公开(公告)号：US10919832B2

公开(公告)日：2021-02-16

申请号：US16461120

申请日：2016-11-25

申请人： Dalian Institute of Chemical Physics, Chinese Academy of Sciences

发明人： Zhanling Ma ,  Wenliang Zhu ,  Xiangang Ma ,  Hongchao Liu ,  Yong Liu ,  Youming Ni ,  Shiping Liu ,  Qiwei Chen ,  Zhongmin Liu

IPC分类号： C07C51/353 ,  C07C67/333 ,  C07C67/343 ,  B01J29/24 ,  B01J29/46 ,  B01J29/68 ,  B01J29/76 ,  B01J29/85 ,  B01J29/70 ,  B01J29/83 ,  B01J29/18 ,  B01J29/80 ,  B01J29/06 ,  B01J29/08 ,  B01J29/65 ,  C07C69/52 ,  C07C69/54 ,  C07C69/533 ,  C07C57/03 ,  C07C57/04

摘要： Provided is a method for preparing a lower unsaturated fatty acid ester, which comprises carrying out an aldol condensation reaction between dimethoxymethane (DMM) and a lower acid or ester with a molecular formula of R1—CH2—COO—R2 on an acidic molecular sieve catalyst in an inert atmosphere to obtain a lower unsaturated fatty acid or ester(CH2═C(R1)—COO—R2), wherein R1 and R2 are groups each independently selected from the group consisting of H— and C1-C4 saturated alkyl group.

公开(公告)号：US10385003B2

公开(公告)日：2019-08-20

申请号：US14367836

申请日：2012-12-21

申请人： Thomas Millar ,  Burkhardt Schuett

发明人： Thomas Millar ,  Burkhardt Schuett

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K31/23 ,  A61K47/14 ,  A61K47/38 ,  A61K9/107 ,  C07C67/14 ,  C07C69/22 ,  C07C69/26 ,  C07C69/58 ,  A61K31/231 ,  A61K31/232 ,  C07C69/533 ,  C07C69/587

摘要： Disclosed herein is an ophthalmic formulation comprising a compound of formula (I): wherein R1 is a linear or branched C9-C33 alkyl or a linear or branched C9-C33 alkenyl with 1 to 4 double bonds; R2 is a linear or branched C9-C19 alkyl or a linear or branched C9-C19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.

公开(公告)号：US20190047974A1

公开(公告)日：2019-02-14

申请号：US16077187

申请日：2017-03-08

申请人： Givaudan SA

发明人： Paul Nicholas DAVEY ,  Simon ELLWOOD

IPC分类号： C07D313/00 ,  C08G61/12 ,  C07C69/533

摘要： A process for preparing a macrocyclic lactone comprising 14 to 17 ring carbon atoms, the process comprising the steps of i) subjecting a reaction mixture comprising an olefin-containing random polyester, formed by metathesis to a cyclo-depolymerization reaction to form the macrocyclic lactone, and ii) concomitant removal of the macrocyclic lactone from the reaction mixture.

公开(公告)号：US20180222812A1

公开(公告)日：2018-08-09

申请号：US15834616

申请日：2017-12-07

申请人： The United States of America, as Represented by the Secretary of Agriculture

发明人： Rex E. Murray ,  Kenneth M. Doll ,  Zengshe Liu

IPC分类号： C07C1/207 ,  C07C2/22 ,  C11C3/14 ,  C10G50/00 ,  C10G3/00 ,  C07C67/333 ,  C07C6/04 ,  C07C51/353 ,  C07C57/03 ,  C07C11/02 ,  C07C69/533

CPC分类号： C07C1/2078 ,  C07C2/22 ,  C07C6/04 ,  C07C51/353 ,  C07C67/333 ,  C07C2521/06 ,  C07C2527/12 ,  C07C2527/13 ,  C07C2531/20 ,  C07C2531/24 ,  C10G3/47 ,  C10G50/00 ,  C11C3/14 ,  Y02P30/20 ,  C07C57/03 ,  C07C11/02 ,  C07C69/533

摘要： Disclosed is the use of a metal catalyst or catalyst precursor that catalyzes the isomerization of an unsaturated fatty acid, unsaturated fatty acid derivative, or an unsaturated triglyceride. Also disclosed is the use of a metal catalyst or catalyst precursor that catalyzes the decarboxylation of an unsaturated organic compound. Also disclosed is the use of a catalyst or catalyst precursor for the dual function isomerization and decarboxylation of an unsaturated fatty acid to an unsaturated organic compound.

