公开(公告)号：US07364543B2

公开(公告)日：2008-04-29

申请号：US11535427

申请日：2006-09-26

申请人： Changhuei Yang ,  Jigang Wu

发明人： Changhuei Yang ,  Jigang Wu

IPC分类号： A61B1/07 ,  G01J3/45

CPC分类号： A61B5/6852 ,  A61B1/00096 ,  A61B1/00172 ,  A61B5/0062 ,  A61B5/0066

摘要： Probes, and systems and methods for optically scanning a conical volume in front of a probe, for use with an imaging modality, such as Optical Coherence Tomography (OCT). A probe includes an optical fiber having a proximal end and a distal end and defining an axis, with the proximal end of the optical fiber being proximate a light source, and the distal end having a first angled surface. A refractive lens element is positioned proximate the distal end of the optical fiber. The lens element and the fiber end are both configured to separately rotate about the axis so as to image a conical scan volume when light is provided by the source. Reflected light from a sample under investigation is collected by the fiber and analyzed by an imaging system. Such probes may be very compact, e.g., having a diameter 1 mm or less, and are advantageous for use in minimally invasive surgical procedures. A fluid medium can be introduced between two lens elements at the distal end of the probe to switch a mode from side viewing to forward viewing.

摘要翻译： 探针，以及用于光学扫描探针前面的锥形体积的系统和方法，用于成像模态，例如光学相干断层扫描（OCT）。 探针包括具有近端和远端并限定轴线的光纤，光纤的近端靠近光源，并且远端具有第一倾斜表面。 折射透镜元件靠近光纤的远端定位。 透镜元件和光纤端都被构造为围绕轴线分开旋转，以便在由光源提供光时对圆锥扫描体积进行成像。 被研究样品的反射光由纤维收集并通过成像系统进行分析。 这种探针可以非常紧凑，例如具有1mm或更小的直径，并且有利于用于微创外科手术。 可以在探针的远端的两个透镜元件之间引入流体介质以将模式从侧视图切换到向前观察。

公开(公告)号：US20080002209A1

公开(公告)日：2008-01-03

申请号：US11770553

申请日：2007-06-28

申请人： Zahid Yaqoob ,  Jigang Wu ,  Marinko Venci Sarunic ,  Changhuei Yang

发明人： Zahid Yaqoob ,  Jigang Wu ,  Marinko Venci Sarunic ,  Changhuei Yang

IPC分类号： G01B9/02

CPC分类号： G01B9/0201 ,  G01B9/02004 ,  G01B9/02081 ,  G01B9/0209 ,  G01B2290/30 ,  G01B2290/45

摘要： A method and device realize shallow gratings-based planar beam splitter/combiner. Non-trivial phase shifts between different ports of resulting interferometers are used to acquire full-field phase measurements. The non-trivial phase shifts between different ports of the planar beam splitter/combiner can be adjusted by simply shearing one grating with respect to the second grating. The two shallow diffraction gratings are harmonically-related and can be recorded on a single substrate for compact interferometric based schemes. During the recording process, the two gratings are aligned such that the grating planes and the grating vectors are parallel to that of each other. The relative phase of the recording beams controls the shearing between the recorded harmonically-related shallow phase gratings. The relative shearing of the two gratings defines the non-trivial phase shift between different ports of the compact planar beam splitter/combiner.

摘要翻译： 一种方法和装置实现了基于光栅的平面光束分离器/组合器。 所得干涉仪的不同端口之间的非平凡相移用于获取全场相位测量。 平面分束器/组合器的不同端口之间的非平凡相移可以通过相对于第二光栅简单地剪切一个光栅来调节。 两个浅衍射光栅是谐波相关的，并且可以记录在单个基板上，用于紧凑的基于干涉的方案。 在记录过程中，两个光栅对齐，使得光栅平面和光栅矢量彼此平行。 记录光束的相对相位控制记录的谐波相关浅相位光栅之间的剪切。 两个光栅的相对剪切定义了紧凑型平面分束器/组合器的不同端口之间的非平凡相移。

公开(公告)号：US20120267515A1

公开(公告)日：2012-10-25

申请号：US13451543

申请日：2012-04-20

申请人： Jigang Wu ,  Shuo Pang ,  Zheng Li ,  Guoan Zheng ,  Changhuei Yang

发明人： Jigang Wu ,  Shuo Pang ,  Zheng Li ,  Guoan Zheng ,  Changhuei Yang

IPC分类号： G01J1/04 ,  G02B5/18 ,  G01J1/44

CPC分类号： G02B21/086 ,  G02B21/0044 ,  G02B21/244 ,  G02B21/361 ,  G02B27/4227

摘要： A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate san array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.

摘要翻译： 一种用于焦平面调谐的Talbot照明成像系统，该装置包括Talbot元件，可调谐照明源，扫描机构，光检测器和处理器。 该元素在聚焦平面上产生聚焦光斑的圣阵列。 可调谐照明源通过调节入射到Talbot元件的光的波长将焦平面移动到感兴趣的平面。 扫描机构沿着扫描方向的聚焦光点阵列扫描物体。 光检测器确定随着对象扫描光点阵列而与聚焦光点阵列相关联的时变光数据。 处理器基于时变数据构建对象的图像。

公开(公告)号：US20120061587A1

公开(公告)日：2012-03-15

申请号：US13228448

申请日：2011-09-09

申请人： Jigang Wu ,  Shuo Pang ,  Changhuei Yang

发明人： Jigang Wu ,  Shuo Pang ,  Changhuei Yang

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G01N15/1427

摘要： Embodiments of the present invention relate to a delayed emission detection device comprising a time-gated illumination source configured to provide excitation light to fluorophore during an excitation period and a light detector configured to receive emissions released from the fluorophore during a collection period after the excitation period.

摘要翻译： 本发明的实施例涉及延迟发射检测装置，其包括时间门控照明源，其被配置为在激发周期期间向荧光团提供激发光;以及光检测器，被配置为在激发周期之后的收集期间接收从荧光团释放的排放 。

公开(公告)号：US09041938B2

公开(公告)日：2015-05-26

申请号：US13344550

申请日：2012-01-05

申请人： Guoan Zheng ,  Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer

发明人： Guoan Zheng ,  Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer

IPC分类号： G01B9/02 ,  G02B6/122 ,  B82Y20/00 ,  G01N21/552 ,  G02B5/00 ,  G02B21/00 ,  G02B21/14 ,  G02B27/52

CPC分类号： G02B6/1226 ,  B82Y20/00 ,  G01N21/554 ,  G02B5/008 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0056 ,  G02B21/0068 ,  G02B21/14 ,  G02B27/52

摘要： A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical transfer function at the aperture by inducing a surface wave for interfering with transmission of light of a range of spatial frequency.

摘要翻译： 表面波辅助系统，具有具有表面和孔径的孔层，以及围绕孔的多个凹槽。 多个槽被配置为通过诱导表面波来干扰空间频率范围的光的透射来在孔处产生光学传递函数。

公开(公告)号：US08633432B2

公开(公告)日：2014-01-21

申请号：US12886779

申请日：2010-09-21

申请人： Shuo Pang ,  Changhuei Yang

发明人： Shuo Pang ,  Changhuei Yang

IPC分类号： H01J3/14 ,  G01J3/50 ,  G01N15/06

CPC分类号： G01B9/04 ,  G02B5/10 ,  G02B17/002 ,  G02B19/0028 ,  G02B19/0076 ,  G02B21/0076 ,  G02B21/16 ,  G02B27/40

摘要： Embodiments of the present invention relate to a reflective focusing and transmissive projection device having a body, a set of reflective-focusing components and a light detector. The body has a surface layer with first and second surfaces, and a detecting layer outside the second surface. The set of reflective-focusing components is in the surface layer. Each reflective-focusing component has a contouring element and a curved reflective element conformed to the contouring element. The curved reflective element is configured to reflect light of a first type, transmit light of a second type and focus the light of the first type outside the first surface of the surface layer. The light detector is in the detecting layer, and is configured to receive light and generate light data associated with the received light. Also, the contouring element can be configured to focus the light of the second type on the light detector.

摘要翻译： 本发明的实施例涉及一种具有主体，一组反射聚焦部件和光检测器的反射聚焦和透射投影装置。 主体具有第一表面和第二表面的表面层，以及位于第二表面外部的检测层。 该组反射聚焦组件位于表面层。 每个反射聚焦部件具有轮廓元件和符合轮廓元件的弯曲反射元件。 弯曲反射元件被配置为反射第一类型的光，透射第二类型的光并将第一类型的光聚焦在表面层的第一表面之外。 光检测器在检测层中，并且被配置为接收光并产生与所接收的光相关联的光数据。 此外，轮廓元件可以被配置为将第二类型的光聚焦在光检测器上。

公开(公告)号：US08334982B2

公开(公告)日：2012-12-18

申请号：US12494605

申请日：2009-06-30

申请人： Christopher Fang-Yen ,  Gabriel Popescu ,  Changhuei Yang ,  Adam Wax ,  Ramachandra Dasari ,  Michael Feld

发明人： Christopher Fang-Yen ,  Gabriel Popescu ,  Changhuei Yang ,  Adam Wax ,  Ramachandra Dasari ,  Michael Feld

IPC分类号： G01B11/02

CPC分类号： G01B9/02091 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7232 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02011 ,  G01B9/02057 ,  G01B9/02063 ,  G01B9/02067 ,  G01B9/02069 ,  G01B9/02071 ,  G01B9/02072 ,  G01B9/02078 ,  G01B9/02083 ,  G01B9/0209 ,  G01B2290/45 ,  G01B2290/60 ,  G01B2290/70 ,  G01J9/04 ,  G01N21/45

摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.

