发明人： Hiroyuki Minakata ,  Eiko Iwakoshi ,  Kyoko Kuroda

    IPC分类号： A61K38/00 ,  C07K7/23 ,  C07K14/59

    CPC分类号： C07K7/23 ,  A01K2217/05 ,  A61K38/00 ,  Y10S530/857

    摘要： A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and the activities of GnRH and the information processing mechanisms of the nervous systems in higher animals. It can also serve as a base compound in the development of pesticides and drugs. The peptide has the GnRH activity and has the following amino acid sequence (I):

    摘要翻译： 在章鱼中发现作为促性腺激素释放激素（GnRH）的新型肽，是软体动物的成员。 肽的结构和活性已经消失了。 该肽可用作研究GnRH的结构和活性与高等动物神经系统的信息处理机制之间的相关性的试剂。 它也可以作为农药和药物开发的基础化合物。 该肽具有GnRH活性并具有以下氨基酸序列（I）：<？in-line-formula description =“In-line Formulas”end =“lead”？> Glu-Zaa-Zaa-His-Zaa- Ser-Zaa-Zaa-Zaa-Zaa-Pro-Gly-NH 2（I）<？in-line-formula description =“In-line Formulas”end =“tail”？> Glu表示焦谷氨酸，Zaa表示任何氨基酸。 具体而言，该肽具有以下氨基酸序列（I）：<？in-line-formula description =“In-line formula”end =“lead”→> Glu-Asn-Tyr-His-Phe-Ser-Asn -Gly-Trp-His-Pro-Gly-NH 2（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中

    Novel Tachykinin Peptides, Precursor Peptides Thereof And Genes Encoding The Same
    8.
    发明申请
    Novel Tachykinin Peptides, Precursor Peptides Thereof And Genes Encoding The Same 审中-公开
    新型速激肽，前体肽及其编码基因

    公开(公告)号：US20090023184A1

    公开(公告)日：2009-01-22

    申请号：US12099272

    申请日：2008-04-08

    申请人： Hiroyuki MINAKATA ,  Eiko Iwakoshi ,  Kyoko Kuroda

    发明人： Hiroyuki MINAKATA ,  Eiko Iwakoshi ,  Kyoko Kuroda

    IPC分类号： C12P21/00 ,  C12N15/12 ,  C12N15/63 ,  C12N1/21

    CPC分类号： C07K7/22 ,  A61K38/00

    摘要： Tachykinin peptide isolated and purified from the posterior salivary gland Octopus vulgaris which is mollusc. The tachykinin peptide provides a new approach for developing medicaments and pesticides through studies on the structural activity correlation at the molecular level, is characterized by:(1) number of an amino acid resides is 12;(2) N terminal of the peptide is Lys;(3) an amino acid sequence of 5 amino acids from C terminal is represented by the following amino acid sequence (I), —Phe-Xaa-Gly-Leu-Met-NH2  (I), (wherein, Xaa is Val, Ile, Phe or Tyr), especially following amino acid sequence (1) and (2) are provided: H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Val-Gly-Leu-Met-NH2  (1) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met-NH2  (2)

    摘要翻译： 从后唾液腺中分离和纯化速效肽，其为软体动物。 速激肽肽通过研究分子水平的结构活性相关性，提供了开发药物和农药的新方法，其特征在于：（1）氨基酸数目为12; （2）肽的N末端为Lys; （3）来自C末端的5个氨基酸的氨基酸序列由以下氨基酸序列（I）表示，<？in-line-formula description =“In-line Formulas”end =“lead”→Phe -Xaa-Gly-Leu-Met-NH 2（I），<β在线公式描述=“内联式”末端=“尾”→（其中，Xaa是Val，Ile，Phe或Tyr） 特别是在提供了氨基酸序列（1）和（2）之后：<？in-line-formula description =“In-line formula”end =“lead”？> H-Lys-Pro-Pro-Ser-Ser-Ser -Glu-Phe-Val-Gly-Leu-Met-NH2（1）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In 线型公式“end =”lead“→H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met-NH2（2） “直线公式”end =“tail”？>

    Protein having hemolytic activity and gene encoding the protein
    10.
    发明授权
    Protein having hemolytic activity and gene encoding the protein 失效
    具有溶血活性的蛋白质和编码蛋白质的基因

    公开(公告)号：US06855803B2

    公开(公告)日：2005-02-15

    申请号：US09979275

    申请日：2001-03-21

    申请人： Hiroshi Nagai ,  Terumi Nakajima ,  Kyoko Kuroda

    发明人： Hiroshi Nagai ,  Terumi Nakajima ,  Kyoko Kuroda

    IPC分类号： C12N15/09 ,  A01N63/00 ,  A61K35/56 ,  A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  C07K14/435 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C07K14/00 ,  C07K1/00

    CPC分类号： C07K14/43595 ,  A61K38/00

    摘要： Novel proteins having hemolytic activity giving the new approach of development of the drugs, and having the following property are provided: (1) having hemolytic activity; (2) having a molecular weight of about 50,000 Da (determined by SDS gel electrophoresis); and (3) having an amino acid sequence represented by any of SEQ ID NO 1 and SEQ ID NO 2 as a partial amino acid sequence represented by the following amino acid sequences (1) and (2); Amino acid sequence (1): Tyr-Arg-Asp-Gln-Glu-Leu-Glu-Asp-Asn-Val-Lys Amino acid sequence (2): Lys-Trp-Pro-Asp-Tyr-Phe-Val-Tyr-Met-Glu-Ser-Ser-Ala-His-Gly-Tyr-Ile-Arg (wherein, an amino acid residue is written by the 3 letters notation defined by IUPAC and IUB) obtained from nematocyst of Carybdea alata.

    摘要翻译： 提供具有溶血活性的新型蛋白质，提供新的药物开发方法，具有以下性质：（1）具有溶血活性;（2）分子量约50,000Da（通过SDS凝胶电泳测定）; 和（3）具有由SEQ ID NO 1和SEQ ID NO 2中任一个表示的氨基酸序列作为由以下氨基酸序列（1）和（2）表示的部分氨基酸序列;氨基酸序列（1）： Tyr-Arg-Asp-Gln-Glu-Leu-Glu-Asp-Asn-Val-Lys氨基酸序列（2）：Lys-Trp-Pro-Asp-Tyr-Phe-Val-Tyr-Met-Glu-Ser-Ser -Ala-His-Gly-Tyr-Ile-Arg（其中，氨基酸残基由IUPAC和IUB定义的3个字母符号写成）从Carybdea alata的线虫获得。