Patent search cpc:"C07D277/56" Page 10

91.

发明授权
Guanidine compound 有权
Title translation: 胍化合物

公开(公告)号：US08716470B2

公开(公告)日：2014-05-06

申请号：US13755822

申请日：2013-01-31

Applicant: Astellas Pharma Inc.

Inventor： Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Hiroyoshi Yamada , Hisashi Mihara , Norio Seki

IPC: C07D417/04 , A61K31/5377

CPC classification number: C07D413/12 , A61K31/4412 , C07D205/04 , C07D211/60 , C07D211/78 , C07D213/38 , C07D213/64 , C07D213/74 , C07D217/06 , C07D217/22 , C07D237/20 , C07D239/26 , C07D239/34 , C07D239/42 , C07D239/48 , C07D241/20 , C07D267/10 , C07D277/42 , C07D277/46 , C07D277/56 , C07D295/06 , C07D295/08 , C07D295/18 , C07D295/192 , C07D295/20 , C07D309/08 , C07D309/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14

Abstract: [Problem]The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases.[Means for Solution]The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that the compound or a salt thereof of the present invention exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. In addition, the present invention relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound or a salt thereof of the present invention, and an excipient.

Abstract translation: [问题]本发明提供了作为药物组合物的活性成分，特别是用于预防和/或治疗VAP-1相关疾病的药物组合物有用的化合物。 [解决方案]本发明人对具有VAP-1抑制活性的化合物进行了深入研究，结果发现本发明的化合物或其盐表现出优异的VAP-1抑制活性并且可用于预防和/或治疗VAP-1相关疾病，特别是糖尿病性肾病或糖尿病性黄斑水肿，从而完成本发明。此外，本发明涉及包含本发明的化合物或其盐和赋形剂的药物组合物，特别是用于预防和/或治疗VAP-1相关疾病的药物组合物。

92.

发明授权
Cyclic protein tyrosine kinase inhibitors 有权
Title translation: 循环蛋白酪氨酸激酶抑制剂

公开(公告)号：US08716323B2

公开(公告)日：2014-05-06

申请号：US11271626

申请日：2005-11-10

Applicant: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak

Inventor： Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak

IPC: A61K31/426 , C07D277/18

CPC classification number: C07D277/56 , C07C233/65 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113

Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

Abstract translation: 新的环状化合物及其盐，含有这些化合物的药物组合物，以及使用这些化合物治疗蛋白质酪氨酸激酶相关疾病如免疫学和肿瘤学疾病的方法。

93.

发明授权
Amide derivatives, process for preparation thereof and use thereof as insecticide 有权
Title translation: 酰胺衍生物，其制备方法和用作杀虫剂

公开(公告)号：US08710234B2

公开(公告)日：2014-04-29

申请号：US14033005

申请日：2013-09-20

Applicant: Mitsui Chemicals, Inc.

Inventor： Kei Yoshida , Takeo Wakita , Hiroyuki Katsuta , Akiyoshi Kai , Yutaka Chiba , Kiyoshi Takahashi , Hiroko Kato , Nobuyuki Kawahara , Michikazu Nomura , Hidenori Daido , Junji Maki , Shinichi Banba

IPC: C07D213/04 , A01N43/40

CPC classification number: C07D333/38 , A01N37/22 , A01N37/44 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/16 , A01N43/30 , A01N43/40 , A01N43/42 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/78 , A01N43/80 , C07C237/42 , C07C237/48 , C07C317/40 , C07C323/42 , C07C327/48 , C07D207/34 , C07D207/416 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/52 , C07D231/14 , C07D231/16 , C07D239/28 , C07D239/30 , C07D241/24 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D307/24 , C07D307/68 , C07D307/84 , C07D307/85 , C07D309/08 , C07D309/28 , C07D317/46 , C07D317/62 , C07D333/68

Abstract: A compound represented by Formula (1): The compound can be used as insecticides.

Abstract translation: 由式（1）表示的化合物：该化合物可以用作杀虫剂。

94.

发明授权
Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same 有权
Title translation: 化合物，其异构体或其药学上可接受的盐作为香草素受体拮抗剂和含有它们的药物组合物

公开(公告)号：US08691855B2

公开(公告)日：2014-04-08

申请号：US13002289

申请日：2009-07-02

Applicant: Byoung Young Woo , Sun-Young Kim , Yeonjoon Kim , Song Seok Shin , Jin Kwan Kim , Ki-Wha Lee , Dong Hyun Kim , Kyung Min Lim , Joo-Hyun Moh , Yeon Su Jeong , Jin Kyu Choi , Hyun Ju Koh , Jeongho Lee , Hyuk Kim , Jeong Hoon Yoon , Funan Li , Jee-Suk Kim , Young-Ger Suh

Inventor： Byoung Young Woo , Sun-Young Kim , Yeonjoon Kim , Song Seok Shin , Jin Kwan Kim , Ki-Wha Lee , Dong Hyun Kim , Kyung Min Lim , Joo-Hyun Moh , Yeon Su Jeong , Jin Kyu Choi , Hyun Ju Koh , Jeongho Lee , Hyuk Kim , Jeong Hoon Yoon , Funan Li , Jee-Suk Kim , Young-Ger Suh

IPC: C07D263/42 , C07D263/38 , C07D307/52 , C07D277/42

CPC classification number: C07D263/42 , C07D263/34 , C07D263/38 , C07D263/48 , C07D277/42 , C07D277/56 , C07D307/52 , C07D307/68 , C07D333/38 , C07D413/04 , C07D413/12

Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Abstract translation: 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激，眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。

95.

