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11 条记录 (耗时 0.026 秒)

    Conjugates of agents and transglutaminase substrate linking molecules
    1.
    发明授权
    Conjugates of agents and transglutaminase substrate linking molecules 失效
    试剂和转谷氨酰胺酶底物连接分子的结合物

    公开(公告)号：US06919076B1

    公开(公告)日：2005-07-19

    申请号：US09359920

    申请日：1999-07-22

    申请人： Howard Green ,  Bruce Compton ,  George Corey ,  Philippe Djian

    发明人： Howard Green ,  Bruce Compton ,  George Corey ,  Philippe Djian

    IPC分类号： A61K8/02 ,  A61K8/37 ,  A61K8/49 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K38/00 ,  A61K38/45 ,  A61K38/48 ,  A61K47/48 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  C07K17/02 ,  C12N11/02

    CPC分类号： A61K8/49 ,  A61K8/0208 ,  A61K8/37 ,  A61K8/602 ,  A61K8/64 ,  A61K8/66 ,  A61K38/45 ,  A61K38/465 ,  A61K47/557 ,  A61K47/65 ,  A61K47/665 ,  A61K2800/57 ,  A61K2800/70 ,  A61K2800/88 ,  A61K2800/94 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  C07K14/685 ,  C07K14/78 ,  C07K17/02 ,  C12N9/16 ,  C12N9/18 ,  C12Y203/02013 ,  C12Y301/01007 ,  Y10S530/812

    摘要： Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the agent is not a transglutaminase substrate and the linking molecule is a substrate for transglutaminase containing at least two contiguous linked glutamines or at least three contiguous linked lysines, and may be a polymer. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule. A complementary linking molecule rich in lysines may be first attached to the tissue in the presence of transglutaminase, and then covalently bonded to a glutamine-containing linking molecule of the conjugate in the presence of transglutaminase. In another embodiment a linking molecule containing multiple glutamines is covalently bonded to tissue in the presence of transglutaminase, and an agent containing multiple lysines is covalently bonded to the linking molecule in the presence of transglutaminase. Alternatively, the linking molecule contains multiple lysines and the agent contains multiple glutamines. Two tissues can be sealed together by holding the tissues in contact with each other in the presence of transglutalinase.

    摘要翻译： 提供方法，产品，组合物和试剂盒用于在转谷氨酰胺酶存在下用连接分子将试剂连接到组织。 连接分子和/或试剂是转谷氨酰胺酶的底物。 该试剂可以是非蛋白质或酶如胆碱酯酶或磷酸二酯酶。 转谷氨酰胺酶可外源性加入或在组织中是内源性的。 在具体实施方案中，所述试剂不是转谷氨酰胺酶底物，并且所述连接分子是含有至少两个相邻连接的谷氨酰胺或至少三个连续相连的赖氨酸的转谷氨酰胺酶的底物，并且可以是聚合物。 试剂和连接分子的缀合物可以施用于组织，并且在通过连接分子共价键合到组织的转谷氨酰胺酶的存在下。 富含赖氨酸的互补连接分子可以在转谷氨酰胺酶存在下首先连接到组织上，然后在转谷氨酰胺酶存在下共价键合到缀合物的含谷氨酰胺的连接分子。 在另一个实施方案中，含有多个谷氨酰胺的连接分子在转谷氨酰胺酶的存在下共价结合到组织上，并且含有多个赖氨酸的试剂在转谷氨酰胺酶存在下共价键合到连接分子上。 或者，连接分子含有多个赖氨酸，并且该试剂含有多个谷氨酰胺。 在转谷氨酰胺酶的存在下，通过保持组织彼此接触将两个组织密封在一起。

    Rack and pinion wave motor power plant
    8.
    发明授权
    Rack and pinion wave motor power plant 失效
    机架齿轮波马达发电厂

    公开(公告)号：US4108578A

    公开(公告)日：1978-08-22

    申请号：US717107

    申请日：1976-08-24

    申请人： George Corey

    发明人： George Corey

    IPC分类号： F03B13/18 ,  F04B17/00 ,  F04B35/00 ,  F16H19/04

    CPC分类号： F03B13/186 ,  Y02E10/38 ,  Y10T74/18096 ,  Y10T74/1967

    摘要： This disclosure pertains to a plurality of individual floats, each connected to an individual shaft. A pier is provided which supports the shafts in a substantially vertical direction. The shafts are free to move vertically as the floats rise and descend in accordance with the waves and tides at the ocean front. Each shaft is connected to a rotary hydraulic pump which is caused to rotate as the float ascends and descends. The pump in turn charges a tank with oil at high pressure, which in turn is fed to an engine. The engine drives an electric generator.

