公开(公告)号：US20240352421A1

公开(公告)日：2024-10-24

申请号：US17753946

申请日：2020-09-18

申请人： Chondro Engineering AS

发明人： Oddmund Johannes Johansen

IPC分类号： C12N5/077 ,  A61L27/38

CPC分类号： C12N5/0655 ,  A61L27/3852 ,  A61L27/3895 ,  C12N2500/02 ,  C12N2513/00 ,  C12N2527/00

摘要： A method for in-vitro production of a cohesive cartilage construct includes the following steps: a) propagating chondrogenic cells derived from a subject to allow formation of one or more cartilage micro constructs; b) putting a plurality of the cartilage micro constructs in motion to facilitate contact between the cartilage micro constructs and thereby allow formation of one or more fused cartilage micro constructs; and c) subjecting one or more of the fused cartilage micro constructs to mechanical stimulation in a hypoxic environment to allow formation of a cohesive cartilage construct.

公开(公告)号：US20240350710A1

公开(公告)日：2024-10-24

申请号：US18034443

申请日：2021-11-01

申请人： POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

发明人： Jin Ah JANG ,  Dong Gyu HWANG

IPC分类号： A61L27/38 ,  A61F2/08 ,  A61L27/52

CPC分类号： A61L27/3826 ,  A61F2/08 ,  A61L27/52 ,  A61L2430/20 ,  A61L2430/30

摘要： A multiaxial artificial muscle tissue is provided. The multiaxial artificial muscle tissue according to an embodiment of the present invention is a multiaxial artificial muscle tissue contractible or stretchable about a plurality of axes and comprises: a first module formed by gelling a hydrogel including muscle cells and extending in a first axial direction so as to be contractible or stretchable in the first axial direction; and a second module formed by gelling the hydrogel and extending in a second axial direction to be contractible or stretchable in the second axial direction, wherein a portion of the hydrogel and a portion of the hydrogel which constitute the first module and the second module, respectively, are integrated with each other such that a portion of the first module and a portion of the second module are connected to each other.

公开(公告)号：US12115058B2

公开(公告)日：2024-10-15

申请号：US17431295

申请日：2020-02-14

申请人： TORAY INDUSTRIES, INC.

发明人： Kenichi Harimoto ,  Hirokazu Sakaguchi ,  Satoshi Yamada

IPC分类号： A61L27/38 ,  A61F2/02 ,  A61F2/06

CPC分类号： A61F2/02 ,  A61F2210/0004

摘要： A nerve regeneration-inducing tube includes a cylindrical body, and a plurality of fibers that are housed in the body and extend in a longitudinal direction of the body. At least a part of the fibers is a modified cross-section fiber that has an axis extending in a longitudinal direction of the fibers, and at least three protrusions that continue in the longitudinal direction of the fibers, protrude from the axis, and have a height of 0.5 μm or more from the axis.

公开(公告)号：US20240335593A1

公开(公告)日：2024-10-10

申请号：US18297417

申请日：2023-04-07

申请人： Wisconsin Alumni Research Foundation

发明人： James THOMSON ,  Jue Zhang ,  John Maufort

IPC分类号： A61L27/50 ,  A61L27/38 ,  C12N5/071

CPC分类号： A61L27/507 ,  A61L27/3808 ,  C12N5/0692 ,  A61L2430/34

摘要： Provided herein are allogeneic human endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described.

公开(公告)号：US20240335585A1

公开(公告)日：2024-10-10

申请号：US18573671

申请日：2022-04-06

申请人： GEORGIA TECH RESEARCH CORPORATION

发明人： Chen JIANG ,  Kan WANG ,  Ben WANG

IPC分类号： A61L27/18 ,  A61L27/34 ,  A61L27/38

CPC分类号： A61L27/18 ,  A61L27/34 ,  A61L27/38

摘要： Described are scaffolds for tissue engineering and method of making and using the scaffold. The method of making can include providing a textile layer formed of a plurality of yarns, wherein the plurality of yarns are formed of interlocking bundles of fibers formed from a first polymer or a first polymer mixture; and forming one or more substrate layer of a second polymer or a second polymer mixture onto the textile layer having a pre-defined thickness.

公开(公告)号：US12097304B2

公开(公告)日：2024-09-24

申请号：US15591728

申请日：2017-05-10

申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Karrer M. Alghazali ,  Zeid A. Nima ,  Alexandru S. Biris

IPC分类号： A61L27/36 ,  A61L27/12 ,  A61L27/14 ,  A61L27/18 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61K9/14 ,  A61K31/4453 ,  A61K31/704 ,  C07C211/38 ,  C07C229/36 ,  C07D209/14 ,  C07D209/24 ,  C07D211/22 ,  C07D215/22 ,  C07D265/18 ,  C07D277/56 ,  C07D405/12 ,  C07D473/18 ,  C07D473/30 ,  C07D491/22 ,  C07D501/22 ,  C07H15/252 ,  C07H17/08

CPC分类号： A61L27/3695 ,  A61L27/12 ,  A61L27/14 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3608 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2430/02 ,  A61L27/18 ,  C08L67/04

摘要： A method for forming a biocompatible structure includes the steps of forming a layered structure having alternatively disposed first layers and second layers, where the first layers includes at least one polymer and first particles, and the second layers includes second particles; and treating the layered structure with a washing solvent to form the biocompatible structure, where the first particles are solvable in the washing solvent.