公开(公告)号：US10010519B2

公开(公告)日：2018-07-03

申请号：US15358388

申请日：2016-11-22

申请人： Biosuccess Biotech Co. Ltd.

发明人： Zheng Tao Han ,  Hung-Fong Chen

IPC分类号： A61K31/215 ,  A61K31/23 ,  A61K31/235 ,  A61K45/06 ,  A61K31/22 ,  A61K31/216 ,  C07C69/18 ,  C07C69/21 ,  C07C69/612 ,  C07C69/533 ,  C07C69/33 ,  A61K31/225

CPC分类号： A61K31/23 ,  A61K31/216 ,  A61K31/22 ,  A61K31/225 ,  A61K45/06 ,  C07C69/21 ,  C07C69/33 ,  C07C69/612 ,  A61K2300/00

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.

公开(公告)号：US09896702B2

公开(公告)日：2018-02-20

申请号：US14740554

申请日：2015-06-16

申请人： INVISTA North America S.á r.l.

发明人： Alex Van Eck Conradie ,  Adriana Leonora Botes

IPC分类号： C12P7/62 ,  C12P13/00 ,  C12P7/42 ,  C12N9/18 ,  C12P7/44 ,  C12P7/18 ,  C12P11/00 ,  C12N9/16 ,  C12N9/10 ,  C12N9/02 ,  C07C69/533 ,  C12P7/24 ,  C12P7/40 ,  C12P17/10

CPC分类号： C12P7/62 ,  C07C69/533 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/18 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P11/00 ,  C12P13/001 ,  C12P13/005 ,  C12P17/10 ,  C12Y102/99006 ,  C12Y203/01016 ,  C12Y206/01018 ,  C12Y206/01019 ,  C12Y206/01029 ,  C12Y206/01048 ,  C12Y206/01082 ,  C12Y301/01085 ,  C12Y301/02

摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.

公开(公告)号：US09815780B2

公开(公告)日：2017-11-14

申请号：US14867251

申请日：2015-09-28

申请人： Stepan Company

发明人： Dave R Allen ,  Marcos Alonso ,  Randal J Bernhardt ,  Aaron Brown ,  Sangeeta Ganguly-Mink ,  Andrew Malec ,  Teresa Manuel ,  Ronald A. Masters ,  Lawrence A. Munie ,  Dennis S. Murphy ,  Patti Skelton ,  Brian Sook ,  Michael R. Terry ,  Jeremy Aaron Weitgenant ,  Laura Lee Whitlock ,  Michael Wiester ,  Patrick Shane Wolfe

IPC分类号： A01N25/00 ,  A01N57/20 ,  A01N37/30 ,  A61K31/205 ,  C07C309/69 ,  C07C6/04 ,  C07C41/03 ,  C07C43/11 ,  C07C67/26 ,  A01N25/02 ,  A01N25/04 ,  A01N25/30 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/92 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/02 ,  B01F17/00 ,  C07C69/533 ,  C07C69/593 ,  C07C209/12 ,  C07C211/21 ,  C07C219/08 ,  C07C231/12 ,  C07C237/16 ,  C07C303/18 ,  C08G65/26 ,  C08K5/01 ,  C08K5/20 ,  C09K15/28 ,  C11C3/00 ,  C11C3/08 ,  C11D1/00 ,  C11D1/04 ,  C11D1/28 ,  C11D1/62 ,  C11D1/65 ,  C11D1/74 ,  C11D1/83 ,  C11D1/90 ,  C11D1/92 ,  C11D1/94 ,  C11D3/48 ,  A61Q5/02 ,  C04B24/12 ,  C04B24/16 ,  C07C211/63 ,  C07C229/12 ,  C07C233/36 ,  C09K8/54 ,  C09K8/60 ,  C09K15/22 ,  C09K8/00