    摘要翻译： 本公开涉及多个单独的浮子，每个浮子连接到单个轴。 提供了一个在大致垂直方向上支撑轴的码头。 随着浮标上升和下降，随着海浪的波浪和潮汐，这些轴可以自由地垂直移动。 每个轴连接到旋转液压泵，随着浮子上升和下降，其旋转。 泵又在高压油中对油箱充油，油箱又被送入发动机。 发动机驱动发电机。

    Apparatus for Guiding Sample and Reagent Manipulations and Receptacles for Holding Same
    9.
    发明申请
    Apparatus for Guiding Sample and Reagent Manipulations and Receptacles for Holding Same 审中-公开
    用于指导样品和试剂操作的装置以及用于保持的试剂和容器

    公开(公告)号：US20080031774A1

    公开(公告)日：2008-02-07

    申请号：US11734716

    申请日：2007-04-12

    申请人： Gary Magnant ,  Michael Finney ,  Todd Barbera ,  George Corey ,  T. Boles

    发明人： Gary Magnant ,  Michael Finney ,  Todd Barbera ,  George Corey ,  T. Boles

    IPC分类号： G01N33/00

    CPC分类号： G01N35/00722 ,  B01L3/5085 ,  B01L3/50855 ,  B01L2200/142 ,  B01L2300/02 ,  B01L2300/023 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0829 ,  G01N35/0092 ,  G01N2035/00891

    摘要： A system has utility is guiding and tracking the execution of manual procedures. The system includes a support that holds multiple sample receptacles, computational circuitry to execute a protocol script that delivers instructions for executing various steps of the procedure, and a protocol progress sensor that advances the execution of the protocol script. The computer may be comparable in size to a support for holding the receptacles The receptacles be arranged in a frame, may be sealed with peelable or puncturable films and may include identifiers that are read by the system. The receptacles may be filled with a high heat capacity material to maintain a given temperature range. A variety of companion devices may interact with the system using the protocol script. An instrumented pipettor can communicate with the system for semi-automated execution of protocols.

    摘要翻译： 系统的实用程序是指导和跟踪手动过程的执行。 该系统包括一个支持多个样本插座的支持，执行一个协议脚本的计算电路，该协议脚本提供用于执行该过程的各个步骤的指令，以及协议进程传感器，其执行协议脚本的执行。 计算机的尺寸可以与用于保持插座的支撑件相当。插座布置在框架中，可以用可剥离的或可穿刺的膜密封，并且可以包括由系统读取的标识符。 容器可以填充高热容材料以保持给定的温度范围。 各种伴侣设备可以使用协议脚本与系统进行交互。 仪器化移液器可与系统进行通信，以实现协议的半自动执行。

    METHOD AND SYSTEM FOR BLOCK TRADING OF SECURITIES
    10.
    发明申请
    METHOD AND SYSTEM FOR BLOCK TRADING OF SECURITIES 有权
    证券交易的方法和系统

    公开(公告)号：US20050246261A1

    公开(公告)日：2005-11-03

    申请号：US10711889

    申请日：2004-10-12

    申请人： Ross Stevens ,  George Corey ,  Vlad Portnoy

    发明人： Ross Stevens ,  George Corey ,  Vlad Portnoy

    IPC分类号： G06Q40/00 ,  G06F17/60

    CPC分类号： G06Q40/04 ,  G06Q40/00

    摘要： Method and system for block trading of securities. Embodiments of the present invention can provide an automated dealer system that formulates customized, risk-controlled, two-sided indicative quotations for block quantities of a security. A quotation can be delivered to requesting counterparties via a secured network or Web-based platform. The system can also allow counterparties to submit orders for block trades based on the customized quotations. A customized quote can be based on the size of the block and historical characteristics of the security. The quoting service can be customized to take into account a minimum premium to be charged for a trade, profitability considerations discounts, and time considerations.

    摘要翻译： 证券交易方法和制度。 本发明的实施例可以提供一种自动化经销商系统，其为安全的块数量制定定制的，风险控制的双面指示性报价。 可以通过安全网络或基于Web的平台将报价交付给请求交易对手。 该系统还可以允许交易对手根据定制报价提交块交易订单。 定制报价可以基于块的大小和安全性的历史特征。 报价服务可以定制，以考虑到为交易收取的最低保费，盈利能力考虑折扣和时间考虑。