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    IMMOBILIZED ENZYMATIC REACTOR
    25.
    发明申请
    IMMOBILIZED ENZYMATIC REACTOR 审中-公开

    公开(公告)号：US20180171379A1

    公开(公告)日：2018-06-21

    申请号：US15884902

    申请日：2018-01-31

    Applicant: Waters Technologies Corporation

    Inventor： Joomi Ahn ,  Moon Chul Jung ,  Kevin D. Wyndham

    IPC: C12Q1/37 ,  C12Q1/48 ,  C12N11/06 ,  C12M1/40 ,  C12N11/14 ,  C12M1/34

    CPC classification number: C12Q1/37 ,  C12M21/18 ,  C12M41/40 ,  C12N11/06 ,  C12N11/14 ,  C12Q1/48

    Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

    DRIED SAMPLE CARRIER HAVING DISSOLVABLE SAMPLE REGIONS
    26.
    发明申请
    DRIED SAMPLE CARRIER HAVING DISSOLVABLE SAMPLE REGIONS 有权
    具有不可分割样品区域的干燥样品载体

    公开(公告)号：US20140373644A1

    公开(公告)日：2014-12-25

    申请号：US14375337

    申请日：2013-02-01

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Pamela C. Iraneta ,  Kevin D. Wyndham ,  Moon Chul Jung

    IPC: G01N1/00 ,  G01N1/28 ,  G01N1/10

    CPC classification number: G01N1/00 ,  B01L3/5025 ,  B01L3/5635 ,  B01L2300/069 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2400/0677 ,  G01N1/10 ,  G01N1/28 ,  G01N1/4055 ,  G01N33/49 ,  G01N2001/288 ,  G01N2001/4061 ,  G01N2035/00108

    Abstract: Described are sample carriers and methods of extracting a fluid sample from a dried sample on a sample carrier. The sample carrier has a first carrier portion that receives a fluid sample, and includes a material that adsorbs the fluid sample and dissolves upon application of a solvent. A second carrier portion is attached to the first carrier portion and includes a material that is indissolvable in the solvent. The first carrier portion having a dried sample is dissolved into a solution upon application of the solvent. The solution can be analyzed to determine constituents in the extracted sample. The sample carrier can conveniently be in the form of a card or a dipstick. In alternative embodiments, a carrier portion that includes the dried sample is indissolvable in the solvent but is released from another carrier portion through application of a solvent to an intervening dissolvable carrier portion.

    Abstract translation: 描述了样品载体和从样品载体上的干燥样品中提取流体样品的方法。 样品载体具有接收流体样品的第一载体部分，并且包括吸附流体样品并在施加溶剂时溶解的材料。 第二载体部分附接到第一载体部分并且包括在溶剂中不溶解的材料。 具有干燥样品的第一载体部分在施加溶剂时溶解于溶液中。 可以分析溶液以确定提取的样品中的成分。 样品载体可以方便地以卡片或量油尺的形式。 在替代实施例中，包括干燥样品的载体部分在溶剂中是可溶解的，但是通过将溶剂施加到中间可溶解载体部分而从另一个载体部分释放。

    Vial cap for a liquid chromatography sample vial
    28.
    发明授权
    Vial cap for a liquid chromatography sample vial 有权

    公开(公告)号：US11938482B2

    公开(公告)日：2024-03-26

    申请号：US17335373

    申请日：2021-06-01

    Applicant: Waters Technologies Corporation

    Inventor： Moon Chul Jung

    IPC: B01L3/00

    CPC classification number: B01L3/50825 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/0832

    Abstract: A vial cap for a sample vial includes a cylindrical cap body defining a first circular opening at a first end. The vial cap also includes a cap lid extending radially inward from a second end of the cylindrical cap body. The cap lid defines a second circular opening. The vial cap also includes a septum located within the cylindrical cap body and in contact with the cap lid. The septum spans the second circular opening defined by the cap lid portion. The vial cap also includes a number of flexible threads extending from an internal surface of the cylindrical cap body.

    Immobilized enzymatic reactor
    29.
    发明授权
    Immobilized enzymatic reactor 有权

    公开(公告)号：US11434517B2

    公开(公告)日：2022-09-06

    申请号：US16715764

    申请日：2019-12-16

    Applicant: Waters Technologies Corporation

    Inventor： Joomi Ahn ,  Moon Chul Jung ,  Kevin D. Wyndham

    IPC: C12Q1/37 ,  C12N11/06 ,  C12N11/14 ,  C12M1/40 ,  C12M1/34 ,  C12Q1/48

    Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

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