公开(公告)号：US20080031899A1

公开(公告)日：2008-02-07

申请号：US11707627

申请日：2007-02-19

申请人： Sai Reddy ,  Jeffrey Hubbell ,  Melody Swartz ,  Andre Vlies

发明人： Sai Reddy ,  Jeffrey Hubbell ,  Melody Swartz ,  Andre Vlies

IPC分类号： A61K39/00 ,  A61K9/14 ,  A61P43/00

CPC分类号： A61K39/385 ,  A61K2039/55555 ,  A61K2039/6093

摘要： Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.

摘要翻译： 描述了在不存在生物分子的情况下激活补体的纳米颗粒。 显示了纳米颗粒特异性靶向抗原呈递细胞，特别是在淋巴结中，而不用生物分子进行靶向。 这些颗粒是用于递送免疫治疗剂的有用载体。

公开(公告)号：US20050226933A1

公开(公告)日：2005-10-13

申请号：US11062398

申请日：2005-02-22

申请人： Jeffrey Hubbell ,  Julia Kornfield ,  Giyoong Tae

发明人： Jeffrey Hubbell ,  Julia Kornfield ,  Giyoong Tae

IPC分类号： A61F2/00 ,  A61F13/00 ,  A61K9/00 ,  A61K9/14 ,  A61K47/34 ,  A61K47/40

CPC分类号： A61K9/0024 ,  A61K9/0019 ,  A61K47/34 ,  A61K47/40 ,  A61L2400/06

摘要： The invention features materials and methods for the liquid to solid transition of an injectable pre-hydrogel composition to a hydrogel. These methods can be carried out in situ.

公开(公告)号：US20050180957A1

公开(公告)日：2005-08-18

申请号：US11037727

申请日：2005-01-18

申请人： David Scharp ,  Paul Latta ,  Xiaojie Yu ,  Jeffrey Hubbell

发明人： David Scharp ,  Paul Latta ,  Xiaojie Yu ,  Jeffrey Hubbell

IPC分类号： A61K33/06 ,  A61K35/12 ,  A61K35/39 ,  A61K38/18 ,  A61K38/19 ,  A61K38/36 ,  A61K38/48 ,  A61K45/00 ,  A61L24/10 ,  A61L27/38 ,  A61L27/50 ,  C12N5/071

CPC分类号： A61L27/3804 ,  A61K35/12 ,  A61K35/39 ,  A61K38/1866 ,  A61K38/363 ,  A61K38/37 ,  A61K38/4833 ,  A61L24/10 ,  A61L27/507 ,  C12N5/0677 ,  A61K2300/00

摘要： The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material with a growth factor and conjugate into a patient in need of treatment. Several methods are presented to accomplish transplanting several different types of biological materials. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site.

摘要翻译： 本发明涉及通过将生长因子和缀合物的包封的生物材料植入需要治疗的患者中来治疗疾病如糖尿病的组合物和方法。 提出了几种方法来实现移植几种不同类型的生物材料。 本发明还提供了利用这些封装的生物材料通过将它们植入包括皮下部位在内的身体的若干区域来治疗不同的人和动物疾病或病症的方法。

公开(公告)号：US20050014151A1

公开(公告)日：2005-01-20

申请号：US10489688

申请日：2001-09-12

申请人： Marcus Textor ,  Roger MIchel ,  Janos Voros ,  Jeffrey Hubbell ,  Jost Lussi

发明人： Marcus Textor ,  Roger MIchel ,  Janos Voros ,  Jeffrey Hubbell ,  Jost Lussi

IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  G01N33/543 ,  C12Q1/68 ,  C12M1/34

CPC分类号： B82Y30/00 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  B82Y15/00 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/54373 ,  C08L71/02

摘要： A device with chemical surface patterns (defined surface areas of at least two different chemical compositions) with biochemical or biological relevance on substrates with prefabricated patterns of at least two different types of regions (α, β, . . . ), whereas at least two different, consecutively applied molecular self-assembly systems (A, B, . . . ) are used in a way that at least one of the applied assembly systems (A or B or . . . ) is specific to one type of the prefabricated patterns (α or β or . . . ).