公开(公告)号：US20240307588A1

公开(公告)日：2024-09-19

申请号：US18675481

申请日：2024-05-28

申请人： Boston Scientific Scimed, Inc.

发明人： Joseph T. Delaney, JR. ,  Mark W. Boden ,  John Murphy ,  Viktoria Molnar ,  Tatyana Dyndikova ,  Allison Zipp ,  Kolbein K Kolste

IPC分类号： A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/50

CPC分类号： A61L27/16 ,  A61L27/18 ,  A61L27/3839 ,  A61L27/50

摘要： Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

公开(公告)号：US12083246B2

公开(公告)日：2024-09-10

申请号：US16783494

申请日：2020-02-06

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Ferenc Horkay ,  Peter Joel Basser

IPC分类号： A61L27/48 ,  A61K9/06 ,  A61K47/32 ,  A61L27/38 ,  C08J3/075 ,  C08J3/24 ,  C08L29/04

CPC分类号： A61L27/48 ,  A61K9/06 ,  A61K47/32 ,  A61L27/3817 ,  A61L27/3834 ,  C08J3/075 ,  C08J3/24 ,  C08L29/04 ,  A61L2430/00 ,  C08J2329/04 ,  C08J2433/02

摘要： A self-reinforcing composite gel includes a solvent, and a plurality of swellable crosslinked polymer particles dispersed in a crosslinked polymer matrix, wherein the crosslinked polymer matrix and the plurality of swellable crosslinked polymer particles are immersed in the solvent, wherein the swellable crosslinked polymer particles absorb more solvent at equilibrium than the matrix polymer, and wherein the plurality of swellable crosslinked polymer particles swell in the solvent and are present in an amount sufficient to maintain or increase the elastic modulus and/or load-bearing ability of the self-reinforcing composite gel, i.e., compared to that of the crosslinked matrix polymer alone, upon swelling in the solvent.

公开(公告)号：US12077638B2

公开(公告)日：2024-09-03

申请号：US15335184

申请日：2016-10-26

申请人： University of Wyoming

发明人： John Oakey ,  Kaspars Krutkramelis ,  Bingzhao Xia

IPC分类号： A61K36/9066 ,  A61K9/50 ,  A61K35/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B01F23/41 ,  B01F25/433 ,  B01F33/3011 ,  B01J2/06 ,  B01J13/00 ,  B01J19/00 ,  C08F2/32 ,  C08F2/48 ,  C08J3/075 ,  C08J9/26 ,  C12N5/00 ,  C08F216/12 ,  C08F222/10

CPC分类号： C08J3/075 ,  A61K9/5026 ,  A61K35/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B01F23/41 ,  B01F25/4331 ,  B01F33/3011 ,  B01J2/06 ,  B01J13/0052 ,  B01J19/0093 ,  C08F2/32 ,  C08F2/48 ,  C08J9/26 ,  C12N5/0012 ,  B01J2219/00792 ,  B01J2219/00936 ,  C08F216/125 ,  C08F222/102 ,  C08J2201/046 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2335/02 ,  C08J2345/00

摘要： Provided herein are methods utilizing microfluidics for the oxygen-controlled generation of microparticles and hydrogels having controlled microparticle sizes and size distributions and products from provided methods. The included methods provide the generation of microparticles by polymerizing an aqueous solution dispersed in a non-aqueous continuous phase in an oxygen-controlled environment. The process allows for control of size of the size of the aqueous droplets and, thus, control of the size of the generated microparticles which may be used in biological applications.

公开(公告)号：US20240287463A1

公开(公告)日：2024-08-29

申请号：US17793287

申请日：2021-01-22

申请人： Massachusetts Institute of Technology ,  TRUSTEES OF BOSTON UNIVERSITY

发明人： Christopher S. Chen ,  Sangeeta N. Bhatia ,  Arnav Chhabra ,  Amanda Chen ,  Hyun Ho Song

IPC分类号： C12N5/071 ,  A61L27/38 ,  C12N5/00 ,  C12N5/077 ,  C12N9/64

CPC分类号： C12N5/0671 ,  A61L27/3886 ,  A61L27/3895 ,  C12N5/0062 ,  C12N5/0656 ,  C12N9/6472 ,  C12Y304/22062 ,  C12N2502/1323 ,  C12N2513/00

摘要： Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided.