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    Chromatography apparatus and method
    241.
    发明授权
    Chromatography apparatus and method 有权
    色谱仪和方法

    公开(公告)号：US09594007B2

    公开(公告)日：2017-03-14

    申请号：US14309051

    申请日：2014-06-19

    Applicant: EMD Millipore Corporation

    Inventor： Chris Scott ,  Rob Colonna ,  Christopher Barmore ,  Todd Taylor ,  Daniel Morgan

    IPC: G01N1/28 ,  G01N1/40 ,  G01N30/14 ,  B01J20/281 ,  B01D61/18 ,  B01L3/00

    CPC classification number: G01N1/28 ,  B01D61/18 ,  B01J20/281 ,  B01L3/50255 ,  G01N1/4077 ,  G01N30/14 ,  G01N2030/146

    Abstract: Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator. The tray can be disposed in a vacuum chamber defined by the lid and the body, and one or more sample containers can be disposed in the tray. When properly positioned in the tray in the vacuum chamber, each container is in fluid communication with a single respective filter assembly disposed in sealing relation in a respective aperture in the lid. A single actuation of a valve to place the vacuum chamber under vacuum causes the lid to seal to the base and drives the simultaneous filtration of a plurality of samples.

    Abstract translation: 用于以密封关系接收一个或多个过滤器组件和一个或多个样品容器的样品制备装置，每个容器唯一地定位在装置内以从指定的过滤器接收经过滤的样品。 该装置包括主体，设置在主体上的盖，容器托盘，基座，主体上的集成密封件，阀和阀致动器。 托盘可以设置在由盖和主体限定的真空室中，并且一个或多个样品容器可以设置在托盘中。 当适当地定位在真空室中的托盘中时，每个容器与在盖中的相应孔中以密封关系设置的单个相应的过滤器组件流体连通。 将真空室置于真空下的阀的单次致动导致盖子密封到基座并驱动多个样品的同时过滤。

    Device for filtration with a set of least one filter cassette
    242.
    发明授权
    Device for filtration with a set of least one filter cassette 有权
    用于过滤的装置，具有至少一个过滤器盒

    公开(公告)号：US09592577B2

    公开(公告)日：2017-03-14

    申请号：US14311395

    申请日：2014-06-23

    Applicant: EMD Millipore Corporation

    Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

    IPC: B01D25/12 ,  B01D25/127 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B23P19/04

    CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

    Abstract: The invention concerns a filtration device comprising a providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

    Abstract translation: 本发明涉及一种过滤装置，包括提供流体连接和机械连接，其包括可相对于歧管可移动地安装的夹板，并且适于将至少一个盒体压靠在歧管上，用于驱动和引导夹板的装置， 歧管和板，致动器，其设置有主体和可相对于主体移动的构件，该构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由歧管承载，并且构件 承载杆并经由杆驱动板到夹紧位置，在夹紧位置中，构件处于中间缩回位置，在夹紧位置中，其已经相对于其延伸位置移动经过比预定行程更短的行程。

    Rigid disposable flow path
    245.
    发明授权
    Rigid disposable flow path 有权
    刚性一次性流路

    公开(公告)号：US09494259B2

    公开(公告)日：2016-11-15

    申请号：US14074815

    申请日：2013-11-08

    Applicant: EMD Millipore Corporation

    Inventor： Martin Morrissey ,  Neil Schauer

    IPC: F16L9/127 ,  F16L9/00 ,  F16L9/133 ,  F16L9/22 ,  B01L3/00 ,  B01J19/00

    CPC classification number: F16L9/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00808 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00968 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/561 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0887 ,  F16L9/127 ,  F16L9/133 ,  F16L9/22 ,  Y10T137/87153

    Abstract: A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.

