公开(公告)号：US12078578B2

公开(公告)日：2024-09-03

申请号：US18211046

申请日：2023-06-16

申请人： Trustees of Boston University ,  Beth Israel Deaconess Medical Center, Inc.

发明人： Bela Suki ,  Jae Hun Kim ,  Joseph Hall ,  Ramaswamy Krishnan ,  Niccole Schaible

IPC分类号： G01N1/06 ,  G01N1/31 ,  G01N3/08 ,  G01N3/42 ,  G01N35/00

CPC分类号： G01N1/06 ,  G01N1/312 ,  G01N3/08 ,  G01N35/00009 ,  G01N2035/00019

摘要： Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.

公开(公告)号：US20240288367A1

公开(公告)日：2024-08-29

申请号：US18574571

申请日：2022-07-01

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Lev T. Perelman

IPC分类号： G01N21/51 ,  C12Q1/04 ,  G01N21/47 ,  G01N33/49

CPC分类号： G01N21/51 ,  C12Q1/04 ,  G01N33/49 ,  G01N2021/4704 ,  G01N2201/0683

摘要： Methods for identifying bacterial species in biofluid samples (e.g., whole blood samples) are described. The methods rely on optical spectroscopy, and enable rapid detection and identification of bacteria directly from whole blood. Not only can LSS-based techniques detect and identify bacteria in biofluids such as whole blood, but that species-level identification can potentially be made based on a small number of bacterial cells, without the need for observing entire colonies or performing susceptibility testing. The methods may comprise illuminating the biofluid sample with input light, detecting scattered light produced by the biofluid sample in response to the illuminating, generating first data indicative of a measured scattering spectrum associated with the biofluid sample using the detected scattered light, and identifying whether at least one of the bacterial species is present in the biofluid sample using the first data.

公开(公告)号：US20240287142A1

公开(公告)日：2024-08-29

申请号：US18455151

申请日：2023-08-24

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Dan H. BAROUCH ,  Peter ABBINK ,  Mark Justin IAMPIETRO ,  Menzo J. E. HAVENGA

IPC分类号： C07K14/075 ,  A61K31/7088 ,  A61K35/761 ,  A61K39/235 ,  C07K14/54 ,  C12N15/861

CPC分类号： C07K14/075 ,  A61K31/7088 ,  A61K35/761 ,  A61K39/235 ,  C07K14/5425 ,  C12N15/861

摘要： Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).

公开(公告)号：US12061199B2

公开(公告)日：2024-08-13

申请号：US16541707

申请日：2019-08-15

申请人： Massachusetts Institute of Technology ,  Beth Israel Deaconess Medical Center, Inc.

发明人： Edward Stuart Boyden ,  Andrew Hanno Beck ,  Yongxin Zhao ,  Octavian Bucur ,  Humayun Irshad

IPC分类号： G01N15/1433 ,  G01N1/36 ,  G01N33/574 ,  G02B21/16 ,  G16H30/20 ,  G16H50/20 ,  G01N15/10

CPC分类号： G01N33/57415 ,  G01N1/36 ,  G01N15/1433 ,  G02B21/16 ,  G16H30/20 ,  G16H50/20 ,  G01N2015/1006

摘要： A method for diagnosing cancer in an expanded biological tissue sample of a patient comprising providing at least one sample image of the expanded biological tissue sample; providing a computer configured to analyze the sample; analyzing, with the computer, the sample detect and segment nuclei; calculating, with the computer, molecular characteristics of those nuclei; and determining, with the computer, a diagnosis of cancer of the sample by comparing the sample with a benign normal tissue reference.

公开(公告)号：US20240252520A1

公开(公告)日：2024-08-01

申请号：US18408546

申请日：2024-01-09

申请人： Beth Israel Deaconess Medical Center, Inc. ,  President and Fellows of Harvard College

发明人： Aristidis Veves ,  George Theocharidis ,  Zhuqing Li ,  Ioannis Vlachos ,  David J. Mooney ,  Sangmin Lee

IPC分类号： A61K31/662 ,  A61K9/06 ,  A61K9/70 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61K31/662 ,  A61K9/06 ,  A61K9/7023 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/008 ,  A61P17/02 ,  A61L2300/102 ,  A61L2300/216 ,  A61L2300/258 ,  A61L2300/622

摘要： In certain aspects, the disclosure relates to devices and methods for treating wounds wherein an acetylcholinesterase inhibitor is delivered to a wound to promote wound healing. In further aspects, metrifonate can be delivered to the wound by time release from a wound dressing. In further aspects a sequence of wound dressings can be applied to the wound to treat different phases of wound healing.

公开(公告)号：US20240252033A1

公开(公告)日：2024-08-01

申请号：US18629665

申请日：2024-04-08

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Jatinder S. Gill

IPC分类号： A61B1/313 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/06 ,  A61B1/32 ,  A61B17/32 ,  A61B90/00 ,  A61B90/30

CPC分类号： A61B1/3135 ,  A61B1/00094 ,  A61B1/009 ,  A61B1/043 ,  A61B1/0684 ,  A61B1/32 ,  A61B17/320016 ,  A61B90/04 ,  A61B90/30 ,  A61B90/36 ,  A61B2017/320069 ,  A61B2017/32007 ,  A61B2217/005

摘要： The present invention relates to a flexible surgical system for endoscopic spinal decompression and methods thereof. Various methods of accessing the epidural space with this instrument are described. The system design enables placement of the device through several approaches. It is then advanced under direct visualization or fluoroscopic (X-Ray), for example, into areas of the spine including lumbar (low back), thoracic (mid and upper back) and cervical (neck). The pathologies encroaching upon the spinal space can then be visualized wherein the epidural membrane can optionally be displaced to further aid in visualization. The membrane can be used to protect regions of tissue adjacent the site to tissue removal.

