公开(公告)号：US09110068B2

公开(公告)日：2015-08-18

申请号：US14298148

申请日：2014-06-06

Applicant: STC.UNM

Inventor： Laurel Sillerud

IPC: G01N33/53 ,  G01N33/574 ,  G01N33/543 ,  A61M1/34

CPC classification number: G01N33/57438 ,  A61M1/3486 ,  G01N24/08 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54373 ,  G01N33/57488 ,  G01R33/281 ,  G01R33/302 ,  G01R33/448 ,  G01R33/465 ,  Y02A50/58

Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.

Abstract translation: 用于分析具有NMR信号的液体样品的系统和方法，所述液体具有响应于分析物存在的磁场。 包括具有适于容纳液体并对液体施加磁场的测试部分的NMR装置。 复合物由具有与分析物结合的场梯度的共轭物构成，其在测试部分中具有足够的量级以猝灭液体的NMR信号，由此通过不存在NMR信号来确定复合物的存在。 该系统和方法还包括其中具有粘合剂的容器，其对于用于从患者血液或血浆中除去外来试剂的分析物或外来物质具有亲和力。 血液或血浆通过容器分流，以通过体外循环除去或减少外来物质。

公开(公告)号：US09110067B2

公开(公告)日：2015-08-18

申请号：US14213301

申请日：2014-03-14

Applicant: STC.UNM

Inventor： Laurel Sillerud

IPC: G01N24/08 ,  G01N33/574 ,  G01N33/543 ,  G01R33/30

CPC classification number: G01N33/57438 ,  G01N24/08 ,  G01N33/54306 ,  G01N33/574 ,  G01R33/307

Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal.

Abstract translation: 用于分析具有NMR信号的液体样品的系统和方法，所述液体具有响应于分析物存在的磁场。 包括具有适于容纳液体并对液体施加磁场的测试部分的NMR装置。 复合物由具有与分析物结合的场梯度的共轭物构成，其在测试部分中具有足够的量级以猝灭液体的NMR信号，由此通过不存在NMR信号来确定复合物的存在。

公开(公告)号：US20150157747A1

公开(公告)日：2015-06-11

申请号：US14622217

申请日：2015-02-13

Applicant: STC.UNM

Inventor： Yubin Miao ,  Haixun Guo

IPC: A61K51/08 ,  A61K45/06 ,  C07K7/54

CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K45/06 ,  A61K51/08 ,  A61K51/086 ,  A61K51/088 ,  C07K7/54

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于成像癌症的新型非侵入性诊断工具/化合物，特别是黑素瘤，包括体内转移性黑素瘤。 本发明化合物在癌细胞和组织中表现出增强的摄取，并且减少了肾中的肾摄取，证明了本发明化合物的有利的药代动力学。 根据本发明的化合物代表使用非侵入性分子成像技术在黑色素瘤的诊断和治疗中的进展，包括转移性黑素瘤。 本发明的新型探针也可用于开始黑色素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US20150125898A1

公开(公告)日：2015-05-07

申请号：US14596926

申请日：2015-01-14

Applicant: STC.UNM

Inventor： Graham Timmins ,  Terry Wu ,  Seong Won Choi

IPC: C12Q1/04 ,  C07B59/00 ,  C07C275/16

CPC classification number: C12Q1/04 ,  C07B59/001 ,  C07B2200/05 ,  C07B2200/07 ,  C07C275/16 ,  C12Q2304/46 ,  C12Q2304/48

Abstract: The present invention is directed to the use of isotopically labeled citrulline for diagnosing the presence or absence of a bacterial infection in the lungs of a patient.

Abstract translation: 本发明涉及同位素标记的瓜氨酸用于诊断患者肺中细菌感染的存在或不存在的用途。

公开(公告)号：US20150080852A1

公开(公告)日：2015-03-19

申请号：US14544047

申请日：2014-11-19

Applicant: STC.UNM

Inventor： Mark Hauswald

IPC: A61M5/315 ,  A61M5/31

CPC classification number: A61M5/3158 ,  A61M5/141 ,  A61M5/14216 ,  A61M5/1424 ,  A61M5/3148 ,  A61M5/31535 ,  A61M2005/1405 ,  A61M2005/3115 ,  A61M2202/048

Abstract: A mechanical patient-controlled analgesia device for injecting medicine into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger. A mechanical biasing element is provided for exerting bias on the syringe plunger in a first syringe-filling direction to draw medicine from the IV reservoir into the syringe. An injection plunger is operable by the patient to move the syringe plunger in a second injection direction against the bias to inject the medicine in the syringe into a patient's IV. The injection plunger is movable independently of the syringe plunger and is engaged with but unconnected to the syringe plunger when the patient moves the injection plunger to inject the medicine. The patient can inject only a calibrated amount of medicine drawn into the syringe as determined by calibration of the biasing element and a metering element for a given viscosity of the medication.

Abstract translation: 用于将药物注射到患者IV中的机械患者控制的止痛装置包括连接到IV储液器并具有注射器柱塞的IV储液器和注射器。 提供了一种机械偏置元件，用于在第一注射器填充方向上在注射器柱塞上施加偏压，以将药物从IV储液器吸入注射器。 注射柱塞可由患者操作，以抵抗偏压在第二注射方向上移动注射器柱塞，以将注射器中的药物注入患者体内。 注射柱塞可以独立于针筒柱塞移动，并且当患者移动注射柱塞以注射药物时，注射柱塞可以与注射器柱塞接合但不连接。 患者可以仅注射被注入注射器中的校准量的药物，其通过偏置元件的校准和用于给定粘度的药物的计量元件来确定。

公开(公告)号：US20140366927A1

公开(公告)日：2014-12-18

申请号：US14373687

申请日：2013-01-23

Applicant: STC.UNM

Inventor： Olga A. Lavrova ,  Christos G. Christodoulou ,  Sang M. Han ,  Ganesh Balakrishnan

IPC: H01L31/04 ,  H01L31/0735 ,  H01L31/0745 ,  H01L31/18 ,  H01L31/0725

CPC classification number: H01L31/0725 ,  H01L31/043 ,  H01L31/0735 ,  H01L31/0745 ,  H01L31/1085 ,  H01L31/1804 ,  H01Q1/248 ,  H01Q9/27 ,  H02J7/025 ,  H02J17/00 ,  H02J50/00 ,  H02J50/20 ,  H02J50/27 ,  H02J50/40 ,  H02S10/30 ,  Y02E10/547 ,  Y02P70/521

Abstract: Provided is an energy harvesting device, including a solar cell including at least one active layer for receiving a first range of electromagnetic frequencies, at least one layer including antenna structures for receiving RF energy and formed on a first side of the solar cell, and at least one semiconductor for absorbing IR energy, and formed on a second side of the solar cell opposite the first side.

Abstract translation: 提供了一种能量收集装置，其包括太阳能电池，其包括用于接收第一范围的电磁频率的至少一个有源层，至少一个层，包括用于接收RF能量的天线结构并形成在太阳能电池的第一侧上，以及在 至少一个用于吸收IR能量的半导体，并且形成在与第一侧相对的太阳能电池的第二侧上。

公开(公告)号：US20140323292A1

公开(公告)日：2014-10-30

申请号：US14359087

申请日：2012-11-21

Applicant: STC.UNM

Inventor： Claudia Catalina Luhrs ,  Eric Brosha ,  Jonathan Phillips

IPC: B01J23/42 ,  B01J21/04 ,  B01J21/18 ,  B01J21/06

CPC classification number: B01J23/42 ,  B01J21/04 ,  B01J21/063 ,  B01J21/18 ,  B01J23/44 ,  B01J23/745 ,  B01J23/755 ,  B01J35/002 ,  B01J35/006 ,  B01J35/0093 ,  B01J35/1014 ,  B01J35/1028 ,  B01J37/0036 ,  B01J37/04 ,  B01J37/16 ,  H01M4/88 ,  H01M4/8842 ,  H01M4/9041 ,  H01M4/925 ,  H01M4/926

Abstract: Provided is a method for making a supported metal catalyst. The method includes forming a mixture comprising a high surface area support, a reducing agent precursor that decomposes to produce reducing gases below about 1200° C., and a metal catalyst precursor. The mixture is heated to a temperature sufficient to decompose the reducing agent precursor to produce a reducing agent, and then cooled to form the supported metal catalyst.

