公开(公告)号：US20180313753A1

公开(公告)日：2018-11-01

申请号：US16013643

申请日：2018-06-20

申请人： BacterioScan LTD

发明人： Dana A. Marshall ,  Dan Vadim Regelman

IPC分类号： G01N21/51 ,  G01N21/03

CPC分类号： G01N21/51 ,  G01N21/0303 ,  G01N2021/513 ,  G01N2201/0231 ,  G01N2201/0415

摘要： An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.

公开(公告)号：US20180236452A1

公开(公告)日：2018-08-23

申请号：US15750971

申请日：2016-09-20

申请人： Malvern Instruments Limited

发明人： Jason CORBETT

IPC分类号： B01L9/06 ,  G01N15/02 ,  G01N21/03

CPC分类号： B01L9/06 ,  B01L2300/0654 ,  B01L2300/0858 ,  G01N15/0211 ,  G01N21/03 ,  G01N21/51 ,  G01N2015/0053 ,  G01N2015/0222 ,  G01N2021/0367 ,  G01N2021/4792 ,  G01N2021/513

摘要： A cuvette carrier comprising: a plurality of walls defining a holding volume for a cuvette; a first and second transmissive region included in the plurality of walls; and a first optical polariser arranged to polarise light passing through the first transmissive region.

公开(公告)号：US09829525B2

公开(公告)日：2017-11-28

申请号：US14126673

申请日：2012-06-13

申请人： Jason Corbett ,  Fraser McNeil-Watson ,  Robert Jack

发明人： Jason Corbett ,  Fraser McNeil-Watson ,  Robert Jack

IPC分类号： G01N27/416 ,  G01N27/42 ,  G01R29/24 ,  G01N21/51

CPC分类号： G01R29/24 ,  G01N15/00 ,  G01N21/51 ,  G01N27/447 ,  G01N2021/513

摘要： The invention relates to methods and apparatus for determining properties of a surface. Embodiments disclosed include an apparatus for measuring a surface charge of a sample, comprising: a sample holder having an opposed pair of electrodes and configured to hold a sample in position in a measurement volume between the electrodes such that a planar surface of the sample is aligned orthogonal to the electrode surfaces; a measurement chamber for containing a measurement liquid and having an open end configured to receive the sample holder to position the electrodes in a preset orientation; a laser light source positioned and configured to direct a laser beam through the measurement chamber between the electrodes and parallel to the planar surface of the sample when the sample holder is received in the measurement chamber; and a detector positioned and configured to detect scattered light from the measurement volume, wherein the apparatus is configured to allow for detection of the scattered light by the detector over a range of distances from the surface of the sample.

公开(公告)号：US09682375B2

公开(公告)日：2017-06-20

申请号：US15198287

申请日：2016-06-30

申请人： Pixcell Medical Technologies Ltd.

发明人： Avishay Bransky ,  Liron Shlomo

IPC分类号： G01N33/52 ,  B01L3/00 ,  G01N35/00 ,  G01N21/05 ,  G01N21/51 ,  G01N33/53 ,  G01N35/04

CPC分类号： B01L3/50273 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0684 ,  B01L2300/0609 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0493 ,  G01N21/05 ,  G01N21/51 ,  G01N33/521 ,  G01N33/5302 ,  G01N35/00029 ,  G01N35/04 ,  G01N2021/058 ,  G01N2021/513 ,  G01N2035/00039

摘要： A fluid analysis system may include a stage configured to receive a sample holder including a fluid sample to be analyzed. The fluid analysis system may also include a fluid analyzer configured to monitor at least one characteristic of the fluid sample to be analyzed; and an inclined rail; wherein the stage is configured to move along the inclined rail to cause the sample holder to move with a first component of motion along an analysis axis of the fluid analyzer and simultaneously with a second component of motion orthogonal to the analysis axis of the fluid analyzer, wherein the first component of motion affects a focus of the fluid analyzer relative to at least one constituent of the fluid sample to be analyzed.

公开(公告)号：US20170122860A1

公开(公告)日：2017-05-04

申请号：US15293180

申请日：2016-10-13

申请人： MANTA Instruments, Inc.

发明人： Jan J. Tatarkiewicz ,  Monette Karr

IPC分类号： G01N15/14 ,  G01N13/00 ,  G01N21/51

CPC分类号： G01N15/1463 ,  G01N13/00 ,  G01N15/0205 ,  G01N21/51 ,  G01N2015/0038 ,  G01N2015/0053 ,  G01N2015/0092 ,  G01N2015/0277 ,  G01N2021/513 ,  G01N2201/061 ,  G01N2201/12

摘要： A system for determining the growth/dissolution rate of colloidal particles is disclosed and includes multiple light sources and multiple sensors. A light source is constructed to emit a beam of electromagnetic radiation at a specimen chamber that holds the colloidal particles. The chamber allows a portion of the combined beam to scatter perpendicularly or at some other angle to the combined beam. The scattered portion of the beam is directed to a sensor that detects electromagnetic radiation. The sensor is connected to processor that activates the light source and obtains an image from the sensor. Multiple images are taken at a time interval and for each image taken, and a total image intensity level is calculated and normalized. A formula is then calculated that fits the normalized values over time and a slope is determined from the formula.

公开(公告)号：US09494525B2

公开(公告)日：2016-11-15

申请号：US14646150

申请日：2013-11-05

申请人： Hitachi High-Technologies Corporation

发明人： Shinji Tarumi ,  Chie Yabutani ,  Akihisa Makino ,  Chihiro Manri ,  Satoshi Mitsuyama

IPC分类号： G06F19/00 ,  G01N33/86 ,  G01N33/49 ,  G01N21/17 ,  G01N35/00 ,  G01N21/27 ,  G01N21/82 ,  G01N33/53 ,  G01N21/25 ,  G01N21/51 ,  G01N21/59 ,  G01N30/86 ,  G01N35/04

CPC分类号： G01N21/82 ,  G01N21/17 ,  G01N21/25 ,  G01N21/27 ,  G01N21/272 ,  G01N30/8693 ,  G01N33/49 ,  G01N33/4905 ,  G01N33/53 ,  G01N33/86 ,  G01N35/00 ,  G01N35/00584 ,  G01N2021/513 ,  G01N2021/5961 ,  G01N2035/00425 ,  G01N2035/00702 ,  G01N2035/0097 ,  G01N2035/0453 ,  G06F19/00 ,  G06F19/321

摘要： Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2).

摘要翻译： 提供了能够通过精确地检测和去除噪声来分析凝血反应的高精度的血液凝固反应的技术，而不管光强数据中产生噪声的位置如何。 该自动分析仪用近似曲线近似发射到样品上的光的透射光强度或散射光强度的时间序列数据，并且在该过程中，去除偏离近似曲线的异常数据点（参见图2） 。

公开(公告)号：US20160327468A1

公开(公告)日：2016-11-10

申请号：US14992757

申请日：2016-01-11

申请人： ATHEROTECH, INC.

发明人： Krishnaji R. KULKARNI

IPC分类号： G01N15/06

CPC分类号： G01N15/06 ,  G01N21/51 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/513 ,  G01N2201/12

摘要： Although a more accurate estimate of a person's risk of cardiovascular disease can be made on the basis of the number of lipoprotein particles per unit volume in the person's blood, current methods all rely on measuring the mass of lipoprotein cholesterol per unit volume. It has been discovered that a rapid and accurate lipoprotein particle count can be obtained by photometry. A method and apparatus are provided for measuring the number of lipoprotein particles in a sample using photometry.

公开(公告)号：US09400247B2

公开(公告)日：2016-07-26

申请号：US14379356

申请日：2013-02-12

申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION

发明人： Kotaro Yamashita ,  Masahiko Iijima

IPC分类号： G01N21/03 ,  G01N21/11 ,  G01N21/15 ,  G01N21/17 ,  G01N21/31 ,  G01N21/51 ,  G01N21/82 ,  G01N35/00 ,  G01N21/55 ,  G01N21/25 ,  G01N21/27 ,  G01N21/78 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493

CPC分类号： G01N21/55 ,  G01N21/253 ,  G01N21/274 ,  G01N21/51 ,  G01N21/78 ,  G01N21/82 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N35/00 ,  G01N35/00623 ,  G01N2021/0325 ,  G01N2021/0389 ,  G01N2021/3129 ,  G01N2021/513 ,  G01N2021/825 ,  G01N2035/009 ,  G01N2201/0415

摘要： An automatic analyzer has a multi-wavelength light source that irradiates a reaction cuvette containing a liquid mixture of a sample to be analyzed and a reagent. A transmitted-light quantity detector detects the amount of light transmitted through the reaction cuvette and internal contents of the reaction cuvette. A single-wavelength light source irradiates the reaction cuvette with single-wavelength light; and a transmitted-light quantity detector detects the amount of single-wavelength light scattered from the reaction cuvette. A memory stores the results of the transmitted-light quantity detection and the scattered-light quantity detection; and the deterioration states of the single-wavelength light source, multi-wavelength light source, and reaction cuvette are determined in accordance with measurement results of cell blank measurements conducted on the reaction cuvette where a predetermined reference solution is stored to detect the amount of light transmitted through and the amount of light scattered from.