摘要翻译： 具有至少两种不同类型区域（α，β，...）的预制图案的具有生化或生物相关性的具有化学表面图案（至少两种不同化学组成的限定表面积）的装置，而至少两种 使用不同的连续应用的分子自组装系统（A，B ...），其方法是至少一个所应用的组装系统（A或B或...）特定于一种类型的预制模式 （alpha或beta或...）。

公开(公告)号：US20130089594A1

公开(公告)日：2013-04-11

申请号：US13641034

申请日：2011-04-12

申请人： Cheryl Stabler Anderson ,  Eileen Pedraza ,  Christopher A. Fraker ,  Peter Buchwald ,  Norma Sue Kenyon ,  Luca Inverardi ,  Antonello Pileggi ,  Paul Latta ,  Jeffrey Hubbell ,  Jessica Weaver ,  Camillo D. Ricordi

发明人： Cheryl Stabler Anderson ,  Eileen Pedraza ,  Christopher A. Fraker ,  Peter Buchwald ,  Norma Sue Kenyon ,  Luca Inverardi ,  Antonello Pileggi ,  Paul Latta ,  Jeffrey Hubbell ,  Jessica Weaver ,  Camillo D. Ricordi

IPC分类号： A61L27/18 ,  A61L27/26

CPC分类号： A61L27/18 ,  A61K9/0024 ,  A61K35/12 ,  A61L27/26 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  C12N5/0676 ,  C12N2533/30 ,  C08L83/04

摘要： The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets.

摘要翻译： 本发明提供了高度多孔，生物相容性和生物稳定性的支架构架，用于改善整体细胞移植，存活，功能和长期存活力。 这些支架可以为植入细胞提供机械保护，从受试者提供可检索性，并且允许装置内血管化和在装置内空间分配细胞的手段。 支架表面或材料可以用一种或多种不同的粘附蛋白和任选的其它生物因子修饰，以增强细胞粘附和活力。 此外，支架表面或材料可以用一种或多种具有缓释/持续释放特性的试剂进行修饰以有助于植入，存活，功能或长期存活。 本发明的植入细胞可以是胰岛素产生细胞如胰岛。

公开(公告)号：US20070100015A1

公开(公告)日：2007-05-03

申请号：US11644606

申请日：2006-12-22

申请人： Jeffrey Hubbell ,  Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Neil Desai ,  Syed Hossainy

发明人： Jeffrey Hubbell ,  Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Neil Desai ,  Syed Hossainy

IPC分类号： C08F290/14

CPC分类号： C12N11/04 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5073 ,  A61K35/30 ,  A61K35/39 ,  A61K38/42 ,  A61K38/44 ,  A61K47/645 ,  A61K47/6925 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/0019 ,  A61L27/34 ,  A61L27/38 ,  A61L27/52 ,  A61L29/085 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  C08F290/00 ,  C08F290/02 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C09D153/00 ,  C12N5/0012 ,  C12N5/0677 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/74 ,  C08L71/02

摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.

摘要翻译： 本发明提供了使用水溶性分子的光聚合在生物材料周围形成生物相容性膜的新方法。 该膜可以用作包封生物材料或生物医学装置的覆盖物，作为使胶粘剂引起不止一种生物物质粘附在一起，或作为生物活性物质的载体。 提供了形成这些膜的几种方法。 这些方法中的每一种都使用含有水溶性大分子单体的聚合体系，它们是能够进一步聚合的聚合物和大分子。 大分子单体使用光引发剂（例如染料），任选的助催化剂，任选的促进剂和可见或长波长UV光的形式的辐射聚合。 该反应通过悬浮聚合或通过界面聚合进行。 聚合物膜可以直接形成在生物材料的表面上，或者可以在已经被包封的材料上形成。

公开(公告)号：US20050009026A1

公开(公告)日：2005-01-13

申请号：US10487915

申请日：2002-08-24

申请人： Andreas Abel ,  Markus Ehrat ,  Ekkehard Kauffmann ,  Dominic Utinger ,  Vincent Benoit ,  Susan De Paul ,  Marcus Textor ,  Stephanie Vande Vondele ,  Jeffrey Hubbell

发明人： Andreas Abel ,  Markus Ehrat ,  Ekkehard Kauffmann ,  Dominic Utinger ,  Vincent Benoit ,  Susan De Paul ,  Marcus Textor ,  Stephanie Vande Vondele ,  Jeffrey Hubbell

IPC分类号： C12Q1/68 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14 ,  C40B70/00 ,  A61L2/00 ,  C07H21/04 ,  C12M1/34

CPC分类号： C12Q1/6837 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00387 ,  B01J2219/00529 ,  B01J2219/0054 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14 ,  C40B70/00

摘要： The invention relates to a surface for the immobilization of one or several first nucleic acids as recognition elements (“immobilization surface”), for the production of a recognition surface for the detection of one or several second nucleic acids in one or more samples which are brought into contact with the recognition surface, the first nucleic acids being applied to a layer of the graft copolymer poly(L-lysine)-g-poly(ethyleneglycol) (PLL-g-PEG) as surface for immobilization, characterized in that the grafting ratio g, in other words the ratio between the number of lysine units and the number of polyethylene glycol side chains (“PEG” side chains) has an average value between 7 and 13. The invention also relates to a method for the qualitative and/or quantitative detection of one or more second nucleic acids in one or more samples, characterized in that said samples and optionally further reagents are brought into contact with an immobilization surface according to the invention, upon which one or several first nucleic acids are immobilized as recognition elements for specific binding/hybridization with said second nucleic acids and changes in optical or electronic signals resulting from the binding/hybridization of said second nucleic acid, or further, resulting from applied tracer substances applied for analyte detection, are measured.