CPC分类号： C07C309/69 ,  A01N25/02 ,  A01N25/04 ,  A01N25/30 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/416 ,  A61K8/42 ,  A61K8/44 ,  A61K8/447 ,  A61K8/466 ,  A61K8/92 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/0071 ,  B01F17/0028 ,  B01F17/0057 ,  C04B24/121 ,  C04B24/124 ,  C04B24/16 ,  C07C6/04 ,  C07C41/03 ,  C07C43/11 ,  C07C67/26 ,  C07C69/533 ,  C07C69/593 ,  C07C209/12 ,  C07C211/21 ,  C07C211/63 ,  C07C219/08 ,  C07C229/12 ,  C07C231/12 ,  C07C233/36 ,  C07C237/16 ,  C07C303/18 ,  C08G65/2615 ,  C08K5/01 ,  C08K5/20 ,  C09K8/00 ,  C09K8/54 ,  C09K8/60 ,  C09K15/22 ,  C09K15/28 ,  C11C3/00 ,  C11C3/08 ,  C11D1/002 ,  C11D1/04 ,  C11D1/28 ,  C11D1/62 ,  C11D1/652 ,  C11D1/74 ,  C11D1/83 ,  C11D1/90 ,  C11D1/92 ,  C11D1/94 ,  C11D3/48 ,  C07C211/64 ,  C07C233/38 ,  C07C309/14 ,  A01N33/18 ,  A01N39/04 ,  A01N43/653 ,  A01N51/00 ,  A01N57/20 ,  A01N43/40 ,  A01N43/56 ,  A01N53/00

摘要： Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amines, wherein the fatty amine is made by reducing the amide reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and a secondary amine, are disclosed. Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amidoamines, wherein the amidoamine is made by reacting of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and an aminoalkyl-substituted tertiary amine, are also disclosed. The quaternized compositions are advantageously sulfonated or sulfitated. In one aspect, the ester derivative of the C10-C17 monounsaturated acid or octadecene-1,18-dioic acid is a lower alkyl ester. In other aspects, the ester derivative is a modified triglyceride N made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin. The quaternary ammonium, betaine, and sulfobetaine compositions and their sulfonated or sulfitated derivatives are valuable for a wide variety of end uses, including cleaners, fabric treatment, hair conditioning, personal care (liquid cleansing products, conditioning bars, oral care products), antimicrobial compositions, agricultural uses, and oil field applications.

公开(公告)号：US09796657B2

公开(公告)日：2017-10-24

申请号：US15075734

申请日：2016-03-21

申请人： Elevance Renewable Sciences, Inc.

发明人： Paul A. Bertin

IPC分类号： C07C69/533 ,  C09D7/12 ,  C07C69/587 ,  C09D107/02 ,  C09D121/02 ,  C11D3/20

CPC分类号： C07C69/533 ,  C07C69/587 ,  C09D7/40 ,  C09D7/60 ,  C09D7/63 ,  C09D107/02 ,  C09D121/02 ,  C11D3/20 ,  C11D3/2093

摘要： Polyol esters of metathesized fatty acids are generally disclosed herein. Methods of using such compounds, for example, as cleaning agents, solvents, and coalescents for paints and coatings, are also disclosed.

公开(公告)号：US20170137365A1

公开(公告)日：2017-05-18

申请号：US15354916

申请日：2016-11-17

申请人： PROVIVI, INC.

发明人： KEITH M. WAMPLER ,  PETER MEINHOLD ,  PEDRO COELHO ,  VU BUI ,  LEVENTE ONDI ,  HASAN MEHDI

IPC分类号： C07C67/293 ,  B01J31/22 ,  C07C69/533

CPC分类号： B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07B2200/09 ,  C07C6/04 ,  C07C29/147 ,  C07C45/41 ,  C07C67/08 ,  C07C67/293 ,  C07C67/343 ,  C07C2531/22 ,  C07C69/533 ,  C07C33/025 ,  C07C69/145 ,  C07C47/21 ,  C07C11/21

摘要： In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

公开(公告)号：US09573884B2

公开(公告)日：2017-02-21

申请号：US14847041

申请日：2015-09-08

申请人： Stepan Company

发明人： Dave R Allen ,  Marcos Alonso ,  Randal J Bernhardt ,  Aaron Brown ,  Kelly Buchek ,  Sangeeta Ganguly-Mink ,  Brian Holland ,  Gary Luebke ,  Renee Luka ,  Andrew D. Malec ,  Ronald A Masters ,  Dennis S Murphy ,  Irene Shapiro ,  Patti Skelton ,  Brian Sook ,  Michael R Terry ,  Gregory Wallace ,  Laura Lee Whitlock ,  Michael Wiester ,  Patrick Shane Wolfe ,  Lena Titievsky