摘要翻译： 自动分析仪具有多波长光源，其照射含有待分析样品和试剂的液体混合物的反应池。 透射光量检测器检测透射通过反应池的光量和反应池的内部物质。 单波长光源用单波长光照射反应池; 并且透射光量检测器检测从反应容器散射的单波长光的量。 存储器存储透射光量检测和散射光量检测的结果; 并且根据在存储预定参考溶液的反应池中进行的细胞空白测量的测量结果来确定单波长光源，多波长光源和反应池的劣化状态，以检测光量 透过光散射的光量。

公开(公告)号：US09341564B2

公开(公告)日：2016-05-17

申请号：US13123518

申请日：2009-10-09

申请人： Fraser McNeil-Watson

发明人： Fraser McNeil-Watson

IPC分类号： G01N27/453 ,  G01N21/25 ,  B01L3/00 ,  G01N21/51 ,  G01N27/447 ,  G01N21/03 ,  G01N15/14 ,  G01N21/47

CPC分类号： G01N21/253 ,  B01L3/5025 ,  B01L2300/0829 ,  B01L2400/0421 ,  G01N21/03 ,  G01N21/51 ,  G01N27/44721 ,  G01N2015/1493 ,  G01N2021/0346 ,  G01N2021/4707 ,  G01N2021/513 ,  G01N2201/103 ,  G01N2201/105

摘要： A high-throughput optical suspension characterization instrument is disclosed, which can include hydraulically separate and at least partially transparent sample containers. A selection mechanism is operative to selectively direct light from a light source (12) through different ones of the sample containers along an optical axis, and an off-axis scattering detector (38,24) is responsive to scattered light from the light source after it has interacted with a sample. Phase analysis light scattering is used to determine the electrophoretic mobility and zeta potential of samples. A second instrument is disclosed, wherein all sample containers are illuminated simultaneously. Transmitted light is collected by a camera. The electrophoretic mobility and hydrodynamic size of the samples may be determined.

摘要翻译： 公开了一种高通量光学悬浮表征仪器，其可以包括液压分离和至少部分透明的样品容器。 选择机构可操作以沿着光轴选择性地将来自光源（12）的光引导通过不同的样本容器，并且离轴散射检测器（38,24）响应于来自光源的散射光， 它已经与样本进行了互动。 相位分析光散射用于确定样品的电泳迁移率和ζ电位。 公开了第二种仪器，其中所有的样品容器都是同时照射的。 透射光被照相机收集。 可以确定样品的电泳迁移率和流体动力学尺寸。

公开(公告)号：US20160109365A1

公开(公告)日：2016-04-21

申请号：US14890428

申请日：2013-05-13

申请人： HACH LANGE GMBH

发明人： BARBARA HAASE ,  MANFRED BATTEFELD ,  ANDREAS MITREITER ,  MICHAEL KUSSMANN ,  BAS DE HEIJ ,  CLEMENS HANSCHKE ,  WAYNE PERDUE

IPC分类号： G01N21/51

CPC分类号： G01N21/51 ,  G01N21/53 ,  G01N2021/513 ,  G01N2201/0633 ,  G01N2201/0636

摘要： A turbidimeter for measuring a turbidity of a liquid sample in a sample cuvette includes a cuvette receiving device configured to position the sample cuvette in a defined cuvette position, a light source configured to generate a parallel light beam in the sample cuvette, an annular 45° collecting mirror configured to surround the sample cuvette, a scattering body arranged concentric to the annular 45° collecting minor, a scattering light detector arranged to receive light scattered by the scattering body, and an annular 45° concentration minor arranged coaxially to the annular 45° collecting minor and optically opposite to the annular 45° collecting mirror. The annular 45° collecting minor is arranged concentric to the light beam. The annular 45° concentration minor is configured to surround the scattering body.

摘要翻译： 用于测量样品比色皿中的液体样品的浊度的浊度计包括配置成将样品比色皿定位在规定的比色杯位置的比色皿接收装置，被配置为在样品比色皿中产生平行光束的光源，环形45° 收集反射镜，被配置为围绕样品比色皿，散射体，其与环形45°收集小体同心地布置;散射光检测器，被布置成接收由散射体散射的光;以及环形45°浓度， 收集较小的并且与环形45°收集镜的光学相对。 环形45°收集小号与光束同心设置。 环形45°浓度次要构造成围绕散射体。