摘要翻译： 本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。 实施例涉及用于用光成像小生物物体的光学装置。 这些实施方案可以应用于例如细胞生理学和神经科学领域。 这些优选实施例基于相位测量和成像技术的原理。 使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。 亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。 相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。 因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。 这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生 在本发明的系统中。

公开(公告)号：US08314933B2

公开(公告)日：2012-11-20

申请号：US12398050

申请日：2009-03-04

申请人： Xiquan Cui ,  Xin Heng ,  Lap Man Lee ,  Changhuei Yang

发明人： Xiquan Cui ,  Xin Heng ,  Lap Man Lee ,  Changhuei Yang

IPC分类号： G01N21/00

CPC分类号： G01N21/53 ,  G01N21/6458

摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.

摘要翻译： 本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。 可以使用的一种技术消除了覆盖光检测器层的孔径层。 其他技术保留孔径层，反转光源和光检测器的相对位置，使得光在通过流体通道之前通过孔层，到达光检测器。 另一种技术增加了用于控制移动通过流体通道的物体运动的光学镊子。 另一种技术增加了光纤束，以将来自光透射区域的光中继到远程光检测器。 另一种技术在流体通道的端部添加两个电极，以产生能够通过流体通道移动物体同时抑制旋转的电场。 这些技术可以单独使用或组合使用以提高OFM设备的能力。

公开(公告)号：US20120223217A1

公开(公告)日：2012-09-06

申请号：US13411302

申请日：2012-03-02

申请人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang

发明人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Shuo Pang ,  Changhuei Yang

IPC分类号： G01J1/02

CPC分类号： B01L3/508 ,  B01L3/502792 ,  B01L2300/0654 ,  C12M23/10 ,  G01N21/03 ,  G01N21/25 ,  G01N21/272 ,  G01N2201/10 ,  G02B21/0008 ,  G02B21/06 ,  G02B21/367 ,  G03H1/0443 ,  G03H1/0465 ,  G03H2001/0447 ,  G03H2222/34 ,  G03H2240/56

摘要： An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.

摘要翻译： 一种电子培养皿，包括具有样本表面的透明层和被配置为对位于样本表面上的样本的亚像素偏移的投影图像的序列进行采样的光检测器。 子像素偏移与由照明源提供的多个照明角度的光相关联的投影图像。

公开(公告)号：US20120070817A1

公开(公告)日：2012-03-22

申请号：US13237796

申请日：2011-09-20

申请人： Ying Min Wang ,  Changhuei Yang

发明人： Ying Min Wang ,  Changhuei Yang

IPC分类号： C12Q3/00 ,  C12M1/42

CPC分类号： A61B5/0059 ,  G01N21/1717 ,  G01N21/47 ,  G01N21/49 ,  G01N21/65 ,  G01N2021/1727 ,  G01N2021/4709

摘要： A method, apparatus, and article of manufacture for irradiating one or more targets within a sample with electromagnetic (EM) radiation. One or more targets within the sample are controllably defined with an acoustic field. The sample is irradiated with input EM radiation having an input wavefront. An amount of frequency shifted EM radiation is detected, wherein at least some of the input EM radiation that passes through the acoustic field at the targets is shifted in frequency to form the frequency shifted EM radiation. The input wavefront is modified, using feedback comprising the amount of the frequency shifted EM radiation that is detected, into a modified wavefront. The sample is irradiated using the input EM radiation comprising the modified wavefront, and the process is repeated as desired.

摘要翻译： 一种用于用电磁（EM）辐射照射样品内的一个或多个靶的方法，装置和制品。 样本内的一个或多个目标是可控地用声场定义的。 用具有输入波前的输入EM辐射照射样品。 检测到一定量的频移EM辐射，其中穿过目标处的声场的输入EM辐射中的至少一些频率偏移以形成频移的EM辐射。 输入波前被修改，使用包括被检测的频移EM辐射的量的反馈到修改的波前。 使用包括经修改的波前的输入EM辐射照射样品，并根据需要重复该过程。