摘要翻译： 本发明涉及用于将一个或几个第一核酸作为识别元件（“固定表面”）固定的表面，用于产生用于检测一个或多个样品中一个或多个第二核酸的识别表面，所述一个或多个第二核酸是 与识别表面接触，将第一核酸施加到作为用于固定的表面的接枝共聚物聚（L-赖氨酸）-g-聚（乙二醇）（PLL-g-PEG）的层上，其特征在于， 接枝率g，换句话说，赖氨酸单元数与聚乙二醇侧链（“PEG”侧链）的数量之间的平均值为7-13之间。本发明还涉及一种定性和 /或一个或多个样品中一种或多种第二核酸的定量检测，其特征在于所述样品和任选的其它试剂与根据本发明的固定化表面接触，u pon，其中一个或几个第一核酸被固定为用于与所述第二核酸特异性结合/杂交的识别元件，以及由所述第二核酸的结合/杂交产生的光学或电子信号的变化，或者进一步由施用的示踪物质 应用于分析物检测。

公开(公告)号：US20070202178A1

公开(公告)日：2007-08-30

申请号：US11739607

申请日：2007-04-24

申请人： Jason Schense ,  Hugo Schmoekel ,  Jeffrey Hubbell ,  Franz Weber

发明人： Jason Schense ,  Hugo Schmoekel ,  Jeffrey Hubbell ,  Franz Weber

IPC分类号： A61K9/00

CPC分类号： A61L31/046 ,  A61L24/0015 ,  A61L24/106 ,  A61L27/225 ,  A61L27/227 ,  A61L27/54 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/45

摘要： Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule may be modified to reduce its effective solubility in the matrix to retain it more effectively within the matrix, such as through the deglycosylation of members within the cystine knot growth factor superfamily and particularly within the TGFβ superfamily. The matrix may be modified to include sites with binding affinity for different bioactive molecules, for example, for heparin binding.

摘要翻译： 生物活性分子被包埋在基质内，用于受控递送这些化合物用于治疗性愈合应用。 基质可以由天然或合成的化合物形成。 捕获生物活性分子的主要方法是通过体外或体内在基质凝胶化过程中沉淀生物活性分子。 可以修饰生物活性分子以降低其在基质中的有效溶解度，从而更有效地将其保留在基质内，例如通过胱氨酸结生长因子超家族内，特别是在TGFbeta超家族内的成员的去糖基化。 可以修饰基质以包括对不同生物活性分子具有结合亲和力的位点，例如用于肝素结合的位点。

公开(公告)号：US20060127595A1

公开(公告)日：2006-06-15

申请号：US11333090

申请日：2006-01-17

申请人： Jane Bearinger ,  Jeffrey Hubbell ,  Kenneth Michlitsch

发明人： Jane Bearinger ,  Jeffrey Hubbell ,  Kenneth Michlitsch

IPC分类号： B41M5/00 ,  C08F2/46

CPC分类号： B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/2014 ,  G03F7/2043 ,  Y10S430/143 ,  Y10T428/24802

摘要： The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.

公开(公告)号：US08702684B2

公开(公告)日：2014-04-22

申请号：US12524918

申请日：2008-02-01

申请人： Nicholas Bodor ,  Peter Buchwald ,  Christopher A. Fraker ,  Jeffrey Hubbell ,  Luca Inverardi ,  Norma Sue Kenyon ,  Paul Latta ,  Antonello Pileggi ,  Cheryl Stabler Anderson ,  Fabio Grassi ,  Camillo Ricordi

发明人： Nicholas Bodor ,  Peter Buchwald ,  Christopher A. Fraker ,  Jeffrey Hubbell ,  Luca Inverardi ,  Norma Sue Kenyon ,  Paul Latta ,  Antonello Pileggi ,  Cheryl Stabler Anderson ,  Fabio Grassi ,  Camillo Ricordi

IPC分类号： A61K9/22 ,  A61M31/00

CPC分类号： A61F2/022 ,  A61K35/39 ,  A61K38/18 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/19 ,  A61K38/22 ,  A61K38/55 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1452 ,  A61M2202/097

摘要： A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

摘要翻译： 用于接收植入的生物材料的装置（10）包括限定相邻空间的机械保护表面（16），用于将介质局部输送到所述空间的组件（26,28），以及泵或缓/缓释储存器结构（14） 可操作地联接到组件。 该装置可以包括用于设置在所述空间中的附加柱塞体。 植入的生物材料可以被包封或非包封。