Abstract translation: 提供一种制备负载型金属催化剂的方法。 该方法包括形成包含高表面积载体，分解产生低于约1200℃的还原气体的还原剂前体和金属催化剂前体的混合物。 将混合物加热到足以分解还原剂前体以产生还原剂的温度，然后冷却以形成负载的金属催化剂。

公开(公告)号：US08834838B2

公开(公告)日：2014-09-16

申请号：US13854560

申请日：2013-04-01

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg ,  Richard S. Larson

IPC: A61K51/00 ,  A61M36/14 ,  C07F9/94 ,  C07F5/00 ,  A61K51/04 ,  A61K49/10

CPC classification number: C07F5/003 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0474 ,  A61K51/0482 ,  A61K51/0485 ,  A61K51/0497 ,  C07F9/94

Abstract: The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US08716045B2

公开(公告)日：2014-05-06

申请号：US13783219

申请日：2013-03-01

Applicant: STC.UNM

Inventor： Stephen D Hersee ,  Xin Wang ,  Xinyu Sun

IPC: H01L21/00 ,  H01L29/41

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10-1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

Abstract translation: 示例性实施例提供包括高质量（即，无缺陷）III-N族纳米线和均匀III-N纳米线阵列的半导体器件及其可制造的可扩展工艺，其中位置，取向，横截面特征，长度和 可以精确地控制每个纳米线的结晶度。 可以使用脉冲生长模式来制造公开的提供约10nm至约1000微米的均匀长度的III-N族纳米线和/或纳米线阵列，其具有恒定的横截面特征，包括约10-1000nm的示例性直径。 此外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构，以便制造可见的LED和激光器。 此外，核 - 壳纳米线/ MQW活性结构可以通过在每个纳米线的非极性侧壁上的核 - 壳生长形成。

公开(公告)号：US20140064312A1

公开(公告)日：2014-03-06

申请号：US14032904

申请日：2013-09-20

Applicant: STC.UNM

Inventor： Seung Chang Lee ,  Steven R.J. Brueck

IPC: H01L21/02 ,  H01S5/32 ,  H01L29/15

CPC classification number: H01L21/02603 ,  B82Y10/00 ,  B82Y40/00 ,  B82Y99/00 ,  H01L21/0237 ,  H01L21/02439 ,  H01L21/02507 ,  H01L21/02521 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/127 ,  H01L29/158 ,  H01L29/7783 ,  H01L29/7853 ,  H01L33/06 ,  H01L33/18 ,  H01S5/32 ,  Y10S977/951 ,  Y10S977/962

Abstract: Exemplary embodiments provide semiconductor nanowires and nanowire devices/applications and methods for their formation. In embodiments, in-plane nanowires can be epitaxially grown on a patterned substrate, which are more favorable than vertical ones for device processing and three-dimensional (3D) integrated circuits. In embodiments, the in-plane nanowire can be formed by selective epitaxy utilizing lateral overgrowth and faceting of an epilayer initially grown in a one-dimensional (1D) nanoscale opening. In embodiments, optical, electrical, and thermal connections can be established and controlled between the nanowire, the substrate, and additional electrical or optical components for better device and system performance.

Abstract translation: 示例性实施例提供用于其形成的半导体纳米线和纳米线器件/应用和方法。 在实施例中，平面内纳米线可以在图案化衬底上外延生长，其比用于器件处理和三维（3D）集成电路的垂直纳米线更有利。 在实施方案中，可以通过使用最初在一维（1D）纳米尺度开口中生长的外延层的横向过生长和刻面的选择性外延来形成平面内纳米线。 在实施例中，可以在纳米线，衬底和附加电气或光学部件之间建立和控制光学，电气和热连接，以获得更好的器件和系统性能。