发明申请
2-(3-AMINOARYL) AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITIORS 审中-公开
Title translation: 2-（3-氨基）氨基-4-芳基 - 噻唑并作为C-CIT抑制剂使用

公开(公告)号：US20140088108A1

公开(公告)日：2014-03-27

申请号：US14089946

申请日：2013-11-26

Applicant: AB SCIENCE

Inventor： Marco CIUFOLINI , Camille WERMUTH , Bruno GIETHLEN , Alain MOUSSY

IPC: C07D417/04

CPC classification number: C07D417/04 , C07D277/42 , C07D277/56 , C07D417/14

Abstract: Novel compounds selected from 2-(3-aminoaryl) amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors.

Abstract translation: 选自式（I）的2-（3-氨基芳基）氨基-4-芳基 - 噻唑的新型化合物，其选择性调节，调节和/或抑制由某种天然和/或突变体酪氨酸激酶介导的信号转导，人类和动物疾病如细胞增殖代谢，过敏性和退行性疾病。更具体地说，这些化合物是有效和选择性的c-kit抑制剂。

96.

发明申请
PHENICOL ANTIBACTERIAL AGENTS 有权
Title translation: PHICICOL抗菌剂

公开(公告)号：US20140088046A1

公开(公告)日：2014-03-27

申请号：US14018993

申请日：2013-09-05

Applicant: Denis Billen , Michael Curtis , Richard Andrew Ewin , Richard M. Goodwin , Paul D. Johnson , Timothy Allan Johnson , Graham M. Kyne , Todd M. Maddux , Susan Mary Kult Sheehan , Rajendran Vairagoundar

Inventor： Denis Billen , Michael Curtis , Richard Andrew Ewin , Richard M. Goodwin , Paul D. Johnson , Timothy Allan Johnson , Graham M. Kyne , Todd M. Maddux , Susan Mary Kult Sheehan , Rajendran Vairagoundar

IPC: C07D213/40 , C07D261/08 , C07D409/04 , C07D213/64 , C07F9/6558 , C07F9/58 , C07D213/50 , C07D333/24 , C07D333/22 , C07D401/06 , C07D277/56 , C07D285/12 , C07D405/04 , C07D401/04

CPC classification number: C07D213/40 , C07D213/50 , C07D213/56 , C07D213/57 , C07D213/64 , C07D231/12 , C07D261/08 , C07D277/30 , C07D277/56 , C07D285/12 , C07D333/22 , C07D333/24 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D417/04 , C07F7/2208 , C07F9/58 , C07F9/65586

Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

Abstract translation: 本发明提供了新型酚酞衍生物，其用于治疗哺乳动物感染的药物组合物，含有这些新化合物的药物组合物，以及制备这些化合物的方法。

97.

发明授权
Sulfonylhydrazide compounds for treating proliferative disorders 失效
Title translation: 用于治疗增殖性疾病的磺酰肼化合物

公开(公告)号：US08680100B2

公开(公告)日：2014-03-25

申请号：US13132106

申请日：2009-12-01

Applicant: Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun

Inventor： Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun

IPC: A61K31/5375 , A61K31/4965 , A61K31/445 , A61K31/4409 , A61K31/426 , A61K31/421 , A61K31/402 , A61K31/381 , A61K31/357 , A61K31/341 , A61K31/27 , A61K31/16 , C07D295/215 , C07D241/28 , C07D211/98 , C07D213/78 , C07D277/56 , C07D263/34 , C07D207/12 , C07D333/68 , C07D317/46 , C07D307/68 , C07C333/12 , C07C327/18 , A61P35/00

CPC classification number: C07D295/195 , C07C327/56 , C07C333/12 , C07C335/40 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/04 , C07D211/72 , C07D213/86 , C07D213/87 , C07D241/24 , C07D277/56 , C07D295/155 , C07D307/68 , C07D317/68 , C07D333/38 , C07D333/68

Abstract: The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex of a deprotonated form of the compound. Pharmaceutical composition and method of use for these compounds are also included.

Abstract translation: 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐或过渡金属螯合物，其配位体或络合物或过渡金属螯合物，化合物去质子化形式的配位体或络合物。也包括这些化合物的药物组合物和使用方法。

98.

发明授权
Heterocyclic inhibitors of necroptosis 有权
Title translation: 人工神经节的杂环抑制剂

公开(公告)号：US08658689B2

公开(公告)日：2014-02-25

申请号：US13589867

申请日：2012-08-20

Applicant: Gregory D. Cuny , Xin Teng , Junying Yuan , Alexei Degterev , John A. Porco, Jr.

Inventor： Gregory D. Cuny , Xin Teng , Junying Yuan , Alexei Degterev , John A. Porco, Jr.

IPC: A61K31/40 , C07D207/36

CPC classification number: C07D417/12 , C07D207/34 , C07D231/14 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/68 , C07D307/84 , C07D333/38

Abstract: The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.

Abstract translation: 本发明具有抑制肿瘤坏死因子α（TNF-α）诱导的人工坏死的一系列杂环衍生物。本发明的杂环化合物由式（I）和（Ia） - （Ie）描述，并且显示出抑制人Jurkat T细胞的FADD缺陷型变体中的TNF-α诱导的人工死亡。本发明还涉及以本发明化合物为特征的药物组合物。本发明的化合物和组合物也可以用于治疗棘球菌根可能起重要作用的病症。