    Abstract translation: 一次性流路，其具有为一次性装置提供耐压性的歧管系统。 一次性装置包括第一刚性塑料片和第二刚性塑料片。 每片具有两个主表面和它们之间的厚度。 至少一个片材表面上形成有流动通道。 流动通道远离第一主表面并超过板的第二主表面的法线平面。 片材在相邻的第一主要表面彼此液体密封。 当每个纸张包含流动通道时，流动通道对齐并彼此对准。 一个或多个配件可以固定在两个液密封片的边缘处的流动通道中。 或者，在片彼此固定之前，将管道放置在通道中。

    Holding needle comprising gripping cheeks
    247.
    发明授权
    Holding needle comprising gripping cheeks 有权
    保持针包括抓握的脸颊

    公开(公告)号：US09475157B2

    公开(公告)日：2016-10-25

    申请号：US14162823

    申请日：2014-01-24

    Applicant: EMD Millipore Corporation

    Inventor： Stephane Olivier ,  Jerome Geyer ,  Gerard Muller

    IPC: B23P19/00 ,  B23P19/04 ,  A61M5/162 ,  A61M5/158 ,  A61B17/34 ,  A61M25/06

    CPC classification number: B23P19/04 ,  A61B17/3417 ,  A61B17/3421 ,  A61M5/158 ,  A61M5/162 ,  A61M25/06 ,  A61M25/065 ,  A61M2005/1623 ,  Y10T29/49826 ,  Y10T29/49892 ,  Y10T29/49895 ,  Y10T29/49897 ,  Y10T29/49899 ,  Y10T29/49947

    Abstract: A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle timber comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.

    Abstract translation: 起飞针包括具有适于执行插入操作的远端的中空喷枪，所述中空喷枪连接到至少一个设置有插口的管子，以将其连接到管，并且包括用于保持 空心枪和管相对于彼此，使得插口从保持体突出，所述针木由包括设置在每个凸缘和保持体之间的间隔件而保持在保持体的相应侧面并与保持体间隔开的两个凸缘， 凸缘从纵向方向延伸到中空喷枪的近端附近，每个凸缘的宽度大于保持体面对凸缘的部分的宽度。

    Stirred Cell And Method of Using Same
    249.
    发明申请
    Stirred Cell And Method of Using Same 审中-公开
    搅拌细胞和使用方法

    公开(公告)号：US20160228870A1

    公开(公告)日：2016-08-11

    申请号：US14994402

    申请日：2016-01-13

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: B01L3/00 ,  G01N1/40

    CPC classification number: G01N1/4005 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/085 ,  B01L2200/087 ,  B01L2300/042 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0681 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0633 ,  B01L2400/065

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

    Abstract translation: 流体容纳压力容器，其消除了存在于某些常规容器中的外部支撑壳体，并提供了改进的盖对体界面。 在某些实施例中，盖被螺纹并构造成与压力容器的主体螺纹接合，并且具有足够的结构完整性以承受装置中的压力而不需要支撑壳体。 在某些实施例中，提供了一种互锁机构，其在设备处于压力下时防止盖被打开（例如，从主体移除）。 在某些实施例中，泄压阀设置有预加载偏置机构以实现所需的压力释放速率。 该容器可用于样品制备，包括样品的纯化或浓缩，特别是蛋白质样品。

    Fluid Transfer Device
    250.
    发明申请
    Fluid Transfer Device 审中-公开

    公开(公告)号：US20160208927A1

    公开(公告)日：2016-07-21

    申请号：US15082495

    申请日：2016-03-28

    Applicant: EMD Millipore Corporation

    Inventor： Jeff Hartnett ,  Alf Lofving ,  Lars Hultquist ,  Jan Davidsson ,  Lennart Myhrberg

    IPC: F16K1/12 ,  F04B39/00

    CPC classification number: F16K1/12 ,  A61M39/22 ,  F04B39/0005 ,  F16K31/528 ,  Y10T137/0391 ,  Y10T137/8593 ,  Y10T137/85986

    Abstract: A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component. When the device is closed, the upstream end of the plunger is in alignment with the upstream flange of the body, forming a steamable sterilized in place face and a sterile barrier.

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