IPC分类号： C11D3/32 ,  C07C233/09 ,  A01N25/02 ,  A01N25/04 ,  A01N25/30 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/92 ,  A61Q5/12 ,  A61Q19/10 ,  A62D1/02 ,  B01F17/00 ,  C07C69/533 ,  C07C69/593 ,  C07C209/12 ,  C07C211/21 ,  C07C219/08 ,  C07C231/12 ,  C07C237/16 ,  C07C303/18 ,  C08G65/26 ,  C08K5/01 ,  C08K5/20 ,  C09K8/00 ,  C09K15/28 ,  C11C3/00 ,  C11C3/08 ,  C11D1/00 ,  C11D1/04 ,  C11D1/28 ,  C11D1/62 ,  C11D1/65 ,  C11D1/74 ,  C11D1/83 ,  C11D1/90 ,  C11D1/92 ,  C11D1/94 ,  C11D3/48 ,  A61Q5/02 ,  C07C233/20 ,  C07C233/38 ,  C07C309/15 ,  C07D233/24 ,  C09D7/02 ,  C09K8/54 ,  C11D1/66

CPC分类号： C07C233/09 ,  A01N25/02 ,  A01N25/04 ,  A01N25/30 ,  A01N33/12 ,  A01N37/18 ,  A01N37/44 ,  A01N41/04 ,  A61K8/416 ,  A61K8/42 ,  A61K8/44 ,  A61K8/466 ,  A61K8/92 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/005 ,  A61Q19/10 ,  A62D1/0071 ,  B01F17/0028 ,  B01F17/0057 ,  C07C69/533 ,  C07C69/593 ,  C07C209/12 ,  C07C211/21 ,  C07C219/08 ,  C07C231/12 ,  C07C233/20 ,  C07C233/38 ,  C07C237/16 ,  C07C303/18 ,  C07C309/15 ,  C07C309/70 ,  C07D233/24 ,  C08G65/2615 ,  C08K5/01 ,  C08K5/20 ,  C08K5/42 ,  C09D7/45 ,  C09D7/63 ,  C09K8/00 ,  C09K8/524 ,  C09K8/54 ,  C09K15/28 ,  C11C3/00 ,  C11C3/08 ,  C11D1/002 ,  C11D1/04 ,  C11D1/28 ,  C11D1/62 ,  C11D1/652 ,  C11D1/66 ,  C11D1/74 ,  C11D1/83 ,  C11D1/90 ,  C11D1/92 ,  C11D1/94 ,  C11D3/48 ,  C11D11/0017 ,  C07C211/63 ,  C07C211/64 ,  C07C309/14 ,  A01N33/18 ,  A01N39/04 ,  A01N43/653 ,  A01N51/00 ,  A01N57/20 ,  A01N43/40 ,  A01N43/56 ,  A01N53/00

摘要： Fatty amide compositions and their derivatives are disclosed. The fatty amides comprise a reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with a primary or secondary amine. Derivatives made by reducing, quaternizing, sulfonating, alkoxylating, sulfating, and sulfitating the fatty amide are also included. The amine reactant can be diethylenetriamine or (2-aminoethyl)ethanolamine, which provide imidazoline amides or esters, respectively. In one aspect, the ester derivative of the C10-C17 monounsaturated acid or octadecene-1,18-dioic acid is a lower alkyl ester. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin. The compositions are valuable for cleaners, fabric treatment, hair conditioning, personal care, antimicrobial compositions, agricultural uses, and oil field applications.

摘要翻译： 公开了脂肪酰胺组合物及其衍生物。 脂肪酰胺包含由复分解衍生的C10-C17单不饱和酸，十八碳烯-1,18-二酸或其酯衍生物与伯胺或仲胺的反应产物。 还包括通过还原，季铵化，磺化，烷氧基化，硫酸化和硫酸化而制得的衍生物。 胺反应物可以是二亚乙基三胺或（2-氨基乙基）乙醇胺，其分别提供咪唑啉酰胺或酯。 一方面，C10-C17单不饱和酸或十八碳烯-1,18-二酸的酯衍生物是低级烷基酯。 在其它方面，酯衍生物是通过天然油或不饱和甘油三酸酯通过天然油与烯烃的交叉复分解而制备的改性甘油三酸酯。 组合物对于清洁剂，织物处理，头发调理，个人护理，抗微生物组合物，农业用途和油田应用是有价值的。