公开(公告)号：US20240238473A1

公开(公告)日：2024-07-18

申请号：US18408498

申请日：2024-01-09

申请人： Beth Israel Deaconess Medical Center, Inc. ,  President and Fellows of Harvard College

发明人： Aristidis Veves ,  George Theocharidis ,  Zhuqing Li ,  Ioannis Vlachos ,  David Mooney ,  Sangmin Lee

IPC分类号： A61L15/32 ,  A61K38/00 ,  A61K47/69 ,  A61L15/28 ,  C07K14/47 ,  C07K14/55 ,  C12Q1/6811

CPC分类号： A61L15/32 ,  A61K47/6929 ,  A61L15/28 ,  C07K14/473 ,  C07K14/55 ,  C12Q1/6811 ,  A61K38/00

摘要： In certain aspects, the disclosure relates to a recombinant nucleic acid molecule (e.g. RNA molecule) encoding one or more polypeptides selected from the group consisting of chitinase-3-like protein 1 (CHI3L1), a fibroblast growth factor (FGF), interleukin-2 ORF7 (IL-2 ORF7), interleukin-2 (IL-2), an interleukin-17 (IL-17) protein, and an IL-17 receptor, wherein the recombinant RNA molecule comprises at least one chemical modification. Cells, pharmaceutical compositions and wound dressings comprising one or more of the recombinant nucleic acid molecules are also disclosed. Methods of promoting wound healing in a subject are further disclosed.

公开(公告)号：US20240230641A1

公开(公告)日：2024-07-11

申请号：US18550008

申请日：2022-03-11

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： George C. Tsokos ,  Rhea Bhargava

IPC分类号： G01N33/564 ,  C12Q1/6851 ,  C12Q1/6883 ,  A61B10/00

CPC分类号： G01N33/564 ,  C12Q1/6851 ,  C12Q1/6883 ,  A61B10/007 ,  C12Q2600/158 ,  G01N2333/54 ,  G01N2333/912 ,  G01N2800/104 ,  G01N2800/347

摘要： Provided herein are methods of identifying and/or diagnosing an active lupus nephritis (LN) flare in a subject, the method comprising obtaining a sample from the subject; isolating cells from the urine sample; and determining a level of expression of calcium/calmodulin dependent protein kinase IV (CaMK4), IL-23, IL-17 receptor, and/or arginase 1, wherein an increased level of expression of CaMK4, IL-23, and/or IL-17 receptor as compared to a control or a decreased level of expression of arginase 1 as compared to a control indicates an active lupus nephritis (LN) flare in the subject.

公开(公告)号：US20230416413A1

公开(公告)日：2023-12-28

申请号：US18459892

申请日：2023-09-01

申请人： Children's Medical Center Corporation ,  Beth Israel Deaconess Medical Center, Inc.

发明人： James D. McCully ,  Sidney Levitsky ,  Douglas B. Cowan ,  Pedro J. del Nido ,  Sitaram M. Emani

IPC分类号： C07K16/46 ,  A61K35/12 ,  A61K49/00 ,  A61K49/18 ,  A61K51/04 ,  A61K51/12 ,  A61K35/28 ,  A61K35/34 ,  A61K47/69 ,  A61K9/00 ,  A61B6/00 ,  C12N15/11

CPC分类号： C07K16/468 ,  A61B8/0883 ,  A61K49/0002 ,  A61K49/1821 ,  A61K49/1896 ,  A61K51/0421 ,  A61K51/1203 ,  A61K35/28 ,  A61K35/34 ,  A61K47/6901 ,  A61K9/0019 ,  A61B6/42 ,  A61K51/1282 ,  C12N15/11 ,  A61B6/503 ,  A61K35/12

摘要： The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.

公开(公告)号：US20230346286A1

公开(公告)日：2023-11-02

申请号：US18335497

申请日：2023-06-15

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： Benjamin Sanchez ,  Seward B. Rutkove ,  Hyeuknam Kwon

IPC分类号： A61B5/296 ,  A61B5/0536 ,  A61B5/0538 ,  A61B5/00 ,  A61B5/262

CPC分类号： A61B5/296 ,  A61B5/0536 ,  A61B5/0538 ,  A61B5/6848 ,  A61B5/262

摘要： Described herein are embodiments of methods and apparatus for diagnosing neuromuscular diseases using an impedance-EMG needle, and for generating electrical impedance images using an impedance needle. Some embodiments provide an apparatus including an impedance-EMG needle, including both EMG electrodes and impedance electrodes, to measure both active and passive electrical properties of muscle. Other embodiments provide an apparatus including an impedance needle, including a plurality of impedance electrodes to measure impedance in tissue surrounding the impedance needle to generate an electrical impedance image. Use of such methods and apparatus may be advantageous in improving the accuracy of assessing and diagnosing neuromuscular disease.